NCT01233544

Radiofrequency Ablation Versus Stereotactic Radiotherapy in Colorectal Liver Metastases

The International Liver Tumor Group RAS-trial Radiofrequency Ablation Versus Stereotactic Body Radiation Therapy for Colorectal Liver Metastases: A Randomized Trial

• Status: Terminated
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 300 (estimated)
• Sponsor: University of Aarhus · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Not accepted

Summary

This randomized clinical phase III trial is testing the efficacy of radiofrequency ablation (RFA) and stereotactic body radiotherapy (SBRT) in the treatment of colorectal carcinoma liver metastases. Primary end point is local progression free survival.

Detailed description

Patients with 1-4 inoperable colorectal liver metastases, no more 4 cm in diameter are randomized to either RFA or SBRT. Primary end point i local progression free survival. Chemotherapy is allowed before and after study treatment.

Conditions

• Colorectal Carcinoma
• Liver Metastases

Interventions

Type	Name	Description
PROCEDURE	SBRT or RFA	Patients are allocated to one of the two arms in a 1:1 randomization

Timeline

• Start date: 2010-09-01
• Primary completion: 2014-12-01
• Completion: 2014-12-01
• First posted: 2010-11-03
• Last updated: 2016-05-12

Locations

2 sites across 2 countries: Denmark, Sweden