NCT05546788

Hydroxylated Polymethoxy Flavones Solid Dispersion in Treatment of Periodontitis

The Effectiveness of Hydroxylated Polymethoxy Flavones Solid Dispersion Incorporated Sodium Carboxymethyl Cellulose Gel With Periodontal Debridement in the Treatment of Periodontitis. Clinical- Biochemical Study

• Status: Unknown
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Assiut University · Academic / Other
• Sex: All
• Age: 20 Years – 50 Years
• Healthy volunteers: Accepted

Summary

Periodontitis is a serious gum infection that damages the soft tissue and, without treatment, can destroy the bone that supports your teeth. Hydroxylated poly methoxy flavones are a combination of naturally occurring flavonoids extracted from the orange peel and exert anti-inflammatory, antibacterial, and antifungal activity however, this extract is poorly soluble and poorly absorbable. In this work, this extract was formulated as a solid dispersion formulation to enhance its biological activity and then incorporated into a gel base and used in the treatment of periodontitis after clinical debridement.

Detailed description

In the study, there are 3 groups; the first one first one received plain sodium carboxymethylcellulose. Group II received chlorhexidine gel. GroupIII received Hydroxylated poly methoxy flavones solid dispersion incorporated into sodium carboxymethylcellulose gel. In all groups, there is clinical debridement before injection of gels.

Conditions

• Inflammatory Disease
• Periodontal Diseases

Interventions

Type	Name	Description
PROCEDURE	scaling and root planing	subgingival Depridement
DRUG	hydroxylated poly methoxy flavones	Received hydroxylated poly methoxy flavones extract solid dispersion incorporated into sodium carboxymethylcellulose gel
DRUG	chlorhexidine	Received chlorhexidine gel
DRUG	placebo	Received placebo gel

Timeline

• Start date: 2023-10-20
• Primary completion: 2023-11-20
• Completion: 2023-11-20
• First posted: 2022-09-21
• Last updated: 2023-10-10