Clinical Trials Directory

Trials / Recruiting

RecruitingNCT06723236

A Study of MGC028 in Participants With Advanced Solid Tumors

A Phase 1, First-in-Human, Open Label, Dose Escalation and Cohort Expansion Study of MGC028 in Participants With Advanced Solid Tumors

Status
Recruiting
Phase
Phase 1
Study type
Interventional
Enrollment
124 (estimated)
Sponsor
MacroGenics · Industry
Sex
All
Age
18 Years
Healthy volunteers
Not accepted

Summary

The goal of this clinical trial is to characterize the safety, tolerability, dose-limiting toxicities (DLT), and maximum tolerated dose (MTD) or maximum administered dose of MGC028 (if no MTD is defined). The study will enroll adult participants with relapsed or refractory, unresectable, locally advanced of metastatic solid tumors known to express ADAM9. The main question the study aims to answer is: * What types of side effects will participants experience when receiving MGC028? * Can MGC028 cause cancer to shrink, remain stable, or able to control disease progression of participants with advanced solid tumors? Participants will * Undergo screening procedures to determine eligibility * Receive study treatments initially every 3 weeks. * Have blood samples taken for routine and research tests * Have other examinations to check heart and lung function, and general health status * Be asked about any side effects that may be happening or other medications you are taking. The study doctor will provide treatment for side effects, if necessary. * Have the study doctor assess your tumor status at regular intervals to determine how you are responding to treatment.

Conditions

Interventions

TypeNameDescription
BIOLOGICALMGC028MGC028 is an antibody-drug conjugate targeted against ADAM9.

Timeline

Start date
2025-02-13
Primary completion
2026-11-01
Completion
2027-04-01
First posted
2024-12-09
Last updated
2025-09-17

Locations

6 sites across 1 country: United States

Regulatory

Source: ClinicalTrials.gov record NCT06723236. Inclusion in this directory is not an endorsement.