NCT05275127

Impact of Periodontal Treatment on Local miRNA Expression

Analysis of Gingival Crevicular Fluid miRNA Changes After Periodontal Treatment.

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 89 (actual)
• Sponsor: University of Catania · Academic / Other
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

To assess the impact of Fill Mouth Scaling and Root planing or Quadrant Scaling and Root planing gingival crevicular fluid (GCF) levels of miRNA 7a-5p, miRNA 21-3p, miRNA 21-5p, miRNA 100-5p, miRNA 125-5p, miRNA 200b-3p and miRNA 200b-5p and their correlation with periodontitis extent.

Detailed description

The patients selected for the study were divided into 2 groups: group 1 (FM-SRP), group 2 (Q-SRP). Any selected subject underwent anamnestic and periodontal examination, blood and GCF sampling. MiRNA in the GCF was extracted through a commercially available kit and then measured carrying out real-time quantitative polymerase chain reaction (RT-PCR).

Conditions

• Cardiovascular Diseases
• Periodontal Diseases

Interventions

Type	Name	Description
OTHER	changes of gingival crevicular fluid miRNA	Evaluation of changes of gingival crevicular fluid miRNA after periodontal treatment

Timeline

• Start date: 2022-03-14
• Primary completion: 2022-11-15
• Completion: 2022-11-20
• First posted: 2022-03-11
• Last updated: 2023-04-07

Locations

1 site across 1 country: Italy