Clinical Trials Directory

Trials / Sponsors / Hoffmann-La Roche

Hoffmann-La Roche

Industry · 2,068 registered clinical trials96 currently recruiting.

StatusTrialPhaseStarted
Not Yet RecruitingA Study to Evaluate Pharmacokinetics, Safety, Tolerability, Immunogenicity and Pharmacodynamic Effects of Subc
Relapsing-remitting Multiple Sclerosis
Phase 22026-08-01
Not Yet RecruitingA Study to Assess the Pharmacokinetics, Effectiveness and Safety of Afimkibart for Induction and Maintenance T
Moderately to Severely Active Crohns Disease
Phase 32026-05-29
Not Yet RecruitingA COPD Data Registry for Participants With Frequent Exacerbations
COPD
2026-05-18
RecruitingA Clinical Study to Evaluate the Effects of NXT007 Compared to Factor VIII Prophylaxis in Participants With He
Hemophilia A
Phase 32026-05-09
RecruitingA Study To Evaluate Pharmacokinetics, Efficacy, Safety, Tolerability, And Pharmacodynamics Of Satralizumab In
Neuromyelitis Optica Spectrum Disorder, NMOSD
Phase 32026-04-30
RecruitingA Phase II Study Evaluating the Efficacy and Safety of Inavolisib Plus Ribociclib Plus Fulvestrant Versus Plac
Breast Cancer
Phase 22026-04-30
Not Yet RecruitingRO7771950 Versus Tucatinib in Combination With Trastuzumab and Capecitabine in People With Locally Advanced or
HER2-positive Breast Cancer
Phase 2 / Phase 32026-04-30
RecruitingA Clinical Study to Evaluate the Effects of NXT007 Compared to Emicizumab Prophylaxis in People With Hemophili
Hemophilia A
Phase 32026-04-30
RecruitingA Study to Investigate CEA-PRIT 2.0 in Participants With Metastatic Colorectal Cancer (mCRC)
Metastatic Colorectal Cancer
Phase 12026-04-21
Not Yet RecruitingA Study of Risdiplam in Participants With Type I and Type II Spinal Muscle Atrophy (SMA)
Spinal Muscle Atrophy
2026-04-15
RecruitingA Study to Evaluate the Pharmacokinetics, Safety and Efficacy of Afimkibart (RO7790121) in Children With Moder
Moderately to Severely Active Ulcerative Colitis
Phase 32026-04-15
RecruitingA Study to See How RO7763505 Works and How Safe it is When Given to Healthy People and People With Stable Hear
Stable Coronary Artery Disease, Healthy Volunteers
Phase 12026-03-31
Not Yet RecruitingA Gene Therapy Study of SPK-8011QQ in Adults With Severe or Moderately Severe Hemophilia A
Hemophilia A
Phase 1 / Phase 22026-03-31
RecruitingA Study of Multiple Doses of Orally Administered RO7795081 in Otherwise Healthy Chinese Adult Participants Wit
Healthy Volunteers, Overweight or Obesity
Phase 12026-03-30
RecruitingA Clinical Study to Evaluate the Effects of RO7795068 in Participants With Obesity or Overweight and Type 2 Di
Obesity or Overweight, Type 2 Diabetes Mellitus
Phase 32026-03-23
RecruitingA Clinical Study to Evaluate the Effects of RO7795068 in Participants With Obesity or Overweight Without Type
Obesity or Overweight
Phase 32026-03-16
WithdrawnA Study to Evaluate Crovalimab in People With Antiphospholipid Syndrome (APS)
Antiphospholipid Syndrome
Phase 22026-03-16
RecruitingA Study to Test Inavolisib Treatment in Participants With Metastatic Castration-Resistant Prostate Cancer
Metastatic Castration-Resistant Prostate Cancer
Phase 22026-03-11
RecruitingA Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of RO7268489 as Add-on Therap
Progressive Multiple Sclerosis
Phase 22026-03-10
RecruitingA Study to Assess Treatment Patterns and Treatment Adherence in Early HER2-positive Breast Cancer Participants
Early-stage HER2+ Breast Cancer
2026-02-23
RecruitingTo Study the Effect of Inavolisib in Combination With Fulvestrant in Participants With Breast Cancer
Breast Cancer
Phase 22026-02-18
RecruitingA Study to Develop a Blood-based Test for Aiding the Diagnosis/Prognosis of Traumatic Brain Injury in Adults a
Traumatic Brain Injury
2026-02-09
WithdrawnA Study to Evaluate the Efficacy and Safety of Inavolisib When Administered in Combination With Bevacizumab an
Colorectal Cancer
Phase 22026-02-01
RecruitingA Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7812653 in Partic
Alzheimer's Disease
Phase 12026-01-27
RecruitingA Study to Evaluate the Effectiveness and Safety of Inavolisib in Participants With Endocrine-resistant, PIK3C
Locally Advanced Breast Cancer, Metastatic Breast Cancer
2026-01-21
RecruitingA Long Term Extension Study to Evaluate the Safety and Efficacy of Afimkibart (RO7790121) in Participants With
Atopic Dermatitis
Phase 22026-01-08
RecruitingA Study to Determine the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7806881 in Healthy
Healthy Volunteers
Phase 12025-12-22
RecruitingA Study to Assess the Efficacy and Safety of RO7790121 in Participants With Moderate to Severe Rheumatoid Arth
Rheumatoid Arthritis
Phase 22025-12-05
RecruitingA Study of 36-Week Refill Exchanges of Port Delivery System (PDS) With Ranibizumab in nAMD
Neovascular Age-related Macular Degeneration
Phase 32025-11-27
RecruitingA Study to Evaluate the Efficacy and Safety of Intravenous (IV) Prasinezumab in Participants With Early-Stage
Parkinson's Disease
Phase 32025-11-24
RecruitingA Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RG6496 in Huntington's
Huntington's Disease
Phase 12025-11-19
RecruitingA Study to Assess Bioequivalence of Two Subcutaneous (SC) Formulations of Ocrelizumab in Participants With Mul
Multiple Sclerosis
Phase 22025-11-13
RecruitingA Clinical Trial of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease
Alzheimers Disease
Phase 32025-11-12
RecruitingA Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed
Non-Small Cell Lung Cancer, KRAS G12C Lung Cancer
Phase 32025-10-24
RecruitingA Pharmacokinetics (PK), Pharmacodynamics (PD), Safety and Tolerability Study of Fenebrutinib in Children and
Relapsing Multiple Sclerosis
Phase 22025-10-06
Active Not RecruitingA Study to Evaluate the Effect of RO7204239 on Insulin Sensitivity and Muscle Composition in Participants With
Type 2 Diabetes Mellitus, Obesity, Overweight
Phase 12025-09-30
RecruitingAn Observational Study of Glofitamab in Chinese Adult Participants With 2L Diffuse Large B-Cell Lymphoma
Diffuse Large B-Cell Lymphoma
2025-09-29
RecruitingA Study of Trontinemab in Participants With Early Symptomatic Alzheimer's Disease
Alzheimers Disease
Phase 32025-09-17
RecruitingA Study to Test Inavolisib Treatments in Participants With Early-Stage, PIK3CA-Mutated Breast Cancer
Breast Cancer
Phase 22025-09-09
Active Not RecruitingA Study to Compare Different Doses of RO7795081 With a Placebo or Semaglutide in People With Type 2 Diabetes
Type 2 Diabetes Mellitus
Phase 22025-08-19
Active Not RecruitingA Study Evaluating the Effect of Daily Oral RO7795081 in Participants With Obesity or Overweight With at Least
Obesity or Overweight
Phase 22025-07-29
RecruitingA Study to Evaluate Patient-Reported Satisfaction, Effectiveness, and Safety of Atezolizumab in Participants T
Lung Cancer, Hepatocellular Carcinoma
2025-07-17
RecruitingA Study to Investigate Safety, Tolerability, Pharmacokinetics (PK), Pharmacodynamics (PD), and Immunogenicity
Geographic Atrophy, Age-related Macular Degeneration
Phase 12025-07-16
RecruitingA Study to Explore Signs, Symptoms, and Biomarkers in Dry Eye Disease Participants Following Anti-inflammatory
Dry Eye Disease
Phase 42025-07-09
RecruitingA Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Ocrelizumab in Participant
Relapsing Multiple Sclerosis, Primary Progressive Multiple Sclerosis
Phase 42025-07-04
RecruitingScreening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies
Alzheimers Disease
Phase 32025-07-02
RecruitingA Study to Assess the Efficacy and Safety of Emicizumab in Participants With Type 3 Von Willebrand Disease
Von Willebrand Disease, Type 3
Phase 32025-06-27
WithdrawnA Study to Evaluate Eciskafusp Alfa in Combination With Bacillus Calmette-guerin (BCG) in Participants With BC
Non-muscle Invasive Bladder Cancer
Phase 12025-06-15
RecruitingA Study Investigating the Safety of RO7795081 and the Effect of RO7795081 on How the Body Processes Pitavastat
Overweight, Obesity
Phase 12025-06-04
RecruitingA Study Evaluating the Pharmacokinetics, Safety, and Efficacy of Cevostamab in Chinese Participants With Relap
Multiple Myeloma
Phase 12025-05-13
RecruitingA Study to Assess the Efficacy and Safety of Induction Therapy With Afimkibart (RO7790121) in Participants Wit
Moderately to Severely Active Crohns Disease
Phase 32025-05-12
Active Not RecruitingA Study to Assess Efficacy, Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of RO7204239
Obesity, Overweight, Overweight With One Weight Related Comorbidity
Phase 22025-05-05
RecruitingReal World Clinical Outcomes of Resected ALK-Positive Early Stage NSCLC Patients Treated With Alectinib as Adj
Carcinoma, Non-Small-Cell Lung
2025-04-30
RecruitingA Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) and Preliminary Clinical Activity of RO767
Neoplasms
Phase 12025-04-30
RecruitingAn Observational Study of Participants With Type 3 Von Willebrand Disease on Prophylactic Standard-of-Care Tre
Von Willebrand Disease, Type 3
2025-04-29
RecruitingA Study Evaluating the Safety and Efficacy of Glofitamab + Gemcitabine + Oxaliplatin in U.S. Patients With Rel
Lymphoma
Phase 12025-04-28
RecruitingClinical Study to Evaluate the Impact of the Accu-Chek SmartGuide CGM Solution on the Mean Change in Time in R
Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus
N/A2025-04-14
Active Not RecruitingA Study to Assess the Safety, Pharmacokinetics, and Activity of RO7790121 in Participants With Advanced MASH L
MASH
Phase 12025-04-14
RecruitingA Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4
Breast Cancer
Phase 32025-04-09
Active Not RecruitingA Study to Assess the Efficacy and Safety of Satralizumab in Duchenne Muscular Dystrophy (DMD)
Duchenne Muscular Dystrophy
Phase 22025-04-04
RecruitingA Study to Assess the Efficacy and Safety of Afimkibart (RO7790121) in Participants With Moderate to Severe At
Atopic Dermatitis
Phase 22025-04-01
RecruitingA Study to Assess the Efficacy and Safety of Induction and Maintenance Therapy With Afimkibart (RO7790121) in
Moderately to Severely Active Crohns Disease
Phase 32025-03-17
Active Not RecruitingA Study to Determine the Efficacy, Safety, and Durability of Faricimab in Participants With Neovascular Age-Re
Neovascular Age-related Macular Degeneration (nAMD)
Phase 42025-03-14
RecruitingA Study to Evaluate the Optimization of the Cytokine Release Syndrome Profile for Glofitamab in Combination Wi
B-Cell Non-Hodgkins Lymphoma
Phase 22025-03-05
RecruitingA Randomized Study of SPK-10001 Gene Therapy in Participants With Huntington's Disease
Huntington Disease
Phase 1 / Phase 22025-02-21
CompletedA Study Investigating the Effect of Different Approved Medications on How the Body Processes the Study Compoun
Healthy Participants
Phase 12025-02-13
RecruitingA Real-World Study to Gain Clinical Insights Into Faricimab (FaReal Study)
Neovascular Age-related Macular Degeneration, Diabetic Macular Edema
2025-02-05
CompletedA Study Investigating [14C]-Labeled RO7269162 in Healthy Male Participants
Healthy Volunteers
Phase 12025-01-08
CompletedA Study Conducted to Evaluate the Conjunctiva and Tenon's Capsule Status of Healthy Subjects and in Participan
Neovascular Age-related Macular Degeneration, Diabetic Macular Edema
2024-12-31
CompletedPerformance Study of the Cobas® BV/CV Test on Samples From Participants With and Without Symptoms of Bacterial
Bacterial Vaginosis, Candida Vaginitis
2024-12-30
RecruitingAn Extension Study to Assess Impact of Multiple Sclerosis (MS) on Physical Function and Provide Continued Ocre
Multiple Sclerosis
Phase 32024-12-13
RecruitingA Study to Assess the Efficacy and Safety of Induction Therapy With Afimkibart (Also Known as RO7790121) in Pa
Moderately to Severely Active Ulcerative Colitis
Phase 32024-12-11
RecruitingA Study to Evaluate the Efficacy and Safety of Autogene Cevumeran With Nivolumab Versus Nivolumab Alone in Par
Muscle-invasive Urothelial Carcinoma
Phase 22024-12-09
WithdrawnA Study of Adjuvant Atezolizumab or Atezolizumab Plus Tiragolumab in Solid Tumors with Resectable Disease with
Solid Tumors
Phase 22024-11-30
Active Not RecruitingA Study to See How Well and How Safely Different Treatments Work in a Group of Participants With Non-Small Cel
Non-Small Cell Lung Cancer
Phase 1 / Phase 22024-11-18
CompletedStudy to Assess the Safety, Pharmacokinetics, and Efficacy of Baloxavir Marboxil in Chinese Pediatric Particip
Influenza
Phase 32024-10-27
RecruitingStudy to Evaluate the Usability and Value of Integrated Digital Solutions in Medical Care of Participants With
Relapsing Remitting Multiple Sclerosis
2024-10-21
RecruitingA Study to Investigate Effects of Ocrelizumab Treatment on Neurofilament Light Chain (NfL) Levels and Particip
Multiple Sclerosis
2024-09-26
Active Not RecruitingA Study Evaluating the Efficacy and Safety of Divarasib Versus Sotorasib or Adagrasib in Participants With Pre
Non-Small Cell Lung Cancer, KRAS G12C Lung Cancer
Phase 32024-09-23
Active Not RecruitingA Study to Assess the Efficacy and Safety of Afimkibart (Also Known as RO7790121) for Induction and Maintenanc
Moderately to Severely Active Ulcerative Colitis
Phase 32024-09-17
Active Not RecruitingA Dose-escalation Study of RO7567132 as Single Agent and in Combination With Atezolizumab in Participants With
Cancer-Neoplasms
Phase 12024-09-16
RecruitingFrequency of Selected Single Nucleotide Polymorphisms in Huntington Disease Gene Expansion Carriers
Huntington Disease
2024-09-02
RecruitingA Study Evaluating the Effectiveness and Safety of Risdiplam Administered in Pediatric Patients With Spinal Mu
Muscular Atrophy, Spinal
Phase 42024-08-14
CompletedA Study of the Cobas® Liat CT/NG/MG Test Versus Current Standard Practice for Managing Participants at Increas
Chlamydia Trachomatis Infection, Neisseria Gonorrhoeae Infection, Mycoplasma Genitalium Infection
N/A2024-07-29
CompletedA Study of Participants With Initially Unresectable Hepatocellular Carcinoma That is Treated With Atezolizumab
Unresectable Hepatocellular Carcinoma
2024-07-19
RecruitingA Study of the Efficacy, Safety, and Pharmacokinetics (PK) of the Port Delivery System With Ranibizumab (PDS)
Neovascular Age-related Macular Degeneration, nAMD
Phase 32024-06-17
RecruitingA Study Evaluating the Effectiveness and Safety of Risdiplam Administered as an Early Intervention in Pediatri
Muscular Atrophy, Spinal
Phase 42024-05-30
RecruitingReal World Evidence in China: Faricimab Use in Diabetic Macular Edema, Retinal Vein Occlusion, and Neovascular
Diabetic Macular Edema, Neovascular Age-related Macular Degeneration, Retinal Vein Occlusion
2024-05-09
Active Not RecruitingA Study to Evaluate the Safety and Biomarker Effects of RO7269162 in Participants at Risk for or at the Prodro
Alzheimer's Disease
Phase 22024-05-02
RecruitingA Study to Investigate the Pharmacokinetics and Safety of Risdiplam in Infants With Spinal Muscular Atrophy
Muscular Atrophy, Spinal
Phase 22024-04-26
RecruitingA Study to Investigate Mechanisms of Resistance to Breast Cancer Therapies
Breast Cancer
Phase 42024-04-02
CompletedA Study of Tiragolumab Plus Atezolizumab Compared With Placebo Plus Atezolizumab in Participants With Complete
Non-small Cell Lung Cancer (NSCLC)
Phase 32024-03-21
Active Not RecruitingA Study to Evaluate the Efficacy and Safety of Faricimab in Patients With Choroidal Neovascularization Seconda
Choroidal Neovascularization Secondary to Pathologic Myopia
Phase 32024-03-06
CompletedA Study to Evaluate Single Subcutaneous Doses of NXT007 Among Injection Sites Abdomen, Upper Arm, and Thigh in
Healthy Male Participants
Phase 12024-02-14
WithdrawnA Study Of The Effectiveness And Safety Of A 36-Week Refill Regimen For The Port Delivery System With Ranibizu
Neovascular Age-Related Macular Degeneration
Phase 32023-12-29
RecruitingA First-in-Human Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of RO750
Systemic Lupus Erythematosus
Phase 12023-12-18
CompletedA Study Evaluating Safety, Tolerability, and Clinical Activity of Forimtamig-Based Treatment Combinations in P
Relapsed or Refractory Multiple Myeloma
Phase 1 / Phase 22023-12-12
RecruitingA Study Evaluating Single-agent Inavolisib, Inavolisib Plus Atezolizumab, and Inavolisib Plus Pembrolizumab in
PIK3CA-Mutated Cancers
Phase 12023-12-11
RecruitingA Study to Evaluate Efficacy and Safety of Giredestrant Compared With Fulvestrant (Plus a CDK4/6 Inhibitor), i
Estrogen Receptor-Positive, HER2-Negative Advanced Breast Cancer
Phase 32023-12-11
CompletedA Study Evaluating The Efficacy and Safety of Neoadjuvant Immunotherapy Combinations in Patients With Surgical
Carcinoma, Hepatocellular
Phase 1 / Phase 22023-12-05
WithdrawnA Study of Pralsetinib Versus Standard of Care (SOC) for Treatment of RET-Mutated Medullary Thyroid Cancer (MT
Medullary Thyroid Cancer
Phase 32023-11-30
Active Not RecruitingA Gene Delivery Study to Evaluate the Safety and Expression of Delandistrogene Moxeparvovec in Participants Un
Duchenne Muscular Dystrophy
Phase 22023-11-29
RecruitingA Surveillance Study of Susceptibility to Baloxavir Marboxil in Pediatric Participants With Influenza and Tran
Influenza
Phase 32023-11-22
Active Not RecruitingA Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Satralizumab in Participan
Thyroid Eye Disease
Phase 32023-11-15
RecruitingA Study Evaluating the Safety and Efficacy of Multiple Treatments in Participants With Multiple Myeloma
Multiple Myeloma
Phase 1 / Phase 22023-11-14
Active Not RecruitingA Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Satralizumab in Participan
Thyroid Eye Disease, TED
Phase 32023-10-26
RecruitingA Study to Evaluate Glofitamab as a Single Agent vs. Investigator's Choice in Participants With Relapsed/Refra
Lymphoma
Phase 32023-10-22
RecruitingA Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of NXT007 in Pe
Hemophilia A
Phase 1 / Phase 22023-09-21
Active Not RecruitingAn Open-Label Study Comparing Glofitamab and Polatuzumab Vedotin + Rituximab, Cyclophosphamide, Doxorubicin, a
Large B-Cell Lymphoma
Phase 32023-09-18
WithdrawnA Study To Determine The Effect Of Ocrelizumab On Leptomeningeal Inflammation In Multiple Sclerosis
Multiple Sclerosis
Phase 42023-09-15
Active Not RecruitingA Study Evaluating Atezolizumab and Bevacizumab, With or Without Tiragolumab, in Participants With Untreated L
Hepatocellular Carcinoma
Phase 32023-09-14
CompletedA Study to Evaluate the Impact of Liquid Biopsy in Participants With a Clinical Diagnosis of Advanced Cancer
Metastatic Lung Cancer, Metastatic Gastrointestinal Cancer
N/A2023-09-14
CompletedA Study to Evaluate the Safety and Effectiveness of Trastuzumab Emtansine (T-DM1) as Therapy in Chinese Partic
Breast Cancer
2023-09-13
RecruitingA Study to Evaluate the Efficacy and Safety of Inavolisib in Combination With Phesgo Versus Placebo in Combina
Metastatic Breast Cancer
Phase 32023-09-08
Active Not RecruitingA Study to Evaluate the Effectiveness and Safety of Polatuzumab in Real World Clinical Practice Among Adult Ch
Diffuse Large B-Cell Lymphoma
2023-08-25
Active Not RecruitingA Study of Participants in China With Non-Small-Cell Lung Cancer That is Unable to be Treated With Surgery
Carcinoma, Non-Small-Cell Lung
2023-08-11
RecruitingA Study to Evaluate the Efficacy and Safety of Sefaxersen (RO7434656) in Participants With Primary Immunoglobu
Primary IgA Nephropathy
Phase 32023-08-08
CompletedA Study to Investigate the Pharmacokinetics (PK) and Safety and to Provide Proof of Mechanism of Alogabat in C
Angelman Syndrome
Phase 22023-07-27
Active Not RecruitingAfimkibart (RO7790121) for the Treatment of Moderate to Severe Active Crohn's Disease
Crohns Disease
Phase 22023-07-24
Active Not RecruitingA Study of Tobemstomig + Nab-Paclitaxel Compared With Pembrolizumab + Nab-Paclitaxel in Participants With Prev
Breast Cancer
Phase 22023-07-18
RecruitingA Study to Evaluate the Long-Term Safety of Astegolimab in Participants With Chronic Obstructive Pulmonary Dis
Chronic Obstructive Pulmonary Disease
Phase 32023-06-28
Active Not RecruitingA Study of Giredestrant in Participants With Grade 1 Endometrial Cancer
Endometrial Cancer
Phase 22023-06-27
RecruitingA Study Evaluating the Safety, Activity, and Pharmacokinetics of Divarasib as a Single Agent or in Combination
Non-Small Cell Lung Cancer
Phase 1 / Phase 22023-06-20
TerminatedStudy of RO7515629 in Participants With HLA-G Positive Solid Tumors
Renal Cell Carcinoma, Non-small Cell Lung Cancer, Pancreatic Adenocarcinoma
Phase 12023-06-15
Active Not RecruitingA Study Evaluating the Efficacy and Safety of Inavolisib Plus Fulvestrant Compared With Alpelisib Plus Fulvest
Breast Cancer
Phase 32023-06-07
RecruitingA Rollover Study for Participants Previously Enrolled in a Genentech and/or F. Hoffman-La Roche Sponsored Stud
Cancer
Phase 32023-06-01
CompletedA Study to Evaluate the Safety and Pharmacokinetics of the Intravenous Fixed-Dose Combination (IV FDC) of Tira
PD-L1-selected Solid Tumors
Phase 22023-05-04
TerminatedA Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7565020 in Healthy Pa
Chronic Hepatitis B
Phase 12023-04-28
Active Not RecruitingA Study of Immune Checkpoint Inhibitor Combinations With Axitinib in Participants With Untreated Locally Advan
Renal Cell Carcinoma
Phase 22023-04-21
Active Not RecruitingA Study Evaluating Different Immunotherapies (LAG-3 and PD-1 With or Without TIGIT, Compared to PD-L1 Alone) i
Urothelial Cancer
Phase 22023-04-13
CompletedA Study Evaluating Efficacy and Safety of Multiple Treatment Combinations in Patients With Locally Advanced Sq
Squamous Cell Carcinoma of the Head and Neck
Phase 1 / Phase 22023-04-12
Active Not RecruitingA Study to Evaluate the Efficacy and Safety of Obinutuzumab Versus MMF in Participants With Childhood Onset Id
Childhood Idiopathic Nephrotic Syndrome
Phase 32023-03-29
CompletedVamikibart in Participants With Uveitic Macular Edema
Uveitic Macular Edema
Phase 32023-03-23
Active Not RecruitingA Study of Tobemstomig Plus Platinum-Based Chemotherapy vs Pembrolizumab Plus Platinum-Based Chemotherapy in P
Non-small Cell Lung Cancer
Phase 22023-03-15
TerminatedClinical Impact and Utility of Digital Health Solutions in Participants Receiving Systemic Treatment in Clinic
Cancer
Phase 2 / Phase 32023-02-27
Active Not RecruitingA Study to Evaluate RO7204239 in Participants With Facioscapulohumeral Muscular Dystrophy
Facioscapulohumeral Muscular Dystrophy (FSHD)
Phase 22023-02-07
Active Not RecruitingGENERATION HD2. A Study to Evaluate the Safety, Biomarkers, and Efficacy of Tominersen Compared With Placebo i
Huntington Disease
Phase 22023-02-03
CompletedA Study to Evaluate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Anti-tumor Activ
Small Cell Lung Cancer, Neuroendocrine Carcinoma
Phase 12023-01-23
CompletedA Study to Investigate Vamikibart in Participants With Uveitic Macular Edema
Uveitic Macular Edema
Phase 32023-01-09
RecruitingA Study to Evaluate Astegolimab in Participants With Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease (COPD)
Phase 32022-12-29
TerminatedA Study to Evaluate the Safety and Efficacy of Basmisanil Treatment in Children Aged 2-14 Years With Dup15q Sy
Dup15q Syndrome
Phase 22022-12-16
CompletedA Study to Investigate the Pharmacokinetics of RO7223280 in Critically Ill Participants With Bacterial Infecti
Bacterial Infections
Phase 12022-12-03
WithdrawnA Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Crovalimab in Participants
Guillain-Barré Syndrome
Phase 32022-11-30
Active Not RecruitingA Real-World Study to Gain Clinical Insights Into Roche Ophthalmology Products
Neovascular Age-related Macular Degeneration, Diabetic Macular Edema, Retinal Vein Occlusion
2022-11-21
RecruitingA Study to Evaluate Glofitamab Monotherapy and Glofitamab + Chemoimmunotherapy in Pediatric and Young Adult Pa
Mature B-Cell Non-Hodgkin Lymphoma
Phase 1 / Phase 22022-11-16
CompletedA Study Evaluating the Efficacy, Safety, and Pharmacokinetics of Glofitamab in Combination With Rituximab Plus
Diffuse Large B-Cell Lymphoma (DLBCL)
Phase 12022-11-04
Active Not RecruitingA Study Evaluating the Efficacy and Safety of Multiple Therapies in Cohorts of Participants With Locally Advan
Non-Small Cell Lung Cancer
Phase 32022-11-01
RecruitingA Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Mosunetuzumab or Glofitamab in Combination Wi
Non-Hodgkin Lymphoma
Phase 12022-10-26
Active Not RecruitingA Study Evaluating the Efficacy and Safety of Cevostamab in Prior B Cell Maturation Antigen (BCMA)-Exposed Par
Multiple Myeloma
Phase 1 / Phase 22022-10-17
CompletedA Study in Patients With Neovascular Age-Related Macular Degeneration or Diabetic Macular Edema to Evaluate th
Neovascular Age-related Macular Degeneration, Diabetic Macular Edema
Phase 32022-10-17
RecruitingA Study to Evaluate the Efficacy, Safety, Pharmacokinetics (PK), and Pharmacodynamics (PD) of Satralizumab in
NMDAR Autoimmune Encephalitis, LGI1 Autoimmune Encephalitis
Phase 32022-09-27
CompletedA Study to Investigate The Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of RO7486967 in Partici
Parkinson Disease
Phase 12022-09-22
RecruitingA Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Satralizumab in Participan
Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD)
Phase 32022-08-30
CompletedA Study of Multiple Doses of RO7247669 in Participants With Previously Untreated Unresectable or Metastatic Me
Melanoma
Phase 22022-08-15
TerminatedA Study In Neuromyelitis Optica Spectrum Disorder (NMOSD) With Satralizumab As An Intervention
Neuromyelitis Optica Spectrum Disorder, NMOSD
Phase 42022-08-02
CompletedStudy To Evaluate The Efficacy And Safety Of Balovaptan In Adults With Post-Traumatic Stress Disorder (PTSD)
Stress Disorders, Post-Traumatic
Phase 22022-08-02
CompletedScreening Study for Participants With Malignant Tumors
Solid Tumors
Phase 22022-07-22
Active Not RecruitingA Study to Evaluate the Efficacy and Safety of Giredestrant in Combination With Phesgo (Pertuzumab, Trastuzuma
Locally Advanced or Metastatic Breast Cancer
Phase 32022-07-18
CompletedA Study to Evaluate Patient Preference for Home Administration of Fixed-Dose Combination of Pertuzumab and Tra
Early Breast Cancer, Locally Advanced Breast Cancer, Inflammatory Breast Cancer
Phase 32022-07-05
WithdrawnThe Effect of Hepatic Impairment on the Pharmacokinetics of Balovaptan
Autism Spectrum Disorder
Phase 12022-06-26
WithdrawnStudy to Evaluate The Safety and Efficacy of Balovaptan in Participants With Acute Ischemic Stroke at a High R
Acute Ischemic Stroke
Phase 22022-06-22
Active Not RecruitingA Study to Evaluate Overall Health, Physical Activity, and Joint Outcomes in Participants With Severe or Moder
Severe Hemophilia A, Moderate Hemophilia A
Phase 42022-06-20
Active Not RecruitingA Study of Atezolizumab in High PD-L1 Expression, Chemotherapy-Naïve Patients With Stage IV Non-Squamous or Sq
Non-Small Cell Lung Cancer
Phase 32022-06-14
CompletedA Study Evaluating Tocilizumab in Pediatric Patients Hospitalized With COVID-19
COVID-19
Phase 12022-06-10
Active Not RecruitingA Study to Investigate the Safety and Efficacy of RO7204239 in Combination With Risdiplam (RO7034067) in Parti
Spinal Muscular Atrophy (SMA)
Phase 2 / Phase 32022-06-02
CompletedA Study in Healthy Male Subjects to Investigate the Comparability of Pharmacokinetics of the Fixed-Dose Combin
Healthy Male Subjects
Phase 12022-05-30
Active Not RecruitingA Study to Evaluate Safety and Efficacy of Ocrelizumab in Comparison With Fingolimod in Children and Adolescen
Relapsing-Remitting Multiple Sclerosis
Phase 32022-05-19
RecruitingA Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Obinutuzumab in Adolescents With Active Clas
Lupus Nephritis
Phase 22022-05-12
TerminatedAn Open-Label, Multicenter Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Mosunetuzumab in Com
Non-Hodgkin Lymphoma, Follicular Lymphoma
Phase 1 / Phase 22022-05-10
CompletedA Phase III, Non-Inferiority, Randomized, Open-Label, Parallel Group, Multicenter Study To Investigate The Pha
Relapsing Multiple Sclerosis, Primary Progressive Multiple Sclerosis
Phase 32022-05-03
Active Not RecruitingA Rollover Study to Evaluate the Long-Term Safety and Efficacy of Ocrelizumab In Patients With Multiple Sclero
Multiple Sclerosis
Phase 32022-05-03
Active Not RecruitingA Study Evaluating Efficacy and Safety of Mosunetuzumab in Combination With Polatuzumab Vedotin Compared to Ri
Non-Hodgkin Lymphoma
Phase 32022-04-25
TerminatedA Study to Evaluate the Efficacy and Safety of Gantenerumab in Participants at Risk for or at the Earliest Sta
Alzheimers Disease
Phase 32022-04-19
CompletedA Study Evaluating B Cell Levels In Infants Potentially Exposed To Ocrelizumab During Pregnancy
Multiple Sclerosis, Clinically Isolated Syndrome
Phase 42022-04-13
CompletedA Study Evaluating the Safety, Pharmacokinetic and Anti-tumor Activity of RO7428731 in Participants With Gliob
Glioblastoma
Phase 12022-04-05
CompletedA Study to Evaluate Participant and Healthcare Professional Reported Preference for Subcutaneous Atezolizumab
Non-small Cell Lung Cancer
Phase 22022-04-04
CompletedA Study Evaluating the Safety, Pharmacokinetics, Pharmacodynamics and Efficacy of Crovalimab for the Managemen
Sickle Cell Disease
Phase 12022-03-26
Active Not RecruitingA Study to Evaluate the Safety and Efficacy of Glofitamab in Combination With Rituximab (R) Plus Cyclophospham
Lymphoma
Phase 22022-03-22
Active Not RecruitingA Study of Atezolizumab With or Without Tiragolumab Following Neoadjuvant Chemoradiotherapy in Participants Wi
Rectal Neoplasms, Rectal Cancer
Phase 22022-03-18
CompletedA Study Evaluating the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Crovalimab as Adjunct Treat
Sickle Cell Disease
Phase 22022-03-09
RecruitingA Study Evaluating the Safety, Efficacy, and Pharmacokinetics of Mosunetuzumab and a Combined Regimen of Mosun
Chronic Lymphocytic Leukemia
Phase 12022-03-07
Active Not RecruitingA Study to Investigate the Efficacy of Fenebrutinib in Relapsing Multiple Sclerosis (RMS)
Relapsing Multiple Sclerosis
Phase 22022-03-01
TerminatedAn Umbrella Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Gastr
Gastric and Gastroesophageal Junction Carcinoma
Phase 1 / Phase 22022-03-01
TerminatedA Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of RO7443904 in Combination With
Lymphoma, Non-Hodgkin
Phase 12022-02-18
CompletedA Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Melanoma (Morph
Melanoma
Phase 1 / Phase 22022-02-02
TerminatedA Study to Evaluate Safety, Pharmacokinetics, and Preliminary Anti-tumor Activity of RO7444973 in Participants
Solid Tumors
Phase 12022-01-25
CompletedA Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Subcutaneously Adminis
Systemic Lupus Erythematosus
Phase 12022-01-11
CompletedA Study to Investigate Vamikibart (RO7200220) in Diabetic Macular Edema
Diabetic Macular Edema
Phase 22021-12-31
CompletedA Study to Investigate Vamikibart (RO7200220) in Combination With Ranibizumab in Diabetic Macular Edema
Diabetic Macular Edema
Phase 22021-12-17
Active Not RecruitingAn Extension Study in Participants Previously Enrolled in a Genentech and/or F. Hoffmann-La Roche Ltd Sponsore
Neoplasms
Phase 32021-12-01
TerminatedA Study of Atezolizumab With or Without Tiragolumab Consolidation in Limited Stage Small Cell Lung Cancer
Carcinoma, Small Cell Lung
Phase 22021-12-01
Active Not RecruitingA Phase III, Open-Label Study of Maintenance Lurbinectedin in Combination With Atezolizumab Compared With Atez
Small-Cell Lung Cancer
Phase 32021-11-18
Active Not RecruitingA Study Evaluating the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Crovalimab in Pediatric Part
Atypical Hemolytic Uremic Syndrome
Phase 32021-11-17
CompletedA Study of Elecsys® Troponin T hs Gen 6 in Participants With Symptoms of Acute Coronary Syndrome
Acute Coronary Syndrome, Myocardial Infarction
2021-11-15
Active Not RecruitingA Study Evaluating the Efficacy and Safety of Mosunetuzumab in Combination With Lenalidomide in Comparison to
Relapsed or Refractory Follicular Lymphoma
Phase 32021-10-27
Active Not RecruitingA Study to Evaluate the Efficacy and Safety of Obinutuzumab in Participants With Systemic Lupus Erythematosus
Systemic Lupus Erythematosus
Phase 32021-10-26
Active Not RecruitingA Study Evaluating the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Crovalimab in Adult and Adol
Atypical Hemolytic Uremic Syndrome
Phase 32021-10-22
RecruitingA Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic
Metastatic Colorectal Cancer
Phase 12021-10-22
TerminatedA Study To Evaluate Efficacy, Safety, Pharmacokinetics, And Pharmacodynamics Of Satralizumab In Patients With
Generalized Myasthenia Gravis
Phase 32021-10-19
Active Not RecruitingA Study Evaluating the Efficacy and Safety of Biomarker-Driven Therapies in Patients With Persistent or Recurr
Ovarian Cancer
Phase 22021-10-07
Active Not RecruitingA Study to Compare the Efficacy and Safety of Entrectinib and Crizotinib in Participants With Advanced or Meta
Carcinoma, Non-Small-Cell Lung
Phase 32021-09-30
CompletedA Study Evaluating B Cell Levels In Infants Of Lactating Women With CIS Or MS Receiving Ocrelizumab
Multiple Sclerosis, Clinically Isolated Syndrome
Phase 42021-09-16
RecruitingA Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Alectinib in Pediatric Participants With ALK
ALK Fusion-positive Solid or CNS Tumors
Phase 1 / Phase 22021-09-14
TerminatedA Study to Evaluate Long Term Safety and Efficacy of Recombinant Human Pentraxin-2 (rhPTX-2; PRM-151) in Parti
Idiopathic Pulmonary Fibrosis
Phase 32021-08-30
Active Not RecruitingA Study Evaluating the Efficacy and Safety of Adjuvant Giredestrant Compared With Physician's Choice of Adjuva
Early Breast Cancer
Phase 32021-08-27
CompletedA Phase 1 Study of RO7623066 Alone and in Combination in Patients With Advanced Solid Tumors
Advanced Solid Tumors
Phase 12021-08-26
RecruitingA Study to Investigate the Safety, Tolerability, and Processing by the Body of Intravenous and Subcutaneous RO
Multiple Sclerosis
Phase 12021-08-11
TerminatedA Study to Explore the Efficacy and Safety of Atezolizumab Plus Tiragolumab and Chemotherapy in 1st Line HER2
Stomach Neoplasms, Gastric Cancer, Gastroesophageal Junction Adenocarcinoma
Phase 22021-08-06
CompletedStudy To Evaluate Safety, Pharmacokinetics, Pharmacodynamics, And Preliminary Anti-Tumor Activity Of RO7122290
Metastatic Colorectal Cancer
Phase 12021-07-14
Active Not RecruitingA Study of the Efficacy, Safety, and Pharmacokinetics of a 36-Week Refill Regimen for the Port Delivery System
Neovascular Age-related Macular Degeneration (nAMD)
Phase 32021-07-14
TerminatedA Study Evaluating the Safety, Efficacy and Pharmacokinetics of Venetoclax in Combination With Polatuzumab Ved
Lymphoma, Large B-Cell, Diffuse
Phase 12021-07-02
WithdrawnA Study Evaluating the Efficacy and Safety of Adjuvant Platinum-Doublet Chemotherapy, With or Without Atezoliz
Carcinoma, Non-Small Cell Lung
Phase 22021-07-01
CompletedA Study of Lomvastomig (RO7121661) and Tobemstomig (RO7247669) Compared With Nivolumab in Participants With Ad
Advanced or Metastatic Esophageal Squamous Cell Carcinoma
Phase 22021-06-25
Active Not RecruitingA Study Evaluating the Efficacy and Safety of Obinutuzumab in Participants With Primary Membranous Nephropathy
Primary Membranous Nephropathy
Phase 32021-06-25
RecruitingA Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Participants With Breast Canc
Inoperable, Locally Advanced or Metastatic, ER-positive Breast Cancer
Phase 1 / Phase 22021-06-22
TerminatedA Six-Month Follow-Up Study of Participants With Coronavirus Disease 2019 (COVID-19) Previously Enrolled in a
COVID-19, Long COVID
2021-06-15
TerminatedA Study of Trastuzumab Emtansine in Combination With Atezolizumab or Placebo as a Treatment for Participants W
Metastatic Breast Cancer
Phase 32021-06-07
TerminatedA Home-Based Approach Study to Evaluate the Efficacy and Safety of Alectinib in Locally-Advanced or Metastatic
Neoplasms, Colorectal Neoplasms, Melanoma
Phase 22021-05-24
CompletedA Study to Evaluate Safety, Pharmacokinetics and Anti-Tumor Activity of RO7300490, as Single Agent or in Combi
Solid Tumors
Phase 12021-05-18
Active Not RecruitingAn Observational Study to Evaluate the Real-World Clinical Management and Outcomes of ALK-Positive Advanced NS
NSCLC
2021-05-10
Active Not RecruitingA Study to Evaluate the Efficacy and Safety of Intravenous Prasinezumab in Participants With Early Parkinson's
Parkinsons Disease
Phase 22021-05-05
TerminatedA Study of Atezolizumab in Combination With Bevacizumab in Spanish Patients With Unresectable or Unsuitable fo
Carcinoma, Hepatocellular
Phase 32021-05-04
Active Not RecruitingA Study Evaluating the Efficacy and Safety of Adjuvant Atezolizumab or Placebo and Trastuzumab Emtansine for P
Breast Cancer
Phase 32021-05-04
Active Not RecruitingA Study of Atezolizumab Versus Placebo as Adjuvant Therapy in Participants With High-risk Muscle-invasive Blad
Muscle-invasive Bladder Cancer
Phase 32021-05-03
CompletedA Study To Assess Distribution Of RO7248824 In The Central Nervous System Following Single Intrathecal Doses O
Angelman Syndrome
Phase 12021-04-29
TerminatedStudy to Evaluate the Effects of RO7496998 (AT-527) in Non-Hospitalized Adult and Adolescent Participants With
COVID-19
Phase 32021-04-28
Active Not RecruitingA Study of Atezolizumab With Lenvatinib or Sorafenib Versus Lenvatinib or Sorafenib Alone in Hepatocellular Ca
Unresectable Hepatocellular Carcinoma
Phase 32021-04-26
TerminatedA Study Evaluating the Safety and Efficacy of Neoadjuvant and Adjuvant Tiragolumab Plus Atezolizumab, With or
Non-Small Cell Lung Cancer (NSCLC)
Phase 22021-04-23
CompletedA Study to Evaluate the Long-Term Safety and Tolerability of Faricimab in Participants With Neovascular Age-Re
Neovascular Age-related Macular Degeneration
Phase 32021-04-19
TerminatedEffect of RO7049665 on the Time to Relapse Following Steroid Tapering in Participants With Autoimmune Hepatiti
Autoimmune Hepatitis, Autoimmune Chronic Hepatitis
Phase 22021-04-19
WithdrawnA Study of the Efficacy and Safety of RO7198457 in Combination With Atezolizumab Versus Atezolizumab Alone Fol
Non-small Cell Lung Cancer (NSCLC)
Phase 22021-03-31
CompletedMass Balance and Absolute Bioavailability Study of RO7049389 in Healthy Volunteers
Healthy Volunteers
Phase 12021-03-31
CompletedA 12-Week Placebo-Controlled Study to Investigate the Efficacy, Safety, and Tolerability of RO7017773 in Parti
Autism Spectrum Disorder (ASD)
Phase 22021-03-31
Active Not RecruitingStudy to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Teriflunomide in Relapsing Multiple Sc
Relapsing Multiple Sclerosis
Phase 32021-03-24
TerminatedA Study to Evaluate the Efficacy and Safety of Recombinant Human Pentraxin-2 (rhPTX-2; PRM-151) in Participant
Idiopathic Pulmonary Fibrosis
Phase 32021-03-19
Active Not RecruitingA Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Teriflunomide in Relapsing Multiple
Relapsing Multiple Sclerosis
Phase 32021-03-17
Active Not RecruitingA Study Evaluating the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Crovalimab in Participants W
Paroxysmal Nocturnal Hemoglobinuria
Phase 32021-03-17
Active Not RecruitingBrainshuttle AD: A Multiple Ascending Dose Study to Investigate the Safety, Tolerability, Pharmacokinetics, an
Alzheimers Disease
Phase 1 / Phase 22021-03-15
Active Not RecruitingA Study of Atezolizumab and Trastuzumab in Combination With Capecitabine and Oxaliplatin in Patients With HER2
Gastric Cancer, Gastroesophageal Junction Adenocarcinoma
Phase 22021-03-12
Active Not RecruitingA Study of TACE Combined With Atezolizumab Plus Bevacizumab or TACE Alone in Patients With Untreated Heaptocel
Hepatocellular Carcinoma
Phase 32021-03-12
CompletedA Study to Evaluate the Efficacy and Safety of Faricimab in Participants With Macular Edema Secondary to Branc
Macular Edema, Branch Retinal Vein Occlusion
Phase 32021-03-02
CompletedA Study of Atezolizumab Plus Tiragolumab and Atezolizumab Plus Placebo as First-Line Treatment in Participants
Squamous Cell Carcinoma of Head and Neck
Phase 22021-03-02
CompletedA Study to Evaluate the Safety and Efficacy of Satralizumab in Participants With Neuromyelitis Optica Spectrum
Neuromyelitis Optica Spectrum Disorder
Phase 32021-03-02
CompletedA Study to Evaluate the Efficacy and Safety of Faricimab in Participants With Macular Edema Secondary to Centr
Macular Edema, Central Retinal Vein Occlusion, Hemiretinal Vein Occlusion
Phase 32021-03-02
CompletedA Study on Pharmacokinetics (PK), Efficacy and Safety of Subcutaneous (SC) Versus Intravenous (IV) Rituximab,
Lymphoma, Large B-Cell, Diffuse
Phase 22021-02-24
Active Not RecruitingA Phase III Study Evaluating Glofitamab in Combination With Gemcitabine + Oxaliplatin vs Rituximab in Combinat
Diffuse Large B-cell Lymphoma
Phase 32021-02-23
CompletedA Study of Atezolizumab With or Without Bevacizumab in Combination With Cisplatin Plus Gemcitabine in Patients
Biliary Tract Cancer
Phase 22021-02-23
CompletedA Study To Monitor Lung Cancer Patients Activity And Assess Performance Status Through A Wearable Device.
Non-Small Cell Lung Cancer (NSCLC)
2021-02-18
Active Not RecruitingA Study to Evaluate the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Subcutaneous Emicizumab in
Severe Hemophilia A
Phase 32021-02-04
CompletedStudy to Evaluate the Effects of AT-527 in Non-Hospitalized Adult Patients With Mild or Moderate COVID-19
COVID-19
Phase 22021-02-03
CompletedBioavailability and Bioequivalence of Two Risdiplam Tablets in Healthy Participants
Muscular Atrophy, Spinal
Phase 12021-02-01
TerminatedA Study to Evaluate the Safety, Tolerability, and Efficacy of Long-Term Gantenerumab Administration in Partici
Alzheimer Disease
Phase 32021-01-26
Active Not RecruitingTumor-agnostic Precision Immuno-oncology and Somatic Targeting Rational for You (TAPISTRY) Platform Study
Solid Tumors
Phase 22021-01-18
CompletedA Study to Evaluate Glofitamab as Single Agent Administered After Pretreatment With Obinutuzumab in Chinese Pa
Lymphoma
Phase 12021-01-08
TerminatedA Study to Evaluate the Safety and Tolerability of RO7296682 in Combination With Atezolizumab in Participants
Solid Tumors
Phase 12021-01-04
Active Not RecruitingStudy of Atezolizumab Plus Carboplatin and Etoposide With or Without Tiragolumab in Participants With Untreate
Small Cell Lung Carcinoma
Phase 32020-12-21
CompletedStudy of Low-Dose Radiotherapy (LDRT) Concurrent Cisplatin/Carboplatin Plus Etoposide With Atezolizumab for Pa
Carcinoma, Small Cell Lung
Phase 22020-12-16
CompletedA Study of Tiragolumab in Combination With Atezolizumab Plus Pemetrexed and Carboplatin/Cisplatin Versus Pembr
Non-small Cell Lung Cancer (NSCLC)
Phase 2 / Phase 32020-12-15
CompletedA Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Immunogenicity of Intravitreal Injections o
Geographic Atrophy
Phase 12020-12-08
CompletedA Study To Investigate The Safety, Tolerability And Pharmacokinetics (PK) Of RO7223280 Following Intravenous A
Healthy Volunteers
Phase 12020-12-07
Active Not RecruitingA Study to Evaluate the Efficacy, Safety and Pharmacokinetics (PK) of a Higher Dose of Ocrelizumab in Adults W
Multiple Sclerosis
Phase 32020-12-03
Active Not RecruitingA Study Evaluating the Efficacy and Safety of Giredestrant Compared With Physician's Choice of Endocrine Monot
Estrogen Receptor-Positive, HER2-Negative, Locally Advanced or Metastatic Breast Cancer
Phase 22020-11-27
Active Not RecruitingA Study to Evaluate the Efficacy, Safety and Pharmacokinetics (PK) of a Higher Dose of Ocrelizumab in Adults W
Multiple Sclerosis
Phase 32020-11-26
CompletedA Study to Investigate Aqueous Humor and Multimodal Imaging Biomarkers in Treatment-Naïve Participants With Di
Diabetic Macular Edema
Phase 22020-11-25
TerminatedA Study to Evaluate the Pharmacodynamic (PD) Effects of Once Weekly Administration of Gantenerumab in Particip
Alzheimer Disease
Phase 22020-11-18
CompletedA Study Evaluating the Safety and Pharmacokinetics of Escalating Doses of Forimtamig in Participants With Rela
Multiple Myeloma
Phase 12020-11-11
CompletedA Dose Escalation and Expansion Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynam
Acute Myeloid Leukemia
Phase 12020-11-04
CompletedA Study Of The Pharmacokinetics And Safety Of Ipatasertib In Chinese Participants With Locally Advanced Or Met
Solid Tumors
Phase 12020-11-03
RecruitingA Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatment Combinations in Patients
Advanced Liver Cancers
Phase 1 / Phase 22020-11-01
CompletedA Study of Atezolizumab Plus Tiragolumab in Combination With Paclitaxel and Cisplatin Compared With Paclitaxel
Esophageal Cancer
Phase 32020-10-30
Active Not RecruitingStudy of Zifibancimig in Participants With Neovascular Age-related Macular Degeneration
Macular Degeneration
Phase 1 / Phase 22020-10-28
CompletedA Study of RO7293583 in Participants With Unresectable Metastatic Tyrosinase Related Protein 1 (TYRP1)-Positiv
Cutaneous Melanoma, Uveal Melanoma, Mucosal Melanoma
Phase 12020-10-28
Active Not RecruitingA Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Ocrelizumab in Adult Participants Wi
Multiple Sclerosis, Primary Progressive
Phase 32020-10-26
Active Not RecruitingA Study Evaluating the Efficacy and Safety of Giredestrant Combined With Palbociclib Compared With Letrozole C
Estrogen Receptor-Positive, HER2-Negative Locally Advanced or Metastatic Breast Cancer
Phase 32020-10-09
Active Not RecruitingA Study Evaluating the Efficacy and Safety of Crovalimab Versus Eculizumab in Participants With Paroxysmal Noc
Paroxysmal Nocturnal Hemoglobinuria
Phase 32020-10-08
CompletedStudy of Atezolizumab in Combination With Cabozantinib Versus Docetaxel in Patients With Metastatic Non-Small
Carcinoma, Non-Small-Cell Lung
Phase 32020-10-01
Active Not RecruitingA Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Crovalimab Versus Eculizumab in Participants
Paroxysmal Nocturnal Hemoglobinuria
Phase 32020-09-30
CompletedA Study of the Safety, Efficacy, and Pharmacokinetics of Tiragolumab in Combination With Atezolizumab and Chem
Triple-Negative Breast Cancer
Phase 12020-09-28
Active Not RecruitingA Study of Atezolizumab With or Without Tiragolumab in Participants With Unresectable Esophageal Squamous Cell
Esophageal Squamous Cell Carcinoma
Phase 32020-09-28
TerminatedA Study Evaluating the Safety and Efficacy of Venetoclax in Combination With Trastuzumab Emtansine in Patients
Breast Cancer
Phase 1 / Phase 22020-09-23
TerminatedA Study Evaluating The Safety, Tolerability, Pharmacokinetics, And Efficacy Of Venetoclax In Combination With
Small Cell Lung Cancer
Phase 12020-09-22
CompletedA Study of Atezolizumab in Combination With Bevacizumab in Patients With EGFR Mutation Positive Stage IIIB-IV
Carcinoma, Non-Small-Cell Lung
Phase 22020-09-09
CompletedA Trial of the Efficacy and the Safety of RO6889450 (Ralmitaront) vs Placebo in Patients With an Acute Exacerb
Schizophrenia, Schizoaffective Disorder
Phase 22020-09-08
CompletedA Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Giredestrant Plus Palbociclib Compared With
Early Breast Cancer
Phase 22020-09-04
Active Not RecruitingA Phase 1 Trial of ZN-A-1041 Enteric Capsules or Combination in Participants With Human Epidermal Growth Facto
Advanced Solid Tumors, HER2-positive Breast Cancer
Phase 1 / Phase 22020-09-03
RecruitingA Worldwide Cancer Registry Enrolling Participants Profiled With a Next-Generation Sequencing Test
Solid Tumours
2020-08-27
CompletedA Study of Atezolizumab (Tecentriq) in Combination With Bevacizumab to Investigate Safety and Efficacy in Pati
Carcinoma, Hepatocellular
Phase 32020-08-25
CompletedA Study of Atezolizumab and Tiragolumab Compared With Durvalumab in Participants With Locally Advanced, Unrese
Non-small Cell Lung Cancer (NSCLC)
Phase 32020-08-24
CompletedA Study to Investigate the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of RO7248824
Angelman Syndrome
Phase 12020-08-19
Active Not RecruitingA Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Mosunetuzumab + Lenalidomide (+Len), and the
Follicular Lymphoma
Phase 1 / Phase 22020-08-12
CompletedA Multicenter, Randomized Study in Participants With Diabetic Retinopathy Without Center-involved Diabetic Mac
Diabetic Retinopathy
Phase 32020-08-10
Active Not RecruitingA Study to Evaluate the Efficacy and Safety of Obinutuzumab in Participants With ISN/RPS 2003 Class III or IV
Lupus Nephritis
Phase 32020-08-10
CompletedA Study to Investigate the Efficacy and Safety of Atezolizumab (Tecentriq) in Previously-Treated Patients With
Carcinoma, Thymic
Phase 22020-08-07
CompletedA Study to Evaluate the Long-Term Safety and Tolerability of Faricimab in Participants With Diabetic Macular E
Diabetic Macular Edema
Phase 32020-08-05
TerminatedA Study of Atezolizumab in Combination With Cabozantinib Compared to Cabozantinib Alone in Participants With A
Carcinoma, Renal Cell
Phase 32020-07-28
TerminatedA Study of Pralsetinib Versus Standard of Care for First-Line Treatment of Advanced Non-Small Cell Lung Cancer
RET-fusion Non Small Cell Lung Cancer, Lung Neoplasm, Carcinoma, Non-Small-Cell Lung
Phase 32020-07-24
CompletedA Study Evaluating Safety, Pharmacokinetics, Pharmacodynamics, And Clinical Activity Of RO7119929 (TLR7 Agonis
Carcinoma, Hepatocellular, Biliary Tract Cancer, Secondary Liver Cancer
Phase 12020-07-16
CompletedA Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Food Effect of RO69539
Autistic Disorder, Autism Spectrum Disorder, Child Development Disorders, Pervasive
Phase 12020-07-15
TerminatedA Study to Evaluate the Efficacy and Safety of Polatuzumab Vedotin in Combination With Bendamustine and Rituxi
Diffuse, Large B-Cell, Lymphoma
Phase 32020-07-10
TerminatedA Study Evaluating The Safety, Efficacy and Pharmacokinetics Of Ipatasertib In Combination With Atezolizumab A
Castration-Resistant Prostatic Cancer
Phase 12020-07-09
CompletedA Trial To Evaluate The Efficacy And Safety Of Multiple Combination Therapies In Participants With Chronic Hep
Hepatitis B, Chronic
Phase 22020-07-05
CompletedA Study of Tiragolumab Plus Atezolizumab and Atezolizumab Monotherapy in Participants With Metastatic and/or R
Cervical Cancer
Phase 22020-06-30
CompletedA Study to Evaluate the Efficacy and Safety of Remdesivir Plus Tocilizumab Compared With Remdesivir Plus Place
COVID-19 Pneumonia
Phase 32020-06-16
CompletedA Study to Investigate the Efficacy and Safety of RG7774 in Patients With Diabetes Mellitus Type 1 or Type 2 W
Diabetic Retinopathy
Phase 22020-06-05
CompletedA Study Evaluating the Safety and Efficacy of Glofitamab or Mosunetuzumab in Combination With Gemcitabine Plus
B-cell Lymphoma
Phase 12020-06-04
CompletedA Study to Compare the Efficacy and Safety of a Combined Regimen of Venetoclax and Obinutuzumab Versus Fludara
Chronic Lymphocytic Leukemia (CLL)
Phase 32020-05-28
TerminatedA Study to Evaluate the Safety and Tolerability of Long-term Administration of Gantenerumab in Participants Wi
Alzheimer Disease
Phase 32020-05-22
CompletedA Study to Investigate Intravenous Tocilizumab in Participants With Moderate to Severe COVID-19 Pneumonia
COVID-19 Pneumonia
Phase 22020-05-05
CompletedA Study to Evaluate Safety and Anti-Tumor Activity of Eciskafusp Alfa (RO7284755) Alone or in Combination With
Solid Tumors
Phase 12020-05-04
CompletedA Study of Bevacizumab, Carboplatin, and Paclitaxel or Pemetrexed With or Without Atezolizumab in Chemotherapy
Carcinoma, Non-Small-Cell Lung
Phase 32020-04-09
CompletedA Study to Evaluate the Safety and Efficacy of Tocilizumab in Patients With Severe COVID-19 Pneumonia
COVID-19 Pneumonia
Phase 32020-04-03
CompletedA Study of Tiragolumab in Combination With Atezolizumab Compared With Placebo in Combination With Atezolizumab
Non-Small Cell Lung Cancer
Phase 32020-03-04
CompletedAn Observational Study to Evaluate Physical Activity, Bleeding Incidence and Health Related Quality of Life, i
Severe Hereditary Factor VIII Deficiency Disease Without Inhibitor, Moderate Hereditary Factor VIII Deficiency Disease Without Inhibitor, Haemophilia A
2020-02-24
Active Not RecruitingA Study to Describe the Diagnosis, Anti-Cancer Treatment and Clinical Outcome in Patients With Newly Diagnosed
Breast Cancer
2020-02-21
CompletedA Study to Investigate the Effect of Impaired Hepatic Function on the Pharmacokinetics of Entrectinib in Volun
Hepatic Insufficiency
Phase 12020-02-11
CompletedA Study to Evaluate the Safety, Efficacy, Pharmacokinetics and Pharmacodynamics of Emicizumab in Participants
Mild Hereditary Factor VIII Deficiency Disease Without Inhibitor, Moderate Hereditary Factor VIII Deficiency Disease Without Inhibitor, Hemophilia A
Phase 32020-02-10
CompletedA Study to Evaluate the Safety and Efficacy of Polatuzumab Vedotin in Combination With Rituximab, Gemcitabine
Diffuse Large B-Cell Lymphoma
Phase 32020-02-07
CompletedA Two-Arm Study to Evaluate the Pharmacokinetics, Efficacy, and Safety of Subcutaneous Administration of the F
HER2-positive Early Breast Cancer
Phase 32020-02-05
CompletedRLY-1971 in Subjects With Advanced or Metastatic Solid Tumors
Solid Tumor, Unspecified, Adult
Phase 12020-02-04
CompletedA Study of Atezolizumab Plus Carboplatin and Etoposide With or Without Tiragolumab in Patients With Untreated
Small Cell Lung Cancer
Phase 32020-02-04
Active Not RecruitingA Study Evaluating the Efficacy and Safety of Inavolisib + Palbociclib + Fulvestrant vs Placebo + Palbociclib
Breast Cancer
Phase 2 / Phase 32020-01-29
TerminatedA Study Evaluating the Safety, Tolerability, Pharmacokinetics and Preliminary Activity of Idasanutlin in Combi
Acute Myeloid Leukemia (AML), Acute Lymphoblastic Leukemia (ALL), Neuroblastoma
Phase 1 / Phase 22020-01-27
Active Not RecruitingA Study of Ocrelizumab in Children and Adolescents With Relapsing-Remitting Multiple Sclerosis
Multiple Sclerosis
Phase 22020-01-09
Active Not RecruitingA Study of Atezolizumab Plus Bevacizumab Versus Active Surveillance as Adjuvant Therapy in Patients With Hepat
Carcinoma, Hepatocellular
Phase 32019-12-31
CompletedA Study to Evaluate the Efficacy and Safety of PF-06480605 in Adults With Moderate to Severe Ulcerative Coliti
Moderate to Severe Ulcerative Colitis
Phase 22019-12-19
TerminatedA Study to Investigate the Pharmacokinetics, Safety, and Tolerability of Balovaptan in Children With Autism Sp
Autism Spectrum Disorder
Phase 12019-12-19
CompletedA Study of Atezolizumab Plus Nab-Paclitaxel in the Treatment of Unresectable Locally Advanced or Metastatic PD
Triple-Negative Breast Cancer
Phase 32019-12-10
TerminatedA Study to Evaluate the Safety and Tolerability of RO7296682 in Participants With Advanced Solid Tumors
Solid Tumors
Phase 12019-12-09
CompletedA Study of Ipatasertib in Combination With Atezolizumab and Paclitaxel as a Treatment for Participants With Lo
Triple-Negative Breast Cancer
Phase 32019-11-25
CompletedAtezolizumab in Combination With Bevacizumab in Patients With Unresectable Locally Advanced or Metastatic Muco
Melanoma
Phase 22019-11-25
TerminatedA Study of Ipatasertib Plus Palbociclib and Fulvestrant Versus Placebo Plus Palbociclib and Fulvestrant in Hor
Breast Cancer
Phase 12019-11-21
CompletedA Study to Investigate the Effect of Esomeprazole and the Effect of Food on the Pharmacokinetics of Balovaptan
Autism Spectrum Disorder
Phase 12019-11-19
Active Not RecruitingDose Escalation Study of a PD1-LAG3 Bispecific Antibody in Patients With Advanced and/or Metastatic Solid Tumo
Solid Tumors, Metastatic Melanoma, Non-small Cell Lung Cancer
Phase 1 / Phase 22019-11-11
CompletedStudy to Assess the Efficacy of Baloxavir Marboxil Versus Placebo to Reduce Onward Transmission of Influenza A
Influenza
Phase 32019-10-10
TerminatedA Study Evaluating the Safety and Pharmacokinetics of Atezolizumab Administered in Combination With Hu5F9-G4 t
Acute Myeloid Leukemia
Phase 12019-10-08
RecruitingA Study to Evaluate Efficacy, Safety & Pharmacokinetics of the Port Delivery System (PDS) With Ranibizumab in
Diabetic Macular Edema
Phase 32019-09-30
CompletedA Study to Investigate the Pharmacokinetics and Pharmacodynamics of RO7234292 (RG6042) in CSF and Plasma, and
Huntingtons Disease
Phase 12019-09-02
CompletedUntreated FolliculaR Lymphoma Treated With OBinituzumAb in a Non-interventional Study (URBAN)
Follicular Lymphoma
2019-09-02
Active Not RecruitingA Study to Evaluate the Safety, Pharmacokinetics and Preliminary Anti-Tumor Activity of Englumafusp Alfa in Co
Lymphoma, Non-Hodgkin
Phase 1 / Phase 22019-08-13
CompletedA Study of Atezolizumab in Combination With Carboplatin Plus Etoposide to Investigate Safety and Efficacy in P
Small Cell Lung Carcinoma
Phase 32019-08-12
CompletedA Study To Investigate The Pharmacokinetics, Safety, And Tolerability Of Subcutaneous Ocrelizumab Administrati
Multiple Sclerosis (MS)
Phase 12019-08-12
Active Not RecruitingA Study to Evaluate the Efficacy and Safety of Ocrelizumab in Adults With Primary Progressive Multiple Scleros
Multiple Sclerosis, Primary Progressive
Phase 32019-08-12
Active Not RecruitingA Study of Risdiplam in Infants With Genetically Diagnosed and Presymptomatic Spinal Muscular Atrophy
Muscular Atrophy, Spinal
Phase 22019-08-07
CompletedA Study to Evaluate the Pharmacokinetics, Pharmacodynamics, and Safety of Tocilizumab (TCZ) Administered to Pa
Giant Cell Arteritis
Phase 12019-08-05
CompletedA Single Ascending Dose Study to Investigate the Safety, Tolerability, Immunogenicity and Pharmacokinetics of
Alzheimers Disease
Phase 12019-08-03
CompletedA Study to Investigate RO7200220 as Monotherapy and in Combination With Ranibizumab in Participants With Diabe
Diabetic Macular Edema, Uveitic Macular Edema
Phase 12019-07-22
CompletedA Study to Investigate the Safety and Efficacy of Atezolizumab in Previously-Treated Patients With Locally Adv
Non-small Cell Lung Cancer
Phase 32019-07-03
CompletedA Study to Evaluate Safety and Therapeutic Activity of RO6874281 in Combination with Pembrolizumab, in Partici
Metastatic Melanoma
Phase 12019-06-24
CompletedStudy to Assess the Pharmacokinetics, Safety and Tolerability of Baloxavir Marboxil in Healthy Chinese Partici
Healthy Volunteer
N/A2019-06-19
CompletedA Drug-drug Interaction Study With Risdiplam Multiple Dose and Midazolam in Healthy Participants
Spinal Muscular Atrophy
Phase 12019-06-18
CompletedA Study Evaluating the Safety, Pharmacokinetics and Efficacy of Ipatasertib Administered in Combination With R
Breast Cancer, Prostate Cancer, Ovarian Cancer
Phase 12019-06-12
CompletedTau Positron Emission Tomography (PET) Longitudinal Substudy Associated With: Study of Crenezumab Versus Place
Alzheimer Disease
Phase 22019-06-10
CompletedStudy Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatments and Combinations in Patien
Urothelial Carcinoma, Bladder Cancer
Phase 1 / Phase 22019-06-01
CompletedTrial of Mosunetuzumab (BTCT4465A) as Consolidation Therapy in Participants With Diffuse Large B-Cell Lymphoma
Diffuse Large B-cell Lymphoma
Phase 1 / Phase 22019-05-23
CompletedA Study to Investigate the Effect of Hepatic Impairment on the Pharmacokinetics and Safety and Tolerability of
Muscular Atrophy, Spinal
Phase 12019-05-16
TerminatedDouble-Blinded, Placebo-Controlled Phase 1b Study for Safety, PK, Efficacy, PD of RO7049665 in Participants Wi
Ulcerative Colitis
Phase 12019-05-13
TerminatedA Phase Ib Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Cibisatamab in Combination With Ate
Colorectal Cancer
Phase 12019-05-07
CompletedAn Open-Label Extension Study to Evaluate Long-Term Safety and Tolerability of RO7234292 (RG6042) in Huntingto
Huntington Disease
Phase 32019-04-23
TerminatedA Study Evaluating the Safety and Efficacy of Idasanutlin in Combination With Cytarabine and Daunorubicin in P
Acute Myeloid Leukemia
Phase 1 / Phase 22019-03-25
CompletedA 2 Part Study to Assess the Relative Bioavailability of Tablet Formulation Compared to Capsule Formulation an
Healthy Volunteers
Phase 12019-03-12
CompletedA Study to Evaluate the Efficacy and Safety of Faricimab in Participants With Neovascular Age-Related Macular
Wet Macular Degeneration
Phase 32019-03-11
CompletedA Phase Ib/II Study Investigating the Safety, Tolerability, Pharmacokinetics, and Efficacy of Mosunetuzumab (B
B-cell Non-Hodgkin Lymphoma
Phase 1 / Phase 22019-03-08
Active Not RecruitingA Study in Patients Previously Enrolled in a Genentech and/or F. Hoffmann-La Roche Ltd Sponsored Atezolizumab
Cancer
Phase 32019-02-28
CompletedAn Open-Label, Single Arm Study of Obinutuzumab Short Duration Infusion in Patients With Previously Untreated
Advanced Follicular Lymphoma
Phase 42019-02-26
CompletedA Study to Evaluate the Efficacy and Safety of Faricimab in Participants With Neovascular Age-Related Macular
Wet Macular Degeneration
Phase 32019-02-19
Active Not RecruitingA Study Investigating the Outcomes and Safety of Atezolizumab Under Real-World Conditions in Patients Treated
Urothelial Carcinoma, Non-Small Cell Lung Cancer, Small Cell Lung Cancer
2019-02-07
CompletedStudy to Investigate the Effect of Balovaptan on the QTC Interval in Healthy Subjects
Healthy Volunteers
Phase 12019-02-07
CompletedStudy to Assess the Safety, Pharmacokinetics, and Efficacy of Baloxavir Marboxil in Healthy Pediatric Particip
Influenza
Phase 32019-01-23
CompletedA Study to Evaluate the Efficacy and Safety of Intrathecally Administered RO7234292 (RG6042) in Participants W
Huntingtons Disease
Phase 32019-01-23
CompletedA Study To Evaluate the Efficacy and Safety Of Atezolizumab or Placebo in Combination With Neoadjuvant Doxorub
Breast Cancer
Phase 32019-01-11
WithdrawnA Study of Atezolizumab in Combination With Bevacizumab in Untreated Locally Advanced or Metastatic Clear Cell
Renal Cell Carcinoma
Phase 32019-01-11
CompletedA Study Investigating the Absolute Oral Bioavailability of Balovaptan After Single and Multiple Daily Oral Dos
Healthy Volunteers
Phase 12019-01-10
CompletedA Clinical Study of Cobimetinib Administered in Combination With Niraparib, With or Without Atezolizumab to Pa
OVARIAN CANCER
Phase 12019-01-09
CompletedStudy to Assess Efficacy and Safety of Baloxavir Marboxil In Combination With Standard-of-Care Neuraminidase I
Influenza
Phase 32019-01-08
CompletedA Study to Investigate Atezolizumab Subcutaneous in Patients With Previously Treated Locally Advanced or Metas
Non-Small Cell Lung Cancer
Phase 32018-12-27
CompletedA Study to Evaluate Patient Preference and Satisfaction of Subcutaneous Administration of the Fixed-Dose Combi
HER2-Positive Early Breast Cancer
Phase 22018-12-19
CompletedA Study to Investigate the Effect of CYP3A Inhibition on the Pharmacokinetics of RO7017773 in Healthy Particip
Healthy Volunteers
Phase 12018-12-17
TerminatedA Study of RO7239958 to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics in Healthy Volunt
Hepatitis B Virus Infection
Phase 12018-12-14
CompletedA Study Evaluating the Safety and Efficacy of Cobimetinib Plus Atezolizumab in BRAFV600 Wild-type Melanoma Wit
Metastatic Melanoma
Phase 22018-12-13
CompletedStudy to Measure Cerebrospinal Fluid Mutant Huntingtin Protein in Participants With Early Manifest Stage I or
Huntington's Disease
Phase 12018-12-05
CompletedAn Interventional Study of Avastin (Bevacizumab) in Patients With Advanced/Metastatic Epithelial Ovarian Cance
Ovarian Neoplasms, Peritoneal Neoplasms, Fallopian Tube Neoplasms
Phase 42018-12-05
TerminatedA Study to Assess the Effects of RO6889450 (Ralmitaront) in Participants With Schizophrenia or Schizoaffective
Schizophrenia, Schizoaffective Disorder
Phase 22018-12-04
CompletedStudy to Assess the Safety, Pharmacokinetics, and Efficacy of Baloxavir Marboxil in Healthy Pediatric Particip
Influenza
Phase 32018-11-20
CompletedNon-interventional Study of Ocrelizumab in Participants With Relapsing or Primary Progressive Multiple Scleros
Multiple Sclerosis
2018-11-12
Completed18F-Dihydroxyphenylalanine (DOPA) Positron Emission Tomography (PET) Study to Explore Dopamine Synthesis Capac
Schizophrenia
Phase 12018-11-07
CompletedA Study to Investigate the Effect of RO7049389 on the Pharmacokinetics of Pitavastatin in Healthy Volunteers
Healthy Volunteers
Phase 12018-11-07
CompletedA Dose Escalation and Expansion Study of Lomvastomig, a PD-1/TIM-3 Bispecific Antibody, in Participants With A
Solid Tumors, Metastatic Melanoma, Non-small Cell Lung Cancer (NSCLC)
Phase 12018-10-15
CompletedA Study to Evaluate the Efficacy and Safety of Faricimab (RO6867461) in Participants With Diabetic Macular Ede
Diabetic Macular Edema
Phase 32018-10-09
TerminatedA Study Evaluating the Efficacy and Safety of Multiple Immunotherapy-Based Treatment Combinations in Patients
Colorectal Cancer
Phase 1 / Phase 22018-09-27
Active Not RecruitingA Study to Evaluate the Safety and Efficacy of Mosunetuzumab (BTCT4465A) in Combination With Polatuzumab Vedot
B-cell Non-Hodgkin Lymphoma
Phase 1 / Phase 22018-09-25
RecruitingExtension Study for the Port Delivery System With Ranibizumab (Portal)
Neovascular Age-Related Macular Degeneration
Phase 32018-09-20
CompletedA Phase III Study to Evaluate the Port Delivery System With Ranibizumab Compared With Monthly Ranibizumab Inje
Neovascular Age-Related Macular Degeneration
Phase 32018-09-12
TerminatedA Phase II Study Comparing The Efficacy Of Venetoclax + Fulvestrant Vs. Fulvestrant In Women With Estrogen Rec
Estrogen Receptor-positive (ER+)/Human Epidermal Growth Factor Receptor (HER2)-Negative Locally Advanced or Metastatic Breast Cancer
Phase 22018-09-06
CompletedA Study to Evaluate the Efficacy and Safety of Faricimab (RO6867461) in Participants With Diabetic Macular Ede
Diabetic Macular Edema
Phase 32018-09-05
CompletedA Double-Blind Single-Ascending Dose (SAD) and Multiple-Ascending Dose (MAD) Study to Investigate the Safety,
Hepatitis B Virus
Phase 12018-08-24
TerminatedSafety and Efficacy Study of Gantenerumab in Participants With Early Alzheimer's Disease (AD)
Alzheimer Disease
Phase 32018-08-22
Active Not RecruitingA Study Comparing Adjuvant Alectinib Versus Adjuvant Platinum-Based Chemotherapy in Patients With ALK Positive
Carcinoma, Non-Small-Cell Lung
Phase 32018-08-16
CompletedA Study of the Efficacy and Safety of Bevacizumab in Chinese Women With Newly Diagnosed, Previously Untreated
Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer
Phase 32018-08-15
CompletedA Study to Evaluate Scales for Repetitive and Restricted Behaviors in Children, Adolescents, and Adults With A
Autism Spectrum Disorder
Phase 12018-08-13
TerminatedA Study of Balovaptan in Adults With Autism Spectrum Disorder With a 2-Year Open-Label Extension
Autism Spectrum Disorder
Phase 32018-08-08
CompletedA Study to Provide Complementary Efficacy, Safety and Patient Reported Outcomes Data in Participants With Acti
Multiple Sclerosis
Phase 42018-08-06
CompletedAscertain the Optimal Starting Dose of Mircera Given Subcutaneously for Maintenance Treatment of Anemia in Ped
Anemia, Renal Insufficiency, Chronic
Phase 22018-08-03
TerminatedA Study Comparing Atezolizumab (Anti PD-L1 Antibody) In Combination With Adjuvant Anthracycline/Taxane-Based C
Triple Negative Breast Cancer
Phase 32018-08-02
CompletedStudy Investigating a Single Oral Dose of Fenebrutinib in Healthy Volunteers
Healthy Participants
Phase 12018-07-27
CompletedA Study to Investigate the Effect of Rifampicin on the PK of Multiple Doses of Balovaptin In Healthy Volunteer
Healthy Volunteers
Phase 12018-07-24
CompletedThis is an Extension Study of the Roche P-trials to Investigate Safety and Effectiveness of Ocrelizumab in Par
Multiple Sclerosis
Phase 32018-07-12
CompletedA Phase II Randomized Study Comparing the Efficacy and Safety of Targeted Therapy or Cancer Immunotherapy Vers
Cancer of Unknown Primary Site
Phase 22018-07-10
CompletedA Study to Investigate the Effect of Itraconazole on the PK of Multiple Doses of Balovaptan in Healthy Volunte
Healthy Volunteers
Phase 12018-07-10
TerminatedA Study of RO7172508 in Patients With Locally Advanced and/or Metastatic CEA-Positive Solid Tumors
Solid Tumors
Phase 12018-07-04
CompletedA Study to Evaluate the Pharmacokinetics, Efficacy, and Safety of Subcutaneous Administration of the Fixed-Dos
Early Breast Cancer
Phase 32018-06-14
CompletedA Study to Assess the Feasibility of an E-Health System (ZEMY) Designed to Manage Symptoms in Participants Wit
Breast Cancer
Phase 22018-06-12
TerminatedEfficacy and Safety Study of Gantenerumab in Participants With Early Alzheimer's Disease (AD)
Alzheimer Disease
Phase 32018-06-06
CompletedThe Effectiveness Of Atezolizumab In Patients With Locally-Advanced Or Metastatic Non-Small Cell Lung Cancer A
Non-Small Cell Lung Cancer (NSCLC)
2018-05-30
Active Not RecruitingA Study to Evaluate Ocrelizumab Treatment in Participants With Progressive Multiple Sclerosis
Progressive Multiple Sclerosis (PMS)
Phase 32018-05-28
CompletedParticipant-Reported Outcomes With the Accu-Chek® Solo Micropump System
Diabetes Mellitus, Type 1
N/A2018-05-17
CompletedA Study to Assess the Safety and Tolerability of Single and Multiple Ascending Doses of Oral RO7020531 in Chin
Healthy Participants
Phase 12018-05-15
CompletedAn Extension Study of Omalizumab in Participants With Chronic Rhinosinusitis With Nasal Polyps
Nasal Polyps, Chronic Rhinosinusitis
Phase 32018-05-09
Active Not RecruitingAn Open-Label Phase lB/II Study of Glofitamab and Atezolizumab or Polatuzumab Vedotin in Adult Patients With R
Non-Hodgkins Lymphoma
Phase 1 / Phase 22018-05-08
CompletedA Study to Evaluate the Safety, Tolerability and Pharmacokinetics of RO7062931 in Healthy Chinese Volunteers.
Healthy Participants
Phase 12018-05-03
CompletedEfficacy, Safety, and Pharmacokinetic Study of Prophylactic Emicizumab Versus No Prophylaxis in Hemophilia A P
Hemophilia A
Phase 32018-04-26
CompletedA Study of Tocilizumab in Chinese Participants With Systemic Juvenile Idiopathic Arthritis (sJIA)
Juvenile Idiopathic Arthritis
Phase 42018-04-26
CompletedA Study of Neoadjuvant Atezolizumab Plus Chemotherapy Versus Placebo Plus Chemotherapy in Patients With Resect
Non-Small-Cell Lung
Phase 32018-04-24
CompletedOpen Label, Adaptive, Parallel Group PET Study Using RO7017773 And [11C] RO15-4513
Autism Spectrum Disorder
Phase 12018-04-24
TerminatedAn Open-Label Crenezumab Study in Participants With Alzheimer's Disease
Alzheimer's Disease
Phase 32018-04-11
TerminatedA Study of Atezolizumab (Anti-PD-L1 Antibody) as Adjuvant Therapy After Definitive Local Therapy in Patients W
Locally Advanced Squamous Cell Carcinoma of the Head and Neck (SCCHN)
Phase 32018-04-03
RecruitingA Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or L
Metastatic Breast Cancer
Phase 1 / Phase 22018-03-30
TerminatedA Phase I Study of Etrolizumab Followed by Open-Label Extension and Safety Monitoring in Pediatric Patients Wi
Ulcerative Colitis, Crohn's Disease
Phase 12018-03-27
CompletedA Study of Atezolizumab in Combination With Bevacizumab Compared With Sorafenib in Patients With Untreated Loc
Carcinoma, Hepatocellular
Phase 32018-03-15
WithdrawnA Study of Atezolizumab in Combination With an Immunotherapy Agent Investigated With or Without Anti-Cd20 Ther
Lymphoma, Non-Hodgkin
Phase 12018-03-14
CompletedA Study of Glofitamab in Combination With Rituximab or Obinutuzumab Plus Cyclophosphamide, Doxorubicin, Vincri
B-Cell Lymphoma, Non-Hodgkin Lymphoma
Phase 12018-03-13
CompletedA Study to Investigate the Pharmacokinetics, Safety, and Tolerability of Emicizumab in Healthy Chinese Volunte
Healthy Volunteers, Hemophilia A
Phase 12018-03-12
CompletedObservational Study to Monitor Safety and Effectiveness of Obinutuzumab in Follicular Lymphoma or Previously U
Chronic Lymphocytic Leukemia, Follicular Lymphoma
2018-03-09
CompletedA French Study to Evaluate the Usefulness of an Implantable Continuous Glucose Monitoring (CGM) Sensor to Impr
Diabetes Mellitus
N/A2018-02-28
TerminatedA Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of Idasanutlin Monotherapy in
Polycythemia Vera
Phase 22018-02-21
TerminatedBasket Study to Evaluate the Therapeutic Activity of Simlukafusp Alfa as a Combination Therapy in Participants
Advanced/Metastatic Head and Neck, Oesophageal and Cervical Cancers
Phase 22018-02-19
CompletedStudy to Explore the Mechanism of Acquired Immune Escape In Participants With Metastatic Cancer Progressing on
Neoplasms
Phase 42018-02-16
TerminatedOral Immunomodulatory Tyrosine Kinase Inhibitor in Patients With Locally Advanced or Metastatic Solid Tumors
Advanced or Metastatic Solid Tumors
EARLY_Phase 12018-02-15
CompletedA Study to Evaluate the Safety and Efficacy of Ipatasertib in Combination With Atezolizumab and Paclitaxel or
Breast Cancer
Phase 12018-02-13
CompletedA Study of the Safety of Atezolizumab in Patients With Advanced or Metastatic Urothelial Carcinoma in Argentin
Urothelial Carcinoma
2018-02-09
CompletedA Study of the Efficacy and Safety of Atezolizumab Plus Chemotherapy for Patients With Early Relapsing Recurre
Triple Negative Breast Neoplasms
Phase 32018-01-11
CompletedA Study of Ipatasertib in Combination With Paclitaxel as a Treatment for Participants With PIK3CA/AKT1/PTEN-Al
Breast Cancer
Phase 32018-01-06
CompletedA Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7234292 (ISIS 443139
Huntington's Disease
Phase 22018-01-02
TerminatedA Study to Investigate The Effectiveness Of Atezolizumab In Patients With Inoperable Locally-Advanced Or Metas
Urothelial Carcinoma
2017-12-28
CompletedA Study of the Safety of Atezolizumab in Participants With Locally Advanced or Metastatic Non Small Cell Lung
Carcinoma, Non-small-cell Lung
2017-12-27
CompletedA Study Of Multiple Immunotherapy-Based Treatment Combinations In Participants With Metastatic Non-Small Cell
Carcinoma, Non-Small-Cell Lung
Phase 1 / Phase 22017-12-27
CompletedA Study to Characterize the Disease Behavior of Idiopathic Pulmonary Fibrosis (IPF) and Interstitial Lung Dise
Idiopathic Pulmonary Fibrosis, Interstitial Lung Disease
N/A2017-12-25
CompletedA Study of Multiple Immunotherapy-Based Treatment Combinations in Hormone Receptor (HR)-Positive Human Epiderm
Breast Neoplasms
Phase 1 / Phase 22017-12-22
TerminatedA Study of Cobimetinib Plus Atezolizumab Versus Pembrolizumab in Participants With Previously Untreated Advanc
Advanced BRAFV600 Wild-type Melanoma
Phase 32017-12-11
CompletedA Study of Atezolizumab (Tecentriq®) in Ministry of Food and Drug Safety (MFDS)-Approved Indication(s)
Urothelial Carcinoma, Carcinoma, Non-Small Cell Lung, Small Cell Lung Carcinoma
2017-11-29
CompletedA Study to Investigate the Bioequivalence or Relative Bioavailability of Three New Idasanutlin Tablet Variants
Solid Tumors
Phase 12017-11-27
CompletedA Study to Investigate the Efficacy and Safety of Cobimetinib Plus Atezolizumab in Participants With Solid Tum
Solid Tumors
Phase 22017-11-23
CompletedA Clinical Trial of Omalizumab in Participants With Chronic Rhinosinusitus With Nasal Polyps
Nasal Polyps, Chronic Rhinosinusitis
Phase 32017-11-21
Active Not RecruitingA Study Comparing the Efficacy and Safety of Polatuzumab Vedotin With Rituximab-Cyclophosphamide, Doxorubicin,
Diffuse Large B-Cell Lymphoma
Phase 32017-11-16
CompletedA Clinical Trial of Omalizumab in Participants With Chronic Rhinosinusitis With Nasal Polyps
Nasal Polyps, Chronic Rhinosinusitis
Phase 32017-11-15
CompletedEvaluate the Effect of Entrectinib on the Pharmacokinetics of Midazolam in Cancer Patients
Advanced Solid Tumor
Phase 12017-11-14
CompletedA Study of Cobimetinib Administered as Single Agent and in Combination With Venetoclax, With or Without Atezol
Multiple Myeloma
Phase 1 / Phase 22017-11-13
CompletedTreatment Registry of Alectinib in Anaplastic Lymphoma Kinase (ALK)-Positive, Locally Advanced or Metastatic N
Non-Small Cell Lung Cancer
2017-11-09
TerminatedA Study to Evaluate the Safety, Pharmacokinetics and Clinical Activity of RO6870810 and Atezolizumab (PD-L1 An
Advanced Ovarian Cancer, Triple Negative Breast Cancer
Phase 12017-11-08
CompletedA Study of Bitopertin (RO4917838) in Adults With Non-Transfusion-Dependent (NTD) Beta-Thalassemia
Beta-Thalassemia
Phase 22017-10-26
CompletedAn Extension Study to Evaluate Long-Term Safety of Subcutaneous (SC) Tocilizumab in Participants With Giant Ce
Giant Cell Arteritis
Phase 32017-10-25
CompletedA Study of Atezolizumab (Tecentriq) to Investigate Long-term Safety and Efficacy in Previously-treated Partici
Carcinoma, Non-Small-Cell Lung
Phase 42017-10-25
CompletedOpen-label Study to Assess the Effectiveness of Pirfenidone in Participants With Idiopathic Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis
Phase 32017-10-23
CompletedA Study of Multiple Immunotherapy-Based Treatment Combinations in Patients With Locally Advanced Unresectable
Gastric Adenocarcinoma or Gastroesophageal Junction Adenocarcinoma or Esophageal Carcinoma
Phase 1 / Phase 22017-10-13
CompletedA Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7058584 Following 7 Days of I
Glaucoma, Open-angle, Ocular Hypertension
Phase 12017-10-10
Active Not RecruitingA Study to Evaluate the Efficacy and Safety of Multiple Targeted Therapies as Treatments for Participants With
Non-Small Cell Lung Cancer
Phase 2 / Phase 32017-09-22
Active Not RecruitingA Study in Participants Previously Enrolled in a Genentech- and/or F. Hoffmann-La Roche Ltd-Sponsored Atezoliz
Cancer
Phase 32017-09-20
CompletedAn Observational Study of MabThera Subcutaneous (SC) Safety in Participants With Non-Hodgkin's Lymphoma (NHL)
Lymphoma, Non-Hodgkin, Leukemia, Lymphocytic, Chronic, B-Cell
2017-09-15
CompletedA Study of Atezolizumab Compared With a Single-Agent Chemotherapy in Treatment Naïve Participants With Locally
Non-Small Cell Lung Cancer
Phase 32017-09-11
CompletedA Study to Evaluate the Safety and Tolerability of Prophylactic Emicizumab in Hemophilia A Patients With Inhib
Hemophilia A
Phase 32017-09-05
CompletedObservational Study: Safety and Effectiveness of Obinutuzumab in Chronic Lymphocytic Leukemia in Argentina
Chronic Lymphocytic Leukemia
2017-08-31
CompletedA Study to Evaluate Safety, Pharmacokinetics, and Clinical Activity of Combination of RO6870810 and Venetoclax
Diffuse Large B-cell Lymphoma, High-Grade B-cell Lymphoma
Phase 12017-08-28
CompletedA Study of Atezolizumab and Paclitaxel Versus Placebo and Paclitaxel in Participants With Previously Untreated
Triple-Negative Breast Cancer
Phase 32017-08-25
CompletedAn Efficacy and Safety Study of Subcutaneous Tocilizumab in Combination With Methotrexate (MTX) and as Monothe
Rheumatoid Arthritis
Phase 32017-08-02
CompletedRelative Bioavailability of Gantenerumab Produced by G4 Process Versus G3 Process Following Subcutaneous (SC)
Healthy Participants
Phase 12017-08-01
CompletedA Study to Investigate Atezolizumab and Chemotherapy Compared With Placebo and Chemotherapy in the Neoadjuvant
Triple-negative Breast Cancer
Phase 32017-07-24
CompletedA Study to Evaluate the Effect of a Potent Cytochrome P450 (CYP) 3A Inhibitor on Ipatasertib
Healthy Volunteers
Phase 12017-07-18
CompletedA Study to Investigate the Pharmacokinetics of RO7079901 and Meropenem in Participants With a Complicated Urin
Urinary Tract Infections
Phase 12017-07-11
CompletedSafety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7049665 in Healthy Volunteers
Healthy Volunteers
Phase 12017-07-10
CompletedA Study of the Efficacy and Safety of Alectinib in Participants With Anaplastic Lymphoma Kinase (ALK)-Rearrang
Carcinoma, Non-Small-Cell Lung
Phase 22017-07-10
CompletedClinical Trial to Evaluate the Efficacy, Safety, and Tolerability of RO7239361 in Ambulatory Boys With Duchenn
Duchenne Muscular Dystrophy
Phase 2 / Phase 32017-07-06
Active Not RecruitingA Rollover Study of Alectinib in Patients With Anaplastic Lymphoma Kinase (ALK)-Positive or Rearranged During
Neoplasms
Phase 32017-07-05
CompletedA Study of Multiple Immunotherapy-Based Treatment Combinations in Participants With Metastatic Pancreatic Duct
Pancreatic Adenocarcinoma
Phase 1 / Phase 22017-07-05
CompletedIpatasertib Plus Abiraterone Plus Prednisone/Prednisolone, Relative to Placebo Plus Abiraterone Plus Prednison
Metastatic Prostate Cancer
Phase 32017-06-30
Active Not RecruitingA Study to Evaluate the Efficacy of Prasinezumab (RO7046015/PRX002) in Participants With Early Parkinson's Dis
Parkinson's Disease
Phase 22017-06-27
CompletedStudy of Bromodomain and Extra-Terminal Protein (BET) Inhibitor RO6870810 as Mono- and Combination Therapy in
Multiple Myeloma
Phase 12017-06-26
CompletedStudy of the Pharmacokinetics and Safety of Trastuzumab Emtansine in Chinese Participants With Locally Advance
Breast Neoplasms
Phase 12017-06-20
CompletedCobimetinib (Targeted Therapy) Plus Atezolizumab (Immunotherapy) in Participants With Advanced Melanoma Whose
Malignant Melanoma
Phase 12017-06-20
TerminatedA Study of Obinutuzumab in Combination With Idasanutlin and Venetoclax in Participants With Relapsed or Refrac
Follicular Lymphoma, Lymphoma, Large B-Cell, Diffuse
Phase 1 / Phase 22017-06-15
CompletedA Study to Investigate the Intrapulmonary Lung Penetration of Nacubactam in Healthy Participants
Gram-negative Bacterial Infections
Phase 12017-06-15
CompletedA Study of Pirfenidone in Patients With Unclassifiable Progressive Fibrosing Interstitial Lung Disease
Lung Diseases, Interstitial
Phase 22017-05-15
CompletedCompare Bioavailability of RO7239361 After Subcutaneous Injection
Healthy
Phase 12017-05-09
CompletedA Study to Assess Programmed Death Ligand-1 (PD-L1) Expression in Cytological Versus Histological Lung Cancer
Carcinoma, Non-Small-Cell Lung, Carcinoma, Small Cell
2017-05-03
CompletedA Combination Study of Rucaparib and Atezolizumab in Participants With Advanced Gynecologic Cancers and Triple
Gynecologic Neoplasms
Phase 12017-04-27
CompletedEfficacy and Safety of Trastuzumab Emtansine in Chinese Participants With Human Epidermal Growth Factor Recept
Breast Cancer
Phase 32017-04-24
CompletedQuality of Life Study in Participants With IPF Under Pirfenidone Treatment
Idiopathic Pulmonary Fibrosis
2017-04-18
CompletedA Study to Evaluate Safety and Effectiveness of Bevacizumab in Combination With Paclitaxel and Cisplatin/Carbo
Cervical Cancer
2017-04-06
CompletedA Study to Evaluate the Use of Glucocorticoids in Combination With Tocilizumab in Daily Clinical Practice
Rheumatoid Arthritis
2017-03-30
TerminatedA Study of Crenezumab Versus Placebo to Evaluate the Efficacy and Safety in Participants With Prodromal to Mil
Alzheimer's Disease
Phase 32017-03-29
TerminatedStudy to Evaluate the Effectiveness and Safety of Ocrelizumab in Participants With Early Stage Relapsing Remit
Multiple Sclerosis, Relapsing-Remitting
Phase 32017-03-24
CompletedA Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Risdiplam (RO7034067
Healthy Volunteers
Phase 12017-03-22

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