| Recruiting | Study of Lurbinectedin in Combination With Doxorubicin Versus Doxorubicin Alone as First-line Treatment in Par Leiomyosarcoma | Phase 3 | 2023-09-21 |
| Recruiting | Clinical Trial of PM54 in Advanced Solid Tumors Patients. Advanced Solid Tumor | Phase 1 | 2023-04-28 |
| Terminated | Plitidepsin Versus Control in Immunocompromised Adult Participants With Symptomatic COVID-19 Requiring Hospita COVID-19 | Phase 2 | 2023-04-19 |
| Recruiting | PM534 Administered Intravenously to Patients With Advanced Solid Tumors Patients With Advanced Solid Tumors | Phase 1 | 2022-12-23 |
| Active Not Recruiting | Clinical Trial of Lurbinectedin as Single-agent or in Combination With Irinotecan Versus Topotecan or Irinotec Relapsed Small Cell Lung Cancer | Phase 3 | 2022-07-22 |
| Completed | Extension Study in a Cohort of Adult Patients With COVID-19 Infection COVID-19 Infection | Phase 1 / Phase 2 | 2022-01-25 |
| Terminated | Trial to Determine the Efficacy/Safety of Plitidepsin vs Control in Patients With Moderate COVID-19 Infection COVID-19 Infection | Phase 3 | 2021-06-04 |
| Unknown | Clinical Pharmacokinetic Study of Lurbinectedin in Patients With Advanced Solid Tumors and Varying Degrees of Advanced Solid Tumor, Hepatic Impairment | Phase 1 | 2021-03-09 |
| Completed | Study to Evaluate the Effect of Bosentan on the Pharmacokinetics of Lurbinectedin in Patients With Advanced So Advanced Solid Tumor | Phase 1 | 2021-01-14 |
| Completed | Clinical Trial of Lurbinectedin (PM01183) in Patients With Advanced Solid Tumors Advanced Solid Tumors | Phase 1 | 2020-10-07 |
| Completed | Proof of Concept Study to Evaluate the Safety Profile of Plitidepsin in Patients With COVID-19 COVID-19 | Phase 1 | 2020-05-12 |
| Completed | Clinical Trial of PM60184 in Advanced Colorectal Cancer After Standard Treatment Advanced Colorectal Cancer | Phase 2 | 2018-01-16 |
| Recruiting | PM14 Administered Intravenously to Patients with Advanced Solid Tumors Advanced Solid Tumor | Phase 1 | 2017-09-06 |
| Terminated | Trial of Plitidepsin (Aplidin®) in Combination With Bortezomib and Dexamethasone in Multiple Myeloma Patients Multiple Myeloma | Phase 2 | 2017-05-08 |
| Terminated | A Study of Plitidepsin in Patients With Relapsed or Refractory Angioimmunoblastic T-cell Lymphoma Lymphoma | Phase 2 | 2016-10-25 |
| Completed | Clinical Trial of Lurbinectedin (PM01183)/Doxorubicin Versus CAV or Topotecan as Treatment in Patients With Sm Small-cell Lung Cancer | Phase 3 | 2016-08-30 |
| Completed | Pharmacokinetic Study of Lurbinectedin in Combination With Irinotecan in Patients With Selected Solid Tumors Advanced Solid Tumors, Glioblastoma, Soft Tissue Sarcoma (Excluding GIST) | Phase 1 / Phase 2 | 2016-05-06 |
| Completed | Clinical Trial of Lurbinectedin (PM01183) in Selected Advanced Solid Tumors Advanced Solid Tumors | Phase 2 | 2015-08-25 |
| Completed | Evaluation of the Effect of Lurbinectedin (PM01183) on Cardiac Repolarization in Patients With Selected Solid Solid Tumors | Phase 2 | 2015-08-12 |
| Completed | Non-interventional European Study of Trabectedin + PLD in the Treatment of Relapsed Ovarian Cancer (ROC) Patie Relapsed Ovarian Cancer | — | 2015-07-28 |
| Completed | Clinical Trial of Lurbinectedin (PM01183) in Platinum Resistant Ovarian Cancer Patients Ovarian Cancer | Phase 3 | 2015-05-01 |
| Completed | Multicenter, Open-label, Clinical and Pharmacokinetic Study of PM060184 in Combination With Gemcitabine in Sel Solid Tumors | Phase 1 | 2014-12-12 |
| Completed | Study of Lurbinectedin (PM01183) in Combination With Cisplatin in Patients With Solid Tumors Advanced Solid Tumors | Phase 1 | 2014-07-30 |
| Completed | Study of Plitidepsin (Aplidin®) in Combination With Bortezomib and Dexamethasone in Patients With Multiple Mye Multiple Myeloma | Phase 1 | 2014-06-01 |
| Completed | A Clinical Study in Three-arm of Lurbinectedin (PM01183) Alone or in Combination With Gemcitabine and a Contro Non-Small Cell Lung Cancer (NSCLC) | Phase 2 | 2013-09-11 |
| Completed | Phase I Study of Lurbinectedin (PM01183) in Combination With Paclitaxel, With or Without Bevacizumab, in Selec Breast Cancer, Ovarian Cancer, Gynecological Cancer | Phase 1 | 2013-09-01 |
| Completed | Study of Lurbinectedin (PM01183) in Combination With Capecitabine in Patients With Metastatic Breast Cancer (M Metastatic Breast Cancer, Pancreatic Cancer, Metastatic Colorectal Cancer | Phase 1 | 2013-04-01 |
| Completed | A Phase II Clinical Trial of PM01183 in BRCA 1/2-Associated or Unselected Metastatic Breast Cancer Breast Cancer | Phase 2 | 2012-06-13 |
| Completed | Study of PM01183 in Non-Colorectal Cancer Patients as a Days 1 and 8 Intravenous Short Infusion Every 3 Weeks Major Advanced Solid Tumors Other Than Colorectal | Phase 1 | 2011-11-01 |
| Completed | Study Escalating Doses of PM01183 in Combination With Fixed Doxorubicin in Patients With Specific Advanced Unr Endometrial Adenocarcinomas, Neuroendocrine Tumors, Small-cell Lung Cancer With Less Than 2 Prior Cytotoxic-containing Lines of Therapy | Phase 1 | 2011-05-25 |
| Completed | Clinical Study of PM01183 in Patients With Acute Leukemia or Relapsed/Refractory Myelodysplastic Syndrome Acute Leukemia | Phase 1 | 2011-05-01 |
| Completed | Escalating Doses of PM01183 in Combination With Gemcitabine in Patients With Specific Unresectable Solid Tumor Specific Advanced Solid Tumors | Phase 1 | 2011-05-01 |
| Completed | Study of PM060184 in Patients With Advanced Solid Tumors Solid Tumors | Phase 1 | 2011-01-01 |
| Completed | Study in Patients With Advanced Soft Tissue Sarcoma (STS) After Failure of Anthracyclines and/or Ifosfamide Soft Tissue Sarcoma | — | 2010-12-01 |
| Completed | Study of Zalypsis® (PM00104) in Patients With Unresectable Locally Advanced and/or Metastatic Ewing Family of Ewing's Sarcoma, Primitive Neuroectodermal Tumor (PNET), Askin's Tumor of the Chest Wall | Phase 2 | 2010-12-01 |
| Completed | Clinical Trial of Aplidin® in Patients With Primary Myelofibrosis Myelofibrosis | Phase 2 | 2010-07-01 |
| Completed | Aplidin - Dexamethasone in Relapsed/Refractory Myeloma Relapsed/Refractory Multiple Myeloma | Phase 3 | 2010-06-01 |
| Terminated | Clinical Trial of PM00104 (Zalypsis®) in Patients With Advanced and/or Metastatic Endometrial or Cervical Canc Uterine Cervical Cancer, Endometrial Cancer | Phase 2 | 2009-08-01 |
| Completed | Phase I, Multicenter, Open-label, Dose-escalating, Clinical and Pharmacokinetic Study of PM01183 in Patients W ADVANCED SOLID TUMORS | Phase 1 | 2009-03-01 |
| Completed | Trial of PM02734 Administered in Combination With Erlotinib in Patients With Advanced Malignant Solid Tumors Advanced Malignant Solid Tumors | Phase 1 | 2009-01-01 |
| Completed | Study of Plitidepsin in Combination With Sorafenib or Gemcitabine in Patients With Advanced Solid Tumors or Ly Advanced Solid Tumors, Lymphomas | Phase 1 | 2008-12-01 |
| Terminated | Clinical Study of Plitidepsin (Aplidin®) in Combination With Cytarabine in Patients With Relapsed/Refractory L Relapsed/Refractory Leukemia | Phase 1 / Phase 2 | 2007-11-01 |
| Terminated | A Phase I Study of Zalypsis (PM00104) in Subjects With Advanced Malignant Solid Tumors or Lymphoma Solid Tumors, Lymphoma | Phase 1 | 2006-05-01 |
| Terminated | A Phase I Study of PM02734 in Subjects With Advanced Malignant Solid Tumors Solid Tumors | Phase 1 | 2005-08-01 |
| Terminated | A Study of Aplidin ( Plitidepsin) in Subjects With Advanced Prostate Cancer Prostate Cancer | Phase 2 | 2005-02-01 |
| Completed | A Study of Aplidin (Plitidepsin) 3 h iv in Subjects With Relapsing or Refractory Multiple Myeloma Multiple Myeloma | Phase 2 | 2005-02-01 |
| Completed | Multicenter Trial to Treat Patients With Relapsed/Refractory Aggressive Non Hodgkin Lymphoma Leukemia, Lymphoma | Phase 2 | 2004-12-01 |
| Terminated | Ecteinascidin 743 in Treating Patients With Malignant Mesothelioma Malignant Mesothelioma | Phase 2 | 2001-07-01 |