NCT06253988

Effect of Probiotics on Periodontitis Stage III Grade C Molar-incisor Pattern

Evaluating the Effect of a Mixture of Lactobacillus Brevis and Lactobacillus Plantarum on the Management of Periodontitis Stage III Grade C Molar-incisor Pattern in Egyptian Patients ( Randomize Control Trial)

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 65 (actual)
• Sponsor: Al-Azhar University · Academic / Other
• Sex: All
• Age: 10 Years – 28 Years
• Healthy volunteers: Accepted

Summary

the research highlight the effectiveness of probiotics as adjuncts to SRP in the treatment of periodontitis stage III grade C molar-incisor pattern

Detailed description

Background data : Periodontitis is a common disease that represents a public health problem. Aggregatibacter actinomycetemcomitans (A. a ) especially the JP2 genotype plays a major role in the pathogenesis of periodontitis. The aim of this study is to evaluate the effect of topically applied probiotics on the management of periodontitis stage III grade C molar-incisor pattern. Methods: Sixty-five patients having periodontitis stage III grade C molar-incisor pattern. Screening for A. actinomycetemcomians (A.a) and the JP2 genotype was done using conventional polymerase chain reaction (PCR). Patients positive for (A. a) were randomly divided into two groups. Group I: received conventional periodontal treatment combined with topically applied probiotic, while Group II: received conventional periodontal treatment only. Both groups were evaluated microbiologically and clinically. Quantitative assessment of A. a levels was done by real time PCR (qPCR) at baseline as well as one week, 4 weeks, and 12 weeks after treatment. Clinical parameters were assessed before treatment as well as 3,6 and 9 months after treatment.

Conditions

• Periodontal Diseases

Interventions

Type	Name	Description
DRUG	Probiotic Formula	intra-pocket formula (local delivery drug)
DRUG	placebo formula	intra-pocket formula (local delivery drug)

Timeline

• Start date: 2023-01-01
• Primary completion: 2023-02-01
• Completion: 2023-09-30
• First posted: 2024-02-12
• Last updated: 2024-02-12

Locations

1 site across 1 country: Egypt