Trials / Completed
CompletedNCT06799182
Periodontal Disease and Colorectal Cancer
The Influence of Periodontal Disease and Periodontal Treatment on Colorectal Cancer
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 20 (actual)
- Sponsor
- University Medical Centre Ljubljana · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The aim of this interventional study is to determine the impact of periodontal disease and periodontal treatment on patients with colorectal cancer. The main questions were: 1. Does periodontal treatment affect the levels of C-reactive protein in the blood of patients undergoing cancer treatment? 2. Can the investigators isolate periodontal pathogenic bacteria Fusobacterium nucleatum and Porphyromonas gingivalis from the mucosa of cancerous colon tissue using the method of quantitative culture? The investigators will compare the levels of C-reactive protein in the blood of patients undergoing treatment for colorectal cancer who have received periodontal treatment with patients who have not received periodontal treatment. CRP levels will be measured during the first examination with the oncological surgeon, on the first and second day after the surgical procedure, and during the first follow-up with the oncological surgeon. Additionally, the investigators collected samples of cancerous colon mucosa from 10 participants for the attempt to isolate F. nucleatum and P. gingivalis using the quantitative culture method.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | periodontal treatment | Based on the results of the dental examination and the diagnosis of the periodontal tissue condition according to the new classification of periodontal disease, we performed appropriate non-surgical treatment of periodontal disease, provided oral hygiene instruction, and took a biofilm sample from the deep periodontal pocket. We then collected a sample of the altered mucosa during bowel surgery for colorectal cancer and conducted a microbiological investigation using quantitative culture to compare the presence of Fusobacterium nucleatum and Porphyromonas gingivalis in the pariodontal pocket and altered intestinal mucosa. |
Timeline
- Start date
- 2023-10-25
- Primary completion
- 2024-09-30
- Completion
- 2024-11-05
- First posted
- 2025-01-29
- Last updated
- 2025-01-29
Locations
1 site across 1 country: Slovenia
Source: ClinicalTrials.gov record NCT06799182. Inclusion in this directory is not an endorsement.