Trials / Completed
CompletedNCT06102616
Osteocalcin Level in Gingival Clavicular Fluid During Canine Retraction in Periodontal Compromised Patients
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 15 (actual)
- Sponsor
- Faculty of Dental Medicine for Girls · Other Government
- Sex
- Female
- Age
- 25 Years – 35 Years
- Healthy volunteers
- Not accepted
Summary
Osteocalcin levels can be measured Gingival crevicular fluid (GCF). Changes in osteocalcin levels can provide important information about the status of bone metabolism and bone remodeling. The levels of this markers in GCF can provide information about the status of bone remodeling in the surrounding bone tissue in periodontal affected teeth.
Detailed description
Osteocalcin levels can be measured using a blood test or by analyzing the levels of osteocalcin in urine or saliva. Changes in osteocalcin levels can provide important information about the status of bone metabolism and bone remodeling. Osteocalcin has been found to be present in Gingival crevicular fluid (GCF), along with other bone metabolism markers such as alkaline phosphatase and tartrate-resistant acid phosphatase. The levels of these markers in GCF can provide information about the status of bone remodeling in the surrounding bone tissue. Orthodontic tooth movement is influenced by the remodelling ability of surrounding bone and soft tissue, such as PDL and gingiva. Bone remodelling occurs in coordination, requiring coupling of bone formation after resorption. Orthodontic force induces an aseptic inflammatory response, involving cytokines and chemokines. . Increased levels of osteocalcin in body fluids indicate abnormal bone turnover activity.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DIAGNOSTIC_TEST | measure Osteocalcin level | in gingival crevicular fluid before and during orthodontic tooth movement |
Timeline
- Start date
- 2022-01-14
- Primary completion
- 2023-03-20
- Completion
- 2023-08-23
- First posted
- 2023-10-26
- Last updated
- 2023-11-28
Locations
1 site across 1 country: Egypt
Source: ClinicalTrials.gov record NCT06102616. Inclusion in this directory is not an endorsement.