NCT01175317

Improvement of Fluid Balance in Patients Undergoing Surgery of the Colon and Rectum

Does Hemodynamic Optimization During and After Colorectal Surgery Result in Improved Intestinal Perfusion, Sustained Intestinal Barrier and Improved Postoperative Recovery?

• Status: Completed
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 58 (actual)
• Sponsor: Maastricht University Medical Center · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

58 patients undergoing surgery of the large bowel are divided into two groups. The control group will receive standard care. The intervention group will receive standard care plus optimization of the blood circulation based on in- or decrease of the output of the heart. Between group differences are measured primarily by markers of intestinal damage in plasma and urine. Also CO2 pressure in the stomach lumen is measured (reflecting blood supply to the gut). The investigators hypothesize that the intervention group will have less intestinal damage, improved blood supply to the bowel and improved recovery of the operation compared to the control group.

Conditions

• Colorectal Carcinoma

Interventions

Type	Name	Description
PROCEDURE	Goal-directed fluid optimization	Fluid administration and optimization based on cardiac output findings during surgery and during the first 8 hours of the postoperative phase.
OTHER	Regimen based on expertise anaesthesist	Fluid regimen based on expertise anaesthesist

Timeline

• Start date: 2010-04-01
• Primary completion: 2013-10-01
• Completion: 2013-10-01
• First posted: 2010-08-04
• Last updated: 2014-06-19
• Results posted: 2014-06-19

Locations

1 site across 1 country: Netherlands