| Not Yet Recruiting | A Study to Learn About the Safety of Diroximel Fumarate (DRF) and Dimethyl Fumarate (DMF) and Their Effects on Relapsing Forms of Multiple Sclerosis | Phase 3 | 2026-11-16 |
| Recruiting | A Study to Learn How BIIB141 (Omaveloxolone) Affects the Health of Participants With Friedrich's Ataxia Who To Friedreich Ataxia | — | 2026-10-26 |
| Not Yet Recruiting | A Study to Learn About the Safety and Effects of Salanersen (BIIB115) When Given to Babies With Spinal Muscula Muscular Atrophy, Spinal | Phase 3 | 2026-09-04 |
| Not Yet Recruiting | A Study to Learn More About the Long-Term Safety and Effects of Felzartamab Infusions in Adults With Kidney Tr Antibody-mediated Rejection | Phase 3 | 2026-04-06 |
| Not Yet Recruiting | A Study to Learn About Salanersen's (BIIB115) Effects on Movement and Its Safety in Participants Aged 15 to 60 Spinal Muscular Atrophy | Phase 3 | 2026-04-03 |
| Recruiting | A Study to Learn About Salanersen's (BIIB115) Effects on Movement and Its Safety When Given Before Symptoms Ap Muscular Atrophy, Spinal | Phase 3 | 2026-01-30 |
| Recruiting | A Study to Learn About the Effects of Felzartamab Infusions in Adults With Kidney Transplants Who Have Late Is Microvascular Inflammation | Phase 2 | 2026-01-05 |
| Recruiting | A Study to Learn More About the Long-Term Safety of Tofersen (Qalsody) in Participants With Superoxide Dismuta Amyotrophic Lateral Sclerosis | — | 2026-01-02 |
| Recruiting | A Long-Term Study of Patient-Reported Changes in Postpartum Depression Symptoms in People Starting Zuranolone Postpartum Depression | — | 2025-12-22 |
| Recruiting | A Study to Learn More About the Safety of BIIB145 and How it is Processed in the Body of Healthy Adult Partici Healthy Volunteer | Phase 1 | 2025-12-18 |
| Recruiting | A Study to Learn How the Body Processes BIIB141 (Omaveloxolone) When Taken as a Capsule or as a Tablet Dissolv Healthy Volunteer | Phase 1 | 2025-12-12 |
| Recruiting | A Study to Learn More About the Long-Term Safety of Tofersen (Qalsody) in Chinese Participants With SOD-1 Amyo Amyotrophic Lateral Sclerosis | Phase 4 | 2025-12-11 |
| Completed | A Study to Learn if Taking BIIB141 (Omaveloxolone) Affects How Omeprazole is Processed in the Body and About B Healthy Volunteer | Phase 1 | 2025-09-02 |
| Recruiting | A Study to Learn About the Safety of BIIB142 and How it is Processed in the Body of Healthy Adult Participants Healthy Volunteer | Phase 1 | 2025-08-29 |
| Recruiting | A Study to Learn More About How Zuranolone Affects Postpartum Depression Symptoms in Participants Who Took it Depression, Postpartum | — | 2025-06-30 |
| Completed | A Study to Learn How BIIB141 (Omaveloxolone) is Processed in the Body When Taken as Capsules Compared to Sprin Healthy Volunteer | Phase 1 | 2025-06-11 |
| Recruiting | A Study to Learn More About the Effects and Long-Term Safety of BIIB141 (Omaveloxolone) in Participants With F Friedreich Ataxia | Phase 3 | 2025-06-09 |
| Recruiting | A Study to Learn More About the Effects and Safety of Felzartamab Infusions in Adults With Primary Membranous Primary Membranous Nephropathy | Phase 3 | 2025-05-22 |
| Recruiting | A Study to Learn About the Effects of Felzartamab Infusions on Adults With Immunoglobulin A Nephropathy (IgAN) Immunoglobulin A Nephropathy (IgAN) | Phase 3 | 2025-05-08 |
| Completed | A Study to Determine the Biodistribution, Safety, and Tolerability of a Microdose of Radiolabeled BIIB080 Co-a Healthy Volunteer | Phase 1 | 2025-01-30 |
| Recruiting | A Study to Find Out How Nusinersen is Processed in the Body When Given Through the ThecaFlex DRx™ System in Ad Muscular Atrophy, Spinal | Phase 1 | 2025-01-16 |
| Completed | A Study to Find Out How Litifilimab is Processed in the Body in Healthy Participants When Given Under the Skin Healthy Volunteer | Phase 1 | 2025-01-02 |
| Recruiting | A Study to Learn More About the Long-Term Safety of BIIB141 (Omaveloxolone) in Participants With Friedreich's Friedreich Ataxia | — | 2024-12-12 |
| Recruiting | A Study to Learn More About the Effects and Safety of Felzartamab Infusions in Adults With Kidney Transplants Antibody-mediated Rejection | Phase 3 | 2024-12-03 |
| Completed | A Study to Find Out How BIIB141 (Omaveloxolone) Moves From the Blood Into the Breastmilk of Healthy Women Who Healthy Volunteer | Phase 1 | 2024-10-18 |
| Completed | A Study to Find Out How Different Forms of BIIB091 is Processed in The Body With and Without Food in Healthy P Healthy Volunteer | Phase 1 | 2024-10-16 |
| Completed | A Study to Find Out How Multiple Doses of BIIB091 Affect the Electrical Activity of the Heart in Healthy Parti Healthy Volunteer | Phase 1 | 2024-08-29 |
| Recruiting | A Study to Find Out How BIIB141 (Omaveloxolone) is Processed in the Body and to Learn More About Its Safety in Friedreich Ataxia | Phase 1 | 2024-07-01 |
| Active Not Recruiting | A Study to Evaluate Long-Term Safety of Vumerity and Tecfidera in Participants With Multiple Sclerosis (MS) Multiple Sclerosis | — | 2024-06-08 |
| Completed | A Study to Look at How a Single Oral Dose of Carbon-14-Labelled [14C] BIIB091 Moves Through and is Processed b Healthy Volunteer | Phase 1 | 2024-04-08 |
| Withdrawn | A Study to Evaluate the Efficacy and Safety of BIIB131 for Participants With Ischemic Stroke Between 4.5 and 2 Ischemic Stroke | Phase 2 | 2024-03-29 |
| Completed | A Study to Assess the Potential for Gastric-pH Dependent Drug-Drug Interactions of BIIB122 With a Proton Pump Healthy Volunteer | Phase 1 | 2024-02-12 |
| Completed | A Study to Evaluate the Pharmacokinetics, Safety and Immunogenicity of BIIB800 Subcutaneously (SC) Compared to Healthy Volunteer | Phase 1 | 2024-01-02 |
| Recruiting | A Study to Learn How Nusinersen (Spinraza) Affects Participants With Spinal Muscular Atrophy (SMA) Who Took it Muscular Atrophy, Spinal | — | 2023-12-15 |
| Completed | A Study to Assess New Participant's Perspectives Beyond Clinical Efficacy of Monoclonal Antibody-Based Relapsi Multiple Sclerosis, Relapsing-Remitting | — | 2023-11-24 |
| Recruiting | Pregnancy Exposure Registry for Vumerity (Diroximel Fumarate) Multiple Sclerosis | — | 2023-10-27 |
| Enrolling By Invitation | A Long-Term Extension Study to Learn More About the Safety of Litifilimab (BIIB059) Injections and Whether The Subacute Cutaneous Lupus Erythematosus, Chronic Cutaneous Lupus Erythematosus | Phase 3 | 2023-10-03 |
| Completed | A Study to Learn About the Safety of BIIB091 and Its Effect on Brain Inflammation When Taken Alone or With Dir Relapsing Forms of Multiple Sclerosis | Phase 2 | 2023-07-25 |
| Completed | A TQTc Study for Omaveloxolone Health Adult Subjects | Phase 1 | 2023-07-11 |
| Completed | An Open-label DDI Study of Omaveloxolone in Healthy Subjects Healthy Adult Subjects | Phase 1 | 2023-07-05 |
| Active Not Recruiting | A Study Utilising Data From European Union (EU) National Multiple Sclerosis (MS) Registries to Assess the Inci Multiple Sclerosis | — | 2023-06-30 |
| Completed | A Study of Dimethyl Fumarate (DMF) in Relapsing Forms of Multiple Sclerosis (RMS) Participants in China Multiple Sclerosis | Phase 4 | 2023-06-09 |
| Withdrawn | 802NP301 Efficacy and Safety Study of BIIB074 in Participants With Trigeminal Neuralgia Trigeminal Neuralgia | Phase 3 | 2023-04-19 |
| Completed | Zuranolone Pharmacokinetics (PK) and Safety Study Adolescent Participants With Major Depressive Disorder (MDD) Major Depressive Disorder | Phase 1 | 2023-04-19 |
| Withdrawn | 802NP302 Efficacy and Safety Study of BIIB074 in Participants With Trigeminal Neuralgia Trigeminal Neuralgia | Phase 3 | 2023-03-01 |
| Terminated | A Study of End of Dose Phenomena in Subcutaneous Natalizumab Treated Multiple Sclerosis (MS) Participants Multiple Sclerosis | — | 2023-02-08 |
| Terminated | A Study to Investigate the Radiological Onset of Action After Treatment Initiation With Subcutaneous (SC) Nata Multiple Sclerosis, Relapsing-Remitting | Phase 4 | 2023-01-23 |
| Active Not Recruiting | Adult Spinal Muscular Atrophy (SMA) China Registry Muscular Atrophy, Spinal | — | 2023-01-06 |
| Active Not Recruiting | A Study to Learn About the Safety of BIIB115 Injections and How BIIB115 is Processed in the Bodies of Healthy Healthy Volunteer, Muscular Atrophy, Spinal | Phase 1 | 2022-10-10 |
| Recruiting | A 2-Part Study to Learn Whether Litifilimab (BIIB059) Injections Can Improve Symptoms of Adult Participants Wh Subacute Cutaneous Lupus Erythematosus, Chronic Cutaneous Lupus Erythematosus | Phase 2 / Phase 3 | 2022-09-13 |
| Terminated | A Study to Assess if BIIB122 Tablets Are Safe and Can Slow Worsening of Early-Stage Parkinson's Disease in Par Parkinson Disease | Phase 3 | 2022-08-26 |
| Active Not Recruiting | A Study to Learn About the Safety of BIIB080 Injections and Whether They Can Improve Symptoms of Participants Mild Cognitive Impairment Due to Alzheimer's Disease, Alzheimer's Disease Dementia | Phase 2 | 2022-08-24 |
| Enrolling By Invitation | An Extension Study to Learn More About the Long-Term Safety of Litifilimab (BIIB059) Injections and Whether Th Systemic Lupus Erythematosus (SLE) | Phase 3 | 2022-06-10 |
| Terminated | A Study to Verify the Clinical Benefit of Aducanumab in Participants With Early Alzheimer's Disease Alzheimer's Disease | Phase 3 | 2022-06-02 |
| Completed | Virtual Reality for the Mitigation of Anxiety During Intrathecal Administration in Participants With Spinal Mu Spinal Muscular Atrophy (SMA) | N/A | 2022-05-11 |
| Terminated | A Study to Evaluate Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of Multiple Doses of Natalizumab Multiple Sclerosis, Relapsing-Remitting | Phase 3 | 2022-04-26 |
| Active Not Recruiting | A Study to Learn About the Safety of BIIB122 Tablets and Whether They Can Slow the Worsening of Early-Stage Pa Parkinson Disease | Phase 2 | 2022-04-19 |
| Completed | A Study to See How BIIB122 Works in the Human Body, and to Evaluate it's Safety, and Tolerability in Healthy A Healthy Volunteer | Phase 1 | 2022-02-17 |
| Completed | A Study to Assess the Clinical Validity of Konectom™ in Adults Living With Neuromuscular Disorders Spinal Muscular Atrophy | N/A | 2022-02-10 |
| Terminated | A Pharmacokinetics and Safety Study of BIIB132 in Adults With Spinocerebellar Ataxia 3 Spinocerebellar Ataxia Type 3 | Phase 1 | 2022-02-02 |
| Completed | A Study to Assess the Pharmacokinetic (PK) Comparability of 2 Fixed Subcutaneous (SC) Doses of Aducanumab (BII Healthy Volunteer | Phase 1 | 2022-02-01 |
| Completed | A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics, With Target Occupancy Study of BIIB113 in Healthy Volunteer | Phase 1 | 2022-01-24 |
| Active Not Recruiting | A Study to Learn About the Effect of Higher Doses of Nusinersen (BIIB058) Given as Injections to Participants Spinal Muscular Atrophy | Phase 3 | 2022-01-21 |
| Completed | A Study to Explore Association Patterns Between Digital Outcome Assessments From the Konectom™ Platform and Ma Multiple Sclerosis (MS) | — | 2021-12-15 |
| Completed | A Study to Evaluate the Relative Bioavailability of Two Formulations of BIIB104 and Assess the Effect of Food Healthy Volunteers | Phase 1 | 2021-12-15 |
| Terminated | Exploring Diroximel Fumarate Real-world Experience in Canada and Israel Relapsing Forms of MS | — | 2021-12-09 |
| Completed | A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Diroximel Fumarate (DRF) in Chinese and Healthy Volunteers | Phase 1 | 2021-12-03 |
| Completed | A Study to Evaluate Safety and Pharmacokinetics of BIIB104 in Healthy Japanese and Non-Japanese Participants Healthy Volunteer | Phase 1 | 2021-11-23 |
| Terminated | An Observational Study of Aducanumab-avwa in Participants With Alzheimer's Disease in the US Alzheimers Disease | — | 2021-11-18 |
| Active Not Recruiting | Pediatric Spinal Muscular Atrophy (SMA) China Registry Muscular Atrophy, Spinal | — | 2021-11-18 |
| Completed | A Study of Diroximel Fumarate (DRF) in Adult Participants From the Asia-Pacific Region With Relapsing Forms of Relapsing Forms of Multiple Sclerosis | Phase 3 | 2021-11-18 |
| Completed | A Study for Tysabri Participant Preference Relapsing-Remitting Multiple Sclerosis (RRMS) | — | 2021-10-12 |
| Recruiting | A Study to Learn More About The Safety of Diroximel Fumarate (VUMERITY®) in Participants Who Took it During Pr Multiple Sclerosis | — | 2021-09-24 |
| Terminated | An Observational Study Using Multimodal Sensors to Measure Cognitive Health in Adults and Distinguish Mild Cog Mild Cognitive Impairment, Normal Aging | — | 2021-09-20 |
| Completed | A Study of Mass Balance, Pharmacokinetics, Metabolite Profile, and Metabolite Identification of BIIB122/DNL151 Healthy Volunteers | Phase 1 | 2021-08-27 |
| Completed | A Natural History Study of Participants With Potassium Sodium-Activated Channel Subfamily T Member 1 (KCNT1)-R KCNT1-Related Epilepsy | — | 2021-08-17 |
| Completed | A Study to Determine the Absolute Bioavailability of BIIB122/DNL151 in Healthy Subjects Healthy Volunteers | Phase 1 | 2021-07-28 |
| Active Not Recruiting | A Study to Learn About the Safety of Litifilimab (BIIB059) Injections and Whether They Can Improve Symptoms of Lupus Erythematosus, Systemic | Phase 3 | 2021-07-16 |
| Terminated | Severe Acute Respiratory Syndrome Coronavirus Type 2 (SARS-CoV-2)-Related Multiple Sclerosis (MS) Vaccination Multiple Sclerosis (MS) | — | 2021-07-01 |
| Withdrawn | Study to Evaluate Oral BIIB061 Added to Interferon-beta1 (IFN-β1) or Glatiramer Acetate in Relapsing Multiple Relapsing Multiple Sclerosis | Phase 2 | 2021-06-30 |
| Completed | A Study to Assess Absolute Bioavailability of Aducanumab in Healthy Volunteers Healthy Volunteers | Phase 1 | 2021-06-30 |
| Active Not Recruiting | A Study to Learn About the Safety of Litifilimab (BIIB059) Injections and Whether They Can Improve Symptoms of Lupus Erythematosus, Systemic | Phase 3 | 2021-05-25 |
| Active Not Recruiting | A Study of BIIB067 (Tofersen) Initiated in Clinically Presymptomatic Adults With a Confirmed Superoxide Dismut Amyotrophic Lateral Sclerosis Associated With a SOD1 Gene Mutation | Phase 3 | 2021-05-17 |
| Completed | Study to Investigate Pregnancy Outcomes in Female Participants Exposed to Subcutaneous (SC) Peginterferon Beta Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting | — | 2021-04-30 |
| Active Not Recruiting | A Study to Learn About the Long-Term Safety of Higher Doses of Nusinersen (BIIB058) Given as Injections to Par Muscular Atrophy, Spinal | Phase 3 | 2021-04-19 |
| Completed | Real World Analysis on Lymphocyte Reconstitution After Lymphopenia in Participants Treated by Tecfidera Multiple Sclerosis, Multiple Sclerosis, Relapsing-Remitting | — | 2021-03-10 |
| Terminated | Study of Diroximel Fumarate in the Real-World Setting Relapsing Forms of MS | — | 2021-03-01 |
| Completed | A Trial of Bardoxolone Methyl in Patients With CKD at Risk of Rapid Progression (MERLIN) Chronic Kidney Diseases | Phase 2 | 2021-02-09 |
| Completed | A Study to Learn About the Effect of Nusinersen (BIIB058) Given as Injections to Children With Spinal Muscular Muscular Atrophy, Spinal | Phase 4 | 2021-01-04 |
| Completed | A Study to Assess Choroideremia (CHM) Health Outcomes Choroideremia | — | 2020-12-15 |
| Completed | MS PATHS COVID-19 Questionnaire Data Linkage Sub-Study Multiple Sclerosis (MS) | — | 2020-12-07 |
| Completed | Non-Interventional, Postmarketing Surveillance Study of Nusinersen Sodium Injection Muscular Atrophy, Spinal | — | 2020-11-18 |
| Completed | A Comparative Study of Sage-217 Plus an Antidepressant (ADT) Versus Placebo Plus an ADT in Adults With Major D Depressive Disorder, Major | Phase 3 | 2020-11-09 |
| Completed | Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BIIB107 in Healthy Adult Part Healthy Volunteers | Phase 1 | 2020-10-30 |
| Completed | A Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BIIB133 (Dapirolizumab Peg Healthy Volunteers | Phase 1 | 2020-10-14 |
| Completed | Validation of DigiCog and Konectom Tools to Support Digitalized Clinical Assessment in Multiple Sclerosis Multiple Sclerosis | N/A | 2020-10-12 |
| Withdrawn | Pharmacodynamic Study of BIIB095 and BIIB074 in Healthy Participants and Participants With Painful Diabetic Po Healthy Volunteers, Diabetic Neuropathies | Phase 1 | 2020-09-30 |
| Terminated | A Study to Assess the Safety, Tolerability, and Effect on Disease Progression of BIIB105 in Participants With Amyotrophic Lateral Sclerosis | Phase 1 / Phase 2 | 2020-09-28 |
| Completed | Study of BIIB091 Formulations in Healthy Participants Healthy Volunteers | Phase 1 | 2020-09-28 |
| Completed | Natural Disease Progression in Participants With Choroideremia Choroideremia | — | 2020-08-26 |
| Completed | A Study to Evaluate the Efficacy and Safety of SAGE-217 in Participants With Severe Postpartum Depression (PPD Depression, Postpartum | Phase 3 | 2020-06-08 |
| Completed | A Study to Evaluate the Efficacy of Sage-217 in the Treatment of Adult Participants With Major Depressive Diso Depressive Disorder, Major | Phase 3 | 2020-05-12 |
| Terminated | Study to Assess the Safety, Tolerability, Pharmacokinetics, and Effect on Disease Progression of BIIB078 Admin Amyotrophic Lateral Sclerosis | Phase 1 | 2020-04-28 |
| Completed | Study of Nusinersen (BIIB058) in Participants With Spinal Muscular Atrophy Muscular Atrophy, Spinal | Phase 3 | 2020-03-26 |
| Terminated | A Study to Evaluate Safety and Tolerability of Aducanumab in Participants With Alzheimer's Disease Who Had Pre Alzheimer's Disease | Phase 3 | 2020-03-02 |
| Completed | Angelman Syndrome (AS) Biomarker Study Angelman Syndrome, Chromosome 15q Duplication (dup15q) Syndrome | EARLY_Phase 1 | 2019-12-18 |
| Completed | A Study to Explore Pharmacodynamic Effects of BIIB104 on Brain Circuitry in Healthy Participants Healthy Volunteers | Phase 1 | 2019-11-15 |
| Active Not Recruiting | A Study to Evaluate the Safety, Tolerability, and Efficacy of BIIB017 (Peginterferon Beta-1a) in Pediatric Par Multiple Sclerosis, Relapsing-Remitting | Phase 3 | 2019-10-18 |
| Completed | Study to Assess the Safety, Tolerability, and Pharmacokinetics of BIIB104 in Healthy Japanese and Non-Japanese Healthy Volunteers | Phase 1 | 2019-10-02 |
| Completed | Dimethyl Fumarate (DMF, Tecfidera®) Persistence in RR-MS Patients Included in the French Patient Support Progr Multiple Sclerosis, Relapsing-Remitting | — | 2019-08-19 |
| Terminated | A Study to Evaluate SAGE-217 for Prevention of Relapse in Adult Participants With Major Depressive Disorder Major Depressive Disorder | Phase 3 | 2019-08-06 |
| Completed | Study to Evaluate DNL151 in Subjects With Parkinson's Disease Parkinson's Disease | Phase 1 | 2019-07-23 |
| Completed | A Pharmacokinetic Study of Omaveloxolone in Subjects With Hepatic Impairment and Normal Hepatic Function Hepatic Impairment | Phase 1 | 2019-07-19 |
| Active Not Recruiting | Observational, Postmarketing Surveillance Study of Spinraza Injection (Nusinersen Sodium) Muscular Atrophy, Spinal | — | 2019-07-02 |
| Completed | A Real-world Study of Imraldi® Use Arthritis, Rheumatoid (RA), Axial Spondyloarthritis (axSpA), Arthritis, Psoriatic (PsA) | — | 2019-06-30 |
| Terminated | Feasibility of the Multiple Sclerosis Performance Test in Participants With Multiple Sclerosis Multiple Sclerosis | — | 2019-06-17 |
| Completed | A Clinical Drug-Drug Interaction (DDI) Study With Omaveloxolone Healthy Adult Subjects | Phase 1 | 2019-06-14 |
| Completed | A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BIIB100 Administered O Amyotrophic Lateral Sclerosis | Phase 1 | 2019-05-30 |
| Terminated | A Trial of Bardoxolone Methyl in Patients With ADPKD - FALCON Autosomal Dominant Polycystic Kidney, ADPKD | Phase 3 | 2019-05-29 |
| Completed | A Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Study of BIIB091, a Bruton's Tyrosine Kinase (BTK Healthy Volunteer | Phase 1 | 2019-05-13 |
| Completed | Quantitative Magnetic Resonance Imaging (MRI) Sub-Study of MS PATHS Multiple Sclerosis | — | 2019-04-30 |
| Completed | A Human AME Study for Omaveloxolone Healthy Male Subjects | Phase 1 | 2019-04-11 |
| Terminated | Study to Evaluate the Efficacy and Safety of Dimethyl Fumarate (Tecfidera) and Peginterferon Beta-1a (Plegridy Multiple Sclerosis, Relapsing-Remitting | Phase 3 | 2019-03-19 |
| Terminated | A Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BIIB054 in Japanese Partic Parkinson's Disease | Phase 1 | 2019-03-12 |
| Terminated | An Extended Access Program for Bardoxolone Methyl in Patients With CKD (EAGLE) Chronic Kidney Diseases, Alport Syndrome, Autosomal Dominant Polycystic Kidney | Phase 3 | 2019-03-08 |
| Completed | A Study to Evaluate SAGE-217 in Adult Participants With Major Depressive Disorder (MDD) Major Depressive Disorder | Phase 3 | 2019-02-27 |
| Terminated | A Study to Evaluate the Safety, Tolerability, and Efficacy of SAGE-217 Compared to Placebo in Adult Participan Major Depressive Disorder, Insomnia | Phase 3 | 2019-02-04 |
| Completed | TOPIK Study: A Study to Report Progressive Multifocal Leukoencephalopathy and Other Serious Opportunistic Infe Multiple Sclerosis | — | 2019-01-01 |
| Terminated | A Study of Aducanumab in Participants With Mild Cognitive Impairment Due to Alzheimer's Disease or With Mild A Cognitive Dysfunction, Alzheimer's Disease | Phase 2 | 2018-12-20 |
| Completed | A Study to Evaluate Safety, Tolerability, and Distribution of a Microdose of Radiolabeled BIIB067 (99mTc-MAG3- Healthy Volunteers | Phase 1 | 2018-12-20 |
| Completed | A Study to Evaluate Efficacy, Safety, and Tolerability of EID of Natalizumab (BG00002) in Participants With RR Multiple Sclerosis, Relapsing-Remitting | Phase 3 | 2018-11-27 |
| Completed | A Study to Evaluate the Efficacy of SAGE-217 in the Treatment of Adult Participants With Major Depressive Diso Major Depressive Disorder | Phase 3 | 2018-11-19 |
| Completed | A Study to Evaluate the Safety and Efficacy of BIIB104 in Participants With Cognitive Impairment Associated Wi Cognitive Impairment Associated With Schizophrenia | Phase 2 | 2018-11-15 |
| Completed | A Pharmacokinetic Study of Omaveloxolone in Healthy Volunteers Healthy | Phase 1 | 2018-10-29 |
| Terminated | An Efficacy and Safety Study of BG00011 in Participants With Idiopathic Pulmonary Fibrosis Idiopathic Pulmonary Fibrosis | Phase 2 | 2018-09-24 |
| Completed | A Study to Assess the Safety, Tolerability, and Pharmacokinetics of BIIB078 in Adults With C9ORF72-Associated Amyotrophic Lateral Sclerosis | Phase 1 | 2018-09-10 |
| Completed | A Study to Evaluate SAGE-217 in Participants With Bipolar I/II Disorder With a Current Major Depressive Episod Bipolar Disorder I, Bipolar Disorder II, Major Depressive Episode | Phase 2 | 2018-08-23 |
| Completed | One-year Persistence to Treatment of Participants Receiving Flixabi or Imraldi: a French Cohort Study Arthritis, Rheumatoid, Spondylitis, Ankylosing, Arthritis, Psoriatic | — | 2018-07-02 |
| Completed | Safety and PK/PD of RTA 1701 in Healthy Adults Healthy | Phase 1 | 2018-06-20 |
| Terminated | Efficacy and Safety Study of BIIB074 in Participants With Small Fiber Neuropathy Small Fiber Neuropathy, Diabetes Mellitus | Phase 2 | 2018-05-31 |
| Terminated | Phase 2 Study of BIIB092 in Participants With Early Alzheimer's Disease Alzheimer's Disease | Phase 2 | 2018-05-03 |
| Completed | Evaluating the Safety, Tolerability, and Pharmacokinetics of BIIB095 in Healthy Participants Healthy Volunteer | Phase 1 | 2018-03-29 |
| Completed | Phase 2 Efficacy, Safety, and Tolerability Study of Natalizumab in Focal Epilepsy Epilepsy, Focal Seizures, Partial Seizures | Phase 2 | 2018-03-20 |
| Completed | Cognitive, Behavioral, and Functional Change in Behavioral Variant Frontotemporal Dementia (bvFTD) Frontotemporal Dementia, Behavioral Variant Frontotemporal Dementia | — | 2018-01-19 |
| Terminated | Evaluating the Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of BIIB054 in Participants With Parkin Parkinson's Disease | Phase 2 | 2018-01-10 |
| Completed | A Phase 2 Trial of the Safety and Efficacy of Bardoxolone Methyl in Patients With Rare Chronic Kidney Diseases IgA Nephropathy, CKD Associated With Type 1 Diabetes, Focal Segmental Glomerulosclerosis | Phase 2 | 2017-12-26 |
| Completed | MS PATHS Normative Sub-Study Healthy Volunteer | — | 2017-12-12 |
| Completed | Efficacy and Safety of BIIB111 for the Treatment of Choroideremia Choroideremia | Phase 3 | 2017-12-11 |
| Completed | A Safety Study of Retinal Gene Therapy for Choroideremia With Administration of BIIB111 Choroideremia | Phase 2 | 2017-11-29 |
| Completed | A Post-Authorization Safety Study of Interferon Beta Therapy in Participants With Multiple Sclerosis Multiple Sclerosis, Relapsing-Remitting | — | 2017-11-27 |
| Terminated | Efficacy and Safety of BIIB033 (Opicinumab) as an Add-on Therapy to Disease-Modifying Therapies (DMTs) in Rela Multiple Sclerosis | Phase 2 | 2017-11-15 |
| Completed | A Drug Interaction Study of BIIB074 and an Oral Contraceptive Regimen Drug Interactions | Phase 1 | 2017-11-11 |
| Completed | Effect of Itraconazole on the Pharmacokinetics of Bardoxolone Methyl in Healthy Adults Healthy Volunteers | Phase 1 | 2017-10-16 |
| Completed | Safety, Tolerability, and Pharmacokinetics of Single Doses of BIIB059 in Healthy Japanese Subjects. Healthy Subjects | Phase 1 | 2017-10-04 |
| Completed | A Study to Assess the Pharmacodynamic Effects of SAGE-217 in Healthy Adults Using an Insomnia Model Healthy | Phase 1 | 2017-09-14 |
| Completed | Study to Evaluate the Effect of UGT Inhibition by Valproic Acid on the Pharmacokinetics of BIIB074 Drug Interaction | Phase 1 | 2017-09-12 |
| Completed | Benepali® PEN Patient Satisfaction Survey Rheumatoid Arthritis, Spondyloarthropathies | — | 2017-08-10 |
| Terminated | Study of BIIB092 in Participants With Progressive Supranuclear Palsy Supranuclear Palsy, Progressive | Phase 2 | 2017-06-01 |
| Completed | Observational Study to Evaluate the Real-Life Effectiveness of Benepali Following Transition From Enbrel Rheumatoid Arthritis, Axial Spondyloarthritis | — | 2017-06-01 |
| Completed | Tysabri Observational Cohort Study - Multiple Sclerosis (MS) Registries Progressive Multifocal Leukoencephalopathy | — | 2017-06-01 |
| Terminated | Extended Access Program to Assess Long-term Safety of Bardoxolone Methyl in Patients With Pulmonary Hypertensi Pulmonary Hypertension | Phase 3 | 2017-04-18 |
| Terminated | Efficacy and Safety of Daclizumab in Participants With RRMS Switching From Natalizumab Relapsing-Remitting Multiple Sclerosis (RRMS) | Phase 3 | 2017-04-18 |
| Completed | A Study to Evaluate SAGE-217 in Participants With Essential Tremor Essential Tremor | Phase 2 | 2017-03-24 |
| Completed | A Tolerability Study of ALKS 8700 in Subjects With Relapsing Remitting Multiple Sclerosis (RRMS) EVOLVE-MS-2 Relapsing Remitting Multiple Sclerosis | Phase 3 | 2017-03-15 |
| Completed | Effects of Vitamin K on Redness Associated With Injection Site Reactions in Participants Treated With Plegridy Relapsing-Remitting Multiple Sclerosis | Phase 4 | 2017-03-10 |
| Completed | A Clinical Trial of Retinal Gene Therapy for X-linked Retinitis Pigmentosa Using BIIB112 X-Linked Retinitis Pigmentosa | Phase 1 / Phase 2 | 2017-03-08 |
| Completed | Long-Term Evaluation of BIIB067 (Tofersen) ALS Caused by Superoxide Dismutase 1 (SOD1) Mutation | Phase 3 | 2017-03-08 |
| Completed | A Phase 2/3 Trial of the Efficacy and Safety of Bardoxolone Methyl in Patients With Alport Syndrome - CARDINAL Alport Syndrome | Phase 2 / Phase 3 | 2017-03-02 |
| Completed | Single-Ascending-Dose Study of BIIB076 in Healthy Volunteers and Participants With Alzheimer's Disease Alzheimer's Disease, Healthy Volunteer | Phase 1 | 2017-02-17 |
| Completed | Scan-Rescan Sub-Study of MS PATHS Multiple Sclerosis | — | 2017-02-11 |
| Terminated | Extension Study to Evaluate the Long-Term Safety, Tolerability, and Maintenance of Effect of BIIB074 Neuropathic Pain From Lumbosacral Radiculopathy | Phase 2 | 2017-02-10 |
| Completed | Evaluate Safety/Tolerability in Portuguese Participants With RRMS Transitioning From Current Therapy Relapsing Remitting Multiple Sclerosis | Phase 4 | 2017-01-30 |
| Completed | A Study to Evaluate SAGE-217 in Participants With Severe Postpartum Depression Postpartum Depression | Phase 3 | 2017-01-04 |
| Completed | A Study of the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Doses of RTA 901 in Healthy A Healthy | Phase 1 | 2017-01-01 |
| Completed | Study of Utilization Patterns of Dimethyl Fumarate in Germany Multiple Sclerosis | — | 2016-12-30 |
| Completed | A Study to Evaluate SAGE-217 in Participants With Moderate to Severe Major Depressive Disorder Major Depression | Phase 2 | 2016-12-07 |
| Completed | New Formulation and Food Effect Study of BIIB074 Trigeminal Neuralgia (TN), Other Neuropathic Pain | Phase 1 | 2016-12-01 |
| Completed | A Study to Evaluate SAGE-217 in Participants With Parkinson's Disease Parkinson Disease | Phase 2 | 2016-11-30 |
| Completed | Study to Evaluate the Efficacy and Safety of BIIB074 in Neuropathic Pain From Lumbosacral Radiculopathy Lumbosacral Radiculopathy | Phase 2 | 2016-10-31 |
| Completed | Study to Evaluate BIIB059 (Litifilimab) in Cutaneous Lupus Erythematosus (CLE) With or Without Systemic Lupus Systemic Lupus Erythematosus, Active Cutaneous Lupus Erythematosus | Phase 2 | 2016-10-20 |
| Terminated | Bardoxolone Methyl in Patients With Connective Tissue Disease-associated Pulmonary Arterial Hypertension - CAT Connective Tissue Disease-Associated Pulmonary Arterial Hypertension | Phase 3 | 2016-10-04 |
| Completed | A Phase 2a Study of BIIB074 in the Treatment of Erythromelalgia Primary Inherited Erythromelalgia | Phase 2 | 2016-09-09 |
| Terminated | A Study To Evaluate The Safety And Efficacy Of PF-04958242 In Subjects With Cognitive Impairment Associated Wi Cognitive Impairment Associated With Schizophrenia (CIAS) | Phase 2 | 2016-08-29 |
| Completed | PK and Safety Study of BIIB074 in Healthy Japanese and Caucasian Participants Healthy, Trigeminal Neuralgia | Phase 1 | 2016-08-01 |
| Completed | A Phase 1, Single-Ascending-Dose, Safety, Tolerability, Pharmacokinetic(PK), and Pharmacodynamic(PD) Study of Systemic Lupos Erythematosus, SLE | Phase 1 | 2016-08-01 |
| Completed | Safety and Efficacy of Intravenous Natalizumab in Acute Ischemic Stroke Acute Ischemic Stroke | Phase 2 | 2016-07-18 |
| Completed | Pharmacokinetics, Safety and Tolerability of Single Doses of BIIB033 (Opicinumab) Produced by 2 Manufacturing Multiple Sclerosis, Acute Optic Neuritis | Phase 1 | 2016-07-01 |
| Completed | Absolute Bioavailability of a Single, Fixed Subcutaneous Dose of Aducanumab in Healthy Participants Alzheimer's Disease | Phase 1 | 2016-05-01 |
| Completed | Observational Study to Characterize Real-world Clinical Outcomes With Relapsing-remitting Multiple Sclerosis ( Multiple Sclerosis | — | 2016-05-01 |
| Withdrawn | Placebo-Controlled Study of the Efficacy and Safety of BG00012 in Pediatric Subjects With Relapsing-Remitting Relapsing-Remitting Multiple Sclerosis, Relapsing Forms of Multiple Sclerosis | Phase 3 | 2016-05-01 |
| Completed | Absorption, Metabolism, and Excretion Study of BIIB074 Neuropathic Pain | Phase 1 | 2016-04-01 |
| Completed | Multiple Dose Study Of BIIB118 (PF-05251749) In Healthy Volunteers Healthy Adult Subjects, Healthy Elderly Subjects | Phase 1 | 2016-03-28 |
| Completed | Long-Term Assessment of Remyelinating Therapy Acute Optic Neuritis | Phase 2 | 2016-03-10 |
| Completed | MSPT Device Usability Study Multiple Sclerosis | — | 2016-03-01 |
| Terminated | Extension Study of BIIB092 in Participants With Progressive Supranuclear Palsy (PSP) Who Participated in CN002 Supranuclear Palsy, Progressive | Phase 1 | 2016-02-22 |
| Completed | Extension Study of BG00012 in Pediatric Subjects With Relapsing Remitting Multiple Sclerosis (RRMS) Multiple Sclerosis, Relapsing-Remitting | Phase 3 | 2016-02-22 |
| Completed | Plegridy Satisfaction Study in Participants Relapsing-Remitting Multiple Sclerosis (RRMS) | Phase 4 | 2016-02-03 |
| Completed | Effect of Itraconazole on the Pharmacokinetics of BIIB074 Neuropathic Pain | Phase 1 | 2016-02-01 |
| Withdrawn | Brimonidine Tartrate for the Treatment of Injection Related Erythema Relapsing-Remitting Multiple Sclerosis (RRMS) | Phase 4 | 2016-02-01 |
| Completed | Safety, Tolerability, and Pharmacokinetics of Single and Multiple Doses of BIIB033 in Healthy Japanese Partici Central Nervous System (CNS) Demyelinating Disease, Multiple Sclerosis | Phase 1 | 2016-02-01 |
| Completed | An Efficacy, Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of BIIB067 (Tofersen) in Adults Amyotrophic Lateral Sclerosis | Phase 3 | 2016-01-20 |
| Completed | Methodology Study of Novel Outcome Measures to Assess Progression of ALS Amyotrophic Lateral Sclerosis | — | 2016-01-06 |
| Completed | Clinical Disease Activity With Long Term Natalizumab Treatment Relapsing-Remitting Multiple Sclerosis | — | 2015-12-31 |
| Completed | A Study of ALKS 8700 in Adults With Relapsing Remitting Multiple Sclerosis (MS) EVOLVE-MS-1 Multiple Sclerosis | Phase 3 | 2015-12-10 |
| Withdrawn | Systemic Sclerosis Clinical and Biomarker Study Healthy, Systemic Sclerosis | — | 2015-12-01 |
| Completed | Tecfidera and the Gut Microbiota Multiple Sclerosis, Relapsing-Remitting | Phase 4 | 2015-11-06 |
| Completed | A Study for Participants With Spinal Muscular Atrophy (SMA) Who Previously Participated in Nusinersen (ISIS 39 Spinal Muscular Atrophy | Phase 3 | 2015-11-04 |
| Completed | Multiple Ascending Dose Study of Intravenously Administered BMS-986168 (BIIB092) in Patients With Progressive Progressive Supranuclear Palsy | Phase 1 | 2015-10-02 |
| Terminated | Single Ascending Doses of BIIB063 in Healthy Volunteers Healthy | Phase 1 | 2015-09-30 |
| Completed | Study of the Effect of BG00012 on MRI Lesions and Pharmacokinetics in Pediatric Subjects With RRMS Multiple Sclerosis, Relapsing-Remitting | Phase 2 | 2015-09-30 |
| Terminated | 221AD302 Phase 3 Study of Aducanumab (BIIB037) in Early Alzheimer's Disease Alzheimer's Disease | Phase 3 | 2015-09-15 |
| Terminated | A Study to Assess the Safety and Tolerability of Nusinersen (ISIS 396443) in Participants With Spinal Muscular Spinal Muscular Atrophy | Phase 2 | 2015-08-19 |
| Terminated | 221AD301 Phase 3 Study of Aducanumab (BIIB037) in Early Alzheimer's Disease Alzheimer's Disease | Phase 3 | 2015-08-13 |
| Completed | Effect of BG00012 on Lymphocyte Subsets and Immunoglobulins in Subjects With Relapsing Remitting Multiple Scle Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis | Phase 3 | 2015-08-11 |
| Terminated | Fampridine Pregnancy Exposure Registry Multiple Sclerosis, Pregnancy | — | 2015-08-01 |
| Completed | Single-Ascending Dose Study of BIIB054 in Healthy Participants and Early Parkinson's Disease Parkinson's Disease, Healthy | Phase 1 | 2015-07-01 |
| Withdrawn | Study to Explore the Onset of Efficacy on Magnetic Resonance Disease Activity of BG00012 (Dimethyl Fumarate) i Relapsing Remitting Multiple Sclerosis | Phase 4 | 2015-07-01 |
| Completed | Single-Dose Study of a New Formulation of BIIB061 Multiple Sclerosis | Phase 1 | 2015-07-01 |
| Completed | Tecfidera Lymphocyte Chart Review Multiple Sclerosis | — | 2015-07-01 |
| Completed | Single and Multiple Ascending Dose Study of Aducanumab (BIIB037) in Japanese Participants With Alzheimer's Dis Alzheimer's Disease | Phase 1 | 2015-06-24 |
| Withdrawn | Study to Evaluate Fatigue in Participants With Relapsing Remitting Multiple Sclerosis When Treated With Dimeth Relapsing-Remitting Multiple Sclerosis, Multiple Sclerosis | Phase 4 | 2015-06-01 |
| Completed | Safety, Tolerability and Pharmacokinetics of BIIB118 (PF-05251749) Healthy | Phase 1 | 2015-05-31 |
| Completed | A Study of Multiple Doses of Nusinersen (ISIS 396443) Delivered to Infants With Genetically Diagnosed and Pres Spinal Muscular Atrophy | Phase 2 | 2015-05-18 |
| Completed | RTA 408 Capsules in Patients With Mitochondrial Myopathy - MOTOR MItochondrial Myopathies | Phase 2 | 2015-05-05 |
| Terminated | Effectiveness of DMF (Dimethyl Fumarate) and Its Impact on PROs (Patient Reported Outcomes) in Treatment-Naive Multiple Sclerosis, Relapsing-Remitting, Relapsing-Remitting Multiple Sclerosis | — | 2015-05-01 |
| Terminated | BG00012 and Delay of Disability Progression in Secondary Progressive Multiple Sclerosis Multiple Sclerosis, Secondary Progressive | Phase 3 | 2015-05-01 |
| Completed | Study to Evaluate the Interaction Between a Drug and CNV1014802 in Healthy Subjects Healthy | Phase 1 | 2015-04-30 |
| Terminated | Tecfidera Slow-Titration Study Multiple Sclerosis | Phase 3 | 2015-04-01 |
| Completed | A Longitudinal, Observational Biomarker Study in Participants With Primary Sjogren's Syndrome Healthy, Sicca Syndrome, Sjögren's Syndrome | — | 2015-03-26 |
| Completed | Observational Study to Assess the Correlation of EDSS With Quality of Life in MS Participants Treated With Nat Multiple Sclerosis | — | 2015-03-20 |
| Completed | Study of Montelukast on Gastrointestinal Tolerability in Patients With Relapsing Forms of Multiple Sclerosis R Multiple Sclerosis | Phase 4 | 2015-03-12 |
| Completed | Vaccination Response in Tecfidera-Treated Versus Interferon-Treated Participants With Relapsing Forms of Multi Relapsing Forms of Multiple Sclerosis | Phase 2 | 2015-02-28 |
| Terminated | Study to Evaluate Whether a Medication Event Monitoring System (MEMS) Can Improve Adherence to Tecfidera Treat Multiple Sclerosis | Phase 4 | 2015-02-28 |
| Completed | A Study to Evaluate the Effect of Itraconazole on the Pharmacokinetics of PF-04958242 in Healthy Subjects Healthy | Phase 1 | 2015-02-05 |
| Completed | PK & Tolerability of CNV1014802 in Young and Elderly Healthy Volunteers Trigeminal Neuralgia | Phase 1 | 2015-02-03 |
| Completed | A Study to Learn About the Effects and Safety of RTA 408 (Omaveloxolone) in People Aged 16 to 40 With Friedrei Friedreich Ataxia | Phase 2 | 2015-01-31 |
| Completed | Multiple Ascending Doses of PF-04958242 in Subjects With Stable Schizophrenia Schizophrenia | Phase 1 | 2015-01-06 |
| Completed | A Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose Study of Intravenously Administered BMS- Tauopathies | Phase 1 | 2014-12-31 |
| Terminated | Natalizumab Subcutaneous Immunogenicity and Safety Study Relapsing Multiple Sclerosis | Phase 2 | 2014-12-01 |
| Terminated | Impact of Natalizumab Versus Fingolimod in Relapsing-Remitting Multiple Sclerosis (RRMS) Participants Relapsing-Remitting Multiple Sclerosis | Phase 4 | 2014-11-30 |
| Completed | A Study to Assess the Efficacy and Safety of Nusinersen (ISIS 396443) in Participants With Later-onset Spinal Spinal Muscular Atrophy | Phase 3 | 2014-11-24 |
| Completed | Plegridy Observational Program Relapsing Forms of Multiple Sclerosis | — | 2014-11-12 |
| Completed | Observational Study to Establish Patient-Matched Population Norms for the Multiple Sclerosis Cognition Assessm Healthy | — | 2014-11-01 |
| Completed | RTA 408 Capsules in Patients With Melanoma - REVEAL Melanoma, Unresectable (Stage III) Melanoma, Metastatic (Stage IV) Melanoma | Phase 1 / Phase 2 | 2014-10-31 |
| Withdrawn | Transition to Peginterferon Beta-1a (BIIB017) From Subcutaneous Interferon Therapy Relapsing Multiple Sclerosis | Phase 4 | 2014-10-01 |
| Completed | Study to Evaluate the Pharmacokinetic Profiles of BIIB017 (Peginterferon Beta-1a) and Rebif® (Interferon Beta- Multiple Sclerosis | Phase 1 | 2014-10-01 |
| Terminated | Natalizumab as an Efficacy Switch in Participants With Relapsing Multiple Sclerosis After Failure on Other The Relapsing Multiple Sclerosis | Phase 4 | 2014-09-30 |
| Completed | Study To Evaluate The Safety, Tolerability And Pharmacokinetics Of Single Doses Of PF-04958242 In Healthy Volu Healthy | Phase 1 | 2014-09-22 |
| Completed | Efficacy and Safety Study of Prolonged-Release Fampridine in Participants With Multiple Sclerosis Multiple Sclerosis | Phase 3 | 2014-09-01 |
| Completed | Phase 3 Efficacy and Safety Study of BG00012 in Pediatric Subjects With Relapsing-remitting Multiple Sclerosis Relapsing-Remitting Multiple Sclerosis | Phase 3 | 2014-08-28 |
| Terminated | A Study to Assess the Efficacy and Safety of Nusinersen (ISIS 396443) in Infants With Spinal Muscular Atrophy Spinal Muscular Atrophy | Phase 3 | 2014-08-19 |
| Completed | Study to Assess the Safety, Tolerability, and Pharmacokinetics of BIIB061 in Healthy Adult Volunteers Healthy | Phase 1 | 2014-08-01 |
| Completed | Real-world Outcomes on Tecfidera (BG00012, Dimethyl Fumarate) Post-Tysabri (BG00002, Natalizumab) Relapsing-Remitting Multiple Sclerosis | — | 2014-07-01 |
| Completed | A Study of ALKS 8700, a Monomethyl Fumarate (MMF) Molecule, in Healthy Adults Multiple Sclerosis | Phase 1 | 2014-07-01 |
| Completed | RTA 408 Lotion in Patients at Risk for Radiation Dermatitis - PRIMROSE Breast Cancer | Phase 2 | 2014-06-30 |
| Completed | A Healthy Volunteer Study to Establish the Bioequivalence of BG00012 Supplied by 2 Different Commercial Manufa Healthy | Phase 1 | 2014-06-01 |
| Completed | Gastrointestinal Tolerability Study Of Dimethyl Fumarate In Participants With Relapsing-Remitting Multiple Scl Relapsing-Remitting Multiple Sclerosis | Phase 4 | 2014-06-01 |
| Completed | RTA 408 Ophthalmic Suspension for the Prevention of Corneal Endothelial Cell Loss Following Cataract Surgery - Corneal Endothelial Cell Loss, Ocular Pain, Ocular Inflammation | Phase 2 | 2014-05-31 |
| Completed | Bardoxolone Methyl Evaluation in Patients With Pulmonary Hypertension (PH) - LARIAT Pulmonary Arterial Hypertension, Pulmonary Hypertension, Interstitial Lung Disease | Phase 2 | 2014-05-31 |
| Completed | Phase 4 Study of Effect of Aspirin on Flushing in Dimethyl Fumarate-Treated Participants With Relapsing-Remitt Relapsing-Remitting Multiple Sclerosis | Phase 4 | 2014-05-01 |
| Completed | Pilot Tape Harvesting Study Atopic Dermatitis, Healthy, Discoid Lupus Erythematosus | — | 2014-05-01 |
| Completed | Study Evaluating the Safety, Tolerability, and Pharmacokinetics of Single Doses and Multiple Doses of BIIB059 Systemic Lupus Erythematosus, Healthy Volunteers | Phase 1 | 2014-04-30 |
| Completed | Study Assessing Cognition in Relapsing Remitting Multiple Sclerosis (RRMS) Patients Treated With BG00012 Multiple Sclerosis, Relapsing-Remitting | Phase 3 | 2014-04-30 |
| Completed | Safety and Efficacy in Pediatric MS Patients Prescribed Tysabri Multiple Sclerosis | — | 2014-03-01 |
| Completed | RTA 408 Ophthalmic Suspension for the Treatment of Ocular Inflammation and Pain Following Ocular Surgery Inflammation and Pain Following Ocular Surgery | Phase 2 | 2014-02-28 |
| Completed | An Open-label Safety and Tolerability Study of Nusinersen (ISIS 396443) in Participants With Spinal Muscular A Spinal Muscular Atrophy | Phase 1 | 2014-01-31 |
| Completed | Effect of Natalizumab on Infarct Volume in Acute Ischemic Stroke Acute Ischemic Stroke | Phase 2 | 2014-01-01 |
| Completed | RTA 408 in the Treatment of Advanced Solid Tumors (NSCLC & Melanoma) - DISCOVER Metastatic or Incurable Non-small Cell Lung Cancer, Relapsed, Refractory Melanoma | Phase 1 | 2013-12-31 |
| Completed | RTA 408 Lotion in Healthy Volunteers Healthy | Phase 1 | 2013-12-31 |
| Completed | Pharmacokinetic Study of Peginterferon Beta-1a in Japanese and Caucasian Adult Healthy Participants. Healthy | Phase 1 | 2013-12-01 |
| Completed | Single Ascending Dose Study of the Safety, Tolerability, and Pharmacokinetics of BIIB061 in Healthy Adult Volu Healthy | Phase 1 | 2013-12-01 |
| Completed | Dimethyl Fumarate (DMF) Observational Study Multiple Sclerosis | — | 2013-11-19 |
| Completed | Study of Tysabri in Early Relapsing Remitting Multiple Sclerosis Participants Relapsing Remitting Multiple Sclerosis | — | 2013-11-12 |
| Completed | Characterize Flu-like Symptoms in Relapsing Multiple Sclerosis Patients Transitioning From Non-Pegylated Inter Relapsing Multiple Sclerosis | Phase 3 | 2013-11-01 |
| Terminated | BIIB023 Long-Term Extension Study in Subjects With Lupus Nephritis Lupus Nephritis | Phase 2 | 2013-11-01 |
| Completed | A Study Evaluating the Effectiveness of Tecfidera (Dimethyl Fumarate) on Multiple Sclerosis (MS) Disease Activ Relapsing-Remitting Multiple Sclerosis, Multiple Sclerosis | Phase 4 | 2013-10-31 |
| Completed | Biogen Multiple Sclerosis Pregnancy Exposure Registry Multiple Sclerosis, Exposure During Pregnancy | — | 2013-10-30 |
| Completed | A Study of the Effect of BIIB023 on Muscle Atrophy in Healthy Male Volunteers Healthy | Phase 1 | 2013-10-01 |
| Completed | Daclizumab Japanese PK Study Healthy | Phase 1 | 2013-10-01 |
| Completed | PeptoBismol® Use to Reduce Gastrointestinal Events in Healthy Volunteers Receiving DMF [Tecfidera®] Twice Dail Healthy | Phase 1 | 2013-08-01 |
| Completed | Effectiveness of DMF and Its Impact on PROs in Suboptimal GA Responders With RMS Relapsing Forms of Multiple Sclerosis | — | 2013-08-01 |
| Completed | Study to Assess the Efficacy, Safety, Tolerability, and Pharmacokinetics of BIIB033 in Participants With Relap Multiple Sclerosis | Phase 2 | 2013-08-01 |
| Completed | A Safety and Efficacy Study of Oral Prolonged-Release Fampridine (BIIB041) in Japanese Participants With Multi Multiple Sclerosis, Remittent Progressive, Multiple Sclerosis, Primary Progressive, Relapsing-Remitting Multiple Sclerosis | Phase 3 | 2013-08-01 |
| Completed | BG00012 Regional Absorption Study Healthy | Phase 1 | 2013-08-01 |
| Completed | Tolerability and Quality of Life Study in Participants Who Switched to Avonex Pen Relapsing-Remitting Multiple Sclerosis, Clinical Isolated Syndrome (CIS), Multiple Sclerosis | — | 2013-07-01 |
| Completed | PK and PD Study of Natalizumab in Pediatric Subjects With RRMS Relapsing-Remitting Multiple Sclerosis | Phase 1 | 2013-07-01 |
| Completed | Functional MRI in Lupus Nephritis Healthy, Lupus Nephritis | — | 2013-06-01 |
| Completed | BG00010 (Neublastin) Phase 2 Multiple Dose Adaptive Design in Participants With Painful Lumbar Radiculopathy Painful Lumbar Radiculopathy, Sciatica, Radiculopathy | Phase 2 | 2013-06-01 |
| Completed | A Study to Assess the Efficacy, Safety and Pharmacokinetics of Nusinersen (ISIS 396443) in Infants With Spinal Spinal Muscular Atrophy | Phase 2 | 2013-05-08 |
| Completed | Phase 4 Gastrointestinal Tolerability Study of Dimethyl Fumarate in Patients With Relapsing Forms of Multiple Relapsing Forms of Multiple Sclerosis | Phase 4 | 2013-05-01 |
| Completed | Phase 1 Subcutaneous Single and Multiple Ascending Dose Study of BG00010 (Neublastin) Painful Lumbar Radiculopathy, Healthy | Phase 1 | 2013-04-01 |
| Completed | An Efficacy and Safety Study of BG00012 (Dimethyl Fumarate) in Asian Subjects With Relapsing Remitting Multipl Relapsing-Remitting Multiple Sclerosis, Multiple Sclerosis | Phase 3 | 2013-03-28 |
| Terminated | Long-Term Extension Study in Participants With Multiple Sclerosis Who Have Completed Study 205MS301 (NCT010644 Relapsing-Remitting Multiple Sclerosis, Multiple Sclerosis | Phase 3 | 2013-02-15 |
| Completed | An Open-label Safety and Tolerability Study of Nusinersen (ISIS 396443) in Participants With Spinal Muscular A Spinal Muscular Atrophy | Phase 1 | 2013-01-31 |
| Completed | A Study To Examine The Effects Of PF-04958242 On Ketamine-Induced Cognitive Impairment In Healthy Volunteers Schizophrenia | Phase 1 | 2012-12-01 |
| Completed | BIIB033 In Acute Optic Neuritis (AON) Acute Optic Neuritis | Phase 2 | 2012-12-01 |
| Completed | Avonex-evaluation of Quality of Life and Convenience in Belgian Participants - The AVAIL Study Multiple Sclerosis | — | 2012-12-01 |
| Terminated | Canadian Multicenter Observational Study of Tysabri in Early Relapsing Remitting Multiple Sclerosis Participan Relapsing-Remitting Multiple Sclerosis | — | 2012-11-07 |
| Completed | An Open-label Safety, Tolerability and Dose-Range Finding Study of Multiple Doses of Nusinersen (ISIS 396443) Spinal Muscular Atrophy | Phase 1 / Phase 2 | 2012-10-31 |
| Terminated | Multiple Dose Study of Aducanumab (BIIB037) (Recombinant, Fully Human Anti-Aβ IgG1 mAb) in Participants With P Alzheimer's Disease | Phase 1 | 2012-10-05 |
| Withdrawn | A Double-Blind, Randomized, Placebo-Controlled Study Evaluating the Effects of Bardoxolone Methyl on Body Comp Renal Insufficiency, Chronic, Diabetes Mellitus, Type 2 | Phase 2 | 2012-09-30 |
| Completed | Multiple-Dose Study of Effect of Bardoxolone Methyl on QT/QTC Interval Volunteers Healthy Volunteers | Phase 1 | 2012-08-31 |
| Completed | Exploratory Study to Assess the Effect of Fampridine (BIIB041) on Walking Ability and Balance in Participants Multiple Sclerosis | Phase 2 | 2012-08-01 |
| Withdrawn | BIIB057 in Subjects With Rheumatoid Arthritis and Inadequate Response to Disease-Modifying Antirheumatic Drugs Rheumatoid Arthritis | Phase 2 | 2012-08-01 |
| Withdrawn | A Double-Blind, Randomized, Placebo-Controlled Safety Study Evaluating the Effects of Residual Renal Function End-Stage Renal Disease, Type 2 Diabetes Mellitus | Phase 2 | 2012-07-31 |
| Completed | STX-100 in Patients With Idiopathic Pulmonary Fibrosis (IPF) Idiopathic Pulmonary Fibrosis (IPF) | Phase 2 | 2012-07-16 |
| Completed | Study in Healthy Volunteers to Establish the Bioequivalence of Two Different Manufacturers. Healthy Volunteers | Phase 1 | 2012-07-01 |
| Completed | Study Of The PF-04958242 Blood Concentrations Of A Capsule Formulation Of PF-04958242 Compared To A Solution F Healthy | Phase 1 | 2012-07-01 |
| Terminated | BIIB023 Proof-of-Concept Study in Participants With Lupus Nephritis Lupus Nephritis | Phase 2 | 2012-07-01 |
| Completed | An Open-Label Study of the Effect of Bardoxolone Methyl on the Single Dose Pharmacokinetics of Digoxin and Ros Healthy Volunteers | Phase 1 | 2012-06-30 |
| Completed | Peginterferon Beta-1a (BIIB017) Autoinjector Pharmacokinetic Study in Healthy Volunteers Healthy, Multiple Sclerosis | Phase 1 | 2012-06-01 |
| Completed | Safety and Efficacy of Natalizumab (BG00002, Tysabri®) in Russian Participants With Relapsing Remitting Multip Relapsing-Remitting Multiple Sclerosis | Phase 4 | 2012-05-01 |
| Withdrawn | Pilot Assessment of the Effects of Bardoxolone Methyl on Renal Perfusion, Systemic Haemodynamics and Cardiac F Renal Insufficiency, Chronic, Diabetes Mellitus, Type 2 | Phase 1 | 2012-04-30 |
| Terminated | Pharmacokinetic and Pharmacodynamic Study of Bardoxolone Methyl in Patients With Chronic Kidney Disease and Ty Renal Insufficiency, Chronic, Diabetes Mellitus, Type 2 | Phase 1 | 2012-04-30 |
| Completed | Single-Dose, Open-Label Pharmacokinetic Study of Bardoxolone Methyl in Subjects With Mild, Moderate, and Sever Hepatic Impairment, Healthy | Phase 1 | 2012-04-30 |
| Completed | An Observational Study to Collect Information on Safety and to Document the Drug Utilization of Fampyra (BIIB0 Multiple Sclerosis | — | 2012-04-16 |
| Completed | Effect of Aspirin Pretreatment or Slow Dose Titration on Flushing and Gastrointestinal Events in Healthy Volun Healthy | Phase 3 | 2012-04-01 |
| Completed | A Phase IIa Withdrawal Study of CNV1014802 in Patients With Trigeminal Neuralgia Trigeminal Neuralgia | Phase 2 | 2012-03-31 |
| Completed | Canadian Avonex PEN Productivity Study Multiple Sclerosis | — | 2012-03-01 |
| Completed | Observational Study of Tysabri in Early Relapsing-Remitting Multiple Sclerosis in Anti-JC Virus Antibody Negat Relapsing-Remitting Multiple Sclerosis | — | 2012-02-07 |
| Completed | Open-Label Study to Assess the Effect of Long-Term Prolonged-Release Fampridine (BIIB041) on Quality of Life a Multiple Sclerosis | Phase 4 | 2012-02-01 |
| Terminated | A Pharmacodynamic Study of Measured Glomerular Filtration Rate in Patients With Chronic Kidney Disease and Typ Chronic Kidney Disease, Type 2 Diabetes | Phase 1 | 2012-01-31 |
| Completed | Demonstrate the Bioequivalence of Interferon Beta-1a (INFB) Manufactured by Two Different Processes in Healthy Multiple Sclerosis | Phase 1 | 2012-01-01 |
| Completed | Phase 1 Study to Evaluate the PK, Safety, and Tolerability of BG00012 in Chinese, Japanese, and Caucasian Heal Healthy | Phase 1 | 2012-01-01 |
| Completed | A Phase I Study to Investigate the Absorption, Metabolism and Excretion in Healthy Male Subjects Healthy | Phase 1 | 2011-12-01 |
| Completed | A Study Of The Effects Of PF-04958242 In Subjects With Age-Related Hearing Loss Hearing Loss, Sensorineural | Phase 1 | 2011-12-01 |
| Completed | Ireland Natalizumab (TYSABRI) Observational Program Relapsing-Remitting Multiple Sclerosis | — | 2011-11-30 |
| Completed | An Open-label Safety, Tolerability, and Dose-range Finding Study of Nusinersen (ISIS 396443) in Participants W Spinal Muscular Atrophy | Phase 1 | 2011-11-30 |
| Completed | A Study To Examine The Safety, Tolerability And Pharmacokinetics Of PF-04958242 In Psychiatrically Stable Subj Schizophrenia | Phase 1 | 2011-11-01 |
| Completed | An Open-Label Immunogenicity and Pharmacokinetics Study of Daclizumab High Yield Process Prefilled Syringe in Relapsing-Remitting Multiple Sclerosis | Phase 3 | 2011-11-01 |
| Completed | A Single-Dose, Open-Label, Randomized, Food Effect and Blinded, Randomized, Dose Proportionality Study in Heal Healthy Volunteers | Phase 1 | 2011-10-31 |
| Terminated | A Clinical Study of the Efficacy of Natalizumab on Reducing Disability Progression in Participants With Second Secondary Progressive Multiple Sclerosis | Phase 3 | 2011-09-13 |
| Completed | Phase 1 Study to Evaluate the PK, Safety, Tolerability of BIIB023 in Chinese, Japanese, and Caucasian Healthy Healthy Volunteers | Phase 1 | 2011-09-01 |
| Completed | Persistence, Adherence, Quality of Life, and Treatment Satisfaction With Avonex® PEN™. Multiple Sclerosis | — | 2011-09-01 |
| Completed | Exploratory Study of the Safety, Tolerability and Efficacy of Multiple Regimens of Natalizumab in Adult Partic Relapsing-Remitting Multiple Sclerosis | Phase 2 | 2011-08-01 |
| Completed | A Multiple-Dose, Open-Label, Phase 1, Pharmacokinetic, Pharmacodynamic, and Safety Study of Avonex® in Chinese Healthy | Phase 1 | 2011-08-01 |
| Completed | Study in Healthy Volunteers to Establish the BioEquivalence of Two Formulations of BG00012 Healthy Volunteers | Phase 1 | 2011-08-01 |
| Completed | Study of the Safety, Tolerability, Pharmacokinetics and Safety of BG00010 (Neublastin) in Subjects With Sciati Sciatica | Phase 1 | 2011-07-01 |
| Terminated | Bardoxolone Methyl Evaluation in Patients With Chronic Kidney Disease and Type 2 Diabetes Renal Insufficiency, Chronic, Diabetes Mellitus, Type 2 | Phase 3 | 2011-06-30 |
| Completed | A Study To Assess Effects Of PF-04958242 On Bold Functional Magnetic Resonance Imaging During Working Memory A Healthy Volunteer | Phase 1 | 2011-06-24 |
| Completed | Single Ascending Dose Study of BIIB037 in Participants With Alzheimer's Disease Alzheimer's Disease | Phase 1 | 2011-06-01 |
| Completed | Avonex PEN Satisfaction and Patients Experience Clinical Trial Multiple Sclerosis | — | 2011-06-01 |
| Completed | Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Repeated Doses of PF-04958242 in Healthy Vo Schizophrenia | Phase 1 | 2011-06-01 |
| Completed | Crossover Study of CNV1014802 in Subjects With Neuropathic Pain From Lumbosacral Radiculopathy Lumbosacral Radiculopathy | Phase 2 | 2011-04-30 |
| Completed | Long-Term Safety and Efficacy Study of Peginterferon Beta-1a Relapsing Multiple Sclerosis | Phase 3 | 2011-04-01 |
| Terminated | A Safety Study in Healthy Volunteers of the Single-Use Autoinjector Containing Placebo of BG9418 Interferon Be Healthy | Phase 1 | 2011-03-01 |
| Completed | MATRIX: Measuring Neutralizing Antibodies in the Patients Treated With Interferon Beta 1a IM, in Mexico and Co Multiple Sclerosis | Phase 4 | 2011-03-01 |
| Completed | Alternate Dosing Regimens of BG00012 in Healthy Volunteers Healthy | Phase 1 | 2011-02-01 |
| Completed | Open Label Extension Study to Evaluate the Safety and Tolerability of Oral Fampridine-Sustained Release (SR) i Multiple Sclerosis | Phase 3 | 2010-12-01 |
| Terminated | Study to Evaluate the Safety, Tolerability and Pharmacokinetics of PF-04958242 in Healthy Adult Volunteers Healthy Volunteers | Phase 1 | 2010-11-24 |
| Completed | Natalizumab (BG00002, Tysabri) Study in Japanese Participants With Relapsing-Remitting Multiple Sclerosis (RRM Multiple Sclerosis | Phase 2 / Phase 3 | 2010-11-01 |
| Completed | A Pharmacokinetics (PK) and Safety Study of Oral Fampridine-PR 10 mg in Chinese, Japanese, and Caucasian Adult Healthy | Phase 1 | 2010-10-01 |
| Terminated | Genetic Evaluation of Natalizumab-Treated Patients With Progressive Multifocal Leukoencephalopathy Progressive Multifocal Leukoencephalopathy | — | 2010-10-01 |
| Completed | Safety Study of BIIB033 in Subjects With Multiple Sclerosis Relapsing-Remitting Multiple Sclerosis, Multiple Sclerosis | Phase 1 | 2010-10-01 |
| Completed | Extension Study to Evaluate Safety and Efficacy of Natalizumab in Japanese Participants With Relapsing-Remitti Relapsing-Remitting Multiple Sclerosis, Multiple Sclerosis | Phase 2 | 2010-10-01 |
| Withdrawn | Dose Escalation Study to Evaluate the Penetration and Pharmacodynamic Effects of Baminercept in the Cerebrospi Secondary Progressive Multiple Sclerosis | Phase 1 / Phase 2 | 2010-09-01 |
| Terminated | Corticosteroids for Immune Reconstitution Inflammatory Syndrome (IRIS) Immune Reconstitution Inflammatory Syndrome, Leukoencephalopathy, Progressive Multifocal | Phase 4 | 2010-09-01 |
| Completed | JC-virus (JCV) Epidemiology in Multiple Sclerosis (MS) Multiple Sclerosis | — | 2010-09-01 |
| Completed | First-in-Human Study of PF-04958242 in Healthy Volunteers Healthy Volunteer | Phase 1 | 2010-07-15 |
| Completed | Biomarkers of Anti-TNF-α Therapy Efficacy in Rheumatoid Arthritis to Define Unresponsive Patients Arthritis, Rheumatoid | — | 2010-06-01 |
| Terminated | Controlled High Risk AVONEX® Multiple Sclerosis Prevention Study In Ongoing Neurological Surveillance Multiple Sclerosis | — | 2010-06-01 |
| Completed | A Single-blinded, Controlled, Multi-centre Study of Effects of Exercise in Participants With Multiple Sclerosi Exercise | — | 2010-06-01 |
| Completed | BG00012 Phase 2 Combination Study in Participants With Multiple Sclerosis Relapsing-Remitting Multiple Sclerosis, Multiple Sclerosis | Phase 2 | 2010-06-01 |
| Completed | A Study of Avonex to Determine the Effects of Dose Titration on the Incidence of Flu Like Symptoms in Healthy Healthy Volunteers | Phase 1 | 2010-05-05 |
| Completed | A Single-Dose, Pharmacokinetic/Pharmacodynamic (PK/PD), & Safety Study of BIIB017 in Participants With Renal I Healthy, Renal Insufficiency | Phase 1 | 2010-05-01 |
| Completed | Efficacy and Safety of BIIB019 (Daclizumab High Yield Process) Versus Interferon β 1a in Participants With Rel Relapsing-Remitting Multiple Sclerosis | Phase 3 | 2010-05-01 |
| Completed | Avonex Safety and Tolerability in Chinese Subjects With Relapsing Multiple Sclerosis (MS) Multiple Sclerosis | Phase 3 | 2010-04-01 |
| Completed | Safety and Efficacy Extension Study of Daclizumab High Yield Process (DAC HYP) (BIIB019) in Participants Who H Relapsing-Remitting Multiple Sclerosis | Phase 2 | 2010-03-31 |
| Completed | JC Virus Antibody Study of Participants With Relapsing Forms of MS Receiving Treatment With Natalizumab Relapsing Multiple Sclerosis | — | 2010-03-01 |
| Terminated | Study Evaluating Rebif, Copaxone, and Tysabri for Active Multiple Sclerosis Relapsing Remitting Multiple Sclerosis | Phase 3 | 2010-03-01 |
| Completed | JC-Virus (JCV) Antibody Program Multiple Sclerosis | — | 2010-03-01 |
| Completed | Treatment Interruption of Natalizumab Relapsing Remitting Multiple Sclerosis | Phase 2 | 2010-03-01 |
| Completed | Phase II Pharmacodynamic Trial to Determine the Effects of Bardoxolone Methyl on eGFR in Patients With Type 2 Renal Insufficiency, Chronic, Diabetes Mellitus, Type 2 | Phase 2 | 2010-01-31 |
| Completed | Safety Study of RP-1127 (Glyburide for Injection) in Healthy Volunteers Traumatic Brain Injury, Stroke | Phase 1 | 2010-01-07 |
| Completed | BIIB033 Single Ascending Dose Study in Healthy Volunteer Subjects Healthy | Phase 1 | 2010-01-01 |
| Completed | BIIB014 Cardiovascular Monitoring Study Healthy | Phase 1 | 2009-12-01 |
| Completed | Effect of Food and Antacid on BIIB021 With Advanced Solid Tumors Advanced Solid Tumors | Phase 1 | 2009-11-01 |
| Completed | BIIB014 Effects on the Pharmacokinetics (PK) of Rosiglitazone, Warfarin, and Midazolam Healthy | Phase 1 | 2009-11-01 |
| Completed | Hormone Receptor Positive Metastatic Breast Cancer (HR+ mBC) BIIB021 Plus Aromasin Schedule Finding Breast Cancer | Phase 2 | 2009-11-01 |
| Completed | A Study of BIIB022 in Combination With Paclitaxel and Carboplatin in Subjects With Non-Small Cell Lung Cancer Non-Small Cell Lung Cancer | Phase 1 | 2009-10-01 |
| Completed | Pharmacokinetics Profile Study of BG00012 Standard Formulation and BG00012 Active Pharmaceutical Ingredient Healthy | Phase 1 | 2009-10-01 |
| Completed | A Prospective, Open-label, Non-randomized, Clinical Trial to Determine if Natalizumab (Tysabri®) Improves Ambu Relapsing Remitting Multiple Sclerosis (RRMS) | Phase 4 | 2009-08-01 |
| Completed | Sorafenib With BIIB022 in Hepatocellular Carcinoma (HCC) Hepatocellular Carcinoma | Phase 1 | 2009-08-01 |
| Completed | Evaluate the Safety, Tolerability and Pharmacokinetics of BG00010 (Neublastin) Administered to Sciatica Partic Sciatica | Phase 1 | 2009-08-01 |
| Terminated | Effect of GSK1014802 on Electrical Hyperalgesia and Threshold Tracking in Healthy Subjects Pain, Neuropathic, Neuropathic Pain | Phase 1 | 2009-07-31 |
| Completed | Study to Investigate the Effect of GSK1014802 on Ambulatory Blood Pressure Healthy Volunteer | Phase 1 | 2009-07-31 |
| Completed | Efficacy and Safety Study of Peginterferon Beta-1a in Participants With Relapsing Multiple Sclerosis Relapsing Multiple Sclerosis | Phase 3 | 2009-06-01 |
| Completed | Trial to Determine the Effects of Bardoxolone Methyl on eGFR in Patients With Type 2 Diabetes and Chronic Kidn Chronic Kidney Disease, Type 2 Diabetes, Diabetic Nephropathy | Phase 2 | 2009-04-30 |
| Completed | BG9928 in Subjects With Hepatic Impairment Hepatic Impairment | Phase 1 | 2009-04-01 |
| Completed | Effects of Tysabri (BG00002) Over 12 Months on MS Related Fatigue in Participants With RRMS Relapsing-Remitting Multiple Sclerosis, Fatigue | — | 2009-03-23 |
| Completed | A Proof of Concept Study to Evaluate the Effectiveness of Tysabri in Relapsing Remitting Multiple Sclerosis (R Relapsing-Remitting Multiple Sclerosis | — | 2009-03-01 |
| Completed | A 24-Hour Pharmacokinetic Determination of BG00012 After Single-Day Oral Administration in Subjects With MS Relapsing Remitting Multiple Sclerosis | Phase 1 | 2009-02-28 |
| Completed | BG00012 Monotherapy Safety and Efficacy Extension Study in Multiple Sclerosis (MS) Relapsing-Remitting Multiple Sclerosis | Phase 3 | 2009-02-03 |
| Terminated | Oral Tonapofylline (BG9928) in Patients With Heart Failure and Renal Insufficiency Renal Insufficiency, Heart Failure | Phase 2 | 2009-02-01 |
| Completed | Safety and Efficacy Extension Study of Daclizumab High Yield Process (DAC HYP) in Participants With Multiple S Relapsing-Remitting Multiple Sclerosis | Phase 2 | 2009-02-01 |
| Terminated | Study to Explore the Effect of Mefloquine in Participants With Progressive Multifocal Leukoencephalopathy (PML Progressive Multifocal Leukoencephalopathy | Phase 1 / Phase 2 | 2009-01-01 |
| Completed | Evaluate the Safe and Effective Use of the Avonex® Single-Use Autoinjector in Multiple Sclerosis Subjects Multiple Sclerosis | Phase 3 | 2009-01-01 |
| Withdrawn | Study of Tysabri (Natalizumab) in Patients Who Failed Anti-TNF-α Therapy Crohn's Disease | Phase 4 | 2008-12-01 |
| Completed | Efficacy and Safety Study of BG00012 With Methotrexate in Patients With Active Rheumatoid Arthritis Rheumatoid Arthritis | Phase 2 | 2008-12-01 |
| Withdrawn | A Proof-of-Concept Study to Correlate Retinal Nerve Fiber Layer Changes in Patients With Multiple Sclerosis Tr Relapsing-remitting Multiple Sclerosis | Phase 4 | 2008-11-01 |
| Completed | A Pharmacokinetic (PK) Study of Natalizumab (Tysabri) at Steady State Multiple Sclerosis | Phase 4 | 2008-11-01 |
| Completed | BIIB023 (Anti-TWEAK) in Subjects With Rheumatoid Arthritis Rheumatoid Arthritis | Phase 1 | 2008-10-01 |
| Terminated | Immunogenicity and Safety of Subcutaneously-administered Avonex (Interferon Beta-1a) in Multiple Sclerosis (MS Multiple Sclerosis | Phase 3 | 2008-10-01 |
| Terminated | Study of Natalizumab in Relapsed/Refractory Multiple Myeloma Multiple Myeloma | Phase 1 / Phase 2 | 2008-09-01 |
| Terminated | Mechanism of Action of Galiximab in Subjects With Previously Untreated Follicular Non-Hodgkin's Lymphoma Lymphoma, Non-Hodgkin's | Phase 1 | 2008-08-01 |
| Completed | Study to Assess the Safety and Tolerability of IV Tonapofylline in Subjects With Acute Decompensated Heart Fai Renal Insufficiency, Congestive Heart Failure | Phase 3 | 2008-07-31 |
| Terminated | CD INFORM: Investigating Natalizumab Through Further Observational Research and Monitoring Crohn's Disease | — | 2008-06-30 |
| Completed | Administration of BIIB028 to Subjects With Solid Tumors Advanced Solid Tumors | Phase 1 | 2008-06-01 |
| Completed | A Phase I Study of BIIB015 in Relapsed/Refractory Solid Tumors Solid Tumors | Phase 1 | 2008-06-01 |
| Completed | Safety, Tolerability and Pharmacokinetics of Repeat Doses of GSK1014802. Bipolar Depression, Bipolar Disorder | Phase 1 | 2008-05-31 |
| Completed | COMPliance With Avonex® PS in Patients With Relapsing-Remitting MS Multiple Sclerosis, Relapsing-Remitting | — | 2008-05-01 |
| Completed | A Phase 2 Study of Interferon Beta-1a (Avonex®) in Ulcerative Colitis Active Ulcerative Colitis | Phase 2 | 2008-05-01 |
| Completed | Phase IIa Trial to Determine the Effects of Bardoxolone Methyl on Renal Function in Patients With Diabetic Nep Diabetic Nephropathy | Phase 2 | 2008-04-30 |
| Completed | A Multiple Dose Safety Study of PEG-IFN in Healthy Volunteers Healthy | Phase 1 | 2008-03-01 |
| Completed | ATP Expression in Lymphocytes of MS Patients by Means of "ImmuKnow®" Assay. Multiple Sclerosis | — | 2008-03-01 |
| Terminated | Evaluation of Safety and Efficacy of Fludarabine, Cyclophosphamide, and Rituximab (FCR) +/- Lumiliximab in Sub Chronic Lymphocytic Leukemia | Phase 2 | 2008-02-01 |
| Completed | An Open-Label, 18FDG-PET Pharmacodynamic Assessment of the Effect of BIIB021 in Subjects With Gastrointestinal GIST | Phase 2 | 2008-02-01 |
| Completed | Once or Twice Daily Administration of BIIB021 to Subjects With Advanced Solid Tumors Advanced Solid Tumors | Phase 1 | 2008-02-01 |
| Completed | Safety and Efficacy Study of Daclizumab High Yield Process (DAC HYP) to Treat Relapsing-Remitting Multiple Scl Relapsing-Remitting Multiple Sclerosis | Phase 2 | 2008-02-01 |
| Completed | Phase 1 Study of BIIB022 (Anti-IGF-1R Monoclonal Antibody) in Relapsed/Refractory Solid Tumors Solid Tumors | Phase 1 | 2008-01-01 |
| Completed | The Effects of Tysabri Treatment on Vaccination Response and Lymphocyte Subsets in Subjects With Relapsing For Multiple Sclerosis | Phase 4 | 2008-01-01 |
| Completed | CNF2024 (BIIB021) HER2- (QD) HER2+ (BIW w/Herceptin) PK/PD Study Breast Cancer | Phase 1 | 2007-12-01 |
| Terminated | Retreatment Study of Galiximab + Rituximab in Follicular Non-Hodgkin's Lymphoma (NHL) Lymphoma, Non-Hodgkin's | Phase 3 | 2007-11-01 |
| Terminated | 104RA204 Assessment of the Safety and Efficacy of BG9924 in Rheumatoid Arthritis (RA) Participants Rheumatoid Arthritis | Phase 2 | 2007-11-01 |
| Terminated | RTA 744 in Breast Cancer Patients With Progression of Previously Irradiated Brain Metastases Brain Metastases | Phase 2 | 2007-10-31 |
| Completed | Safety Study of Natalizumab to Treat Multiple Sclerosis (MS) Relapsing-Remitting Multiple Sclerosis, Secondary Progressive Multiple Sclerosis | Phase 1 | 2007-10-01 |
| Terminated | Study With Gemcitabine and RTA 402 for Patients With Unresectable Pancreatic Cancer Pancreatic Neoplasms, Pancreatic Cancer | Phase 1 | 2007-09-30 |
| Completed | Using PET Scans to Study Brain Receptor Occupancy of BIIB014 in Healthy Male Volunteers Healthy | Phase 1 | 2007-09-01 |
| Completed | Dose-Finding Safety Study of BIIB014 in Early-Stage Parkinson's Disease Parkinson's Disease | Phase 2 | 2007-08-01 |
| Terminated | BG9924 in Combination With Methotrexate Extension of Study 104RA203 (NCT 00458861) Rheumatoid Arthritis | Phase 2 | 2007-08-01 |
| Completed | Evaluation of Natalizumab for thE Relief of MS Associated FatiGue Multiple Sclerosis | — | 2007-08-01 |
| Completed | Assessment Of The Safety And Efficacy Of BG9924 In Rheumatoid Arthritis (RA) Participants Rheumatoid Arthritis | Phase 2 | 2007-07-01 |
| Completed | Tysabri Observational Program Relapsing-Remitting Multiple Sclerosis | — | 2007-06-29 |
| Completed | Efficacy and Safety Study of Oral BG00012 With Active Reference in Relapsing-Remitting Multiple Sclerosis Relapsing-Remitting Multiple Sclerosis | Phase 3 | 2007-06-01 |
| Terminated | How Side Effects of Avonex Are Affected by Gradually Increasing to Full Dose vs Starting at Full Dose Relapsing Remitting Multiple Sclerosis | Phase 4 | 2007-06-01 |
| Completed | GSK Drug Single Dose Escalation And Their Effect On Resting Motor Threshold In Healthy Volunteers Bipolar Disorder | Phase 1 | 2007-05-31 |
| Terminated | Study to Assess the Safety, Tolerability, and Pharmacodynamics of RTA 402 in Patients With Hepatic Dysfunction Liver Disease | Phase 1 / Phase 2 | 2007-04-30 |
| Completed | Dose-Finding Safety Study of BIIB014 in Combination With Levodopa in Moderate to Late Stage Parkinson's Diseas Parkinson's Disease | Phase 2 | 2007-04-01 |
| Terminated | BG9924 in Combination With Methotrexate for Participants With Active Rheumatoid Arthritis Rheumatoid Arthritis | Phase 2 | 2007-03-01 |
| Completed | Avonex 15 Year Long Term Follow-up Study Multiple Sclerosis | — | 2007-03-01 |
| Completed | Pregnancy Exposure Registry for Tysabri® Crohn's Disease, Prenatal Exposure, Multiple Sclerosis | — | 2007-01-01 |
| Completed | TYSABRI Global Observational Program in Safety Multiple Sclerosis | — | 2007-01-01 |
| Completed | A Multicenter Study to Assess the Effect of Plasma Exchange in Accelerating the Clearance of Natalizumab in Su Relapsing Forms of Multiple Sclerosis | EARLY_Phase 1 | 2007-01-01 |
| Completed | Efficacy and Safety of Oral BG00012 in Relapsing-Remitting Multiple Sclerosis Relapsing-Remitting Multiple Sclerosis | Phase 3 | 2007-01-01 |
| Terminated | Lumiliximab With Fludarabine, Cyclophosphamide, and Rituximab (FCR) Versus FCR Alone in Subjects With Relapsed Chronic Lymphocytic Leukemia | Phase 2 | 2006-11-01 |
| Terminated | A Safety Study of RTA 744 in Recurrent, Progressive or Refractory Neoplastic Meningitis Leptomeningeal Carcinomatosis | Phase 1 | 2006-10-31 |
| Completed | Natalizumab High Titer Immunogenicity and Safety Multiple Sclerosis | Phase 2 | 2006-10-01 |
| Completed | TYGRIS - ROW: TYSABRI Global Observational Program in Safety - Rest of World Multiple Sclerosis | — | 2006-09-01 |
| Terminated | A Study of Galiximab + Rituximab Versus Rituximab + Placebo in Follicular Non-Hodgkin's Lymphoma (NHL) Lymphoma, Non-Hodgkin's | Phase 3 | 2006-09-01 |
| Terminated | Safety and Tolerability of Rituxan With Methotrexate and Etanercept or Methotrexate and Adalimumab in Patients Rheumatoid Arthritis | Phase 2 | 2006-05-01 |
| Completed | RTA 402 in Patients With Advanced Solid Tumors or Lymphoid Malignancies Advanced Solid Tumors, Lymphoid Malignancies | Phase 1 | 2006-04-30 |
| Completed | GER-009-06-AVX Early Therapy in Multiple Sclerosis Relapsing-Remitting Multiple Sclerosis | — | 2006-04-01 |
| Terminated | Natalizumab (Tysabri) Re-Initiation of Dosing Relapsing-Remitting Multiple Sclerosis | Phase 3 | 2006-03-01 |
| Completed | Natalizumab Re-Initiation of Dosing Multiple Sclerosis, Relapsing-Remitting | Phase 3 | 2006-03-01 |
| Completed | Simvastatin as an Add-on Treatment to Interferon-beta-1a for the Treatment of Relapsing-Remitting Multiple Scl Multiple Sclerosis | Phase 4 | 2006-02-01 |
| Completed | Study of Oral CNF2024 (BIIB021) in Advanced Solid Tumors Tumors, Lymphoma | Phase 1 | 2006-02-01 |
| Terminated | Phase 1, Dose-Escalation Study of Oral CNF2024(BIIB021) in CLL B-Cell Chronic Lymphocytic Leukemia | Phase 1 | 2006-02-01 |
| Completed | A Serologic Study to Correlate Beta-IFN NAb Titers to Beta-IFN Induced Biomarker Response in Patients With Mul Multiple Sclerosis | — | 2006-01-01 |
| Completed | A Safety Study of RTA 744 in Patients With Recurrent High-Grade Gliomas Glioma | Phase 1 | 2005-11-30 |
| Completed | Dose-Escalating Study of BG9924 in Combination With Methotrexate in Active Rheumatoid Arthritis Rheumatoid Arthritis | Phase 2 | 2005-11-01 |
| Completed | Patient Satisfaction Study of Single-Use Autoinjector for the Delivery of Pre-Filled Avonex Syringe Multiple Sclerosis | Phase 3 | 2005-08-01 |
| Completed | Interferon-Beta Gene Transfer (Ad.hIFN-β) as Treatment for Refractory Colorectal Carcinoma With Liver Metastas Colorectal Carcinoma, Metastases | Phase 1 / Phase 2 | 2005-05-01 |
| Terminated | Phase 1, Dose-Escalation, Pharmacodynamic Study of IV CNF1010 in ZAP-70 Positive CLL Chronic Lymphocytic Leukemia | Phase 1 | 2005-05-01 |
| Terminated | Safety and Tolerability of hCBE-11 in Subjects With Advanced Solid Tumors Tumors | Phase 1 | 2005-01-01 |
| Terminated | Safety and Activity of 90Y-Labeled IDEC-159 in Subjects With Metastatic Colorectal Adenocarcinoma Colorectal Cancer, Metastases | Phase 1 / Phase 2 | 2005-01-01 |
| Completed | Efficacy and Safety of BG00012 in MS Multiple Sclerosis | Phase 2 | 2004-10-01 |
| Terminated | A Phase II, Multicenter, Open-Label, Long-Term Study of the Safety, Tolerability, and Efficacy of Intravenous Rheumatoid Arthritis | Phase 2 | 2004-09-01 |
| Completed | Safety of Avonex Treatment in Multiple Sclerosis Patients With Neutralizing Antibodies to Interferon Beta Ther Multiple Sclerosis | Phase 4 | 2004-05-01 |
| Terminated | Natalizumab in the Treatment of Rheumatoid Arthritis in Subjects Receiving Methotrexate Rheumatoid Arthritis | Phase 2 | 2004-05-01 |
| Completed | A Clinical Trial of Natalizumab in Individuals With Moderately to Severely Active Crohn's Disease Crohn's Disease | Phase 3 | 2004-03-01 |
| Completed | Lumiliximab in Combination With FCR in Subjects With Relapsed Chronic Lymphocytic Leukemia (CLL) Chronic Lymphocytic Leukemia | Phase 1 / Phase 2 | 2004-03-01 |
| Completed | Safety and Efficacy of Avonex in Subjects With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP Chronic Inflammatory Demyelinating Polyradiculoneuropathy | Phase 2 | 2004-02-01 |
| Completed | Pregnancy Exposure Registry for Avonex (Interferon Beta-1a) Prenatal Exposure Delayed Effects, Multiple Sclerosis, Pregnancy | — | 2004-02-01 |
| Completed | Open-Label Natalizumab Safety Extension Study Multiple Sclerosis | Phase 3 | 2003-12-01 |
| Completed | Effect of Rituximab on Immunological Recall Response to Specific Antigens in the Treatment of Non-Hodgkin's Ly Non-Hodgkin's Lymphoma | Phase 4 | 2003-10-01 |
| Completed | Is IFN-beta Treatment in MS Useful After a Washout Period in Patients With Neutralizing Antibodies to Interfer Relapsing-Remitting Multiple Sclerosis | Phase 4 | 2003-10-01 |
| Completed | A Bioequivalence Study of Serum Free Avonex and Serum Containing Avonex in Healthy Volunteers Multiple Sclerosis | Phase 1 | 2003-08-01 |
| Completed | Zevalin® Followed by Rituxan® Maintenance in Previously Treated Low Grade Non-Hodgkin's Lymphoma Lymphoma, Non-Hodgkin, Lymphoma, Low-Grade | Phase 4 | 2003-06-01 |
| Completed | AVONEX® Combination Trial - "ACT" Multiple Sclerosis, Relapsing-Remitting | Phase 4 | 2003-06-01 |
| Completed | Natalizumab in Combination With Glatiramer Acetate (GA) in Patients With Relapsing-Remitting Multiple Sclerosi Multiple Sclerosis, Relapsing-Remitting | Phase 2 | 2003-06-01 |
| Terminated | Safety and Efficacy of Zevalin in the Treatment of Non-Hodgkin's Lymphoma Non-Hodgkin's Lymphoma | Phase 3 | 2003-03-01 |
| Completed | Investigating if Interferon-Beta Can be Used in Patients With MS After They Have Developed Neutralizing Antibo Relapsing-Remitting Multiple Sclerosis | Phase 4 | 2003-03-01 |
| Completed | Avonex (Interferon-beta-1a) and Avonex Plus Methylprednisolone for the Treatment of Relapsing-remitting MS Relapsing-remitting Multiple Sclerosis | Phase 4 | 2003-01-01 |
| Completed | Immunogenicity and Safety Study of Serum-Free Avonex Multiple Sclerosis | Phase 2 | 2003-01-01 |
| Completed | Safety and Tolerability of Repeat Courses of IM Alefacept Chronic Plaque Psoriasis | Phase 3 | 2002-12-01 |
| Completed | Pharmacodynamic Study to Better Understand the Therapeutic Response and Immunomodulatory Effects of Avonex in Multiple Sclerosis | Phase 4 | 2002-11-01 |
| Completed | Safety and Efficacy of IDEC-114 in Combination With Rituxan in the Treatment of Non-Hodgkin's Lymphoma Non-Hodgkin's Lymphoma | Phase 1 / Phase 2 | 2002-11-01 |
| Completed | Safety and Efficacy of IDEC-152 in the Treatment of Chronic Lymphocytic Leukemia (CLL) Chronic Lymphocytic Leukemia | Phase 1 | 2002-09-01 |
| Completed | Study to Determine if Avonex and Rebif Work Comparably Well in Subjects With Relapsing Multiple Sclerosis Multiple Sclerosis | — | 2002-08-01 |
| Completed | Open Label Natalizumab Safety Extension Study for Subjects With Crohn's Disease Crohn's Disease | Phase 4 | 2002-07-01 |
| Completed | Dose Escalation Study to Determine the Safety of IFN-Beta Gene Transfer in the Treatment of Grade III & Grade Glioblastoma Multiforme, Anaplastic Astrocytoma, Oligoastrocytoma, Mixed | Phase 1 | 2002-04-02 |
| Completed | Safety and Efficacy of Natalizumab in Combination With Remicade in the Treatment of Crohn's Disease Crohn's Disease | Phase 2 | 2002-04-01 |
| Completed | Safety, Tolerability and Effectiveness of Natalizumab in Adolescents With Active Crohn's Disease Crohn's Disease | Phase 2 | 2002-04-01 |
| Completed | Safety and Efficacy of Natalizumab in the Treatment of Crohn's Disease Crohn's Disease | Phase 3 | 2002-03-01 |
| Completed | Safety and Efficacy of Natalizumab in Combination With Avonex in the Treatment of Multiple Sclerosis Multiple Sclerosis, Relapsing-Remitting | Phase 3 | 2002-01-01 |
| Completed | Safety and Efficacy of IDEC-114 in the Treatment of Non-Hodgkin's Lymphoma Non-Hodgkin's Lymphoma | Phase 1 / Phase 2 | 2002-01-01 |
| Completed | Safety and Efficacy of Natalizumab in the Treatment of Crohn's Disease Crohn's Disease | Phase 3 | 2001-12-01 |
| Completed | Safety and Efficacy of Natalizumab in the Treatment of Multiple Sclerosis Multiple Sclerosis, Relapsing-Remitting | Phase 3 | 2001-11-01 |
| Completed | Does Quality of Life Improve in Multiple Sclerosis Patients Treated With Interferon Beta-1a? Relapsing Remitting Multiple Sclerosis | Phase 4 | 1999-11-01 |
| Completed | Open-Label Safety Extension Study of Avonex Multiple Sclerosis | Phase 4 | 1999-09-01 |