NCT03803436

Improving Outcome of Selected Patients With Non-resectable Hepatic Metastases From Colo-rectal Cancer With Liver Transplantation

Improving Outcome of Selected Patients With Non-resectable Hepatic Metastases From Colo-rectal Cancer With Liver Transplantation: a Prospective Parallel Trial

• Status: Unknown
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 22 (estimated)
• Sponsor: Fondazione IRCCS Istituto Nazionale dei Tumori, Milano · Academic / Other
• Sex: All
• Age: 18 Years – 69 Years
• Healthy volunteers: Not accepted

Summary

The COLT trial is an investigator-driven, multicenter, non-randomized, open-label, controlled, prospective, parallel trial, aimed at assessing the efficacy (in terms of overall survival: OS) of liver transplantation (LT) in liver-only CRC metastases, compared with a matched cohort of patients bearing the same tumor characteristics, collected during the same time period and included in a phase III Italian RCT on triplet chemotherapy+antiEGFR

Conditions

• Liver Metastases
• Colorectal Cancer Metastatic
• Liver Neoplasm
• Neoplasms

Interventions

Type	Name	Description
PROCEDURE	Liver transplant	Liver transplant from cadaveric donors
DRUG	Chemotherapy	mFOLFOX
DRUG	Chemotherapy	Panitumumab

Timeline

• Start date: 2019-01-02
• Primary completion: 2024-01-01
• Completion: 2024-01-01
• First posted: 2019-01-14
• Last updated: 2023-03-16

Locations

12 sites across 1 country: Italy