Trials / Not Yet Recruiting
Not Yet RecruitingNCT07476417
Oral Health, Dento-facial Condition and OHRQoL in Subjects With Mowat-Wilson Syndrome: an Epidemiologic Study.
- Status
- Not Yet Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 25 (estimated)
- Sponsor
- University of Milan · Academic / Other
- Sex
- All
- Age
- —
- Healthy volunteers
- Not accepted
Summary
Mowat-Wilson Syndrome (MWS) is a rare syndrome characterized by the presence of facial gestalt and delayed psychomotor development, variably associated with intellectual disability, epilepsy, Hirschsprung's disease (HSCR) and multiple congenital malformations. Although there is evidence of the presence of dental and craniofacial anomalies in MWS, little epidemiological data is available to date. The goal of this observational study is to assess oral health and dento-facial phenotype of people affected by Mowat-Wilson Syndrome (MWS). In addition, the Oral Health Related Quality of Life (OHRQoL) will be investigated.
Detailed description
Subjects will be recruited from those attending the annual meeting of Mowat Wilson Italian Association, whose parents/guardians will have agreed and signed informed consent for their participation in the study. Parents/guardians will be asked to answer to a series of questionnaires regarding comprehensive medical and dental history, oral habits, socioeconomic status, and oral-health related quality of life (OHRQoL). Participants will then undergo intraoral and extraoral examination, extraoral photographs of the face; dental and facial digital scans will be also collected. Parents/guardians will be asked to provide any dental radiographs of subjects (panoramic dental x-ray, dental computer tomography, lateral skull radiographs for cephalometry) if previously performed .
Conditions
- Mowat-Wilson Syndrome
- Dental Caries
- Periodontal Diseases
- Sleep Related Breathing Disorder
- Tooth Diseases
- Malocclusion
- Tooth Abnormalities
- Oral Health Related Quality of Life (OHRQoL)
- Craniofacial Abnormalities
- Oral Mucosal Disease
Timeline
- Start date
- 2026-04-01
- Primary completion
- 2026-05-31
- Completion
- 2026-08-30
- First posted
- 2026-03-17
- Last updated
- 2026-03-24
Locations
1 site across 1 country: Italy
Source: ClinicalTrials.gov record NCT07476417. Inclusion in this directory is not an endorsement.