| Recruiting | Hepzato Kit and Opdualag for Metastatic Melanoma and Liver Metastasis NCT07281924 | University of Wisconsin, Madison | Phase 1 / Phase 2 |
| Not Yet Recruiting | Neoadjuvant Dupilumab and Toripalimab in MSS CRC Subjects With Resectable Liver Metastases NCT07277322 | Dan Feng | Phase 1 / Phase 2 |
| Not Yet Recruiting | SAMe in Prevention of Oxaliplatin-associated Liver Injury NCT06258525 | Cedars-Sinai Medical Center | Phase 2 |
| Not Yet Recruiting | EUS-guided CTCs + Multi-omics: Predicting Pancreatic Cancer Recurrence and Metastases NCT07448376 | Huazhong University of Science and Technology | — |
| Not Yet Recruiting | An Open-Label, Single-Arm, Dose-Escalation Phase I Study Evaluating the Safety, Tolerability, and Preliminary NCT07461727 | Cancer Institute and Hospital, Chinese Academy of Medical Sciences | Phase 1 |
| Recruiting | REGULUS: MRI-guided Adaptive SABR for Liver Cancers NCT07223307 | Stanford University | Phase 2 |
| Recruiting | Promoting Immunotherapy Efficacy With Low-Dose Liver RT NCT07225036 | Jordan Kharofa | N/A |
| Recruiting | Functional Liver After SBRT NCT07033364 | The Netherlands Cancer Institute | — |
| Recruiting | HepQuant: Study to Assess the Role of Blood-based Biomarkers and Quantitative MR Imaging for Patients Receivin NCT06899152 | Montefiore Medical Center | N/A |
| Recruiting | Histotripsy Plus Chemotherapy vs Chemotherapy Alone for Advanced Colorectal Liver Metastasis NCT07044362 | Case Comprehensive Cancer Center | N/A |
| Recruiting | Transarterial Chemoembolization (TACE) Plus Bevacizumab for Liver Metastases NCT06311851 | Pardis Noor Medical Imaging and Cancer Center | Phase 1 / Phase 2 |
| Recruiting | CRISPR-Edited HLA Donor Liver Transplant to Reduce Rejection NCT07053488 | AMERICAN ORGAN TRANSPLANT AND CANCER RESEARCH INSTITUTE LLC | Phase 1 / Phase 2 |
| Recruiting | SBRT + PD-1 Monoclonal Antibody in Unresectable Colorectal Liver Metastases NCT06794086 | Jun Huang | Phase 3 |
| Not Yet Recruiting | Part of the Modern Art Study NCT06768242 | Erasmus Medical Center | N/A |
| Not Yet Recruiting | NON-COlorectal Liver METastases Undergoing Liver Resection NCT06542926 | Azienda Ospedaliero Universitaria Maggiore della Carita | — |
| Recruiting | Ultra-high Dose Radiation for Liver Metastasis Using MR-guided TReatment With Stereotactic Ablative Single-fra NCT06362395 | University Health Network, Toronto | Phase 3 |
| Recruiting | Induction Treatment for Initially Unresectable Colorectal Liver Metastases: Combined Hepatic Arterial Infusion NCT06857773 | The Netherlands Cancer Institute | Phase 3 |
| Recruiting | Improved Recovery by Iron Following Surgery With Blood Loss, the IRIS-trial NCT05744219 | Jon Unosson | Phase 3 |
| Recruiting | TANGO-LIVER Three Arm Nuclear Growth Observation in Liver Surgery NCT06050200 | Medical University of Warsaw | N/A |
| Active Not Recruiting | The Significance and Indications of Surgery for Synchronous Liver Metastatic Pancreatic Cancer NCT06873178 | China-Japan Friendship Hospital | — |
| Recruiting | COLDFIRE-III Trial: Efficacy of Irreversible Electroporation and Stereotactic Body Radiotherapy for Perivascul NCT06185556 | Amsterdam UMC, location VUmc | Phase 2 / Phase 3 |
| Recruiting | Study of Bevacizumab in Combination With Chemoimmunotherapy and Atezolizumab in Patients With Extensive Stage NCT05588388 | Kamya Sankar | Phase 2 |
| Terminated | Comparison of Adjuvant Treatment With 177Lu-DOTATATE to Best Supportive Care in Patients After Resection of Ne NCT05987176 | Imperial College London | Phase 2 |
| Not Yet Recruiting | Prospective Observational Cohort Study NCT06493448 | Lin Chen | — |
| Recruiting | Dose Finding, Efficacy and Immunological Response of IP-001 Following MWA or IRE for CRLM NCT06630624 | M.R. Meijerink | Phase 1 / Phase 2 |
| Recruiting | PHP in Combination With IPI1/NIVO3 Compared to IPI3/NIVO1 Only in Patients With Uveal Melanoma Liver Metastase NCT06519266 | Vastra Gotaland Region | Phase 3 |
| Recruiting | Simultaneous vs. Staged Resection of Colorectal Cancer With Synchronous Liver Metastases NCT06200831 | Oslo University Hospital | N/A |
| Recruiting | Platform Study of Immunotherapy Combinations in Colorectal Cancer Liver Metastases NCT06300463 | Weill Medical College of Cornell University | Phase 2 |
| Not Yet Recruiting | French Assessment of MRD by Liquid Biopsies in Colorectal With Liver Metastasis Patients (FRENCH.MRD.CRLM) NCT06287723 | University Hospital, Montpellier | — |
| Not Yet Recruiting | Liver Transplantation After ex Vivo Liver Perfusion NCT05951231 | Oslo University Hospital | N/A |
| Unknown | Quantitative MRI and Outcomes of Liver Resection NCT06181318 | University Hospital Heidelberg | — |
| Recruiting | Neoadjuvant Serplulimab & Bevacizumab With FOLFOX vs. FOLFOX Alone in RAS/BRAF WT, pMMR/MSS CRC Patients NCT06280495 | Sun Yat-sen University | Phase 2 / Phase 3 |
| Recruiting | Prospective Cohort Study on Thermal Ablation of Malignant Liver Tumors NCT06179602 | Leiden University Medical Center | — |
| Unknown | Toripalimab,Celecoxib and Regorafenib in the Treatment of Refractory Advanced Colorectal Cancer NCT05933980 | Sun Yat-sen University | Phase 2 |
| Unknown | Open Versus Laparoscopic Ablation of Liver Malignancies NCT06304766 | Rigshospitalet, Denmark | N/A |
| Completed | An Observational Study to Learn More About the Impact of Gadoxetate Sodium-Enhanced Magnetic Resonance Imaging NCT06106568 | Bayer | — |
| Recruiting | A Study of Single Fraction Stereotactic Body Radiation Therapy (SBRT) Guided by Magnetic Resonance Imaging (MR NCT06130280 | Memorial Sloan Kettering Cancer Center | Phase 2 |
| Unknown | Radioembolisation and Chemotherapy in Liver Metastatic Breast Cancer Patients NCT06142344 | The Netherlands Cancer Institute | N/A |
| Recruiting | Alpha Radiation Emitters Device for the Treatment of Liver Metastases (DaRT) NCT05829291 | Alpha Tau Medical LTD. | N/A |
| Unknown | Postoperative Chemotherapy With/Without Radiotherapy and Immunotherapy for Colorectal Liver Metastases With Hi NCT06120127 | Fudan University | Phase 2 |
| Not Yet Recruiting | Multimodal Deep Learning Signature for Evaluation of Response to Bevacizumab in Patient With Colorectal Cancer NCT05354674 | Fudan University | — |
| Active Not Recruiting | A Study of QBECO Versus Placebo in the Treatment of Colorectal Cancer That Has Spread to the Liver NCT05677113 | Sunnybrook Health Sciences Centre | Phase 2 |
| Not Yet Recruiting | Cetuximab+mFOLFOX6 VS. mFOLFOX6 Alone in RAS/BRAF Wild Type Patients With High-Risk Resectable CRLM NCT05948072 | Fudan University | Phase 3 |
| Not Yet Recruiting | Anatomical Resection VS. Nonanatomical Resection for Colorectal Liver Metastases With Gene Mutation or Right-s NCT05881746 | Fudan University | N/A |
| Active Not Recruiting | Senior Adult Hepatobiliary Prehab Study NCT05921552 | H. Lee Moffitt Cancer Center and Research Institute | N/A |
| Unknown | Serplulimab+Regorafenib +Hepatic Artery Bicarbonate Infusion in Patients With Colorectal Cancer and Liver Meta NCT05894837 | Second Affiliated Hospital, School of Medicine, Zhejiang University | Phase 2 |
| Recruiting | COLLISION RELAPSE Trial NCT05861505 | Amsterdam UMC, location VUmc | Phase 3 |
| Unknown | Effect of Hepatectomy on the Prognosis of Patients With Nasopharyngeal Carcinoma Liver Metastases NCT05771025 | Fudan University | N/A |
| Unknown | Impact of a European Training Program for Robotic Liver Surgery (LIVEROBOT) NCT05723705 | Amsterdam UMC, location VUmc | — |
| Unknown | Clinical, Histological and In-depth Molecular Characterization as Well as Experimental Models of Liver Metasta NCT05720676 | KU Leuven | — |
| Recruiting | ctDNA-guided Adjuvant Chemotherapy in Liver Metastasis of Colorectal Cancer NCT05815082 | Sixth Affiliated Hospital, Sun Yat-sen University | Phase 3 |
| Recruiting | Postoperation Maintenance Therapy for Resectable Liver Metastases of Colorectal Cancer Guided by ctDNA NCT05797077 | Sixth Affiliated Hospital, Sun Yat-sen University | Phase 3 |
| Completed | Study of Different Gating Techniques for PET Image of Lung and Liver Lesions NCT05779865 | Centre Hospitalier Princesse Grace | — |
| Unknown | Recombinant Human Adenovirus Type 5 Injection Combined With PD-1 Monoclonal Antibody and Nab-paclitaxel in the NCT05664139 | Fujian Cancer Hospital | Phase 2 |
| Unknown | Exploratory Study on Combined Conversion Immunotherapy for Liver Metastasis of MSS Type Initial Unresectable C NCT05409417 | Second Affiliated Hospital, School of Medicine, Zhejiang University | Phase 2 / Phase 3 |
| Recruiting | Incremental Value of Magnetic Resonance Imaging in Selection of Pancreatic Cancer Patients for Surgery NCT05428358 | University of Aarhus | N/A |
| Completed | Hepatic Ablation of Melanoma Metastases to Enhance Immunotherapy Response, a Phase I Clinical Trial (HAMMER I) NCT05169957 | University of Michigan Rogel Cancer Center | Phase 1 |
| Unknown | Study for the Multidimensional Analyses of Resistance and Toxicity to Immune- and Targeted-therapies. NCT06321640 | European Institute of Oncology | — |
| Unknown | VALIDATION OF THE VIBe INTRAOPERATIVE BLEEDING SCALE IN LIVER SURGERY NCT05369988 | Hospital Miguel Servet | — |
| Recruiting | Liver SBRT in Combination With Immune Checkpoint Inhibition in Patients With Metastatic Non-small Cell Lung Ca NCT05430009 | VA Ann Arbor Healthcare System | Phase 1 |
| Unknown | Comparison Between LDCT With DL Recontruction and Standard Dose CT NCT05324046 | Seoul National University Hospital | — |
| Unknown | Liver Transplantation for Unresectable GIST Liver Metastases NCT04825470 | Hospital Universitario Virgen de la Arrixaca | N/A |
| Recruiting | ctDNA-Directed Post-Hepatectomy Chemotherapy for Patients With Resectable Colorectal Liver Metastases NCT05062317 | M.D. Anderson Cancer Center | Phase 2 |
| Unknown | Study of Tislelizumab in Combination With SOX for the Treatment of Gastric Cancer With Liver Metastases NCT05325528 | Zhejiang University | Phase 2 / Phase 3 |
| Recruiting | Liver Transplantation for Non-resectable Colorectal Liver Metastases: Translational Research NCT05398380 | Hospital Vall d'Hebron | N/A |
| Terminated | FUDR/Oxaliplatin HAI Plus Irinotecan vs. FOLFOXIRI Chemotherapy in Treating Initially Unresectable CRCLM NCT03678428 | Sun Yat-sen University | Phase 3 |
| Completed | Perioperative Intravenous Lidocaine in Liver Surgery NCT05153785 | Lund University Hospital | Phase 2 / Phase 3 |
| Recruiting | Cryoablation Combined with Sintilimab Plus Regorafenib in Previously Treated Colorectal Cancer Liver Metastasi NCT05057052 | Fudan University | Phase 2 |
| Recruiting | Intra-arterial Hepatic (IAH) Infusion of Radiolabelled Somatostatin Analogs in GEP-NET Patients With Dominant NCT04837885 | University Hospital, Bordeaux | Phase 2 |
| Completed | Low Dose ICG for Biliary Tract and Tumor Imaging NCT04942665 | University of Florida | Phase 2 |
| Recruiting | Liver Transplantation in Patients With Unresectable Colorectal Liver Metastases NCT04616495 | Hospital Universitario La Fe | — |
| Active Not Recruiting | HAI-Floxuridine, or Liver-Tx, Combined With 2nd Line Chemotherapy Versus 2nd Line Chemotherapy Alone for Patie NCT04898504 | Oslo University Hospital | Phase 2 |
| Recruiting | Standard Versus Radiobiologically-Guided Dose Selected SBRT in Liver Cancer NCT04745390 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | N/A |
| Unknown | Preoperative Irinotecan Drug-eluting Beads for Patients With Unresectable Colorectal Liver Metastasis NCT04912258 | Fudan University | Phase 3 |
| Completed | Clinical Trial Comparing Standard Care Versus Prehabilitation in Patients Undergoing Cancer Surgery NCT04880772 | East Lancashire Hospitals NHS Trust | N/A |
| Terminated | Comparison of Contrast Agents in Liver MR for the Detection of Hepatic Metastases NCT04973007 | University of Colorado, Denver | Phase 4 |
| Active Not Recruiting | An Exploratory Study of Atezolizumab and Bevacizumab in Hepatocellular Carcinoma and Non-Small Cell Lung Cance NCT04563338 | University Health Network, Toronto | Phase 2 |
| Active Not Recruiting | The HistoSonics System for Treatment of Primary and Metastatic Liver Tumors Using Histotripsy (#HOPE4LIVER EU/ NCT04573881 | HistoSonics, Inc. | N/A |
| Unknown | A Trial of Camrelizumab Combined With Microwave Ablation and Chemotherapy in the Treatment of Colorectal Cance NCT04888806 | Harbin Medical University | Phase 2 |
| Recruiting | Neoantigen Dendritic Cell Vaccine and Nivolumab in HCC and Liver Metastases From CRC NCT04912765 | National Cancer Centre, Singapore | Phase 2 |
| Unknown | mFOLFOXIRI+Bev vs. mFOLFOX6+Bev for RAS Mutant Unresectable Colorectal Liver-limited Metastases NCT04781270 | Fudan University | Phase 3 |
| Suspended | EXtended CriteriA Treatment for LIver Metastases and Heavy Tumour BURden NCT04840186 | Oslo University Hospital | Phase 2 |
| Unknown | Long-term Outcomes After Breast Cancer Liver Metastasis Surgery: an European, Retrospective, Snapshot Study NCT04817813 | Hospital Miguel Servet | — |
| Completed | Isolated Hepatic Perfusion in Combination With Ipilimumab and Nivolumab in Patients With Uveal Melanoma Metast NCT04463368 | Vastra Gotaland Region | Phase 1 |
| Not Yet Recruiting | Microwave Ablation Combined With Chemotherapy for Colorectal Liver Metastases： a Multicenter Cohort Study NCT04562727 | Ping Liang | N/A |
| Completed | Safety, Tolerability, PK, Anti-Tumor Activity of STP705 in Subjects With Advanced/Metastatic or Surgically Unr NCT04676633 | Sirnaomics | Phase 1 |
| Suspended | DNX-2440 for Resectable Colorectal Liver Metastasis NCT04714983 | DNAtrix, Inc. | Phase 1 |
| Recruiting | Multimodal Prehabilitation During Chemotherapy in Patients With Colorectal Liver Metastases NCT04520737 | Institut Investigacio Sanitaria Pere Virgili | N/A |
| Active Not Recruiting | The HistoSonics System for Treatment of Primary and Metastatic Liver Tumors Using Histotripsy NCT04572633 | HistoSonics, Inc. | N/A |
| Recruiting | Conversion Therapy of RAS/BRAF Wild-Type Colorectal Cancer Patients With Initially Unresectable Liver Metastas NCT04687631 | Fudan University | Phase 3 |
| Unknown | CE-IOUS for Patients With Pancreatic Cancer Undergoing Surgery: A Prospective, Proof-of-concept Trial NCT04683497 | University of Thessaly | N/A |
| Active Not Recruiting | The Swedish Study of Liver Transplantation for Non-resectable Colorectal Cancer Metastases NCT04161092 | Vastra Gotaland Region | N/A |
| Completed | Impact of Minimally Invasive and Open Liver Surgery in Different BMI-classes NCT05475054 | Fondazione Poliambulanza Istituto Ospedaliero | — |
| Unknown | Radiotherapy With Iron Oxide Nanoparticles (SPION) on MR-Linac for Primary & Metastatic Hepatic Cancers NCT04682847 | Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) | — |
| Recruiting | TACE Combined With Immune Checkpoint Inhibitors for Liver Malignant Tumors NCT06487663 | Tianjin Medical University Cancer Institute and Hospital | N/A |
| Terminated | Immunotherapy With Y90-RadioEmbolization for Metastatic Colorectal Cancer NCT04108481 | University of Iowa | Phase 1 |
| Unknown | Radiomics Assess of Bevacizumab Plus Chemo in Colorectal Cancer Liver Metastases NCT04213222 | Peking University People's Hospital | — |
| Unknown | Conversion Therapy of RAS/BRAF Wild-Type Right-sided Colon Cancer Patients With Initially Unresectable Liver M NCT04525326 | Fudan University | Phase 3 |
| Recruiting | Resection And Partial Liver Segmental Transplantation With Delayed Total Hepatectomy NCT04865471 | Azienda Ospedaliera di Padova | N/A |
| Completed | Role of EUS in Detection of Liver Metastasis NCT04509492 | Mahmoud Wahba | — |
| Terminated | Intraoperative EXamination Using MAChine-learning-based HYperspectral for diagNosis & Autonomous Anatomy Asses NCT04589884 | IHU Strasbourg | — |
| Unknown | Cetuximab Re-challenge for Colorectal Cancer Liver Metastasis NCT04509635 | Fudan University | Phase 3 |
| Unknown | The Prediction Model of Avastin Plus Chemotherapy in Unresectable Ras Mutant CRLM Patients NCT04525313 | Fudan University | — |
| Completed | A Study Evaluating Safety, Pharmacokinetics, Pharmacodynamics, And Clinical Activity Of RO7119929 (TLR7 Agonis NCT04338685 | Hoffmann-La Roche | Phase 1 |
| Completed | HAIC Combined Sintilimab for Liver Metastasis From Esophageal Squamous Cell Carcinoma NCT06184841 | Peking University Cancer Hospital & Institute | Phase 1 |
| Withdrawn | Irreversible Electroporation of Unresectable Liver Tumors NCT04404647 | Ole Thorlacius-Ussing, MD, DMSc, Professor of Surgery | N/A |
| Terminated | Study of ONCR-177 Alone and in Combination With PD-1 Blockade in Adult Subjects With Advanced and/or Refractor NCT04348916 | Oncorus, Inc. | Phase 1 |
| Recruiting | BreCLIM-2 - A RCT Investigating Local Treatment for Breast Cancer Liver Metastases NCT04079049 | Umeå University | Phase 3 |
| Unknown | ARAPS Study on Accelerated Liver Regeneration NCT04107324 | University of Aarhus | N/A |
| Completed | Real-time Imaging of Holmium Radioembolization: a Feasibility Study NCT04269499 | Radboud University Medical Center | N/A |
| Recruiting | OAR-Based, Dose Escalated SBRT With Real Time Adaptive MRI Guidance for Liver Metastases NCT04020276 | University of Wisconsin, Madison | N/A |
| Recruiting | Tissue Analysis After Tumor Ablation for Liver Metastases Leading to Immediate Retreatment NCT04143516 | Memorial Sloan Kettering Cancer Center | Phase 2 / Phase 3 |
| Recruiting | Stereotactic Magnetic Resonance Guided Radiation Therapy NCT04115254 | Dana-Farber Cancer Institute | N/A |
| Unknown | Impact of Chemotherapy and Regenerative Markers of Liver Regeneration After Liver Resection for Liver Metastas NCT04178759 | Vilnius University | N/A |
| Unknown | Hepatectomy Risk Assessment With Functional Magnetic Resonance Imaging NCT04705194 | University of Leeds | — |
| Completed | Hepatic Artery Infusion Pump Chemotherapy With Floxuridine and Dexamethasone in Combination With Systemic Chem NCT03366155 | National Cancer Institute (NCI) | Phase 2 |
| Completed | Dynamic ctDNA Detection for Colorectal Cancer Liver Metastases NCT06404593 | Peking University Cancer Hospital & Institute | — |
| Unknown | Clinical Efficacy of Stereotactic Radiotherapy and Microwave Ablation for Liver Metastases From Colorectal Can NCT03963726 | Peking University Third Hospital | N/A |
| Not Yet Recruiting | Abdominal Regional Perfusion in Donation After Cardiac Death for Multi-Organ Transplantation NCT03946852 | London Health Sciences Centre | N/A |
| Completed | National Registry of Liver First Approach NCT04683783 | Hospital Miguel Servet | — |
| Withdrawn | Oligometastases of the LIVer Treated With Chemotherapy With ou Without Extracranial Stereotactic Body Radiatio NCT03532204 | UNICANCER | N/A |
| Active Not Recruiting | Stereotactic Body Radiation Therapy (SBRT) Efficiency and Toxicity in Liver Cancer NCT03408665 | Centre Oscar Lambret | N/A |
| Completed | TheraSphere Selective Internal Radiation Therapy (SIRT) as Treatment for Neuroendocrine Tumours With Liver Met NCT04362436 | Imperial College London | Phase 2 |
| Active Not Recruiting | Hepatic Artery Infusional Floxuridine to Treat Pancreatic Cancer Liver Metastases NCT03856658 | Corewell Health West | Phase 2 |
| Recruiting | The MOMENTUM Study: The Multiple Outcome Evaluation of Radiation Therapy Using the MR-Linac Study NCT04075305 | UMC Utrecht | — |
| Unknown | Improving Outcome of Selected Patients With Non-resectable Hepatic Metastases From Colo-rectal Cancer With Liv NCT03803436 | Fondazione IRCCS Istituto Nazionale dei Tumori, Milano | Phase 2 |
| Completed | SBRT for Liver Tumors, Liver Metastases, and Pancreatic Tumors NCT07407257 | Institute of Oncology Ljubljana | N/A |
| Unknown | Irinotecan Drug-eluting Bead Liver Embolisation Registry NCT03697044 | The Christie NHS Foundation Trust | — |
| Completed | Combined Immunotherapy and Radiosurgery for Metastatic Colorectal Cancer NCT03507699 | Sheba Medical Center | Phase 1 |
| Completed | Synergism of Immunomodulation and Tumor Ablation NCT03101475 | European Organisation for Research and Treatment of Cancer - EORTC | Phase 2 |
| Completed | A Study to Evaluate MIV-818 in Patients With Liver Cancer Manifestations NCT03781934 | Medivir | Phase 1 / Phase 2 |
| Unknown | Comparison of Intrathecal and Intravenous Analgesia in Patients Undergoing Liver Resection NCT03620916 | Medical University of Warsaw | N/A |
| Completed | Imaging Response to Immunotherapy and Radiation Therapy in Patients With Liver Metastases NCT03401814 | Mayo Clinic | — |
| Completed | Intra-arterial Lutetium-177-dotatate for Treatment of Patients With Neuro-endocrine Tumor Liver Metastases NCT03590119 | Marnix Lam | Phase 2 / Phase 3 |
| Active Not Recruiting | Microwave Ablation Versus Stereotactic Body Radiotherapy for Colorectal Liver Metastases in Oligometastatic Di NCT03654131 | Rigshospitalet, Denmark | Phase 2 |
| Unknown | Simultaneous Resection of Pancreatic Cancer and Liver Oligometastasis After Induction Chemotherapy NCT03398291 | Fudan University | Phase 3 |
| Terminated | Adjuvant Systemic Chemotherapy With or Without HAI-FUDR in Patients With Resected CRLM NCT03500874 | Sun Yat-sen University | Phase 3 |
| Active Not Recruiting | Hepatic Resection for Metastatic Pancreatic Cancer NCT02892305 | Duke University | — |
| Active Not Recruiting | Cetuximab Plus FOLFOXIRI vs Cetuximab Plus FOLFOX For CRCLM NCT03493048 | Sun Yat-sen University | Phase 2 |
| Recruiting | Living Donor Liver Transplantation With Two Stage Hepatectomy for Patients With Isolated, Irresectable Colorec NCT03488953 | Jena University Hospital | N/A |
| Recruiting | Surgical or Medical Treatment of Breast Cancer Metastasis: A Multicentre Observational Study NCT06093022 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | — |
| Completed | Preoperative Physical Activity Intervention in Patients Before Planned Liver Resection for Cancer (APACHE) NCT03518632 | Célia Turco | N/A |
| Completed | Study to Evaluate VORTX Rx (Theresa) NCT03741088 | HistoSonics, Inc. | N/A |
| Completed | MRI Imaging or CT Abdomen as Standard Work-up Before Treatment Planning for Rectal Cancer? NCT03463616 | Sahlgrenska University Hospital | — |
| Completed | Hyperthermia Combined With Immunotherapy in the Treatment of Abdominal and Pelvic Malignancies or Metastases NCT03757858 | Capital Medical University | Phase 1 / Phase 2 |
| Unknown | Volumetric Imaging Follow up of Patients With Liver Metastases of Small Intestinal Neuroendocrine Tumors (NETs NCT03689231 | Hospices Civils de Lyon | — |
| Completed | A Study of Systemic Chemotherapy With CPT-11 Plus HAI (FUDR+L-OHP) in Patients With Initially Unresectable CRC NCT03493061 | Sun Yat-sen University | Phase 2 |
| Completed | CAVATAK® and Ipilimumab in Uveal Melanoma Metastatic to the Liver (VLA-024 CLEVER) NCT03408587 | Viralytics | Phase 1 |
| Active Not Recruiting | Aspirin in Colorectal Cancer Liver Metastases NCT03326791 | Oslo University Hospital | Phase 2 / Phase 3 |
| Withdrawn | Consolidative Radiotherapy for Colorectal Cancer Liver Metastases Receiving Surgery or Radiofrequency Ablation NCT03135652 | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | Phase 2 |
| Terminated | An Evaluation of Tilmanocept by IV Injection Using SPECT/CT vs PET Imaging in Subjects With Liver Metastases. NCT03029988 | Navidea Biopharmaceuticals | Phase 1 |
| Unknown | COLLISION Trial - Colorectal Liver Metastases: Surgery vs Thermal Ablation NCT03088150 | Amsterdam UMC, location VUmc | N/A |
| Active Not Recruiting | Lesion Detection Assessment in the Liver: Standard vs Low Radiation Dose Using Varied Post-Processing Techniqu NCT03151564 | M.D. Anderson Cancer Center | N/A |
| Unknown | Application of 3D Printing in Laparoscopic Surgery of Liver Tumors NCT03744624 | Jagiellonian University | N/A |
| Completed | Hepatoprotective Effect of Remote vs Local Preconditioning of Liver NCT03130920 | University Hospital Dubrava | N/A |
| Completed | Simultaneous Resection of Colorectal Cancer With Synchronous Liver Metastases NCT02954913 | Hamilton Health Sciences Corporation | N/A |
| Completed | CAR-T Hepatic Artery Infusions or Pancreatic Venous Infusions for CEA-Expressing Liver Metastases or Pancreas NCT02850536 | Roger Williams Medical Center | Phase 1 |
| Completed | Tas-102 and Radioembolization With 90Y Resin Microspheres for Chemo-refractory Colorectal Liver Metastases NCT02602327 | University of California, San Francisco | Phase 1 |
| Unknown | Application of Intrahepatic Arterial Infusion Chemotherapy for Patients With High Risk of Liver Metastases Aft NCT03687853 | Peking University Third Hospital | N/A |
| Recruiting | Liver Transplantation Compared to Chemotherapy in Patients With ColoRectal Cancer NCT03494946 | Oslo University Hospital | N/A |
| Recruiting | Living Donor Liver Transplantation for Unresectable Colorectal Cancer Liver Metastases NCT02864485 | University Health Network, Toronto | N/A |
| Unknown | A Study of MG7 Redirected Autologous T Cells for Advanced MG7 Positive Liver Metastases(MG7-CART) NCT02862704 | Xijing Hospital | Phase 1 / Phase 2 |
| Completed | Multimodal Assessment of Liver Volume and Function NCT03140917 | Karolinska University Hospital | — |
| Withdrawn | A Study to See if we Can Predict How Your Liver Tumor or Liver Metastases Will Respond to Trans-Arterial Embol NCT02772575 | Memorial Sloan Kettering Cancer Center | — |
| Completed | Randomized Embolization Trial for NeuroEndocrine Tumor Metastases to the Liver NCT02724540 | Abramson Cancer Center at Penn Medicine | Phase 2 |
| Completed | Trial to Evaluate the Safety of Talimogene Laherparepvec Injected Into Tumors Alone and in Combination With Sy NCT02509507 | Amgen | Phase 1 / Phase 2 |
| Unknown | Clinical Intervention Modelling, Planning and Proof for Ablation Cancer Treatment NCT02745600 | University of Leipzig | N/A |
| Terminated | Irinotecan-Eluting Beads in Treating Patients With Refractory Metastatic Colon or Rectal Cancer That Has Sprea NCT02110953 | Fox Chase Cancer Center | Phase 1 |
| Completed | Study of Palliative Radiotherapy for Symptomatic Hepatocellular Carcinoma and Liver Metastases NCT02511522 | Canadian Cancer Trials Group | N/A |
| Terminated | Metabolic Radiotherapy After Complete Resection of Liver Metastases in Patient With Digestive Neuroendocrine T NCT02465112 | GERCOR - Multidisciplinary Oncology Cooperative Group | Phase 3 |
| Completed | CAR-T Hepatic Artery Infusions and Sir-Spheres for Liver Metastases NCT02416466 | Roger Williams Medical Center | Phase 1 |
| Unknown | Evaluation of Diffusion Weighted Imaging -MRI in Patients With Resectable Liver Metastases From Colorectal Can NCT02355353 | European Organisation for Research and Treatment of Cancer - EORTC | N/A |
| Active Not Recruiting | Copper Cu 64-DOTA-Trastuzumab PET in Predicting Response to Treatment With Ado-Trastuzumab Emtansine in Patien NCT02226276 | City of Hope Medical Center | N/A |
| Completed | The Role of Tumor-associated Macrophages in Colorectal Liver Metastases NCT03888638 | Humanitas Clinical and Research Center | — |
| Completed | Stereotactic Radiation Therapy and Ipilimumab in Treating Patients With Metastatic Melanoma NCT02107755 | Ohio State University Comprehensive Cancer Center | Phase 2 |
| Completed | Treatment Strategies in Colorectal Cancer Patients With Initially Unresectable Liver-only Metastases NCT02162563 | Dutch Colorectal Cancer Group | Phase 3 |
| Withdrawn | Dynamic Contrast Enhanced MRI in Patients With Advanced Breast or Pancreatic Cancer With Metastases to the Liv NCT01741597 | City of Hope Medical Center | Phase 1 |
| Unknown | ALPPS Versus PVE/PL NCT02215577 | Regionalt Cancercentrum Väst | N/A |
| Recruiting | Stereotactic Body Radiation Therapy (SBRT) for Unresectable Liver Metastases NCT02185443 | University of Sao Paulo | Phase 2 |
| Terminated | Everolimus in Patients With Pancreatic Neuroendocrine Tumors Metastatic to the Liver Previously Treated With S NCT02031536 | ECOG-ACRIN Cancer Research Group | Phase 2 |
| Active Not Recruiting | Pilot Study to Assess Lung Shunting of Yttrium-90 Microspheres Using PET/CT NCT02119065 | University of Cincinnati | — |
| Terminated | AvidinOX + [177Lu]DOTA-biotin (or 177Lu-ST2210) Complex in Patients With Liver Metastases From Colorectal Canc NCT02053324 | Alfasigma S.p.A. | Phase 1 |
| Completed | Treatment of Liver Metastases With Electrochemotherapy (ECTJ) Phase II NCT02352259 | Institute of Oncology Ljubljana | Phase 2 |
| Unknown | Functional Treatment Planning Utilizing 18-FDGal PET/CT in SBRT for Liver Metastases NCT01861873 | University of Aarhus | Phase 2 |
| Terminated | Efficacy of FOLFOX Alone, FOLFOX Plus Bevacizumab and FOLFOX Plus Panitumumab in Patients With Resectable Live NCT01508000 | European Organisation for Research and Treatment of Cancer - EORTC | Phase 2 |
| Completed | The Value of Laparoscopic Ultrasound in Patients Undergoing Laparoscopic Resection for Cancer of the Colon or NCT02079389 | Odense University Hospital | N/A |
| Completed | A Study of Pancreatic Cancer in Xenografts From Liver Metastases NCT01774643 | University Health Network, Toronto | — |
| Withdrawn | Efficacy of FOLFOX Versus FOLFOX Plus Aflibercept in K-ras Mutant Patients With Resectable Liver Metastases NCT01646554 | European Organisation for Research and Treatment of Cancer - EORTC | Phase 2 / Phase 3 |
| Terminated | Radioembolization and Ipilimumab in Treating Patients With Uveal Melanoma With Liver Metastases NCT01730157 | Case Comprehensive Cancer Center | EARLY_Phase 1 |
| Unknown | Metastatic Colorectal Cancer Liver Metastases Outcomes After Resin 90Y Microsphere Radioembolization in the US NCT01815879 | Andrew Kennedy | — |
| Completed | CCR5-blockade in Metastatic Colorectal Cancer NCT01736813 | National Center for Tumor Diseases, Heidelberg | — |
| Completed | Pilot 3D Contrast-Enhanced Ultrasound Imaging to Predict Treatment Response in Liver Metastases NCT01631318 | Stanford University | N/A |
| Withdrawn | Chemoembolisation With CPT11 Loaded DC Bead With Cetuximab and 5FU/LV in First Line in Patients With KRAS Wild NCT01631539 | Universitaire Ziekenhuizen KU Leuven | N/A |
| Unknown | Bevacizumab Therapy Untreated Unresectable Liver Metastases From Colorectal Cancer NCT01763450 | Liaoning Cancer Hospital & Institute | Phase 2 |
| Recruiting | Proton Therapy in the Treatment of Liver Metastases NCT01697371 | Loma Linda University | N/A |
| Completed | Detection of CTCs in Patients Undergoing Surgery for Stage IV Colorectal Cancer NCT01722903 | Milton S. Hershey Medical Center | — |
| Completed | Stereotactic Body Radiation and Monoclonal Antibody to OX40 (MEDI6469) in Breast Cancer Patients With Metastat NCT01862900 | Providence Health & Services | Phase 1 |
| Completed | Stereotactic Body Radiation Therapy (SBRT) for Liver Mets NCT01360606 | Susannah Ellsworth | N/A |
| Completed | A Multicenter Study Evaluating Efficacy and Safety of 177Lu-DOTA-TATE Based on Kidney-Dosimetry in Patients Wi NCT01456078 | Lund University Hospital | Phase 2 |
| Completed | Prognostic Factors and Oncological Outcomes in Laparoscopic Liver Resection for CRLM NCT05036265 | General Hospital Groeninge | — |
| Completed | CEA-Expressing Liver Metastases Safety Study of Intrahepatic Infusions of Anti-CEA Designer T Cells NCT01373047 | Roger Williams Medical Center | Phase 1 |
| Terminated | Combination Chemotherapy and Bevacizumab Before Surgery and Radiolabeled Monoclonal Antibody Therapy in Treati NCT01320683 | City of Hope Medical Center | Phase 2 |
| Completed | Use of DwI-MR to Predict Chemotherapy Response of Liver Metastases and Hepatocarcinoma NCT01411579 | Stefano Colagrande | — |
| Completed | Hepatic Arterial Chemotherapy With Raltitrexed and Oxaliplatin Versus Standard Chemotherapy in Unresectable Li NCT01348412 | Centre Georges Francois Leclerc | Phase 2 |
| Unknown | Study of Cetuximab in Combination With mFOLFOX-6 (Oxaliplatin, Leucovorin, 5-FU) to Treat Colorectal Liver Met NCT01322178 | Fudan University | Phase 2 |
| Unknown | Contrast Enhanced Ultrasound For The Evaluation Of Focal Liver Lesions NCT01329458 | Societatea Romana de Ultrasonografie in Medicina si Biologie | — |
| Completed | Individualized Stereotactic Body Radiotherapy of Liver Metastases NCT01239381 | Massachusetts General Hospital | N/A |
| Terminated | rRp450-Phase I Trial in Liver Metastases and Primary Liver Tumors NCT01071941 | Kenneth K. Tanabe, MD | Phase 1 |
| Terminated | Chemoembolization Using Irinotecan in Treating Patients With Liver Metastases From Metastatic Colon or Rectal NCT01285102 | Fox Chase Cancer Center | Phase 1 |
| Terminated | Radiofrequency Ablation Versus Stereotactic Radiotherapy in Colorectal Liver Metastases NCT01233544 | University of Aarhus | Phase 3 |
| Unknown | Liver-PILP First-in-Man NCT01250158 | Medical Device Works NV SA | N/A |
| Completed | A Study of Perioperative Chemotherapy Plus Panitumumab in Patients With Colorectal Cancer Liver Metastases NCT01260415 | University Health Network, Toronto | Phase 2 |
| Completed | Predictive Value of 99mTc- Albumin Spheres Before 90Y- SIR Therapy NCT01186263 | University of Magdeburg | Phase 2 |
| Completed | Stereotactic Body Radiation Therapy (SBRT) for Patients With Hepatic Metastases NCT01162278 | University of Texas Southwestern Medical Center | Phase 1 |
| Completed | A Pilot Study of EZN-2968, an Antisense Oligonucleotide Inhibitor of HIF-1alpha, in Adults With Advanced Solid NCT01120288 | National Cancer Institute (NCI) | Phase 1 |
| Completed | Intra-hepatic Chemotherapy in Patients With Liver Metastases From Breast Cancer and Limited Extrahepatic Disea NCT01387295 | Dorte Nielsen | Phase 2 |
| Completed | Intra-hepatic Chemotherapy in Patient With Non-resectable Liver Metastases From Breast Cancer NCT01387373 | Dorte Nielsen | Phase 2 |
| Completed | The Inflammatory Response to Stress and Angiogenesis in Liver Resection NCT03131778 | University Hospital, Ghent | N/A |
| Completed | National Registry of Hepatic Metastases From Non-Colorectal Cancer" NCT07180641 | Clinica Universidad de Navarra, Universidad de Navarra | — |
| Completed | Preoperative CRT With or Without Induction Chemotherapy for Rectal Cancer With Liver Metastases NCT01643070 | Asan Medical Center | Phase 2 |
| Terminated | Cetuximab and/or Dasatinib in Patients With Colorectal Cancer and Liver Metastases That Can Be Removed by Surg NCT00835679 | National Cancer Institute (NCI) | EARLY_Phase 1 |
| Completed | A Pharmacodynamic Study of AV-299 (Formerly SCH 900105) in Subjects With Advanced Solid Tumors Who Have Liver NCT00969410 | AVEO Pharmaceuticals, Inc. | Phase 1 |
| Completed | Hypofractionated Image Guided Radiation Therapy in Treating Patients With Stage IV Breast Cancer NCT01706432 | University of Chicago | — |
| Completed | Preventive Effect of Enoxaparin, Pentoxifylline and Ursodeoxycholic Acid to Radiation Induced Liver Toxicity NCT01149304 | University of Magdeburg | Phase 2 |
| Completed | Study of Adecatumumab Relative to FOLFOX After R0 Resection of Colorectal Liver Metastases NCT00866944 | Amgen Research (Munich) GmbH | Phase 2 |
| Completed | Treatment of Liver Metastases With Electrochemotherapy NCT01264952 | Institute of Oncology Ljubljana | Phase 1 / Phase 2 |
| Completed | Stereotactic Body Radiotherapy for Liver Tumors NCT01347333 | Mercy Research | N/A |
| Completed | FOLFIRI and Sunitinib in Metastatic Colorectal Cancer NCT00806663 | Central European Society for Anticancer Drug Research | Phase 2 |
| Withdrawn | FOLFOX6 Plus Sir-Spheres Microspheres Plus Avastin in Patients With Nonresectable Liver Metastases From Colore NCT00735241 | Sirtex Medical | Phase 2 / Phase 3 |
| Unknown | Optimal Control of Liver Metastases From Colorectal Cancer With Cetuximab and Hepatic Artery Infusion of Chemo NCT00852228 | Association pour la Recherche sur le Temps Biologique et la Chronothérapie | Phase 2 |
| Completed | Impact of Surgical Management for Relapse After Conversion Hepatectomy for Initially Unresectable Colorectal L NCT05462470 | Fudan University | — |
| Completed | Comprehensive Electronic Cancer Support System for the Treatment of Cancer Related Symptoms NCT01640522 | University of Pittsburgh | N/A |
| Completed | Phase 3 Trial of Litx™ Plus Chemotherapy vs. Chemotherapy Only Treating Colorectal Cancer Patients With Recurr NCT00440310 | Light Sciences Oncology | Phase 3 |
| Terminated | Adjuvant Xeloda Plus Eloxatin +/- Avastin After Radical Resection of Liver Metastasis of Colorectal Cancer NCT00394992 | Dutch Colorectal Cancer Group | Phase 3 |
| Completed | FOLFOX Plus SIR-SPHERES MICROSPHERES Versus FOLFOX Alone in Patients With Liver Mets From Primary Colorectal C NCT00724503 | Sirtex Medical | N/A |
| Completed | Impact of Positron Emission Tomography Imaging Prior to Liver Resection for Colorectal Adenocarcinoma Metastas NCT00265356 | Ontario Clinical Oncology Group (OCOG) | Phase 3 |
| Completed | Hepatic Arterial Infusion of Floxuridine, Gemcitabine Hydrochloride, and Radiolabeled Monoclonal Antibody Ther NCT00645710 | City of Hope Medical Center | Phase 1 / Phase 2 |
| Completed | Cetuximab in Neoadjuvant Treatment of Non-Resectable Colorectal Liver Metastases (CELIM) NCT00153998 | Technische Universität Dresden | Phase 2 |
| Unknown | Oxaliplatin and Capecitabine Versus Follow-up After Resection of Colorectal Liver Metastases NCT00156975 | Arbeitsgruppe Lebermetastasen und Tumoren | Phase 3 |
| Completed | Halt Growth of Liver Tumors From Uveal Melanoma With Closure of Liver Artery Following Injection of GM-CSF NCT00661622 | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | Phase 2 |
| Completed | Comparison of Triphasic CT, PET and MR Tumour With Pathological Findings in Colorectal Cancer Liver Metastases NCT00242086 | University Health Network, Toronto | N/A |
| Unknown | Accuracy of Endoscopic Ultrasound for Detection of Tumors of the Liver NCT00290316 | Central Texas Veterans Health Care System | Phase 2 |
| Completed | Intensified Chemotherapy in CRC After Resection of Liver Metastases NCT00208260 | Institut du Cancer de Montpellier - Val d'Aurelle | Phase 2 / Phase 3 |
| Completed | Impact of PVE on Patient's Long-term Survival, Complications and Cancer Recurrence. NCT03168230 | Université de Sherbrooke | — |
| Completed | Chemotherapy and Tumor Clearance in Hepatic Resections for Colorectal Liver Metastases. NCT05273489 | Hospital Maciel | — |
| Completed | Carcinoembryonic Antigen-loaded Dendritic Cells in Advanced Colorectal Cancer Patients NCT00228189 | Radboud University Medical Center | Phase 1 / Phase 2 |
| Terminated | Neoadjuvant and Adjuvant Capecitabine and Oxaliplatin in Treating Patients With Resectable Liver Metastases Se NCT00070265 | National Cancer Institute (NCI) | Phase 2 |
| Completed | Phase I Study With AZD2171 in Patients With Advanced Solid Malignant Tumors and Liver Metastases NCT00501605 | AstraZeneca | Phase 1 |
| Completed | Hepatic Arterial Infusion Plus Chemotherapy in Treating Patients With Colorectal Cancer Metastatic to the Live NCT00026234 | National Cancer Institute (NCI) | Phase 2 |
| Completed | Comparison of Clinical Efficacy of Liver Resection, RFA, TACE, and Drug Therapy in Patients with GIST LM NCT06038552 | First Affiliated Hospital, Sun Yat-Sen University | — |
| Completed | Study of 5-FU + Leucovorin + CPT-11 in Patients With Resectable Liver Metastases From Colorectal Adenocarcinom NCT00168155 | Alberta Health services | Phase 2 |
| Completed | Alternative to Two-Stage Hepatectomy NCT00587756 | University of Milan | — |
| Completed | Prognosis of One-stage Hepatectomy for Bilobar Colorectal Metastases NCT01683357 | University of Milan | — |
| Completed | Interleukin-12 and Trastuzumab in Treating Patients With Cancer That Has High Levels of HER2/Neu NCT00004074 | National Cancer Institute (NCI) | Phase 1 |
| Completed | Isolated Hepatic Perfusion With Melphalan Followed By Chemotherapy in Treating Patients With Unresectable Colo NCT00019760 | National Institutes of Health Clinical Center (CC) | Phase 2 |