NCT05475054

Impact of Minimally Invasive and Open Liver Surgery in Different BMI-classes

Indications, Trends, and Perioperative Outcomes of Minimally Invasive and Open Liver Surgery in Non-obese and Obese Patients: an International Multicentre Propensity Score Matched Retrospective Cohort Study of 9963 Patients.

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 9,963 (actual)
• Sponsor: Fondazione Poliambulanza Istituto Ospedaliero · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Despite the worldwide increase of both obesity and use of minimally invasive liver surgery(MILS), evidence regarding the safety and eventual benefits of MILS in obese patients is scarce. The aim of this study is therefore to compare the outcomes of non-obese and obese patients(BMI 18.5-29.9 and BMI≥30, respectively) undergoing MILS and OLS, and to assess trends in MILS use among obese patients. In this retrospective cohort study, patients operated at 20 hospitals in eight countries(2009-2019) will be included and the characteristics and outcomes of non-obese and obese patients will be compared. Thereafter, the outcomes of MILS and OLS were compared in both groups after propensity-score matching(PSM). Changes in the adoption of MILS during the study period will be investigated.

Conditions

• Liver Cancer
• Liver Metastases
• Obesity

Interventions

Type	Name	Description
PROCEDURE	Minimally invasive liver resection	A liver resection performed by minimally invasive (keyhole) surgery

Timeline

• Start date: 2020-12-01
• Primary completion: 2022-07-18
• Completion: 2022-07-22
• First posted: 2022-07-26
• Last updated: 2023-02-15

Locations

1 site across 1 country: Italy