| Not Yet Recruiting | Education-Based Oral Health Promotion Intervention During Pregnancy: Implementation Protocol in Bangladesh NCT07507045 | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | N/A |
| Not Yet Recruiting | Influence of Finishing Clear Aligner Marginal Termination Design on Subgingival Periodontal Microbiota During NCT07533058 | George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures | N/A |
| Not Yet Recruiting | Oral Health, Dento-facial Condition and OHRQoL in Subjects With Mowat-Wilson Syndrome: an Epidemiologic Study. NCT07476417 | University of Milan | — |
| Not Yet Recruiting | Development, Validation, and Assessment of the Diagnostic Accuracy of a Questionnaire for Periodontitis Screen NCT07461753 | Azienda Unità Sanitaria Locale (A.U.S.L.) Ferrara, Italy | — |
| Not Yet Recruiting | Validity of a Self-reported Questionnaire for Periodontal Status in a Saudi Population NCT07397104 | Universiti Sains Malaysia | — |
| Not Yet Recruiting | Klotho Gene, Red Complex Bacteria and Periodontal Viruses in Patients With and Without Periodontitis and Acute NCT07504744 | Meenakshi Ammal Dental College and Hospital | — |
| Not Yet Recruiting | 3D Printed Customized Bone Graft for Alveolar Regeneration: Longitudinal Cohort Evaluation NCT07405918 | University of Guarulhos | — |
| Not Yet Recruiting | Accuracy and Periodontal Outcomes of Three Interproximal Enamel Reduction Techniques During Clear Aligner Ther NCT07377825 | Riyadh Elm University | N/A |
| Not Yet Recruiting | Development of A Self-Assessment Tool for Personalized Preventive Periodontal Care Among the Saudi Population NCT07410351 | Universiti Sains Malaysia | — |
| Not Yet Recruiting | Markers of Bone Destruction and Oxidative Stress in Peri-implantitis NCT07397884 | Saglik Bilimleri Universitesi | — |
| Not Yet Recruiting | Evaluation of the Effects of Levodopa-Benserazide Drug Combination on Periodontal Status in Patients With Park NCT07405268 | Saglik Bilimleri Universitesi | — |
| Not Yet Recruiting | Detection of Microplastics in Patients With Periodontitis NCT07231198 | Sigmund Freud PrivatUniversitat | — |
| Active Not Recruiting | Efficacy of Camel Whey Protein and Camel Whey Protein Nanoparticles for Treating Intra-bony Periodontal Defect NCT07358104 | Kafrelsheikh University | N/A |
| Not Yet Recruiting | AI-Assisted Saliva Diagnostics Using an Electrochemical Sensor Platform for Periodontitis Detection (SALIENCE) NCT07254039 | Ostergotland County Council, Sweden | — |
| Recruiting | HALP Score, Blood-Based Inflammatory Indices, and Salivary MMP-8 in Periodontal Disease and Healing After Non- NCT07312045 | Ömer Faruk Okumuş | — |
| Not Yet Recruiting | Diagnostic Accuracy of Oral Images, OPGs, and Questionnaires vs. Clinical Assessment for Periodontal Disease NCT07164573 | Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University | — |
| Not Yet Recruiting | Inflammation-resolution Therapy in MINST of Periodontal Intrabony Defect: a Pilot Randomised Controlled Trial NCT07203872 | Guy's and St Thomas' NHS Foundation Trust | N/A |
| Recruiting | Periodontal Status and Disease Severity in Pemphigus Vulgaris Patients NCT07384221 | Saglik Bilimleri Universitesi | — |
| Completed | Dental and Periodontal Health Levels of Dental and Medical Faculty Students NCT07425860 | Recep Tayyip Erdogan University Training and Research Hospital | — |
| Recruiting | ORAL HYGIENE, PERIODONTAL STATUS AND QUALITY OF LIFE NCT07530978 | Abant Izzet Baysal University | — |
| Not Yet Recruiting | LONGITUDINAL FOLLOW-UP STUDY TO DETERMINE THE PREDICTIVE ABILITY OF A PANEL OF BIOMARKERS IN SALIVA IN HEALTHY NCT07167771 | Universidad Complutense de Madrid | — |
| Not Yet Recruiting | Occlusal Load Distribution and Periodontal Status NCT07199062 | University of Bari Aldo Moro | — |
| Not Yet Recruiting | The Effect of Regular Home Use of Dual-light Antibacterial Photodynamic Therapy (aPDT) or the Use of a Powered NCT07166224 | Blekinge Institute of Technology | N/A |
| Completed | Prevalence of Periodontitis in Egyptian Multiple Sclerosis Patients. NCT07195110 | Cairo University | — |
| Recruiting | Interdental Hygiene Methods in Young Adults NCT06848790 | Hospices Civils de Lyon | N/A |
| Not Yet Recruiting | Gingival Crevicular Fluid Oxidized Low-Density Lipoprotein Levels in Health and Stage III/IV Periodontitis NCT07157878 | shaimaa hamdy | — |
| Active Not Recruiting | Improving Gum Health Among Older Adults Using AI Based mHealth for Personalized OHI NCT07187453 | The University of Hong Kong | N/A |
| Not Yet Recruiting | Effect of Systemic Retinoic Acid Use on Micro Ribonucleic Acid (mRNA) Expression NCT07142070 | Medipol University | N/A |
| Recruiting | Treatment of Periodontal Intra-bony Defects With a Volume Stable Collagen Matrix or Deproteinized Bovine Bone NCT06676826 | University of Bern | N/A |
| Recruiting | Microsurgery and Periodontal Healing NCT07054008 | The University of Texas Health Science Center at San Antonio | N/A |
| Recruiting | Treatment of Intrabony Defects With Injectable Platelet-Rich Fibrin and Xenogenic Grafts NCT07146776 | Saglik Bilimleri Universitesi | N/A |
| Recruiting | Evaluation Of The Efficacy Of Subgingival Application Of Lovastatin Gel As An Adjunct To Non-Surgical Treatmen NCT07282756 | Medical University of Silesia | N/A |
| Not Yet Recruiting | Micro-Needling Technique Using Ozonated Olive Oil in Periodontal Diseases NCT06990282 | Fayoum University | Phase 2 |
| Recruiting | The Role of Granulation Tissue in Periodontal Regeneration NCT07254117 | Riga Stradins University | — |
| Enrolling By Invitation | Histatin-1 Levels in Smokers and Non-smokers With Periodontitis Patients: A Comparative Study Before and After NCT07367737 | University of Baghdad | N/A |
| Enrolling By Invitation | Assessment of Tooth Mobility After Non-surgical Periodontal Treatment Followed by Tooth Splinting NCT06929676 | University of Campinas, Brazil | N/A |
| Completed | Periodontal Health and Quality of Life in Psoriasis Patients NCT07154420 | Saglik Bilimleri Universitesi | — |
| Not Yet Recruiting | RGD With Minimally Invasive Non-Surgical Technique in Treatment of Periodontal Intrabony Defect NCT06936605 | Minia University | N/A |
| Completed | The Effect of Bristle Brush, Rubber Cup, and Air Polishing on Tooth Surface Roughness of Scaled Teeth NCT06857474 | Khyber Medical University Peshawar | N/A |
| Completed | Propolis Lozenges Extract and Their Effect on Salivary Biomarkers and on Oral Health Condition in (19_24) Year NCT06888453 | Al-Mustansiriyah University | Phase 1 |
| Completed | Food Biodiversity and Human Health NCT06315088 | Hospices Civils de Lyon | N/A |
| Recruiting | Regular Use of aPDT in the Management and Prevention of Periodontitis Symptoms in Diabetic Patients NCT06486012 | Wellbeing Services County of Pirkanmaa | N/A |
| Completed | Assessment of Salivary Biomarker Levels in Individuals With Various Periodontal Diseases NCT07025291 | Izmir Katip Celebi University | N/A |
| Completed | The Role of Smoking in Periodontal Status NCT07295756 | Tuğba ŞAHİN | — |
| Recruiting | An Evaluation of the Effect of the Erchonia FX-405 Laser as an Adjunctive Treatment of Periodontitis NCT06656325 | Erchonia Corporation | N/A |
| Not Yet Recruiting | Periodontal Initial Treatment Combined With Glucocorticoid Therapy for Erosive Oral Lichen Planus NCT06498180 | Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University | N/A |
| Recruiting | Periodontal Health and Sodium Bicarbonate Toothpaste NCT07274189 | University of Plymouth | N/A |
| Not Yet Recruiting | Effect of Internal and External Micro-needling in Treatment of Stage III Periodontitis NCT06578403 | Misr University for Science and Technology | N/A |
| Completed | Association of Coffee With Periodontal Status NCT07166276 | Tuğba ŞAHİN | — |
| Active Not Recruiting | The Effect of an Antioxidant Gel Compared to Chlorhexidine Gel During the Soft Tissue Healing Process: A Rando NCT06894667 | Kuwait University | Phase 4 |
| Completed | Asprosın And Tumor Necrosıs Factor-α Levels In Type 2 Dıabetıc Chronıc Periodontitis NCT06993818 | Eda Cetin Ozdemir | — |
| Recruiting | Hyaluronic Acid and Polynucleotides for Supra-bony Defects NCT06309719 | Queen Mary University of London | N/A |
| Not Yet Recruiting | Photobiomodulation and Platelets Rich in Growth Factors (PRGFs)-Assisted Flap Surgery in Treating Stage III Pe NCT06641739 | Assiut University | N/A |
| Enrolling By Invitation | Hydroxyapetite Nanoparticles and Tricalcium Phosphate Nanoparticles Loaded on Platelet Rich Fibrin Membranes f NCT07088809 | Enas Elgendy | N/A |
| Recruiting | Oral Health Intervention in Adult Primary Care NCT06555029 | Case Western Reserve University | N/A |
| Enrolling By Invitation | A Comparison of Chlorhexidine and Green Tea Mouthwash in Patients With Gingivitis and Their Salivary Neutrophi NCT06875440 | Islamic Azad University, Sanandaj | N/A |
| Completed | Digital PCR for Quantifying Periodontal Pathobionts NCT06692595 | University of Ljubljana | — |
| Not Yet Recruiting | Mechanisms of Acute Inflammation Following Periodontal Treatment NCT05178563 | University College, London | N/A |
| Recruiting | Healthy Plant-based Diet and Periodontal Treatment NCT06753682 | The University of Hong Kong | N/A |
| Recruiting | F.L.O.S.S. Project (Facilitated Lessons on Oral and Systemic Health in Survivors) NCT06315855 | Georgetown University | N/A |
| Recruiting | Assessment of Salivary GM-CSF, MIP, and IL-1β Levels in Subjects With Varying Periodontal Conditions NCT06961409 | Izmir Katip Celebi University | — |
| Completed | Clinical Assessment of Chitosan Nanoparticles on Periodontal Problems Post Steroidal Inhalation in Asthmatic P NCT06525363 | Deraya University | Phase 1 |
| Not Yet Recruiting | Relationships Between Tenascin C, Smoking and Periodontal Status NCT06523205 | Necmettin Erbakan University | — |
| Not Yet Recruiting | Impact of Smoking on Salivary Interleukin (IL)-39, IL-41, IL-1β, TNF-α Levels in Periodontal Disease NCT06528522 | Necmettin Erbakan University | — |
| Not Yet Recruiting | Periodontal Disease and Salivary Mitofusin Levels NCT06510608 | Erzincan University | — |
| Active Not Recruiting | Entire Papilla Preservation Technique in the Treatment of Periodontal IntraBony Defects: a 1-year Follow-up St NCT06744348 | Necmettin Erbakan University | — |
| Not Yet Recruiting | Determination of Salivary Soluble Urokinase Plasminogen Activator Receptor (SuPAR), Hypoxia-inducible Factor-1 NCT06430450 | Karamanoğlu Mehmetbey University | — |
| Recruiting | Impact of Subgingival Instrumentation on Psychological Distress and Mental Health Status in Bruxers With Perio NCT06435208 | Postgraduate Institute of Dental Sciences Rohtak | N/A |
| Unknown | Evaluation of Inflammasome Gene Polymorphisms in Periodontitis Patients NCT06465095 | Marmara University | — |
| Recruiting | Effectiveness of SRP+ Lipo-curcumin Gel for the Treatment of Stage III Periodontitis. NCT06624241 | G. d'Annunzio University | N/A |
| Completed | Effect of Intracanal Medicaments on Post-Operative Pain in Symptomatic Apical Periodontitis: An RCT NCT07123792 | HITEC-Institute of Medical Sciences | N/A |
| Completed | A Clinical Study of Connective Tissue Graft and Enamel Matrix Derivative in the Treatment of Intrabony Periodo NCT07233733 | Phạm Đình Thiên Khải | N/A |
| Unknown | Periodontal Management in Hypertensive Patients (PERIOTENSION Trial I) NCT04328389 | University of L'Aquila | N/A |
| Not Yet Recruiting | Staging and Grading of Periodontitis: Five Years Later NCT06188884 | University of Roma La Sapienza | — |
| Completed | Clinical and Radiographic Evaluation of The Effect of Acetal Resin Versus PEEK on Supporting Structure of Abut NCT06882161 | Al-Azhar University | Phase 3 |
| Completed | Comparison of Salivary Biormarkers Levels With Periodontal Clinical Parameters in Smokers and Non-Smokers With NCT06459037 | Izmir Katip Celebi University | N/A |
| Recruiting | Evaluation of Salivary Galectin-8, Galectin-9 and RANKL Levels of Individuals With Different Periodontal Disea NCT06404476 | Izmir Katip Celebi University | N/A |
| Recruiting | Evaluation of Salivary Gal-7, Gal-10 and MMP-9 Levels of Individuals With Different Periodontal Diseases NCT06186908 | Izmir Katip Celebi University | N/A |
| Completed | Evaluation of Salivary Adseverin, 1-Alpha Defensin and sRANKL Levels of Individuals With Different Periodontal NCT06402877 | Izmir Katip Celebi University | N/A |
| Completed | Shaping the Indications for Periodontal Adjunctive Antibiotics in Dental Practice NCT06131021 | Rutgers, The State University of New Jersey | Phase 3 |
| Completed | Effect of Non-chirurgical Periodontal Treatment on the Immune System From a Gender Perspective NCT06261723 | Milagros Rocha Barajas | — |
| Completed | Dietary Nitrate Functional Gum Effect on Gingivitis and Heart Health NCT06029283 | University of Maryland, Baltimore | N/A |
| Completed | EVALUATION OF SALIVARY BİOMARKER LEVELS IN SMOKING AND NON-SMOKER INDIVIDUALS WITH DIFFERENT PERIODONTAL DISEA NCT06971770 | Izmir Katip Celebi University | N/A |
| Recruiting | Third Molars Extraction and Periodontal Disease NCT06520137 | Azienda Ospedaliera Universitaria Senese | — |
| Enrolling By Invitation | Non-surgical Periodontal Treatment With Adjunctive Use of Lactoferrin Contained in Toothpaste and Mouthwash NCT06311253 | University of Pavia | N/A |
| Enrolling By Invitation | Non-surgical Treatment of Chronic Periodontitis With an Adjunctive Vitamin E and Coenzyme Q10 Supplementation NCT06373848 | Islamic Azad University, Sanandaj | N/A |
| Completed | Treatment of Peri-implant Bone Dehiscence Using Autogenous Tooth Plate NCT06313216 | Kafrelsheikh University | N/A |
| Unknown | Accuracy of an AI-clinical Knowledge-based Hybrid System for Detecting Periodontitis in OPG Images NCT06306677 | Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University | — |
| Enrolling By Invitation | Adjunctive Periodontal Treatment With Coenzyme Q10 in Association With Probiotics for Pregnant Women NCT06308497 | University of Pavia | N/A |
| Completed | The Effect of Non-surgical Periodontal Treatment on Dickkoff-1 and Secreted Frizzled Related Protein-5 Levels NCT06727929 | Cumhuriyet University | — |
| Completed | Interactive School-Based Oral Health Education Program to Reduce Periodontal Disease in Palestinian Adolescent NCT07055932 | Al-Quds University | N/A |
| Completed | Association Between Periodontitis and the Level of Anti-citrullinated Protein Antibodies in Rheumatoid Arthrit NCT05706493 | Misr International University | — |
| Unknown | Minimally Non Surgical Periodontal Therapy Compared to Traditional Approach NCT05060601 | Federico II University | N/A |
| Enrolling By Invitation | CoQ10 and Omega-3 as Adjuncts to Periodontal Therapy, TAC of Saliva. NCT06358963 | Amirhossein Farahmand | N/A |
| Completed | Clinical and Microbiological Evaluation Of The Efficacy Of Herbal Mouthwashes in Gingivitis NCT06904742 | Altinbas University | Phase 4 |
| Recruiting | Periodontal Regeneration With Recombinant Human Platelet Derived Growth Factor (rH-PDGF-BB) and Allograft NCT06162832 | Universidad Autonoma de Nuevo Leon | Phase 2 |
| Unknown | Clinical Efficacy of Saffron Mouth Rinse in Periodontitis Patients With Renal Disease NCT06235021 | British University In Egypt | N/A |
| Withdrawn | Inulin Supplementation During Sanative Therapy to Further Improve Periodontal Healing NCT04670133 | Brock University | N/A |
| Completed | Thyme Honey Mouthwash in Management of Periodontitis in Renal Patients NCT06129097 | British University In Egypt | N/A |
| Active Not Recruiting | Observational Prospective Study on Resective and Regenerative Periodontal Therapy: Short & Longterm Follow-up NCT07283393 | University Hospital, Ghent | — |
| Unknown | Efficacy of Thyme Honey as a Novel Adjunct to Non-surgical Periodontal Therapy NCT06201975 | British University In Egypt | N/A |
| Completed | GCF and Saliva Levels of IL-36α in Periodontal Disease NCT07497828 | Ordu University | N/A |
| Completed | Oral Photographs of Patients on Oral Hygiene Motivation NCT06316505 | Didem OZKAL EMINOGLU | N/A |
| Recruiting | The Accuracy of Infrared Thermographic Imaging for Assessment of Periodontal Status NCT06290414 | Ain Shams University | — |
| Unknown | MRI as Alternative to CBCT for the Assessment of Furcation Involvement in Molars NCT06116487 | Medical University of Vienna | — |
| Completed | The Immediate Effectiveness of a 3D Intraoral Scanner as an Oral Hygiene Educational Tool NCT06349330 | National University Hospital, Singapore | N/A |
| Completed | Effect of TCI188 Probiotic on Oral Health NCT06141083 | TCI Co., Ltd. | N/A |
| Recruiting | Clinical and Microbiological Evaluation of Laser Assisted New Attachment Procedure (LANAP) Using Nd:Yag vs. Di NCT06358937 | Mahmoud Salem | N/A |
| Completed | Evaluation of Microbial Status in Gastritis Patients in Different Periodontal Conditions NCT07378540 | Aydin Adnan Menderes University | — |
| Completed | Periodontal Disease and Colorectal Cancer NCT06799182 | University Medical Centre Ljubljana | N/A |
| Unknown | Hydroxylated Polymethoxy Flavones Solid Dispersion in Treatment of Periodontitis NCT05546788 | Assiut University | Phase 1 |
| Completed | Clinical Relevance of Different Time of Periodontal Re-evaluation NCT06086821 | University of Florence | N/A |
| Unknown | The Severity of Periodontitis at the Buccal and Palatal Site NCT06031896 | The Dental Hospital of Zhejiang University School of Medicine | — |
| Unknown | A Decision Support System Based on Classification Algorithms for the Diagnosis of Periodontal Disease NCT06071338 | Ministry of Health, Saudi Arabia | — |
| Completed | Exploring 8-iso Prostaglandin F2α and Adenosine Deaminase Levels in Periodontal Health and Disease NCT06236555 | Eda Cetin Ozdemir | N/A |
| Unknown | Periodontal Health and Its Impact on Oral Health-related Quality of Life Among Diabetes Mellitus Patients NCT06125561 | Pakistan Institute of Medical Sciences | — |
| Active Not Recruiting | Oral Health In Cirrhosis of the Liver (ORACLE) NCT06052150 | Hunter Holmes Mcguire Veteran Affairs Medical Center | — |
| Active Not Recruiting | Evaluation of Locally Delivered Propolis Gels in Periodontitis NCT06663995 | Ain Shams University | N/A |
| Unknown | Evaluation of Outcomes of Minimally Invasive Non- Surgical Versus Surgical Therapy in Furcation Involvement. NCT06025955 | Postgraduate Institute of Dental Sciences Rohtak | N/A |
| Completed | Low-Level Laser Therapy and Injectable Platelet-Rich Fibrin for Thin Gingival Phenotype. NCT06756854 | Faculty of Dental Medicine for Girls | Phase 3 |
| Completed | Gingival Crevicular Fluid of Adiponectin and Resistin As Predictable Implement in Staging and Grading System o NCT06604013 | Al-Azhar University | N/A |
| Completed | Frequency of Periodontal Disease in Head and Neck Cancer Patients After Radiation Therapy NCT06667362 | Ain Shams University | — |
| Unknown | Toothpaste With Sodium Carbonate in Patients With Gingivitis NCT06224699 | University of Catania | N/A |
| Unknown | Vital Root Amputation in Molars With Advanced Periodontal Furcation Involvement: a Preliminary Study NCT05721313 | Azienda Ospedaliera, Universitaria Policlinico Vittorio Emanuele | N/A |
| Completed | Application of L-PRF in Periodontal Surgery NCT06296498 | The University of Texas Health Science Center at San Antonio | N/A |
| Recruiting | Changes in Microbial Status From Dentate, Edentulous and After Dental Implant Placement NCT06149585 | Case Western Reserve University | — |
| Completed | sTREM-1, sTREM-2, Presepsin, and Periodontitis NCT05924828 | Ataturk University | — |
| Completed | Electroacupuncture as an Adjunct to Non-Surgical Periodontal Therapy NCT06247007 | Didem OZKAL EMINOGLU | N/A |
| Completed | Effect of Low-Level Laser on Crevicular Interleukin-1β Concentration in Patients With Periodontal Disease: A R NCT06677385 | Misr University for Science and Technology | N/A |
| Unknown | High Frequency Intraoral Ultrasound Probe for Early Diagnosis of Periodontal Diseases NCT05809427 | University Hospital, Tours | N/A |
| Enrolling By Invitation | Comparison of Gingival Flap Procedure Using Conventional Surgical Loupes vs. Videoscope for Visualization NCT05932017 | Texas A&M University | — |
| Recruiting | NOVOSYN® Quick Versus MONOSYN® Quick Suture Material in Resective Periodontal Surgery NCT05813236 | Aesculap AG | N/A |
| Unknown | Comparison of Salivary and Crevicular Protein Concentrations of FIBA, PLMN, HEMO and ApoH in Healthy and Perio NCT05511454 | University Hospital, Montpellier | N/A |
| Completed | Effects of Omega-3 as an Adjunct to Non-Surgical Periodontal Therapy on Chemerin Level in Periodontitis Patien NCT06463535 | British University In Egypt | N/A |
| Unknown | Association Between Periodontal Status and Mental Health in Postpartum Women NCT05869981 | Postgraduate Institute of Dental Sciences Rohtak | — |
| Recruiting | Characterization of JAK1 and JAK2 Activation in Gingival Tissues During Homeostasis and Periodontitis NCT07536204 | University of Chile | — |
| Unknown | DKK-3 rs11544814 and CFH rs10737680 Polymorphism and Protein Levels With Non Surgical Periodontal Therapy in P NCT05828368 | Meenakshi Ammal Dental College and Hospital | N/A |
| Recruiting | Three Types of Papilla Incision in Periodontal Surgery NCT06428149 | Universidad de Murcia | N/A |
| Completed | Effectiveness of an Oral Health Literacy Intervention on Oral Health Behaviors and Plaque Index in Orthodontic NCT06666374 | Srinakharinwirot University | N/A |
| Completed | Evaluation of a Herbal Antiseptic Gel as a Supportive Treatment for Teeth Cleaning in Patients With Periodonta NCT07135674 | Rungta College of Dental Sciences and Research | Phase 4 |
| Completed | Papilla Preservation Technique in Combination With Tooth Enamel Proteins and Animal Derived Bone Graft in Trea NCT07119307 | Rungta College of Dental Sciences and Research | Phase 4 |
| Completed | Influence of Local Doxycycline on the Outcomes of Periodontal Regeneration NCT05878353 | University of Turin, Italy | N/A |
| Unknown | Periodontopathogens of Periodontal Patients NCT05940714 | University of Barcelona | N/A |
| Completed | Annexin Levels of Periodontal Inflammatory Regulation NCT06554756 | Medipol University | N/A |
| Completed | A Comparison of the Accurate Diagnosis of the Horizontal & Vertical Bitewing Images NCT04341636 | King Abdulaziz University | N/A |
| Unknown | Efficacy of rhPDGF as an Adjunct to Non-surgical Periodontal Therapy of Intrabony Defects NCT05858411 | G. d'Annunzio University | N/A |
| Completed | Minimally Invasive Surgical Technique in Management of Intrabony Defects NCT06591416 | Misr University for Science and Technology | N/A |
| Active Not Recruiting | Behavioral Intervention Program Based on Motivational Interview NCT05948722 | Universidade Federal de Santa Maria | N/A |
| Completed | Internalized Stigma and Tooth Loss Due to Periodontitis NCT07065019 | Akdeniz University | — |
| Enrolling By Invitation | Evaluation of the Effects of Probiotic Toothpastes on Periodontal Health NCT06514664 | Kutahya Health Sciences University | N/A |
| Unknown | Effect of Ozone Oil After Non-surgical Periodontal Treatment NCT05838209 | Universidade Federal Fluminense | N/A |
| Recruiting | The Role of Diet in Periodontal Inflammation: A Controlled Clinical Study NCT05864768 | G. d'Annunzio University | N/A |
| Unknown | Treatment of Advanced Periodontitis With a Chitosan Brush and a Chitosan Gel NCT05773911 | Caspar Wohlfahrt | N/A |
| Completed | Concordance in Diagnosis of Periodontitis in Diabetic Patients Between an Indirect Method Based on a Photograp NCT05890807 | Centre Hospitalier Universitaire de Nīmes | N/A |
| Unknown | Impact of Full Mouth Erythritol Powder Air Polishing on Systemic Inflammatory Response NCT05812391 | University of Baghdad | N/A |
| Unknown | Efficacy of Subgingival Erythritol Air Polishing in Treatment of Periodontal Pockets NCT05798871 | University of Baghdad | N/A |
| Completed | Anti-inflammatory and Anti-plaque Efficacies of Mouth Rinse Containing Hyaluronic Acid and Hydrogen Peroxide NCT05787600 | University of Baghdad | Phase 3 |
| Completed | Assessment of Pentraxin Levels in the Gingival Fluid of Abutment Teeth in the Context of the Use of Fixed Dent NCT07271563 | Jagiellonian University | — |
| Completed | Guided Tissue Regeneration With a Periodontal Dressing NCT05756946 | Arab American University (Palestine) | N/A |
| Completed | Periodontal Health and Its Relationship With Psychological Stress NCT05849415 | D'Albis Dental | — |
| Completed | Clinical Efficacy of Vector Paro With Hydroxyapatite in the Supportive Therapy of Periodontitis NCT07482280 | Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia | N/A |
| Completed | Interleukin- 17 (IL-17), Bcl-3, and NF-kappa-B Inhibitor Zeta (IκBζ) Expression Levels in the Psoriasis Patien NCT06408454 | Kahramanmaras Sutcu Imam University | — |
| Completed | Periodontal Status in Patients With Chronic Skin Diseases NCT06073613 | University of Medicine and Pharmacy at Ho Chi Minh City | — |
| Completed | Home Use of Dual-light Photodynamic Therapy for Chronic Periodontitis NCT05425784 | Koite Health Oy | N/A |
| Completed | Clinical And Radiographic Evaluation Of Zinc Substituted Nanohyrdoxyappatite Bone Graft And Advanced Platelet NCT07313254 | Suez Canal University | N/A |
| Unknown | Insulin Versus Hyaluronic Acid in Management of Periodontal Defects NCT05746676 | October University for Modern Sciences and Arts | Phase 3 |
| Active Not Recruiting | Microbiological Effect of 0.12% Chlorhexidine Digluconate and 0.05% Cetylpyridinium Chloride vs Probiotics (La NCT07489924 | Universidad de Colima | Phase 4 |
| Completed | Effect of Probiotics on Periodontitis Stage III Grade C Molar-incisor Pattern NCT06253988 | Al-Azhar University | Phase 3 |
| Completed | GCF Levels of Chemokines in Periodontitis NCT06291454 | Ordu University | — |
| Completed | "Effect of CPA/EE Drug on Periodontal Tissue and hsCRP Levels in PCOS Patients With Gingivitis NCT05657171 | Postgraduate Institute of Dental Sciences Rohtak | — |
| Unknown | Application of Hyaluronic Acid in Diabetes NCT05543434 | Cairo University | N/A |
| Completed | Vitamin D Supplementation Prior to Non-surgical Periodontal Therapy NCT05398770 | University of Tromso | N/A |
| Active Not Recruiting | Type I Diabetes and Non-surgical Periodontal Treatment NCT05569525 | University of Florence | N/A |
| Completed | Therapeutic Application of Coconut Oil in Oral Health NCT06049589 | Fundacion Clinica Pardinas | N/A |
| Unknown | Gingival Health and Malocclusion Among Type 1 Diabetic Children and Adolescents NCT06291129 | Universidade Federal Fluminense | N/A |
| Unknown | Flapless Application of Enamel Matrix Derivative in Class II Mandibular Furcation Defects NCT05541614 | Aristotle University Of Thessaloniki | N/A |
| Unknown | Ozone Gel Application in Controlled Type 2 Diabetic Patients With Periodontitis NCT05538078 | Cairo University | N/A |
| Recruiting | Novel Dental Gel as an Adjunct to Scaling and Root Planing NCT05384132 | University of Alabama at Birmingham | N/A |
| Completed | Efficacy of a Probiotic and Microbiological Analysis on Oral Complications in Patients With HNC NCT06122636 | University of Barcelona | N/A |
| Unknown | Assessment of the Effect of Non-surgical Periodontal Treatment on Endothelial Function- a Prospective Study NCT05691426 | University of Sharjah | — |
| Completed | Antipsychotic Induced Hyperprolactinemaia as Risk Factor for Periodontitis in Schizophrenic Patients NCT06040944 | Fayoum University | — |
| Completed | Serum Levels of Vitamin D and IL8 in Patients With Periodontitis NCT06306937 | Mansoura University | — |
| Unknown | Effect of Adjunctive Use of Vitamin B3 and B9 on Myeloperoxidase Level in the GCF of Patients With Stage I and NCT05435378 | Cairo University | EARLY_Phase 1 |
| Completed | Probiotics as Adjunct to Non Surgical Periodontal Therapy for Pregnant Women Oral Health NCT05400538 | University of Pavia | N/A |
| Completed | Immediate Post-Operative Anesthesia With Either Lidocaine or Bupivacaine NCT06293807 | The University of Texas Health Science Center at San Antonio | EARLY_Phase 1 |
| Completed | Azithromycin Versus Doxycycline on Restistin Level in Periodontitis Patients With Type 2 Diabetes NCT06199440 | King Abdulaziz University | Phase 1 / Phase 2 |
| Completed | Effect of Aerosol From THS and Cigarette Smoke on Periodontal Tissues and Its Microbiome NCT06480877 | Clinical Hospital Center Rijeka | — |
| Completed | The Effects of Pregnancy on Oral Health NCT06343337 | Muğla Sıtkı Koçman University | N/A |
| Completed | Kynurenine Pathway in Parkinson's Disease NCT07272564 | Medipol University | N/A |
| Recruiting | Periodontal Granulation Tissue Preservation in Surgical Periodontitis Treatment NCT05533528 | Universidad de Murcia | N/A |
| Unknown | Graphene Oxide in the Surgical Management of Intrabony Periodontal Defects NCT05341245 | Ain Shams University | N/A |
| Completed | Periodontal Gel in NSPT NCT07534449 | University of Roma La Sapienza | N/A |
| Unknown | Effect of Periodontal Maintenance Therapy on Tooth Loss in Regular and Irregular Compliant Smokers and Non-Smo NCT04938089 | Saint-Joseph University | — |
| Completed | Clinical and Microbiologic Outcomes of Adjunctive Antimicrobial Photodynamic Therapy in the Non-surgical and S NCT05252000 | The University of Texas Health Science Center, Houston | N/A |
| Unknown | Role of the Oral Microbiome & Mucosal Immunity in COVID-19 Disease NCT05212766 | King's College London | — |
| Completed | Hyaluronic Gel vs Chlorhexidine in Periodontal Patients NCT05312606 | University of Pavia | N/A |
| Completed | Plaque Control Efficacy Between Interdental Brushes Versus Dental Floss NCT05439785 | Fatima Jinnah Dental College | N/A |
| Unknown | Empowering Older Adults for Healthy Living and Better Dental Health NCT04946292 | National University of Singapore | N/A |
| Completed | Active MMP-8 in Oral Fluid for the Detection of Oral and Oropharyngeal Cancer NCT06701058 | Helsinki University Central Hospital | — |
| Completed | In-office and Domiciliary Use of a New Ozonized Gel for the Management of Periodontal Disease NCT05254288 | University of Pavia | N/A |
| Completed | Guided Biofilm Therapy for Periodontal Patients. NCT05263622 | University of Pavia | N/A |
| Completed | Impact of Periodontal Treatment on Local miRNA Expression NCT05275127 | University of Catania | — |
| Unknown | The Effect of Smoking and Chlorhexidine on Periodontal Tissues After Non- Surgical Periodontal Therapy in Pati NCT06191497 | University of Rijeka | N/A |
| Completed | Clinical Study of a Formulation Containing Phtalox® in Periodontal Disease NCT05119283 | Universidade Federal de Alfenas | N/A |
| Unknown | Effect of Periodontal Treatment on Inflammasome Proteins in Periodontal Diseases NCT06075680 | Marmara University | N/A |
| Completed | Biomimetic Hydroxyapatite in Pediatric Patients With Asthma and/or Allergic Rhinitis NCT05631197 | University of Pavia | N/A |
| Completed | Investigation of Alzheimer's Disease and Periodontal Status NCT05807100 | Bezmialem Vakif University | — |
| Unknown | Comparison of Two Oral Hygiene Routines on the Glycemic Control for Type 2 Diabetes Patients With Chronic Peri NCT05260814 | Harvard School of Dental Medicine | N/A |
| Completed | Clinical and Radiographic Assessment of Efficacy of Modified Minimally Invasive SurgicalTechnique (M-MIST) Alo NCT07310732 | Rungta College of Dental Sciences and Research | N/A |
| Completed | Periodontitis, Sleep Quality and Fatigue NCT05622019 | Necmettin Erbakan University | — |
| Completed | Coconut Oil in Treatment of Periodontitis NCT06384638 | Misr University for Science and Technology | Phase 1 |
| Completed | Periodontal Status and TMAO Levels in Peripheral Artery Disease NCT07449546 | Ankara University | — |
| Completed | Comparative Evaluation of Propolis Mouthwash With 0.2% Chlorhexidine Mouthwash in Improving the Periodontitis NCT05870059 | Ziauddin University | Phase 2 |
| Unknown | Bone Remodeling and Non-surgical Periodontal Therapy NCT05636683 | University of Baghdad | N/A |
| Completed | Evaluation of Galectin-3 Levels in GCF And Saliva of Patients With Different Periodontal Diseases NCT05281796 | Cairo University | — |
| Completed | Slow-release Locally Administered 0.02% Hypochlorite Formulation NCT05846139 | Tuscan Dental Institute | N/A |
| Completed | Osteocalcin Level in Gingival Clavicular Fluid During Canine Retraction in Periodontal Compromised Patients NCT06102616 | Faculty of Dental Medicine for Girls | N/A |
| Recruiting | Quality of Life of Periodontitis Patients Visiting Supportive Periodontal Therapy NCT05339178 | Medical University of Vienna | — |
| Completed | Impact of SASP in the GCF on the Outcomes of Periodontal Regeneration NCT06354972 | University of Turin, Italy | — |
| Completed | Association of Asprosin in Periodontitis and Acute Coronary Syndrome NCT05647902 | Ataturk University | — |
| Completed | Evaluation of Salivary Biomarker Levels of Individuals With Different Periodontal Diseases NCT05774925 | Izmir Katip Celebi University | N/A |
| Completed | Efficacy of Periodontal Risk Communication in Patients With and Without History of Tooth Loss NCT05078411 | Università degli Studi di Ferrara | N/A |
| Unknown | Evaluation of PerioMonitor for Detection of Oral Inflammatory Load (OIL) in Human Subjects NCT05153798 | Oral Science International Inc. | — |
| Completed | Periodontal Maintenance and the COVID-19 Pandemic NCT05125835 | Brock University | — |
| Completed | Effect of Periodontal Treatment on Visfatin, fetuin-a and Sirtuin 1 of Patients With Periodontitis and Type 2 NCT05662475 | Ondokuz Mayıs University | N/A |
| Completed | Photodynamic in Periodontal Treatment NCT05162417 | University of Sulaimani | N/A |
| Recruiting | Oral Health and Adverse Pregnancy Complications NCT06110143 | University Hospital Bispebjerg and Frederiksberg | N/A |
| Completed | Effect of Iodine Deficiency on Periodontitis NCT05724251 | Ataturk University | — |
| Completed | Changes in Oral Health in Tobacco Cigarettes Smokers After Switching to Combustion-Free Nicotine Delivery Syst NCT04649645 | Eclat Srl. | N/A |
| Recruiting | Treatment of Intrabony Defects With Simvastatin and Antimicrobial Photodynamic Therapy NCT05031923 | Kafrelsheikh University | N/A |
| Unknown | Development of an AI App to Improve Compliance in Periodontal Maintenance Patients NCT05068778 | McGuire Institute | — |
| Completed | Oral Health Literacy and Periodontal Status Among Turkish Adults NCT07341945 | Biruni University | — |
| Recruiting | Antibiotics as Adjuncts to Periodontal Therapy:Pharmacokinetic Considerations and Dosing Strategies NCT04669717 | University of Geneva, Switzerland | Phase 4 |
| Unknown | Chlorhexidine and Essential Oil Mouthwashes on Human Beta-Defensin 2 (hbD2) and Kathelicidin (LL-37) Saliva Le NCT04946617 | Istanbul Medeniyet University | — |
| Unknown | Epithelial Mesenchymal Transition and Periodontitis NCT05403164 | University of Baghdad | — |
| Completed | Periodontal Status in Fermented Food and Food Consumption NCT05602545 | Tuğba ŞAHİN | N/A |
| Unknown | Impact of Non-surgical Periodontal Therapy on Oral and Gut Microbiome NCT04580355 | University of Campinas, Brazil | Phase 4 |
| Recruiting | Intake of Nitrate-rich Vegetables and Their Effect on Inflammatory Molecules and Oral Microbiota of Patients W NCT05232331 | University of Guadalajara | N/A |
| Unknown | A Clinical Trial to Evaluate the Safety and Effectiveness of Resorbable Collagen Membrane - MatrixflexTM NCT04851847 | Collagen Matrix | N/A |
| Completed | The Effect of Scaling and Root Planing on Oral Inflammatory Biomarkers Among E-cig Users and Non-smokers NCT05745324 | Kuwait University | N/A |
| Completed | Assessment of the Effect of Periodontal Disease Prediction System on Oral Hygiene Motivation NCT06577246 | Bezmialem Vakif University | N/A |
| Completed | The Role of Anti-inflammatory Cytokines and Antimicrobial Peptide LL-37 Biomarkers in the Treatment of Periodo NCT04404335 | Universidad Rey Juan Carlos | — |
| Unknown | Periodontal Therapy on the Gut Microbiome of Inflammatory Bowel Disease NCT04790825 | University of Turin, Italy | N/A |
| Completed | Periodontal Disease in Patients With Obstructive Sleep Apnea NCT04581798 | I.M. Sechenov First Moscow State Medical University | — |
| Unknown | Low-Level Laser Effects on Orthodontic Tooth Movement of Periodontally Compromised Patients. NCT05739838 | Faculty of Dental Medicine for Girls | N/A |
| Unknown | The Adjunctive Use of Melatonin Therapy in the Treatment of Obese Periodontitis Patients (Clinical and Immunol NCT04788979 | University of Baghdad | Phase 1 / Phase 2 |
| Completed | Comparison of Different Periodontal Classifications NCT05604703 | Kutahya Health Sciences University | — |
| Completed | The Effects of Electroacupuncture on Postoperative Pain NCT05783011 | Didem OZKAL EMINOGLU | N/A |
| Completed | The Use of Biorepair Peribioma Toothpaste and Mousse for Home Oral Care in Patients Undergoing Periodontal The NCT04809831 | University of Pavia | N/A |
| Unknown | A Randomized, Double-blind, Controlled Study to Evaluate the Safety and Feasibility of a Intraoral Electrother NCT04793048 | Shanghai Keku Medical Technology Co., Ltd. | N/A |
| Completed | Treatment of Periodontal Disease With Two Different Bioactive Gels for Home Oral Care NCT04781478 | University of Pavia | N/A |
| Completed | Assessment Of Healing After Periodontal Flap Surgery With And Without The Use Of Placental Extracts NCT05936450 | Dr Prabhuji MLV | Phase 4 |
| Recruiting | Autologous Platelet Concentrate (APC) in Intrabony Defects NCT04254861 | Queen Mary University of London | N/A |
| Completed | Non-invasive Assessment of Inflammatory Markers MIP-1 Alpha and IL-6 in Saliva of Post Myocardial Infarction a NCT05314192 | Ajman University | — |
| Completed | Effect of Stress on Periodontal Therapy (NPT) NCT04739475 | University of Turin, Italy | N/A |
| Unknown | Does the Non-surgical Application of Enamel Matrix Derivative Reduce the Need of Periodontal Surgical Interven NCT05418621 | University of Pisa | Phase 3 |
| Completed | The Impact of Oral Health in HIV Patients on Antiretroviral Therapy NCT04645693 | University of Pennsylvania | — |
| Unknown | Prevalence and Environmental Risk Indicators for Periodontitis. A Cross-sectional Study NCT04771949 | University of Siena | — |
| Unknown | Influence of Environmental Factors on the Efficacy of Non-surgical Periodontal Treatment. A Pre-post Quasi-exp NCT04769622 | University of Siena | — |
| Unknown | Prevalence of Periodontitis in Patients With Plaque Psoriasis. A Cross-sectional Study NCT04722094 | University of Siena | — |
| Completed | Antibacterial and Anti-biofilm Activity of Frankincense Extract Against Porphyromonas Gingivalis NCT04705714 | Tanta University | Phase 1 |
| Completed | The Role of Probiotics in Periodontal Disease NCT05211219 | Gazi University | N/A |
| Completed | Treatment of Intrabony Defects With L-PRF Membrane With or Without Collagen Membranes NCT05496608 | Future University in Egypt | N/A |
| Completed | Effect of Smoking Cessation on Salivary IL-1β and PGE-2 Levels Following Non-Surgical Periodontal Therapy NCT06145685 | October 6 University | N/A |
| Unknown | Enamel Matrix Derivatives & Periodontal Therapy in Diabetic Patients NCT04237662 | University of Pisa | N/A |
| Terminated | Predictors of Periodontal Outcomes Post-sanative Therapy NCT04639661 | Brock University | — |
| Completed | Evaluation of Bone Metabolism Biomarkers in Periodontal Diseases NCT05702892 | Necmettin Erbakan University | N/A |
| Completed | Fractal Analysis Method in Periodontal Disease NCT05639582 | Necmettin Erbakan University | N/A |
| Unknown | Accuracy of Assessing the Gingival Biotype in Upper Anterior in Adult Patients, Using Different Methods. NCT04640506 | Cairo University | — |
| Active Not Recruiting | Addition of Dehydrated Human Amnion-Chorion Membrane During Scaling and Root Planing NCT03836378 | University of Colorado, Denver | N/A |
| Completed | Effect of Waterpipe Smoking on Periodontal Health NCT04509505 | Noha Ayman Ghallab | — |
| Completed | Evaluation of the 1999 and 2018 Periodontal Disease Classifications: a Retrospective Study NCT04815772 | Okan University | — |
| Unknown | Prevalence of Periodontal Diseases Among Obese Egyptian Patients NCT04618068 | Yasmine Abbas Elsayed | — |
| Completed | Lactobacillus Reuteri in the Supportive Therapy of Periodontitis NCT04478643 | Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia | N/A |
| Unknown | Periodontal Health Knowledge Among Patients With Fixed Orthodontic Appliance NCT04532255 | Cairo University | — |
| Completed | Knowledge, Practice and State of Periodontal Health NCT04478864 | Noha Ayman Ghallab | — |
| Recruiting | The Dental Care Revolution: Health Education Using AI or Humanized Counseling on Plague Control and Periodonta NCT06083649 | Kaohsiung Medical University Chung-Ho Memorial Hospital | N/A |
| Unknown | The Effects of Diode Laser as an Adjunct to Non-surgical Periodontal Treatment on Periodontal Status in Patien NCT04477551 | Mohammed Bin Rashid University of Medicine and Health Sciences | N/A |
| Completed | Thiol/Disulphide Homeostasis and Vascular Endothelial Growth Factor Levels in Diabetic Children NCT04470635 | Aydin Adnan Menderes University | — |
| Unknown | The Effects of Subgingival Air-polishing, as an Adjunct to Non-surgical Periodontal Treatment on Periodontal P NCT04477070 | Mohammed Bin Rashid University of Medicine and Health Sciences | N/A |
| Completed | Flap Thickness Upon Root Coverage With the Use of Acellular Dermal Matrix NCT04802473 | Universitat Internacional de Catalunya | N/A |
| Completed | Prevalence of Periodontal Diseases in IBD NCT04380922 | CHU de Reims | — |
| Completed | Periodontal Disease Prediction System NCT05809570 | Bezmialem Vakif University | — |
| Completed | Evaluation of Biomarkers Levels in Gingival Crevicular Fluid, Saliva and Serum for Different Periodontal Disea NCT05435131 | Akdeniz University | N/A |
| Completed | YSGG Application in Periodontal Treatment NCT05588544 | Korea University Anam Hospital | N/A |
| Unknown | Efficacy and Safety of DKF-306 in Patients With Periodontal Diseases NCT05188924 | Dongkook Pharmaceutical Co., Ltd. | Phase 4 |
| Completed | Oral Health and Psychosocial Factors During the Covid-19 Pandemic NCT04381273 | Heidelberg University | — |
| Completed | Hypochlorous Acid Mouthwash, Oral Bacteria, and Staphylococcus Aureus NCT05372835 | Kaohsiung Medical University | N/A |
| Completed | The Effect of Non-Surgical Periodontal Treatment on Bone Metabolism in Type 2 Diabetes and Systemically Health NCT05862311 | Necmettin Erbakan University | N/A |
| Unknown | Periodontal Therapy and Oral-gut-hepatic Axis Cirrhosis: a Randomized Controlled Trial NCT04330469 | Post Graduate Institute of Medical Education and Research, Chandigarh | N/A |
| Unknown | Accuracy of Pulp Sensibility Test on Teeth With Deep Periodontal Pocket NCT04399135 | Qassim University | N/A |
| Completed | Asprosin, Adropin, Irisin Levels in Periodontitis NCT06250764 | AYSAN LEKTEMUR ALPAN | — |
| Unknown | Effect of Trait Anxiety in Women on Oral Health Status and Oral Health Care-Seeking Behavior NCT04274855 | Ain Shams University | — |
| Completed | Treatment of Periodontal Intrabony Defects With A-PRF or OFD NCT04823572 | Semmelweis University | N/A |
| Completed | Periodontal Status and Endothelial Dysfunction in Patients With Polycystic Ovary Syndrome NCT06184412 | Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana | — |
| Completed | The Role of Periodontal Diseases and Stimulation of Saliva Secretion in the Acute Phase of Ischemic Stroke NCT05394090 | Pomeranian Medical University Szczecin | N/A |
| Completed | Oral and Systemic aMMP-8 in Periodontal Disease NCT04268381 | Aydin Adnan Menderes University | — |
| Recruiting | Using Artificial Intelligence-platform on Plaque Control and Periodontal Treatment Outcome in Patients With Pe NCT04567030 | Kaohsiung Medical University Chung-Ho Memorial Hospital | N/A |
| Completed | Determination of the Levels of Lipocalin-2 and Semaphorin3A NCT04390997 | Izmir Katip Celebi University | N/A |
| Completed | The Association Between Periodontal Disease and Malnutrition in a Group of Elderly People in Thailand. NCT05129826 | Mahidol University | N/A |