NCT06199440

Azithromycin Versus Doxycycline on Restistin Level in Periodontitis Patients With Type 2 Diabetes

Azithromycin Versus Doxycycline on Resistin Level in Periodontitis Patients With Type 2 Diabetes. A Randomized Controlled Clinical Trial

• Status: Completed
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 15 (actual)
• Sponsor: King Abdulaziz University · Academic / Other
• Sex: All
• Age: 25 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

The aim of this study is to evaluate the adjunctive effects of systemic antibiotics used in nonsurgical periodontal treatment (NSPT), compared with NSPT alone, on the periodontal clinical parameters and resistin level in diabetic patients with periodontitis, in order to identify which, one provides an additional effect to non-surgical periodontal therapy

Conditions

• Periodontal Diseases
• Type 2 Diabetes

Interventions

Type	Name	Description
DRUG	Group I	First group are chronic periodontitis patients with diabetes mellitus type II who received scaling and root planning.
DRUG	Group II	Second group will receive 250 mg of azithromycin per day for a period of 5 days, after an initial dose of 500 mg one hour before NSPT.
DRUG	Group III	Third group are Type 2 DM patients who received doxycycline 20mg twice/day. Gingival crevicular fluid will be collected at 0, 1, and 3 months to assess Serum Resistin using a human Resistin enzyme-linked immunosorbent assay Kit following the manufacturer's protocol.

Timeline

• Start date: 2022-06-01
• Primary completion: 2023-03-30
• Completion: 2023-03-30
• First posted: 2024-01-10
• Last updated: 2024-01-10

Locations

1 site across 1 country: Saudi Arabia