NCT05702892

Evaluation of Bone Metabolism Biomarkers in Periodontal Diseases

Evaluation Of Biomarkers Associated With Bone Metabolism İn Patients With Different Periodontal Status

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 60 (actual)
• Sponsor: Necmettin Erbakan University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

This study evaluates the levels of biomarkers associated with bone metabolism in patients with different periodontal conditions.

Detailed description

Background: In this study, the levels of bone metabolism markers found in the saliva of individuals with different periodontal conditions were compared and the relationship of these markers with periodontal status was examined. Method: A total of 60 individuals, 20 with periodontitis (P), 20 with gingivitis (G), and 20 with periodontal healthy (S), were included in the study. Periodontal clinical parameters (plaque index, gingival index, bleeding on probing, clinical attachment level and probing pocket depth) and saliva samples were obtained from the individuals. Bone metabolism biomarker (necrotizing factor (TNF)-α, osteoprotegerin (OPG), nuclear factor kappa-β receptor activator ligand (RANKL) and sclerostin) levels in saliva samples were evaluated by enzyme-linked immunosorbent assay (ELISA).

Conditions

• Periodontal Diseases

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	ELISA	ELISA(enzyme-linked immunosorbent assay)

Timeline

• Start date: 2020-11-05
• Primary completion: 2021-05-05
• Completion: 2021-11-05
• First posted: 2023-01-27
• Last updated: 2023-01-27

Locations

1 site across 1 country: Turkey (Türkiye)