NCT04790825

Periodontal Therapy on the Gut Microbiome of Inflammatory Bowel Disease

Effect of Intensive or Conventional Periodontal Therapy on the Gut Microbiome and Systemic Inflammation of Patients With Inflammatory Bowel Disease: a Single-blinded Randomized Clinical Trial

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: University of Turin, Italy · Academic / Other
• Sex: All
• Age: 18 Years – 60 Years
• Healthy volunteers: Not accepted

Summary

Periodontitis and inflammatory bowel disease have been associated by meta-epidemiologic evidence, although their mechanistic connection needs to be further explored. Oral-gut axis is implicated in the pathogenesis of several chronic inflammatory conditions, but to date no studies have evaluated the impact of periodontal treatment on gut ecology. Thus, the present randomised clinical trial is aimed at investigating the effect of intensive or conventional periodontal therapy on the gut microbiome and parameters of systemic inflammation of patients diagnosed with inflammatory bowel disease.

Conditions

• Periodontal Diseases
• IBD
• Dysbiosis
• Inflammation

Interventions

Type	Name	Description
PROCEDURE	Full mouth scaling and root planing (FMSRP)	Subgingival instrumentation with ultrasonic devices and curettes of all periodontal pockets completed within 48 hours

Timeline

• Start date: 2021-05-02
• Primary completion: 2023-05-15
• Completion: 2023-05-15
• First posted: 2021-03-10
• Last updated: 2022-11-02

Locations

1 site across 1 country: Italy