NCT04470635

Thiol/Disulphide Homeostasis and Vascular Endothelial Growth Factor Levels in Diabetic Children

Thiol/Disulphide Homeostasis and Salivary Vascular Endothelial Growth Factor Levels in Type 1 Diabetic Patients With Gingivitis

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 80 (actual)
• Sponsor: Aydin Adnan Menderes University · Academic / Other
• Sex: All
• Age: 7 Years – 14 Years
• Healthy volunteers: —

Summary

The aim of this study to evaluate the vascular endothelial growth factor level and thiol/disulphide homeostasis in saliva of diabetic children with gingivitis.

Detailed description

Eighty children (44 with type 1 diabetes mellitus and 44 systemically healthy) will be recruited for the study. The children will be divided into four subgroups based on their periodontal and systemic condition: 1) systemically and periodontally healthy children, 2) systemically healthy children with gingivitis, 3) periodontally healthy children with T1DM, and 4) children with T1DM and gingivitis. The plaque index, gingival index, probing pocket depth, will recorded. The vascular endothelial growth factor level determined by ELISA. Native thiol, total thiol and disulphide levels will be measured in saliva.

Conditions

• Periodontal Diseases

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	ELISA	Saliva sample collection

Timeline

• Start date: 2020-07-25
• Primary completion: 2020-09-30
• Completion: 2020-10-01
• First posted: 2020-07-14
• Last updated: 2024-01-30

Locations

1 site across 1 country: Turkey (Türkiye)