Trials / Completed
CompletedNCT03717519
Elevated Platelet Count as Prognostic Factor in Colorectal Cancer With Synchronous Liver Metastases
Elevated Platelet Count as Prognostic Factor in Colorectal Cancer With Synchronous Liver Metastases: a Retrospective Single-center Cohort Study
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 196 (actual)
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona · Academic / Other
- Sex
- All
- Age
- 18 Years – 100 Years
- Healthy volunteers
- Not accepted
Summary
Colorectal cancer (CRC) is the third most common malignancy worldwide and is often metastatic at diagnosis. Despite progresses in surgical techniques and the introduction of novel chemotherapy regimens, many patients still suffer from a poor prognosis. It is therefore of utmost importance to identify prognostic markers that may improve selection of patients. In recent years several studies demonstrated that preoperative blood tests as platelet count or neuthophil-to-lymphocyte ratio could be prognostic factors in CRC as well as other malignancies. The aim of this study was to evaluate the role of preoperative platelet count (PC) in patients with synchronous colorectal liver metastases.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| DIAGNOSTIC_TEST | Measurement of platelet count at diagnosis | Blood samples were drawn by expert phlebotomists in vacuum blood tubes containing K2-EDTA (Terumo Europe NV, Leuven, Belgium). The complete blood cell count (CBC) was performed using Advia 2120 (Siemens Healthcare Diagnostics, Tarrytown NY, USA). The local reference range for platelets was 150-400 x 109/L. The same analyser was used throughout the study period, and the quality and reproducibility of test results was validated by data of both internal quality control and external quality assessment |
Timeline
- Start date
- 2018-01-01
- Primary completion
- 2018-05-01
- Completion
- 2018-09-01
- First posted
- 2018-10-24
- Last updated
- 2023-07-20
Locations
1 site across 1 country: Italy
Source: ClinicalTrials.gov record NCT03717519. Inclusion in this directory is not an endorsement.