Trials / Recruiting
RecruitingNCT03494946
Liver Transplantation Compared to Chemotherapy in Patients With ColoRectal Cancer
A Randomized Clinical Trial Comparing Overall Survival in Selected Patients With ColoRectal Carcinoma Treated by Liver Transplantation or Chemotherapy
- Status
- Recruiting
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 30 (estimated)
- Sponsor
- Oslo University Hospital · Academic / Other
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
The trial is a randomized control trial. Patients are randomized between Ltx and other treatment that may include further chemotherapy, TACE, SIRT or other available treatment options. The patients will be randomized 1:1 to Ltx and chemotherapy/other treatment options.
Detailed description
Patients with non-resectable CRC liver metastases evaluated at the liver MDT at Oslo University Hospital, Rikshospitalet will be included in the study. Patients should have progressive disease on 1.line chemotherapy or the treatment should have been stopped due to toxicity. Patients randomized to Ltx will if applicable stop bevazicumab. All patients (both arms) will start further treatment that may include chemotherapy, TACE, SIRT or other available treatment options. Patients not receiving a donor liver graft within 3 months after listing for transplantation will be taken off the waiting list and transferred to the chemotherapy/other treatment option group. Patients randomized to Ltx and developing progressive disease beyond the inclusion/exclusion criteria during the time on the waiting list will be excluded from the study and receive best treatment option at the discretion of the treating physician.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Liver transplantation | |
| DRUG | Chemotherapy | May include chemotherapy, TACE, SIRT or other available treatment options. |
Timeline
- Start date
- 2016-12-05
- Primary completion
- 2027-01-01
- Completion
- 2027-01-01
- First posted
- 2018-04-11
- Last updated
- 2024-02-06
Locations
1 site across 1 country: Norway
Source: ClinicalTrials.gov record NCT03494946. Inclusion in this directory is not an endorsement.