Trials / Unknown
UnknownNCT05212766
Role of the Oral Microbiome & Mucosal Immunity in COVID-19 Disease
Role of the Oral Microbiome & Mucosal Immunity in COVID-19 Disease: Diagnostic/Prognostic Utility in South Asian Populations
- Status
- Unknown
- Phase
- —
- Study type
- Observational
- Enrollment
- 750 (estimated)
- Sponsor
- King's College London · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Accepted
Summary
Determining whether in the mouth there are differences between the participant groups in the nature and activity of mucosal innate immunity, in immune responses to SARS-COV2 antigens, or in the oral microbiome
Detailed description
Cross sectional with longitudinal component * Stimulated whole mouth fluid (SWMF) and blood samples from South Asian and non-Asian populations * Controls, and COVID-19 patients in both populations. * Oral disease questionnaire and clinical examination * Separation of SWMF into pellet for DNA extraction for microbiomics and supernatant for cell phenotype analysis, cytokines and antibodies to SARS-CoV2 antigens
Conditions
- COVID-19
- Microbial Colonization
- Oral Disease
- Periodontal Diseases
- Innate Inflammatory Response
- Mucosal Infection
Interventions
| Type | Name | Description |
|---|---|---|
| BIOLOGICAL | COVID infection | Infections with COVID 19 |
| BIOLOGICAL | COVID vaccination | Vaccination against COVID 19 |
| DIAGNOSTIC_TEST | Oral examination | Assessment of oral and periodontal health status |
Timeline
- Start date
- 2022-04-07
- Primary completion
- 2023-10-30
- Completion
- 2024-12-30
- First posted
- 2022-01-28
- Last updated
- 2023-10-10
Locations
1 site across 1 country: United Kingdom
Source: ClinicalTrials.gov record NCT05212766. Inclusion in this directory is not an endorsement.