NCT07115212

Bromelain for Post-surgery Facial Swelling

Effectiveness of Bromelain Supplement in Reduction of Facial Swelling Caused by Orthognathic Surgery

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 200 (estimated)
• Sponsor: Mohamed Bazina · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to learn if Bromelain Supplement works to decrease the amount of swelling or the amount of time swelling is present following jaw surgery. It will also learn about the safety of Bromelain supplement. The main questions it aims to answer are: Does Bromelain decrease facial swelling following orthognathic, or jaw, surgery? Does Bromelain supplement decrease the amount of time that patients are swollen following orthognathic, or jaw, surgery? Participants will: Take Bromelain supplement once daily for 9 days total. Take 2 days before surgery and 7 days following surgery. Keep a log of when the bromelain supplement is taken as well as another other medications. Visit the clinic with pre and post surgical protocol

Conditions

• Malocclusion

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Bromelain	1 tablet daily with water, for 9 days-starting 2 days before surgery and continuing for 7 days after. Record each dose in the provided log, along with any other medications taken and the time they were taken.

Timeline

• Start date: 2025-09-08
• Primary completion: 2026-04-01
• Completion: 2026-04-01
• First posted: 2025-08-11
• Last updated: 2025-09-24

Locations

1 site across 1 country: United States