NCT05647902

Association of Asprosin in Periodontitis and Acute Coronary Syndrome

Serum Asprosin Concentrations in Patients With Periodontitis and Acute Coronary Syndrome

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 120 (actual)
• Sponsor: Ataturk University · Academic / Other
• Sex: All
• Age: 40 Years – 80 Years
• Healthy volunteers: Accepted

Summary

Asprosin, a recently discovered glucogenic adipokine, is mainly synthesized by white adipose tissue and released during fasting. Appetite, glucose metabolism, insulin resistance, cell apoptosis, etc. asprosin is associated with diseases such as diabetes, obesity, polycystic ovary syndrome, and cardiovascular diseases. Periodontal tissue may act as a source of endocrine-like inflammatory mediators (such as TNF-α, IL-6 and IL-1) that are important in periodontal inflammation and can affect glucose and lipid metabolism. Production of TNF-α and IL-6 in adipose tissues strengthens the relationship between cardiovascular diseases and periodontitis. Investigators postulated that asprosin may be a candidate for explaining the triangular relationship between cardiovascular and periodontal disease.

Detailed description

Periodontal disease is a chronic, multifactorial, and infectious disease caused by bacteria. It is characterized by the formation of an inflammatory response in the supporting bone and connective tissue against microbial dental plaque, and the nature of the resulting inflammatory response determines the course of periodontal disease. Cardiovascular and periodontal diseases are closely related, presenting a triad association. Asprosin circulates in the blood at nanomolar levels and is taken to the liver, where it activatesinvestigators the G protein-cAMP-PKA pathway, causing rapid glucose release into the circulation.

Conditions

• Cardiovascular Diseases
• Periodontal Diseases

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Serum samples will be collected. Asprosin levels will be determined by biochemical analysis	Serum samples will be collected from both groups for biochemical analysis.

Timeline

• Start date: 2022-01-01
• Primary completion: 2022-12-30
• Completion: 2023-01-01
• First posted: 2022-12-13
• Last updated: 2023-07-20

Locations

1 site across 1 country: Turkey (Türkiye)