NCT05496608

Treatment of Intrabony Defects With L-PRF Membrane With or Without Collagen Membranes

Treatment of Periodontal Intrabony Defects With Dense Leukocyte and Platelet-Rich Fibrin (L-PRF) Membrane Alone or in Combination With Collagen Membranes (Randomized Clinical and Biochemical Trial)

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 63 (actual)
• Sponsor: Future University in Egypt · Academic / Other
• Sex: All
• Age: 30 Years – 50 Years
• Healthy volunteers: Accepted

Summary

For patients having periodontal intrabony lesions, three treatment modalities were executed to evaluate the effect of protecting Leukocyte rich -Platelet Rich Fibrin harvests (applied in the bony defects) with resorbable collagen membranes. Clinical Outcomes recorded were the Plaque index (PI), Gingival index (GI), probing depth reduction (PD), Clinical attachment level (CAL), and radiographic defect depth changes. For the biochemical evaluation: levels of PDGF-BB and VEGF obtained from crevicular fluid by Perio-Paper strips were assessed using ELIZA.

Detailed description

* Patients having 2-3 osseous bony wall infrabony periodontal lesions are enrolled in the present study. They have to be free from any systemic disease that contraindicates periodontal surgeries. * Baseline data are obtained including the GI, PI, PD, CAL and preoperative paralleling periapical radiographs. * Full thickness mucoperiosteal flaps are elevated and thorough debridement of the periodontal bony defect is performed. * for OFD group; following debridement and saline irrigation, wound closure proceeds. * for the L-PRF group; L-PRF is prepared and applied within the defect before primary closure. * for the L-PRF + CM: similar procedure like the second group is performed but with an additional protective layer of collagen membrane on top of the defect before wound closure. * from the second day postoperative; Periopaper strips are used to obtain a crevicular fluid sample from the sulcus * At 6 months postoperative: the same baseline clinical measurements are obtained.

Conditions

• Periodontal Bone Loss
• Periodontal Diseases

Interventions

Type	Name	Description
PROCEDURE	L-PRF	a blood sample is obtained from the patient, and centrifuged to prepare a leukocyte platelet rich fibrin harvest that is applied within the derided lesion.
PROCEDURE	OFD	Full thickness flap elevation to gain access to the infrabony lesion for debridement followed by flap closure.
PROCEDURE	CM	Xenogeneic collagen membranes that are used as barrier membranes in guided tissue regeneration of periodontal defects

Timeline

• Start date: 2021-01-01
• Primary completion: 2021-11-30
• Completion: 2022-02-01
• First posted: 2022-08-11
• Last updated: 2022-08-25

Locations

1 site across 1 country: Egypt