| Recruiting | Zanidatamab Before Surgery for the Treatment of HER2 Positive Colon and Rectal Cancer in Patients Planned for NCT07405476 | Emory University | Phase 2 |
| Recruiting | Culturally Adapting an Intervention to Increase Genetic Testing in African American Cancer Survivors NCT07436078 | Barbara Ann Karmanos Cancer Institute | N/A |
| Recruiting | An Investigational Drug (TPST-1495) in Patients With Familial Adenomatous Polyposis NCT06557733 | National Cancer Institute (NCI) | Phase 2 |
| Not Yet Recruiting | The Association Between Deep Endometriosis and the Occurrence of Colorectal Carcinoma NCT07386431 | University Medical Centre Ljubljana | — |
| Recruiting | A Self-Monitoring Platform for Tracking Medication Safety and Concerns in Cancer Patients NCT07291414 | University of Michigan Rogel Cancer Center | N/A |
| Recruiting | The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and NCT07285044 | Mayo Clinic | Phase 2 |
| Enrolling By Invitation | A Multilevel Intervention to Increase Colorectal Cancer Screening Tests in Patients With Abnormal Fecal Immuno NCT06822530 | Fred Hutchinson Cancer Center | N/A |
| Recruiting | Clinical Trial Evaluating the Activity of Zanidatamab for the Treatment of Patients With Solid Tumors With an NCT07192068 | UNICANCER | Phase 2 |
| Recruiting | Testing for Safety and Colorectal Cancer Preventive Effects of ONC201 NCT05630794 | National Cancer Institute (NCI) | Phase 1 |
| Enrolling By Invitation | A Long-Term Follow-Up Study of Participants Treated With A2 Biotherapeutics (A2 Bio) Gene Therapy (GT) Product NCT06885424 | A2 Biotherapeutics Inc. | — |
| Not Yet Recruiting | 5-fluorouracil Plus Panitumumab (Anti-EGFR) and Sotorasib (KRAS G12C Inhibitor) in First-line Treatment of Pat NCT07124884 | Federation Francophone de Cancerologie Digestive | Phase 2 |
| Recruiting | Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors NCT07030257 | Tasca Therapeutics | Phase 1 / Phase 2 |
| Recruiting | Determining the Biodistribution of an Imaging Tracer (68Ga-FAPi-46) in Patients With Solid Tumors or Hematolog NCT07118176 | Jonsson Comprehensive Cancer Center | Phase 1 |
| Not Yet Recruiting | Efficacy Study of Digoxin Combined With Serplulimab and Chemotherapy in First-Line Treatment of MSS Advanced C NCT07025850 | Fudan University | Phase 1 / Phase 2 |
| Recruiting | Evaluating the Effects of an Exercise Intervention on the Gut Microbiota in Stage II-III Colorectal Cancer Sur NCT05930496 | Fred Hutchinson Cancer Center | N/A |
| Not Yet Recruiting | Rectus Sheath Catheters Following Midline Laparotomy NCT07099924 | Asklepios Kliniken Hamburg GmbH | N/A |
| Recruiting | New bioMarkers tO straTIfy cOlorectal caNcer Referrals NCT07035691 | Queen Mary University of London | — |
| Recruiting | The Vanguard Study: Testing a New Way to Screen for Cancer NCT06995898 | National Cancer Institute (NCI) | N/A |
| Recruiting | Immune Response Activation for the Treatment of Unresectable Metastatic Colorectal Cancer or CEA Positive Meta NCT06130826 | City of Hope Medical Center | Phase 1 |
| Recruiting | Clinicopathological Value of p16 Expression in Colorectal Carcinoma NCT07047482 | Sohag University | — |
| Recruiting | Implementation of a ColoRectal Cancer Screening Tool in US Primary Care Practices - Usual Quality Improvement NCT06682650 | University of Kansas Medical Center | N/A |
| Recruiting | SCRT-CAPEOX-Serplulimab for MSS/pMMR Rectal Cancer With Oligometastases NCT06850103 | First Affiliated Hospital of Zhejiang University | Phase 2 |
| Recruiting | A Clinic-wide Intervention (Primary Care-GI Connect) for Improving Rates of Colonoscopy After Abnormal Fecal I NCT06568016 | Jonsson Comprehensive Cancer Center | N/A |
| Recruiting | Intrathecal Morphine Versus Epidural Analgesia for Open Colon Surgery NCT06935708 | Meri Mirceta | Phase 4 |
| Recruiting | A Study to Test Different Doses of BI 765049 in People With Advanced Cancer of the Colon, Rectum, Stomach, or NCT06882746 | Boehringer Ingelheim | Phase 1 |
| Recruiting | Prospective Evaluation of Cornerstone Robotics Sentire Surgical System in Major Gastrointestinal and Urologic NCT06926374 | Chinese University of Hong Kong | N/A |
| Recruiting | A Study of MGC028 in Participants With Advanced Solid Tumors NCT06723236 | MacroGenics | Phase 1 |
| Recruiting | Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology C NCT06418204 | Wake Forest University Health Sciences | — |
| Recruiting | Evaluation of PreveCol's Efficiency As a Second Line Method for the Early Colorectal Cancer Detection NCT06703632 | ADVANCED MARKER DISCOVERY S.L. | N/A |
| Not Yet Recruiting | Phase 1 Dose Escalation and Expansion to Evaluate AROG4-01 in Patients With Advanced Solid Tumors NCT06652529 | Aromics Therapeutics | Phase 1 |
| Recruiting | CDH17 CAR-T Therapy in Advanced Malignant Solid Tumors NCT06937567 | Zhejiang University | EARLY_Phase 1 |
| Not Yet Recruiting | The Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of Injectable SPN01 in Phase I. NCT06710561 | Beijing SonoPhotoNano Medical Technology Co., Ltd. | Phase 1 |
| Not Yet Recruiting | COLORECTUM+ Digital System for Postoperative Quality Improvement in Colorectal Cancer NCT06685497 | RenJi Hospital | N/A |
| Terminated | A Study to Learn About How Different Amounts of the Study Medicine PF-07826390 Act in the Body of People With NCT06546553 | Pfizer | Phase 1 |
| Recruiting | Irinotecan Hydrochloride Liposome Injection (Ⅱ) Combined with Fluorouracil, Folinic Acid, Vermofenib and Cetux NCT06603376 | Shanghai Changzheng Hospital | Phase 2 |
| Recruiting | CoGENES Randomized Controlled Trial (RCT) NCT07229443 | University of Southern California | N/A |
| Recruiting | Encorafenib + Cetuximab Beyond Progression in Combination With FOLFIRI in Patients With BRAF V600E Mutated Met NCT06640166 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | Phase 2 |
| Recruiting | Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors NCT06218914 | AstraZeneca | Phase 1 |
| Recruiting | The Ohio State University (OSU) SCREEN Community Program NCT06666192 | Ohio State University Comprehensive Cancer Center | N/A |
| Terminated | A Study of PF-07820435 as a Single Agent and in Combination in Participants With Advanced Solid Tumors NCT06285097 | Pfizer | Phase 1 |
| Withdrawn | Binimetinib and Palbociclib Before Surgery for the Treatment of Operable KRAS-Positive Lung, Colorectal, or Pa NCT04870034 | Roswell Park Cancer Institute | EARLY_Phase 1 |
| Not Yet Recruiting | Study of Fuquinitinib Combined With Capecitabine First-line Maintenance in the Treatment of Metastatic Colorec NCT06115733 | Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine | N/A |
| Recruiting | Improving Colonoscopy Surveillance for Patients With High Risk Colon Polyps NCT06376565 | Jonsson Comprehensive Cancer Center | N/A |
| Completed | Optimization of Adaptive Text Messages for Cancer Survivors (OATS II) NCT05746195 | University of California, San Francisco | N/A |
| Recruiting | Clinical Research on the Treatment Model of Ambulatory Surgery for Colorectal Cancer NCT06637215 | First Hospital of China Medical University | N/A |
| Completed | Periodontal Disease and Colorectal Cancer NCT06799182 | University Medical Centre Ljubljana | N/A |
| Completed | Online Mindfulness-Based Intervention to Decrease Pre-Procedural Anxiety Before a First-Time Screening Colonos NCT06233253 | Ohio State University Comprehensive Cancer Center | N/A |
| Recruiting | Organ Preservation in Rectal AdenoCa Using Hypofractionated Pelvic RT(Hypo-OPRA) NCT06991465 | Neil Kopek | Phase 2 |
| Recruiting | A Study of NT-175 in Adult Subjects With Unresectable, Advanced, and/or Metastatic Solid Tumors That Are Posit NCT05877599 | AstraZeneca | Phase 1 |
| Not Yet Recruiting | Anatomical Resection VS. Nonanatomical Resection for Colorectal Liver Metastases With Gene Mutation or Right-s NCT05881746 | Fudan University | N/A |
| Active Not Recruiting | Community Genetic Navigation Engagement Specialists to Increase Knowledge About Colorectal Cancer Genetics in NCT07276048 | University of Southern California | N/A |
| Recruiting | Development and Validation of a Blood Test for Early Diagnosis of Colorectal Cancer NCT06889883 | ADVANCED MARKER DISCOVERY S.L. | — |
| Active Not Recruiting | A RC198 Study in Subjects With Locally Advanced Unresectable or Metastatic Solid Tumors NCT05867303 | RemeGen Co., Ltd. | Phase 1 |
| Completed | A Video Intervention to Decrease Patient Fear of Colonoscopy After a Positive Fecal Immunochemical Test NCT05458986 | Fred Hutchinson Cancer Center | N/A |
| Active Not Recruiting | Testing a Combination of Vaccines for Cancer Prevention in Lynch Syndrome NCT05419011 | National Cancer Institute (NCI) | Phase 2 |
| Recruiting | A Web-Based Dyadic Intervention for Colorectal Cancer NCT05663203 | Emory University | N/A |
| Recruiting | Study of JANX008 in Subjects With Advanced or Metastatic Solid Tumor Malignancies NCT05783622 | Janux Therapeutics | Phase 1 |
| Recruiting | Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies NCT05786924 | Institut de Recherches Internationales Servier | Phase 1 / Phase 2 |
| Suspended | Testing Obeticholic Acid for Familial Adenomatous Polyposis NCT05223036 | National Cancer Institute (NCI) | Phase 2 |
| Completed | Blood Test (Guardant Shield™) for Screening of Colorectal Cancer in Underserved Patients NCT05716477 | Ohio State University Comprehensive Cancer Center | — |
| Completed | Artificial Intelligence in Colonoscopy NCT06621225 | Pankaj Patel | N/A |
| Active Not Recruiting | Cancer Preventive Vaccine Nous-209 for Lynch Syndrome Patients NCT05078866 | National Cancer Institute (NCI) | Phase 1 / Phase 2 |
| Active Not Recruiting | Platform Study of JDQ443 in Combinations in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutati NCT05358249 | Novartis Pharmaceuticals | Phase 1 / Phase 2 |
| Terminated | A Multilevel Approach for Improvement in Screening of Colorectal Cancer in Rural Communities, The Screen to Sa NCT05291988 | Fred Hutchinson Cancer Center | N/A |
| Unknown | QL1706 Monotherapy or in Combination With Bevacizumab and XELOX as First-line Treatment of Unresectable Advanc NCT05799820 | Qilu Pharmaceutical Co., Ltd. | Phase 2 |
| Recruiting | Confronting Cancer as a Community NCT06063928 | University of Southern California | N/A |
| Recruiting | Addressing Disparities in Colorectal Cancer Screening in Black and Underserved Phoenix Communities NCT05447923 | Mayo Clinic | N/A |
| Active Not Recruiting | Study of NGM831 as Monotherapy and in Combination With Pembrolizumab or Pembrolizumab and NGM438 in Advanced o NCT05215574 | NGM Biopharmaceuticals, Inc | Phase 1 |
| Recruiting | Collecting Blood and Stool Samples to Detect Colorectal Cancer or Advanced Neoplasia in Lynch Syndrome Patient NCT05410977 | Mayo Clinic | — |
| Recruiting | PACE: PD-1 Antibody For dMMR/MSI-H Stage III Colorectal Cancer NCT05236972 | Sun Yat-sen University | Phase 3 |
| Active Not Recruiting | HOPE-Genomics Intervention for the Improvement of Cancer Patient Knowledge of Genomics NCT04905082 | City of Hope Medical Center | N/A |
| Completed | Audio and Video Brochures for Increasing Colorectal Cancer Screening Among Adults Living in Appalachia NCT05810714 | Ohio State University Comprehensive Cancer Center | N/A |
| Recruiting | Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors NCT04851119 | Children's Oncology Group | Phase 1 / Phase 2 |
| Active Not Recruiting | Testing Atorvastatin to Lower Colon Cancer Risk in Longstanding Ulcerative Colitis NCT04767984 | Northwestern University | Phase 2 |
| Completed | Three Birds With One Stone NCT05022511 | University of Aarhus | N/A |
| Completed | Incorporating ePrognosis for the Encouragement of Smarter Screening for Breast and Colorectal Cancer in Older NCT05021172 | University of California, San Francisco | N/A |
| Completed | Psychological, Psychophysical and Epigenetic Determinants of Chronic Pain After Cytoreductive - Hyperthermic I NCT05083338 | M.D. Anderson Cancer Center | — |
| Completed | Evaluation of a New Blood-based Test to Detect Colorectal Cancer and Its Precursors NCT04980443 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | N/A |
| Active Not Recruiting | Study of Cabozantinib Plus TAS102 in mCRC as Salvage Therapy NCT04868773 | University of California, Irvine | Phase 1 |
| Completed | Screening More Patients for Colorectal Cancer Through Adapting and Refining Targeted Evidence-Based Interventi NCT04890054 | OHSU Knight Cancer Institute | N/A |
| Recruiting | Neoantigen Dendritic Cell Vaccine and Nivolumab in HCC and Liver Metastases From CRC NCT04912765 | National Cancer Centre, Singapore | Phase 2 |
| Unknown | mFOLFOXIRI+Bev vs. mFOLFOX6+Bev for RAS Mutant Unresectable Colorectal Liver-limited Metastases NCT04781270 | Fudan University | Phase 3 |
| Completed | Microsatellite Instability in Colorectal Cancers NCT05162248 | Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey | — |
| Recruiting | Changes in Reproductive and Sexual Health in People With Early Onset Colorectal Cancer NCT04812912 | Memorial Sloan Kettering Cancer Center | — |
| Completed | Feasibility Study of a 4 Stage Bowel Obstruction Cancer Diet NCT04898842 | Royal Surrey County Hospital NHS Foundation Trust | N/A |
| Not Yet Recruiting | Microwave Ablation Combined With Chemotherapy for Colorectal Liver Metastases： a Multicenter Cohort Study NCT04562727 | Ping Liang | N/A |
| Completed | Comparison of Outcomes of Patients With Stage IV Chronic Limb-threatening Ischemia and Colorectal Cancer NCT05116696 | Clinical Centre of Serbia | — |
| Active Not Recruiting | PD-1 Antibody Following Preoperative Chemoradiotherapy for Locally Advanced pMMR/MSS Rectal Cancer NCT04833387 | Sun Yat-sen University | Phase 2 |
| Unknown | Toripalimab Plus Bevacizumab and Chemotherapy as Neoadjuvant Therapy in Advanced MSI-H or dMMR Colorectal Canc NCT04988191 | Peking University | Phase 1 / Phase 2 |
| Terminated | Study to Test the Safety and Tolerability of PF-07209960 in Advanced or Metastatic Solid Tumors NCT04628780 | Pfizer | Phase 1 |
| Completed | Support Program for Adoption of Cancer Screening Interventions at a Rural Community-Based Organization NCT04208724 | Fred Hutchinson Cancer Center | N/A |
| Terminated | Immunotherapy With Y90-RadioEmbolization for Metastatic Colorectal Cancer NCT04108481 | University of Iowa | Phase 1 |
| Recruiting | Role of Diet on the Microbiome of the Digestive System NCT04666727 | M.D. Anderson Cancer Center | — |
| Active Not Recruiting | Tucatinib Plus Trastuzumab and Oxaliplatin-based Chemotherapy or Pembrolizumab-containing Combinations for HER NCT04430738 | Seagen, a wholly owned subsidiary of Pfizer | Phase 2 |
| Terminated | VB-111 in Combination With Nivolumab in People With Metastatic Colorectal Cancer (mCRC) NCT04166383 | National Cancer Institute (NCI) | Phase 2 |
| Recruiting | Collection of Information to Better Understand Young Onset Colorectal Cancer NCT04489238 | Memorial Sloan Kettering Cancer Center | — |
| Completed | Study of Radspherin® in Colorectal Carcinoma Subjects With Peritoneal Carcinomatosis Treated With HIPEC NCT03732781 | Oncoinvent Solutions AS | Phase 1 / Phase 2 |
| Terminated | Study of ONCR-177 Alone and in Combination With PD-1 Blockade in Adult Subjects With Advanced and/or Refractor NCT04348916 | Oncorus, Inc. | Phase 1 |
| Active Not Recruiting | Mechanical Bowel Preparation and Oral Antibiotics Versus Mechanical Bowel Preparation Only Prior Rectal Surger NCT04281667 | Helsinki University Central Hospital | Phase 4 |
| Withdrawn | A Pilot Study to Explore the Role of Gut Flora in Colorectal Cancer NCT04148378 | ProgenaBiome | — |
| Completed | Survivorship Care Plans and Telehealth Education for the Improvement of Access to Cancer Survivorship, the IMP NCT04081779 | Fred Hutchinson Cancer Center | N/A |
| Suspended | A Community-Based Educational Intervention to Improve Colorectal Cancer Screening NCT04392050 | Thomas Jefferson University | — |
| Completed | Combining Risk Factors and Faecal Immunochemical Testing in Colorectal Cancer Screening: a Randomized Controll NCT04490551 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | N/A |
| Active Not Recruiting | Implementation Research to Increase Colorectal Cancer Screening Rates Among Low Income and Ethnic Minority Gro NCT06090643 | Jonsson Comprehensive Cancer Center | N/A |
| Unknown | ePRO for Adjuvant Therapy of Colorectal Adenocarcinoma NCT04069455 | Zhejiang University | N/A |
| Completed | Health Service Intervention for the Improvement of Access and Adherence to Colorectal Cancer Screening NCT04607291 | Roswell Park Cancer Institute | Phase 1 |
| Completed | Microparticles in Peritoneal Carcinomatosis of Colorectal Origin NCT03969784 | Assistance Publique Hopitaux De Marseille | N/A |
| Completed | Home-based HIIT to Improve CRC Survivorship: Feasibility and Relationship With Novel Surrogate Biomarkers of C NCT04080414 | University of Utah | N/A |
| Terminated | Savolitinib in Treating Patients With MET Amplified Metastatic or Unresectable Colorectal Cancer NCT03592641 | National Cancer Institute (NCI) | Phase 2 |
| Completed | Hepatic Artery Infusion Pump Chemotherapy With Floxuridine and Dexamethasone in Combination With Systemic Chem NCT03366155 | National Cancer Institute (NCI) | Phase 2 |
| Completed | A Study of XmAb®22841 Monotherapy & in Combination w/ Pembrolizumab in Subjects w/ Selected Advanced Solid Tum NCT03849469 | Xencor, Inc. | Phase 1 |
| Completed | A Study of XmAb®23104 in Subjects With Selected Advanced Solid Tumors (DUET-3) NCT03752398 | Xencor, Inc. | Phase 1 |
| Completed | The Problem of Colorectal Anastomosis Safety NCT03958500 | Vilnius University | N/A |
| Active Not Recruiting | ABCSG C08-Exercise II: Trial of Endurance Exercise Following Adjuvant Chemotherapy for Colorectal Cancer NCT03822572 | Austrian Breast & Colorectal Cancer Study Group | N/A |
| Completed | EXERCISING TOGETHER for Couples Coping With Cancer NCT03630354 | OHSU Knight Cancer Institute | N/A |
| Withdrawn | Assessment of Current Biomarker Testing Practices for Common Solid Cancers in Precision Oncology in the Commun NCT03804255 | ECOG-ACRIN Cancer Research Group | — |
| Unknown | NBI Versus White Light Endoscopy for Optical Characterization of Neoplastic Polyps in the Colorectum NCT03679429 | Technical University of Munich | — |
| Completed | A Safety, Pharmacokinetic and Efficacy Study of NUC-3373 in Combination With Standard Agents Used in Colorecta NCT03428958 | NuCana plc | Phase 1 / Phase 2 |
| Withdrawn | Nutritional Preferences and Product Accessibility in Oral Nutritional Supplements in Participants With Breast, NCT03563352 | University of Southern California | — |
| Completed | Dolcanatide in Preventing Colorectal Cancer in Healthy Volunteers NCT03300570 | National Cancer Institute (NCI) | Phase 1 |
| Active Not Recruiting | Microwave Ablation Versus Stereotactic Body Radiotherapy for Colorectal Liver Metastases in Oligometastatic Di NCT03654131 | Rigshospitalet, Denmark | Phase 2 |
| Completed | A Study of XmAb®20717 in Subjects With Selected Advanced Solid Tumors NCT03517488 | Xencor, Inc. | Phase 1 |
| Completed | A Study of RGX-202-01 (Ompenaclid) as Combination Therapy in RAS Mutant Advanced Colorectal Cancer NCT03597581 | Inspirna, Inc. | Phase 1 |
| Completed | Novel Stent Placement Technique for Intestinal Stenosis Assisted by an Ultrafine Endoscope NCT04494919 | Ningbo No. 1 Hospital | — |
| Completed | Use of iFOBT in Patients Presenting With Alarm Symptoms of Colorectal Cancer NCT03367611 | University of Aarhus | N/A |
| Completed | Avelumab Plus Autologous Dendritic Cell Vaccine in Pre-treated Metastatic Colorectal Cancer Patients NCT03152565 | Grupo Espanol Multidisciplinario del Cancer Digestivo | Phase 1 / Phase 2 |
| Completed | CIRSE Registry for LifePearl Microspheres NCT03086096 | Cardiovascular and Interventional Radiological Society of Europe | — |
| Completed | An Investigational Immuno-therapy Study Of Nivolumab In Combination With Trametinib With Or Without Ipilimumab NCT03377361 | Bristol-Myers Squibb | Phase 1 / Phase 2 |
| Completed | Pembrolizumab in Combination With Ibrutinib for Advanced, Refractory Colorectal Cancers NCT03332498 | H. Lee Moffitt Cancer Center and Research Institute | Phase 1 / Phase 2 |
| Active Not Recruiting | Aspirin in Preventing Colorectal Cancer in Patients With Colorectal Adenoma NCT02965703 | National Cancer Institute (NCI) | Phase 2 |
| Completed | Impact of the COVID-19 Pandemic on Oncologic Outcomes in Colorectal Cancer NCT06638957 | In Ja Park | — |
| Completed | Elevated Platelet Count as Prognostic Factor in Colorectal Cancer With Synchronous Liver Metastases NCT03717519 | Azienda Ospedaliera Universitaria Integrata Verona | — |
| Completed | A Phase I/II Study of Pexa-Vec Oncolytic Virus in Combination With Immune Checkpoint Inhibition in Refractory NCT03206073 | National Cancer Institute (NCI) | Phase 1 / Phase 2 |
| Completed | Walking for Recovery From Surgery in Improving Quality of Life in Older Adults With Lung or Gastrointestinal C NCT03267524 | City of Hope Medical Center | N/A |
| Completed | FOLFIRI + Panitumumab First-line Treatment in Elderly Patients With Unresectable Metastatic Colorectal Cancer, NCT03142516 | Grupo Espanol Multidisciplinario del Cancer Digestivo | Phase 2 |
| Terminated | An Evaluation of Tilmanocept by IV Injection Using SPECT/CT vs PET Imaging in Subjects With Liver Metastases. NCT03029988 | Navidea Biopharmaceuticals | Phase 1 |
| Completed | The Assessment of the Feasibility of a Home Based Exercise Programme in the Older Patient Following Major Surg NCT03064308 | University of Nottingham | N/A |
| Active Not Recruiting | Perioperative Systemic Therapy for Isolated Resectable Colorectal Peritoneal Metastases NCT02758951 | Koen Rovers | Phase 2 / Phase 3 |
| Completed | Molecular Profiling to Improve Outcome of Patients in Cancer. A Pilot Study NCT03546127 | Institut National de la Santé Et de la Recherche Médicale, France | — |
| Active Not Recruiting | Lesion Detection Assessment in the Liver: Standard vs Low Radiation Dose Using Varied Post-Processing Techniqu NCT03151564 | M.D. Anderson Cancer Center | N/A |
| Completed | Educational Intervention - Improving Knowledge and Screening Rates for Colorectal Cancer NCT03287453 | Ohio State University Comprehensive Cancer Center | N/A |
| Terminated | Standard of Care Alone or in Combination With Ad-CEA Vaccine and Avelumab in People With Previously Untreated NCT03050814 | National Cancer Institute (NCI) | Phase 2 |
| Completed | First-in-human Study of Oral TP-0903 (a Novel Inhibitor of AXL Kinase) in Patients With Advanced Solid Tumors NCT02729298 | Sumitomo Pharma America, Inc. | Phase 1 |
| Terminated | Study Comparing Circular Stapler-assisted Colostomy vs Hand-stitching Colostomy of Colorectal Cancer Patients NCT02652702 | Zhejiang University | Phase 2 |
| Active Not Recruiting | First-in-Human Positron Emission Tomography Study Using the 18F-αvβ6-Binding-Peptide NCT03164486 | Julie L. Sutcliffe, Ph.D | EARLY_Phase 1 |
| Unknown | FOLFIRI Versus Irinotecan as Second-line Treatment in Metastatic Colorectal Cancer Patients NCT02935764 | Fudan University | Phase 3 |
| Terminated | MEDI4736 (Durvalumab) in Patients With Brain Metastasis From Epithelial-derived Tumors NCT02669914 | Washington University School of Medicine | Phase 2 |
| Unknown | CAR-pNK Cell Immunotherapy in MUC1 Positive Relapsed or Refractory Solid Tumor NCT02839954 | PersonGen BioTherapeutics (Suzhou) Co., Ltd. | Phase 1 / Phase 2 |
| Completed | Pharmacokinetic Study of Lurbinectedin in Combination With Irinotecan in Patients With Selected Solid Tumors NCT02611024 | PharmaMar | Phase 1 / Phase 2 |
| Terminated | Trial of Adoptive T Cell Therapy With Activated P53 Specific T Cells for Treatment of Advanced Colorectal Canc NCT02577588 | National Center for Tumor Diseases, Heidelberg | Phase 1 |
| Active Not Recruiting | Study of Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-3475-158/KEYNOTE-158) NCT02628067 | Merck Sharp & Dohme LLC | Phase 2 |
| Completed | Study of Pembrolizumab (MK-3475) vs Standard Therapy in Participants With Microsatellite Instability-High (MSI NCT02563002 | Merck Sharp & Dohme LLC | Phase 3 |
| Unknown | CAR-T Cell Immunotherapy in MUC1 Positive Solid Tumor NCT02617134 | PersonGen BioTherapeutics (Suzhou) Co., Ltd. | Phase 1 / Phase 2 |
| Completed | Study of Pembrolizumab (MK-3475) as Monotherapy in Participants With Previously-Treated Locally Advanced Unres NCT02460198 | Merck Sharp & Dohme LLC | Phase 2 |
| Active Not Recruiting | Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymph NCT02465060 | National Cancer Institute (NCI) | Phase 2 |
| Completed | Predictive Factors for Anastomotic Leakage After Colorectal Surgery NCT02347735 | Maastricht University Medical Center | — |
| Completed | PatientCareAnywhere Internet-Based Software in Improving Communication and Education in Patients With Cancer a NCT02408406 | City of Hope Medical Center | N/A |
| Completed | A Prospective Colorectal Liver Metastasis Database With an Integrated Quality Assurance Program NCT02218801 | European Organisation for Research and Treatment of Cancer - EORTC | — |
| Terminated | Study of Nivolumab Plus Chemotherapy in Patients With Advanced Cancer (NivoPlus) NCT02423954 | Western Regional Medical Center | Phase 1 / Phase 2 |
| Recruiting | Patients With Rectal Cancer: a "Wait-and-see" Approach NCT03001362 | McGill University Health Centre/Research Institute of the McGill University Health Centre | N/A |
| Terminated | A Study Evaluating Safety and Pharmacokinetics of ABBV-221 in Subjects With Advanced Solid Tumor Types Likely NCT02365662 | AbbVie | Phase 1 |
| Unknown | Oxaliplatin Pharmacokinetics With and Without Ca2+/MG2+ Infusion in Colorectal Cancer Patients NCT01157052 | AHS Cancer Control Alberta | Phase 1 |
| Completed | Legume Diet Satiety Pilot Study NCT02269631 | Emory University | N/A |
| Completed | AMP-224, a PD-1 Inhibitor, With Stereotactic Body Radiation Therapy in Metastatic Colorectal Cancer NCT02298946 | National Cancer Institute (NCI) | Phase 1 |
| Unknown | Trial Comparing Ferric(III)Carboxymaltose Infusion With Oral Iron Suppletion as Treatment of Anaemia NCT02243735 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Phase 4 |
| Completed | Multicenter Randomized Parallel Group Phase III Study Comparing the Bowel Cleansing Efficacy, Safety and Toler NCT02273141 | Norgine | Phase 3 |
| Completed | Safety and Efficacy Study of mFOLFOX6 + Panitumumab Combination Therapy and 5-FU/LV + Panitumumab Combination NCT02337946 | Takeda | Phase 2 |
| Completed | Multicenter Randomized Parallel Group Phase III Study Comparing the Bowel Cleansing Efficacy, Safety and Toler NCT02273167 | Norgine | Phase 3 |
| Completed | Phase 1 Study of MGD007 in Relapsed/Refractory Metastatic Colorectal Carcinoma NCT02248805 | MacroGenics | Phase 1 |
| Completed | Cancer Communication Within Hispanic Social Networks NCT04444232 | Fred Hutchinson Cancer Center | N/A |
| Completed | Multicenter Randomized Parallel Group Phase III Study Comparing the Bowel Cleansing Efficacy, Safety and Toler NCT02254486 | Norgine | Phase 3 |
| Unknown | Phase II Study of 2-weekly RAILIRI Versus FOLFIRI as Second-line Treatment in Advanced Colorectal Cancer Patie NCT02376452 | Fudan University | Phase 2 |
| Completed | CATCH-UP Intervention in Increasing Cancer Screening and Prevention Care in Uninsured Patients at Community He NCT02355262 | OHSU Knight Cancer Institute | — |
| Active Not Recruiting | Vaccine Therapy in Treating Patients With Newly Diagnosed Advanced Colon Polyps NCT02134925 | National Cancer Institute (NCI) | Phase 2 |
| Completed | Latinos CARES (Colorectal Cancer Awareness, Research, Education and Screening) NCT03078361 | H. Lee Moffitt Cancer Center and Research Institute | N/A |
| Completed | Accuracy of the Optical Diagnosis of Small Colonic Polyps Using the Nice Classification NCT02009774 | Technical University of Munich | — |
| Completed | A Phase 1 Study of Pegilodecakin (LY3500518) in Participants With Advanced Solid Tumors NCT02009449 | Eli Lilly and Company | Phase 1 |
| Completed | Microparticle Enhanced Cytotoxic Transarterial Embolization Therapy NCT02694562 | Boston Scientific Corporation | N/A |
| Completed | BBI608 and Best Supportive Care vs Placebo and Best Supportive Care in Pretreated Advanced Colorectal Carcinom NCT01830621 | NCIC Clinical Trials Group | Phase 3 |
| Terminated | An Open-Labeled Pilot Study of Biomarker Response Following Short-Term Exposure to Metformin NCT01816659 | M.D. Anderson Cancer Center | Phase 1 |
| Completed | Safety of Labeled Dendritic Cell (DC) Vaccines and Feasibility of Tracking by Magnetic Resonance Imaging (MRI) NCT01671592 | Pawel Kalinski | Phase 1 |
| Terminated | Chemokine-Modulatory Regimen for Recurrent Resectable Colorectal Cancer NCT01545141 | Roswell Park Cancer Institute | Phase 1 / Phase 2 |
| Completed | ISIS 183750 With Irinotecan for Advanced Solid Tumors or Colorectal Cancer NCT01675128 | National Cancer Institute (NCI) | Phase 1 / Phase 2 |
| Active Not Recruiting | Young-Onset Colorectal Cancer NCT02863107 | M.D. Anderson Cancer Center | — |
| Terminated | Axitinib as Maintenance Treatment in Patients With Metastatic CRC NCT01483638 | Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD) | Phase 2 |
| Completed | Lay Health Worker Outreach in Increasing Colorectal Cancer Screening in Asian Americans NCT03115372 | University of California, San Francisco | N/A |
| Completed | Recombinant Vaccinia Virus Administered Intravenously in Patients With Metastatic, Refractory Colorectal Carci NCT01394939 | Jennerex Biotherapeutics | Phase 1 / Phase 2 |
| Completed | Increasing Access to Colorectal Cancer Testing (IACCT) for Blacks NCT03078348 | H. Lee Moffitt Cancer Center and Research Institute | N/A |
| Withdrawn | A Trial of Glutamine to Prevent Oxaliplatin Neurotoxicity and a Pharmacokinetic Analysis of Oxaliplatin NCT01157039 | AHS Cancer Control Alberta | Phase 2 |
| Terminated | Neoadjuvant Study of Recombinant Vaccinia Virus to Treat Metastatic Colorectal Carcinoma in Patients Undergoin NCT01329809 | Jennerex Biotherapeutics | Phase 2 |
| Completed | Assessment of Tumor Vascular Effects of Axitinib With Dynamic Ultrasonography in Patients With Metastatic Colo NCT01486251 | Gustave Roussy, Cancer Campus, Grand Paris | N/A |
| Terminated | SKIP - A Double-blind Placebo-controlled Randomized Multicenter Trial of Skin Toxicity Treatment NCT01418742 | Gesellschaft fur Medizinische Innovation - Hamatologie und Onkologie mbH | Phase 2 |
| Completed | KRAS Mutation and Incidence of the Colorectal Carcinoma in Martinique Between 2007 and 2009 NCT01151007 | University Hospital Center of Martinique | — |
| Terminated | Effect of Sorafenib or Regorafenib on P63 Expression and Keratinocyte Differentiation in Human Skin NCT01466504 | Dartmouth-Hitchcock Medical Center | — |
| Completed | Comparative Study of Lubiprostone and PEG Preparation Versus Conventional PEG Preparation for Colonoscopy NCT01324284 | Asian Institute of Gastroenterology, India | Phase 3 |
| Completed | A Study of Irinotecan, Levofolinate, and 5-Fluorouracil (FOLFIRI) Plus Ramucirumab (IMC-1121B) NCT01286818 | Eli Lilly and Company | Phase 1 |
| Completed | Enteropathogenic Escherichia Coli (EPEC): Does it Have a Role in Colorectal Tumourigenesis? NCT02373020 | Mansoura University | — |
| Unknown | Study With Dendritic Cell Immunotherapy in Resected Hepatic Metastasis of Colorectal Carcinoma NCT01348256 | Clinica Universidad de Navarra, Universidad de Navarra | Phase 2 |
| Completed | Physical Activity for Reduction of Recurrence Rate After Adjuvant Chemotherapy for Localised Colorectal Carcin NCT01210313 | Austrian Breast & Colorectal Cancer Study Group | — |
| Terminated | Radiofrequency Ablation Versus Stereotactic Radiotherapy in Colorectal Liver Metastases NCT01233544 | University of Aarhus | Phase 3 |
| Completed | A Trial of JX-594 in Refractory Colorectal Carcinoma NCT01469611 | Samsung Medical Center | Phase 1 |
| Completed | Safety Study of the Combination of Panitumumab, Irinotecan and Everolimus in the Treatment of Advanced Colorec NCT01139138 | The Queen Elizabeth Hospital | Phase 1 / Phase 2 |
| Completed | Improvement of Fluid Balance in Patients Undergoing Surgery of the Colon and Rectum NCT01175317 | Maastricht University Medical Center | Phase 4 |
| Withdrawn | Comparative Study of Cetuximab and Radiation Vs Surgery Before or After Radiation in Patients With Colorectal NCT00725400 | American Scitech International | Phase 2 |
| Withdrawn | Prospective Randomized Trial Evaluating Mandatory Second Look Surgery With HIPEC and CRS vs. Standard of Care NCT01095523 | National Cancer Institute (NCI) | Phase 2 |
| Completed | The Effect of Environmental Pollution on Colorectal Cancer NCT06686953 | Dong Peng | — |
| Completed | Macrogol 3350-based Oral Osmotic Laxative in Preventing Cancer in Patients at Risk of Colorectal Cancer NCT00828984 | National Cancer Institute (NCI) | Phase 2 |
| Recruiting | Peritoneal Surface Malignancies - Characterization, Models and Treatment Strategies NCT02073500 | Oslo University Hospital | — |
| Terminated | Curative Resectability of Not Optimally Resectable Liver and/or Lung Metastases From Colorectal Carcinoma (CRC NCT01126866 | National Center for Tumor Diseases, Heidelberg | Phase 2 |
| Completed | A Study of IMC-1121B (Ramucirumab) in Colorectal Cancer NCT00862784 | Eli Lilly and Company | Phase 2 |
| Completed | Nelfinavir, a Phase I/Phase II Rectal Cancer Study NCT00704600 | Maastricht Radiation Oncology | Phase 1 / Phase 2 |
| Withdrawn | FOLFOX6 Plus Sir-Spheres Microspheres Plus Avastin in Patients With Nonresectable Liver Metastases From Colore NCT00735241 | Sirtex Medical | Phase 2 / Phase 3 |
| Completed | IMA910 Plus GM-CSF With Low-dose Cyclophosphamide Pre-treatment in Advanced Colorectal Carcinoma Patients Foll NCT00785122 | Immatics Biotechnologies GmbH | Phase 1 / Phase 2 |
| Completed | Comprehensive Electronic Cancer Support System for the Treatment of Cancer Related Symptoms NCT01640522 | University of Pittsburgh | N/A |
| Completed | A Phase 1 Study Investigating the Combination of RAD001, Cetuximab and Irinotecan as Second-line Therapy After NCT00478634 | Novartis Pharmaceuticals | Phase 1 |
| Completed | A Study of Irinotecan Plus Cetuximab With or Without Enzastaurin in Participants With Colorectal Cancer NCT00437268 | Eli Lilly and Company | Phase 2 |
| Completed | Safety Study of PLX4032 in Patients With Solid Tumors NCT00405587 | Plexxikon | Phase 1 |
| Terminated | Study to Evaluate Progression Free Survival in Cancer Patients With Advanced Colorectal Carcinoma With AMT2003 NCT00405561 | Auron Healthcare GmbH | Phase 2 / Phase 3 |
| Completed | FOLFOX Plus SIR-SPHERES MICROSPHERES Versus FOLFOX Alone in Patients With Liver Mets From Primary Colorectal C NCT00724503 | Sirtex Medical | N/A |
| Terminated | SU011248 in Combination With Irinotecan and Cetuximab as a Second Line Regimen for Stage IV Colorectal Cancer NCT00361244 | Massachusetts General Hospital | Phase 1 / Phase 2 |
| Terminated | Interaction of Docetaxel and Lonafarnib in Patients With Advanced Cancer NCT00288444 | Emory University | Phase 1 |
| Completed | Evaluation of the Efficacy of Xaliproden (SR57746A) in Preventing the Neurotoxicity of Oxaliplatin / 5FU/LV Ch NCT00305188 | Sanofi | Phase 3 |
| Completed | A Phase II Study of Cetuximab Plus Irinotecan in Patients With EGFR-detectable Metastatic Colorectal Carcinoma NCT00362102 | Eli Lilly and Company | Phase 2 |
| Unknown | XELOX Plus Cetuximab as First-Line Therapy in Patients With Metastatic Colorectal Cancer NCT00215722 | Grupo de Investigacao do Cancro Digestivo | Phase 2 |
| Completed | Interferon-Beta Gene Transfer (Ad.hIFN-β) as Treatment for Refractory Colorectal Carcinoma With Liver Metastas NCT00107861 | Biogen | Phase 1 / Phase 2 |
| Completed | Safety Study of Radio-labeled huA33 Antibody in Colorectal Cancer NCT00199862 | Memorial Sloan Kettering Cancer Center | N/A |
| Completed | Phase 2b Study of VELCADE Alone and VELCADE Plus Irinotecan in Patients With Relapsed or Refractory Colorectal NCT00051987 | Millennium Pharmaceuticals, Inc. | Phase 2 |
| Completed | XENOX - Evaluation of the Efficacy of Xaliproden in Reducing the Neurotoxicity of the Oxaliplatin + 5-FU/LV Ch NCT00272051 | Sanofi | Phase 3 |
| Completed | Evaluation of Surgically Resected Colorectal Adenomas and Carcinomas After 7 Days Pretreatment With Celecoxib NCT00582660 | University of Alabama at Birmingham | Phase 2 |
| Completed | Yoga-Based Rehabilitation Program in Reducing Physical and Emotional Side Effects in Patients With Cancer NCT00179348 | Albert Einstein College of Medicine | N/A |
| Completed | Irinotecan, 5-Fluorouracil, and Leucovorin in Colorectal Carcinoma NCT00176774 | University of Michigan Rogel Cancer Center | Phase 2 |
| Completed | Safety Study of hMN14 to Treat Either Colorectal or Breast Cancer NCT00041652 | Gilead Sciences | Phase 1 / Phase 2 |
| Completed | Primary Colorectal Signet Ring Cell Carcinoma and the Risk of Multiple Primary Gastrointestinal Malignancies NCT06978595 | asmaa salama ibrahim | — |
| Completed | Safety Study of 90Y-hMN14 to Treat Colorectal Cancer NCT00040599 | Gilead Sciences | Phase 1 / Phase 2 |
| Completed | Utility of PET In the Pre-Operative Assessment of Patients With Hepatic Colorectal Metastases NCT00588549 | Memorial Sloan Kettering Cancer Center | — |
| Completed | Laparoscopic Assisted Versus Open Resection for Colorectal Carcinoma NCT00485316 | Chinese University of Hong Kong | Phase 3 |
| Completed | A Cohort Study of Patients Treated With Brachytherapy for Selected Desmoid Patients in Gardner Syndrome NCT01286662 | Triemli Hospital | — |
| No Longer Available | An Expanded Access Program for AM0010 (Pegilodecakin) NCT03554434 | Eli Lilly and Company | — |