| Recruiting | Treatment of Mild Class II Malocclusion in Adult Patients With Clear Aligners Versus Fixed Multibracket Therap NCT05684510 | Hama University | N/A |
| Not Yet Recruiting | Comparison of Orthodontic Molar Protraction With and Without Adjunctive Surgery NCT03794726 | University of Alabama at Birmingham | N/A |
| Not Yet Recruiting | Influence of Finishing Clear Aligner Marginal Termination Design on Subgingival Periodontal Microbiota During NCT07533058 | George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures | N/A |
| Not Yet Recruiting | Validation of AI-Based Cephalometric Analysis in Orthodontics NCT07315152 | Al-Azhar University | — |
| Not Yet Recruiting | Comparison of Three Orthodontic Separators for Pain, Plaque, and Tooth Separation NCT07532044 | Islamabad Medical and Dental College | N/A |
| Not Yet Recruiting | Oral Health, Dento-facial Condition and OHRQoL in Subjects With Mowat-Wilson Syndrome: an Epidemiologic Study. NCT07476417 | University of Milan | — |
| Not Yet Recruiting | Evaluation of Clinical and Patient-Reported Outcomes of Laceback NCT07039071 | International Islamic University Malaysia | N/A |
| Not Yet Recruiting | Clear Orthodontic Expander Versus Hyrax NCT07362160 | University of Baghdad | N/A |
| Recruiting | A Prospective Multicenter Clinical Investigation Evaluating the Accuracy of the Trimline Design When Treated W NCT07290790 | Dentsply Sirona Implants and Consumables | N/A |
| Not Yet Recruiting | Finite Element Modelling of Le Fort I Osteotomy Fixation : PSI vs Miniplates NCT07365657 | Centre Hospitalier Universitaire de Nice | — |
| Not Yet Recruiting | Comparison of Outcome of Safe T Separators and Conventional Elastomeric Separators NCT07119814 | Khyber College of dentistry | N/A |
| Not Yet Recruiting | Comparing Ligation Methods During Canine Retraction Stage Using Conventional Brackets NCT07063186 | International Islamic University Malaysia | N/A |
| Not Yet Recruiting | Relationship Between Malocclusion Severity and Periodontitis Risk NCT07127744 | Recep Tayyip Erdogan University Training and Research Hospital | — |
| Recruiting | Bromelain for Post-surgery Facial Swelling NCT07115212 | Mohamed Bazina | N/A |
| Not Yet Recruiting | Salivary Stress Markers Associated With Malocclusion Severity NCT07116317 | Recep Tayyip Erdogan University Training and Research Hospital | — |
| Not Yet Recruiting | Epidemiological Investigation of Malocclusion in China NCT06352385 | Shanghai Jiao Tong University School of Medicine | — |
| Recruiting | Effectiveness of Auxiliary Segmental Lingual Appliances in Leveling the Curve of Wilson at Second Molars NCT06858670 | Hanoi Medical University | N/A |
| Active Not Recruiting | Impact of Aligner Replacement Protocols on Predictability of Planned Dental Movements: Evaluation of Double Al NCT06882395 | Neodent | N/A |
| Not Yet Recruiting | Accuracy of Dental Movements Using Clear Aligners Treatment: a Single-center Prospective Observational Study NCT06561945 | IRCCS Ospedale San Raffaele | — |
| Enrolling By Invitation | Efficacy of Orthodontic Tooth Movement Using Beveled and Conventional Attachments in Aligners NCT06873932 | Neodent | N/A |
| Recruiting | Evaluation of the Perceived Experience of Patients Treated With Aligners With Two Different Timings NCT06536335 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | N/A |
| Completed | Evaluation of Taste Sensation Changes During Fixed Orthodontic Treatment NCT06989736 | Biruni University | N/A |
| Recruiting | Evaluation of the Effect of Adenoid Hypertrophy on the Masseter Muscle in Children: A Comparative Ultrasonogra NCT07094581 | Melis AKYILDIZ | — |
| Not Yet Recruiting | Evaluate Cytotoxicity, Leaching, and Structural Conformation of Clear Aligners NCT06503029 | Riyadh Elm University | Phase 4 |
| Recruiting | Orthodontic Screening in Public Healthcare NCT06464003 | University of Helsinki | — |
| Recruiting | "Facially Driven Digital Full-Mouth Rehabilitation" NCT07314034 | Menoufia University | — |
| Completed | Evaluation of Removable Appliances and Clear Aligners in Early Orthodontic Treatments During the Mixed Dentiti NCT07331090 | Neslihan Atmaca | — |
| Recruiting | Prevalence of Long-term Dental Effects of Chemotherapy in Childhood Cancer Survivors Diagnosed With Cancer Bef NCT06517927 | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | N/A |
| Unknown | The Influence of Complex Correction of Dental and Musculoskeletal Systems on the Frequency of Relapses of Func NCT06263504 | NMSI DENTMASTER | N/A |
| Completed | Impact of Dental Composite Viscosity on Attachment Accuracy: a Prospective Clinical Trial NCT06288386 | University of Pavia | N/A |
| Completed | Evaluation of the Accuracy of Palatal Orthodontic Miniscrew Placement. NCT07378618 | University of Roma La Sapienza | N/A |
| Completed | Intra-oral Evaluation of Force Decay of Pigmented and Transparent Elastomeric Power Chains: NCT07300371 | Sana'a University | N/A |
| Withdrawn | Discomfort Perceived by a Cohort of Patients Treated With Aligners and Attachments Placed According to Two Dif NCT06218641 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | N/A |
| Completed | Augmented Reality for Orthognatic Surgery Patient Education NCT06140043 | University Medical Center Groningen | Phase 2 / Phase 3 |
| Unknown | Impact of Clear Aligners and Metal Brackets on Nutritional Status NCT05936463 | Marmara University | — |
| Enrolling By Invitation | A Cohort Prospective Study of Predictors Influencing the Quality of Visualization of the Operating Field Durin NCT05814991 | State Budgetary Healthcare Institution, National Medical Surgical Center N.A. N.I. Pirogov, Ministry of Health of Russia | — |
| Completed | Effect of Customized Lateral Nasal Wall Osteotomy on the Pterygomaxillary Separation During le Fort I Down-fra NCT06233188 | Bezmialem Vakif University | N/A |
| Completed | Impact of Photobiomodulation on Pain During Orthodontic Treatment. NCT05361616 | PBM Healing International Limited | N/A |
| Recruiting | Impact of Anterior Cross Bite Treatment on Children's Speech Performance NCT06168695 | Tanta University | N/A |
| Completed | Clinical Effectiveness of the Calcium Chloride (CaCl2) Surface- Treated Orthodontic Mini Implant (OMI) NCT06607536 | Universiti Teknologi Mara | N/A |
| Unknown | Effects of Modified Fixed Twin Block Versus Removable Twin Block on Skeletal Class 2 Growing Patients With Man NCT05993156 | Cairo University | N/A |
| Completed | Does the Generation to Which the Operator Belongs Influence the Orthodontic Miniscrew Insertion Accuracy in Dy NCT06661551 | University of Roma La Sapienza | N/A |
| Unknown | Gingival Health and Malocclusion Among Type 1 Diabetic Children and Adolescents NCT06291129 | Universidade Federal Fluminense | N/A |
| Recruiting | Optimizing Orthodontic Appliances Efficiency With Remote Dental Monitoring and Artificial Intelligence Algorit NCT05573308 | University of Illinois at Chicago | N/A |
| Unknown | Comparison of Precision in Brackets Position in Two Indirect Bonding Materials NCT05483114 | Fundación Universitaria CIEO | N/A |
| Completed | Miniscrew-assisted Rapid Palatal Expansion With and Without Corticopuncture NCT05543460 | Alexandria University | N/A |
| Completed | Comparing of the Clinical Outcome of Periodontal Accelerated Osteogenic Orthodontics With Horizontal or Vertic NCT05441683 | Second Affiliated Hospital, School of Medicine, Zhejiang University | N/A |
| Completed | The Efficacy of Tow Mechanics for Total-maxillary-arch-distalization NCT04814173 | Hama University | N/A |
| Completed | Factors Affecting Attachment Loss in Clear Aligner Treatment NCT07352644 | Bezmialem Vakif University | N/A |
| Completed | The Effect of Patient Preference on Retention Success NCT06478771 | Hacettepe University | N/A |
| Recruiting | The Effect of Malocclusions on Oral Health Related Quality of Life NCT05038865 | Malmö University | — |
| Active Not Recruiting | Dental Biofilm Control During Orthodontic Treatment NCT05532241 | University of Rijeka | Phase 3 |
| Unknown | Evaluation of Muscle Activity in Unilateral Posterior Crossbite NCT04962685 | Universitat Internacional de Catalunya | N/A |
| Unknown | Effect of Personality Traits on Reporting Outcomes of Orthodontic Treatment NCT05398328 | University of Rijeka | Phase 3 |
| Completed | Comparison of the Accuracy and Reliability of Measurements Made on CBCT and IOS Images With Their made-on Plas NCT05711160 | University of Duhok | — |
| Unknown | Effect of Paracetamol and Ketorolac on RANK-L Levels in Patients Starting Orthodontic Treatment NCT05383820 | University of Guadalajara | Phase 4 |
| Suspended | Premolar Extractions for Obstructive Sleep Apnea in Children With Overjet NCT04946201 | Mohamed Bazina | — |
| Unknown | Effect of Extraction Vs Non-extraction Orthodontic Treatment on Vertical Facial Dimension NCT04151875 | Cairo University | N/A |
| Completed | Changes of the Upper Airway Volume After Orthognathic Surgery NCT05060133 | Lund University Hospital | — |
| Completed | Nutritional Status in Orthognathic Surgery Patients NCT05591963 | Marmara University | — |
| Unknown | Observational Comparison of Tooth-borne, Bone-borne and Hybrid Distraction Following SARPE. NCT04670211 | ZOL | — |
| Unknown | Effectiveness of Two Skeletally Anchored Force Mechanics for Skeletal Class II Correction in Growing Patients NCT04884022 | Alexandria University | N/A |
| Completed | Anxiety, Pain, and Quality of Life in Orthodontic Treatment NCT06133296 | Yuzuncu Yil University | N/A |
| Completed | Does Double With Regular Monitoring Prevent Undesired Tooth Movement? NCT05626335 | Pomeranian Medical University Szczecin | — |
| Unknown | Laser Therapy on Controlling Pain During Orthondontic Treatment NCT04628390 | Fundación Universitaria CIEO | N/A |
| Unknown | Body Posture and the Stomatognathic System of School-age Children NCT04317131 | University of Rzeszow | — |
| Recruiting | The Use of a Pacifier to Correct Malocclusions in Young Children NCT03513003 | University Hospital, Basel, Switzerland | N/A |
| Unknown | Pain and Discomfort With Anterior Versus Posterior Builds-up NCT04105127 | University of Genova | N/A |
| Completed | Orthognathic Surgery With Clear Aligners vs Conventional Brackets NCT07511296 | Centre Hospitalier Universitaire de Nice | — |
| Unknown | Two Low-level Laser Irradiation Protocols on the Rate of Canine Retraction NCT04926389 | Hams Hamed Abdelrahman | N/A |
| Unknown | Tunnel Attachments With Clear Aligners vs Clear Aligners NCT04130477 | Harvard School of Dental Medicine | N/A |
| Completed | Predictability of Orthodontic Tooth Movement With Invisalign Aligners NCT05356780 | University of Turin, Italy | — |
| Recruiting | Orthognathic Speech Pathology: Phonetic Contrasts of Patients With Dental Discrepancies Pre- and Post-Treatmen NCT04117360 | University of North Carolina, Chapel Hill | — |
| Unknown | Precision Orthodontics: Virtual Treatment Planning for Orthodontic Braces NCT04002999 | Harvard School of Dental Medicine | N/A |
| Recruiting | Rapid Maxillary Expansion with Low Level Laser Therapy NCT05586997 | National Research Centre, Egypt | Phase 3 |
| Completed | Treatment of Unilateral Posterior Cross Bite in Children NCT04458506 | Region Örebro County | N/A |
| Completed | Comparison Between Two Rates of Activation of Miniscrew-Supported Upper Jaw Expander in Adolescents NCT04225637 | Alexandria University | N/A |
| Completed | Comparison of Two Tooth-borne Expanders in Rapid Maxillary Expansion NCT03846518 | Pontifícia Universidade Católica de Minas Gerais | N/A |
| Completed | Duration Of Lower Labial Segment Alignment With Repeated Micro-Osteoperforations: NCT03888560 | University of Malaya | N/A |
| Completed | A Comparison of Conventional Versus Digital PAR (Peer Assessment Rating) Scores Using an Intraoral Scanner NCT03405961 | King's College London | — |
| Unknown | EXD-959 Orthodontic Brackets and EXD-961 Related Instruments Trial NCT03606551 | 3M | — |
| Completed | Evaluation of the Accuracy of Measurements Made on Images Taken From the Mouth for Dental Arches NCT03648515 | Damascus University | — |
| Completed | Comparison of 2 Techniques of Surgically Assisted Rapid Maxillary Expansion NCT03503448 | Hospital Universitario Pedro Ernesto | N/A |
| Withdrawn | Changes in Upper Airway Anatomy, Quality of Life Measures, and Polysomnographic Parameters Using A Functional NCT02805764 | Montefiore Medical Center | N/A |
| Completed | Analysis of Orthodontic Tooth Movement Using 3D Imaging NCT03398798 | University of North Carolina, Chapel Hill | N/A |
| Completed | Artificial Intelligence (AI) Empowered Smile Simulations: Do They Accurately Predict Actual Post Treatment Out NCT06123585 | Nourhan M.Aly | N/A |
| Unknown | OrthoPulse 2.0 and 2.1 Feasibility Evaluation NCT03683017 | Biolux Research Holdings, Inc. | N/A |
| Completed | Dentoskeletal Effects of the Expander With Differential Opening and the Fan-type Expander NCT03705871 | University of Sao Paulo | N/A |
| Completed | Personalized Titanium Plates vs CAD/CAM Surgical Splints in Maxillary Repositioning of Orthognathic Surgery NCT02914431 | Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University | N/A |
| Unknown | The Effectiveness of Electronic Reminders in Improving Elastic Compliance in Orthodontic Patients NCT03144323 | Guy's and St Thomas' NHS Foundation Trust | N/A |
| Completed | OHRQoL and Accelerated Orthodontics With Micro-osteoperforations NCT03407261 | University of Sao Paulo | N/A |
| Completed | Anterior Open Bite Treatment With Bonded Spurs Associated With Build-ups Versus Conventional Bonded Spurs NCT03702881 | University of Sao Paulo | N/A |
| Completed | Transfer Accuracy of Indirectly Bonded Orthodontic Braces With Different Transfer Trays NCT03754283 | Yuzuncu Yil University | N/A |
| Completed | Jawline Improvement Using Patient-specific Angle Implants With Virtual Planning in Orthognathic Surgery NCT06235138 | Centre Hospitalier Universitaire de Nice | — |
| Terminated | The Effect of OrthoPulse Photobiomodulation on the Rate of Tooth Movement During Alignment With Fixed Applianc NCT03202355 | Biolux Research Holdings, Inc. | N/A |
| Unknown | A Comparison of the Alignment Achieved Using Computer-guided Indirect Bonding of Orthodontic Brackets to Conve NCT02221856 | Harvard School of Dental Medicine | N/A |
| Completed | Effect of VPro5 Therapy on Clear Aligner Therapy NCT03240770 | Mani Alikhani | N/A |
| Completed | Evaluation of Clear Aligner Trays to Straighten Teeth NCT03141788 | Solventum Orthodontics Corporation | N/A |
| Completed | Clinical Performance of a New Esthetic, Self-ligating Orthodontic Bracket NCT02959671 | University of Minnesota | N/A |
| Completed | Micro-osteoperforations on the Rate of Canine Retraction NCT04968327 | Hams Hamed Abdelrahman | N/A |
| Completed | Oral Functions and Malocclusions NCT04869839 | Centre Hospitalier Universitaire de Nice | — |
| Unknown | Orthodontic Archwire Comparison Trial NCT02983084 | Ormco Corporation | N/A |
| Withdrawn | Nano-Crystalline Ceramic Coating of Orthodontic Archwires NCT02311491 | University of North Carolina, Chapel Hill | N/A |
| Active Not Recruiting | Oral Health for Healthy Cognitive Aging NCT02986386 | Universidad de Granada | N/A |
| Completed | Orthodontic Archwire Effectiveness Trial NCT02659813 | University of Dundee | N/A |
| Completed | Accelerated Invisalign Therapy in Conjunction With Acceledent Aura NCT02868554 | University of North Carolina, Chapel Hill | N/A |
| Completed | Periodontally Accelerated Osteogenic Orthodontics With BMP2 NCT03396900 | SVS Institute of Dental Sciences | Phase 2 |
| Unknown | The Effect of OrthoPulse™ Photobiomodulation on Tooth Movement and Treatment Time When Used With Invisalign Tr NCT02954133 | Biolux Research Holdings, Inc. | N/A |
| Unknown | Early Crossbite Correction - a Randomized Study NCT03353766 | University of Oulu | N/A |
| Unknown | An Electromyography Study Comparing the Impact of Using RMEs on Muscle Activity Among Growing Orthodontic Pati NCT02752347 | Riyadh Colleges of Dentistry and Pharmacy | N/A |
| Completed | Efficacy of Piezosurgey Corticotomy (a Minimally Invasive Surgical Technique) in Accelerating Orthodontic Alig NCT02977221 | Damascus University | N/A |
| Completed | Evaluation of the Levels of Pain and Discomfort Between Two Methods of Correcting Misaligned Teeth NCT02975765 | Damascus University | N/A |
| Completed | One Week Aligner Evaluation NCT02603289 | Align Technology, Inc. | — |
| Completed | Primer Aligner Study NCT02550938 | Align Technology, Inc. | N/A |
| Completed | Accelerated Tooth Movement With AcceleDent® and Aligners - a Pilot Project NCT02438280 | University of Washington | N/A |
| Completed | Three- Dimensional Evaluation of Accelerated Tooth Movement NCT02416297 | LIANA FATTORI ABATI | N/A |
| Completed | Micro-osteoperforations and Tooth Movement NCT02473471 | Jordan University of Science and Technology | N/A |
| Completed | Probiotic Lozenge Reduce Streptococcus Mutans in Plaque in Orthodontic Bracket Patients NCT02357771 | Next Gen Pharma India Pvt. Ltd. | Phase 3 |
| Completed | Assessment of Piezoelectric Periodontal Surgery Effects on Orthodontic Treatment: a Prospective Pilot Study NCT02359760 | Université de Montréal | N/A |
| Completed | Class II Correction Study Using the Invisalign System NCT02376829 | Align Technology, Inc. | N/A |
| Completed | Mandibular Response After Maxillary Orthopedic Expansion in Class II Growing Subjects NCT03159962 | University of Rome Tor Vergata | N/A |
| Completed | Microbiological and Epithelial Evaluation Related to the Use of Orthodontic Thermoplastic Device NCT02427763 | Universidade Positivo | EARLY_Phase 1 |
| Completed | Occlusal Outcomes by OGS After a Finishing Protocol NCT03714087 | Universidad de Antioquia | N/A |
| Completed | The Use of Clear Aligners With Movement Enhancement Techniques NCT02087163 | Align Technology, Inc. | N/A |
| Completed | Effect of AcceleDent® Aura on Orthodontic Tooth Movement With Aligners NCT01962012 | OrthoAccel Technologies Inc. | Phase 4 |
| Completed | The Effect of OrthoPulse™ on the Rate of Orthodontic Tooth Movement NCT02267811 | Biolux Research Holdings, Inc. | N/A |
| Completed | Evaluation of a "Flash-free" Adhesive Resin for Orthodontic Bracket Bonding NCT02030002 | University of Minnesota | N/A |
| Completed | Effects of a Finishing Protocol Implementation in Orthodontic Patients NCT02290158 | Universidad de Antioquia | N/A |
| Completed | Effect of Intra-Oral Photobiomodulation on Orthodontic Treatment Time NCT02267850 | Biolux Research Holdings, Inc. | N/A |
| Completed | Alveolar Microperforation for Inflammation-Enhanced Tooth Movement During Orthodontic Treatment NCT01720797 | University of Florida | N/A |
| Completed | Patient Education Before Orthognathic Surgery NCT01803204 | University of Sao Paulo | N/A |
| Completed | The Effect of Ultrasound on Orthodontic Tooth Movement NCT01828164 | SmileSonica Inc. | N/A |
| Completed | A Randomised Clinical Trial: Conventional Ligation vs Figure of 8 NCT01771692 | Rachel Little | N/A |
| Completed | OrthoPulse™ and Its Effect on the Rate of Orthodontic Tooth Alignment: A Pilot Feasibility Study NCT02267837 | Biolux Research Holdings, Inc. | N/A |
| Unknown | GENOA ORAL GROWTH LONGITUDINAL STUDY (GeOrGS) NCT02798809 | University of Genova | — |
| Unknown | Analysis of Patient Seeking Second Opinion Who Are Undergoing Full Mouth Orthodontic Treatment NCT01538524 | National Taiwan University Hospital | — |
| Completed | The Use of 2D and 3D Imaging Modalities and Its Influence on Diagnosis and Treatment Planning in Orthodontics NCT01246830 | Universitaire Ziekenhuizen KU Leuven | — |
| Unknown | Psychological Assessment of Adults Seeking Orthodontic Treatment NCT01475773 | Universitaire Ziekenhuizen KU Leuven | — |
| Completed | The Effects of Extraoral Photobiomodulation on the Rate of Orthodontic Alignment NCT02267824 | Biolux Research Holdings, Inc. | N/A |
| Completed | Sleep Disorder and Oral Habits in Children NCT01463839 | University of Nove de Julho | — |
| Terminated | Three-dimensional Assessment of Craniofacial Structures NCT01210547 | University of Minnesota | — |
| Unknown | A RCT to Compare OHRQoL Outcome for SLB and CB NCT02084277 | Mackay Memorial Hospital | N/A |
| Completed | Comparison of the Quantity of Distal Movement of the Upper Canine and Molar NCT01654419 | Universidad de Antioquia | N/A |
| Completed | 0.018 or 0.022 Bracket Slot System More Effective in Orthodontic Treatment? NCT02080338 | David Bearn | N/A |
| Completed | Rehabilitative Management of Mastication NCT01562249 | University of Sao Paulo General Hospital | Phase 2 |
| Completed | RMGI v Composite for Orthodontic Bonding NCT01925924 | Sheffield Teaching Hospitals NHS Foundation Trust | N/A |
| Completed | Effect of Cyclic Loading (Vibration) on Orthodontic Tooth Movement NCT00830947 | OrthoAccel Technologies Inc. | Phase 3 |
| Unknown | 3D Craniofacial Cephalometric Analysis NCT01413373 | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | — |
| Completed | Chesterfield Micro-implant Study Involving Three Types of Anchorage Methods in Orthodontics NCT00995436 | Chesterfield and North Derbyshire Royal Hospital | N/A |
| Unknown | Orthodontic Treatment With a Part-Time Wearing Esthetic Removable Appliance NCT00485602 | Hadassah Medical Organization | Phase 1 / Phase 2 |
| Completed | Pharyngeal Size in Patients With Obstructive Tonsils Under Orthodontic Treatment NCT01164631 | University of Sao Paulo General Hospital | Phase 4 |
| Completed | The Regulation of Osteoprotegerin by Mechanical Stimulation NCT00155311 | National Taiwan University Hospital | Phase 1 |
| Unknown | Early Orthodontic Intervention Under Medicaid NCT00067379 | University of Washington | Phase 1 |