| Not Yet Recruiting | A Randomized Clinical Trial of Ex Vivo Corneal Cross-Linking of Donor Keratoplasty Tissue for Keratoconus Used NCT04584125 | Joseph B. Ciolino, MD | N/A |
| Not Yet Recruiting | Artificial Intelligence-assisted Diagnosis in Ophthalmology NCT07497815 | Marisse Masis-Solano | — |
| Not Yet Recruiting | Outcomes of CTAK Surgery NCT07474870 | Stanford University | Phase 4 |
| Recruiting | Placebo-controlled Study to Evaluate the Safety and Efficacy of GLK-221 Ophthalmic Solution in Subjects With K NCT07400952 | Glaukos Corporation | Phase 2 |
| Enrolling By Invitation | Study of TN-001 Topical Eyedrops for Keratoconus NCT07388069 | TheiaNova Ltd. | Phase 1 / Phase 2 |
| Not Yet Recruiting | INTACS (Intrastromal Corneal Ring Segments) For Corneal Ectasia NCT02512432 | University of California, San Diego | N/A |
| Recruiting | PRoTECT: Corneal Wavefront Guided PRK + Epi-off CXL vs. PTK+Epi-off CXL in Keratoconus NCT07372911 | Instituto de Oftalmología Fundación Conde de Valenciana | N/A |
| Active Not Recruiting | Electrophysiological Changes in Cases of Different Stages of Keratoconus NCT07461129 | Minia University | — |
| Recruiting | Effect of Corneal and Scleral RGP Lenses on Ocular Health and Visual Quality in Keratoconus NCT06921967 | University of Aarhus | N/A |
| Recruiting | Comparison of Epi-ON Corneal Collagen Crosslinking Performed Using an 18-Minute UVA Exposure vs. a 24-Minute U NCT07124910 | Woolfson Eye Institute | Phase 3 |
| Recruiting | Compassionate Use Study of Epi-ON Corneal Collagen Crosslinking Performed Using UVA Exposure on Eyes With Ecta NCT07135167 | Woolfson Eye Institute | Phase 3 |
| Completed | KeratoConus Data Acquisition With Topography and Aberrometry NCT06859398 | Azalea Vision | N/A |
| Not Yet Recruiting | Evaluation of Corneal Epithelial Mapping in Diagnosis of Early Keratoconus by Anterior Segment Optical Coheren NCT06914973 | Assiut University | — |
| Enrolling By Invitation | Dextenza Versus Topical Steroid Eye Drops for Postoperative Management Following Corneal Crosslinking NCT06235567 | Maanasa Indaram, MD | Phase 1 / Phase 2 |
| Not Yet Recruiting | Assessing Patient Engagement in Keratoconus Clinical Research NCT06288737 | Power Life Sciences Inc. | — |
| Enrolling By Invitation | AI-Orchestrated Workflow Versus Consultant Ophthalmologist for Refractive Surgery and Keratoconus Diagnosis (A NCT07096232 | Hazem Yassin Clinics | — |
| Active Not Recruiting | Detection of Keratoconus Progression Using Machine Learning NCT06873399 | Vienna Institute for Research in Ocular Surgery | — |
| Enrolling By Invitation | Enhancing Scleral Lens Fit With Advanced Imaging NCT06751615 | Fernando Fernandez Velazquez | — |
| Not Yet Recruiting | Anterior Segment and Corneal Parameters in Keratoconus and High Myopic Astigmatism Using Schiempflug Imaging NCT06739018 | Assiut University | — |
| Recruiting | First in Human Study to Assess Safety and Efficacy of an Implantable Nitinol Device in the Treatment of Kerato NCT06451718 | Recornea Srl | N/A |
| Recruiting | Effects of Topical Insulin on Corneal Epithelium Healing After Corneal Crosslinking in Patients With Keratocon NCT06601101 | University of Campinas, Brazil | Phase 3 |
| Recruiting | Safety and Effectiveness of the PXL-Platinum 330 System for Cornea Crosslinking in Eyes With Cornea Thinning NCT05516004 | Cohen Laser and Vision Center | Phase 2 |
| Recruiting | Clinical Investigation for a Multifunction Ophthalmic Measurement Device NCT06565091 | Essilor International | N/A |
| Active Not Recruiting | Predicting Manifest Astigmatism in Keratoconus Patients. NCT06798779 | Royal Devon and Exeter NHS Foundation Trust | — |
| Recruiting | Investigator Initiated, Prospective Study of Xenia Corneal Lenticule NCT04741230 | The Royal Wolverhampton Hospitals NHS Trust | N/A |
| Completed | Efficacy of Corneal Cross-Linking (CXL) in the Treatment of Pediatric Keratoconus NCT07080983 | Al-Azhar University | N/A |
| Recruiting | Simultaneous pHototherapeutic Keratectomy and corneAl Collagen cRosslinking in Eyes With Keratoconus: a Random NCT06264024 | Oslo University Hospital | N/A |
| Active Not Recruiting | Epithelium-On Corneal Cross-linking in Subjects 8 to 45 Years of Age with Keratoconus NCT06100952 | Epion Therapeutics | Phase 3 |
| Active Not Recruiting | Epithelium-On Corneal Cross-linking in Subjects 8 to 45 Years of Age With Keratoconus NCT06100939 | Epion Therapeutics | Phase 3 |
| Unknown | Cyanocobalamin as Photosensitizing Agent NCT05395650 | EL Romany Ophthalmics Factory | — |
| Completed | Assessment of Corneal Biomechanical Properties Using Corvis ST Following LASIK, PRK, and CXL NCT06818461 | Beni-Suef University | — |
| Withdrawn | PXL-Platinum 330 in Eyes With Corneal Thinning Conditions NCT05489510 | Vishal Jhanji | Phase 1 / Phase 2 |
| Recruiting | Risk Factors and Progression of Keratoconus NCT05676580 | University Hospital, Montpellier | N/A |
| Not Yet Recruiting | Donors Predisposed by Corneal Collagen Cross-linking in Deep Lamellar Keratoplasty for the Patients With Kerat NCT05905978 | Zhongshan Ophthalmic Center, Sun Yat-sen University | N/A |
| Active Not Recruiting | A Study of a Novel Scheimpflug Device in Diagnosing Keratoconus NCT06119321 | Tianjin Eye Hospital | — |
| Recruiting | The Collagen Factors of Rapid Progression of Keratoconus in Children. NCT06722937 | Zhongshan Ophthalmic Center, Sun Yat-sen University | — |
| Unknown | Customized Crosslinking: Safety and Efficacy in an Epithelium-off Accelerated-pulsated Protocol for Thin Kerat NCT06159881 | Instituto de Oftalmología Fundación Conde de Valenciana | N/A |
| Unknown | Long-term Result of Placing Intracorneal Rings in Keratoconus Using Laser NCT05596838 | Elsan | — |
| Completed | Keratoconus Detection Using MS39 and Pentacam NCT05604443 | Johannes Kepler University of Linz | — |
| Completed | Effectiveness and Safety of Corneal Collagen Cross Linking After Induction of Stromal Emphysema in Keratoconus NCT07426029 | Cairo University | N/A |
| Completed | Accelerated Corneal Collagen Crosslinking Protocols NCT05693740 | Assiut University | N/A |
| Completed | Validation of Innovative Scheimpflug Topography Derived RGP Contact Lens Designs In Optometry Network NCT06312163 | Moorfields Eye Hospital NHS Foundation Trust | — |
| Unknown | Evaluation Of Deep Anterior Lamellar Keratoplasty By Anterior Segment Ocular Coherence Tomography NCT05345652 | Assiut University | — |
| Completed | Theranostic Guided Riboflavin/UV-A Corneal Cross-linking NCT05457647 | Regensight | N/A |
| Completed | Autologous Adipose-Derived Adult Stem Cell Implantation for Corneal Diseases (ADASCs-CT-CD) NCT05279157 | Vissum, Instituto Oftalmológico de Alicante | Phase 2 |
| Unknown | Assessment of Corneal Stiffness in Keratoconus After Crosslinking by Corvis ST and OCT. NCT05161052 | Cairo University | N/A |
| Unknown | Customized Contact Lenses NCT05134909 | University of Houston | N/A |
| Completed | Correlation Between Q-value Changes and Progression of Pediatric Keratoconus. NCT05114928 | Benha University | — |
| Recruiting | fMRI and IVCM Cornea Microscopy of CXL in Keratoconus NCT04439552 | Boston Children's Hospital | — |
| Withdrawn | The Role of Antioxidant Supplementation in Keratoconus Patients NCT02827747 | University of Miami | Phase 2 |
| Unknown | Accelerated Corneal Collagen Crosslinking for Keratoconus and Ectasia Using Pulse or Continuous UV-A Light NCT05027295 | Cornea and Laser Eye Institute | Phase 3 |
| Terminated | The Effect of Mitomycin C on Corneal Haze and Scarring After Corneal Crosslinking in Keratoconus Patients NCT04811924 | Ciusss de L'Est de l'Île de Montréal | Phase 2 |
| Active Not Recruiting | Initial Correction Keratoconus NCT04918316 | University of Illinois at Chicago | N/A |
| Unknown | Transepithelial (Epi-on) Corneal Collagen Crosslinking to Treat Keratoconus and Corneal Ectasia NCT04905108 | Cornea and Laser Eye Institute | Phase 3 |
| Enrolling By Invitation | Corneal Biomechanical Analysis Using Brillouin Microscopy NCT04598932 | The Cleveland Clinic | — |
| Unknown | Development of a Keratoconus Detection Algorithm by Deep Learning Analysis and Its Validation on Eyestar Image NCT04763785 | Insel Gruppe AG, University Hospital Bern | — |
| Completed | One-Year Outcomes After Conventional vs Accelerated Epi-Off Corneal Cross-Linking in Progressive Keratoconus ( NCT07194538 | Clinical Hospital Centre Zagreb | — |
| Unknown | Corneal Collagen Crosslinking for Keratoconus and Ectasia Using Riboflavin/Dextran or Riboflavin/Methylcellulo NCT04897503 | Cornea and Laser Eye Institute | Phase 3 |
| Completed | Validation Study on Eye Rubbing Questionnaire in Patients With or Suspected of Having a Keratoconus (KC) NCT04517903 | University Hospital, Bordeaux | N/A |
| Completed | Thyroid Gland Dysfunction and Vitamin D Polymorphism in Keratoconus NCT05073601 | Mansoura University | — |
| Completed | The Effect Of High And Low Molecular Weight Sodium Hyaluronic Acid Eye Drops After Crosslinking NCT06243991 | Marmara University | — |
| Completed | Efficacy of Customized Corneal Cross-linking vs. Standard Corneal Cross-linking NCT04532788 | Maastricht University Medical Center | N/A |
| Unknown | Gamma-Irradiated Corneal Inlay for Keratoconus NCT04895514 | Cornea and Laser Eye Institute | N/A |
| Completed | Safety & Effectiveness of the PXL-Platinum 330 System for CXL Using Riboflavin Solution NCT04667572 | Cornea Associates of Texas | Phase 1 |
| Active Not Recruiting | Wavefront Guided Scleral Lenses for Keratoconus and Irregular Astigmatism NCT04698590 | Cornea and Laser Eye Institute | N/A |
| Completed | Pilot Study to Investigate the Feasibility, Reliability and Efficacy of Utilizing OCT to Automate PROSE Fittin NCT04649177 | Boston Sight | N/A |
| Unknown | Pentacam Findings After Implantation of Intrastromal Corneal Rings in Keratoconus. NCT04562064 | Assiut University | — |
| Unknown | Epithelial Thickness Map NCT04578184 | Vienna Institute for Research in Ocular Surgery | N/A |
| Recruiting | Scleral Lens Fitting Using Wide-Field OCT NCT04570020 | Oregon Health and Science University | — |
| Completed | Safety and Efficacy of Intracanalicular Dexamethasone Compared to Loteprednol Etabonate in Patients With Kerat NCT04418999 | Illinois College of Optometry | EARLY_Phase 1 |
| Completed | Computer-aided Diagnosis of Ocular Diseases Based on Corneal Biomechanics NCT04475900 | Technische Universität Dresden | — |
| Terminated | Safety and Efficacy of Corneal Crosslinking Using the PXL-Platinum 330 for Eyes With Corneal Ectatic Condition NCT04240457 | Arbor Center for Eye Care | Phase 2 |
| Completed | Clinical Study - ES 900 - 2020-2 NCT04392349 | Haag-Streit AG | N/A |
| Unknown | Deep Anterior Lamellar Keratoplasty Using Dehydrated Versus Standard Organ Culture Stored Donor Corneas NCT04430244 | Istituto Internazionale di Ricerca e Formazione in Oftalmologia | N/A |
| Unknown | Safety and Effectiveness of the PXL-Platinum 330 System NCT04401865 | Colorado Eye Consultants/Cornea Consultants of Colorado | Phase 1 / Phase 2 |
| Completed | Safety and Effectiveness of the PXL-Platinum 330 System for CXL Using Riboflavin Solution NCT04177082 | Cornea Associates of Texas | Phase 1 |
| Unknown | The Additional Role of Supplemental Oxygen Therapy in Accelerated Corneal Collagen Cross-linking in Progressiv NCT04343326 | Shahid Beheshti University of Medical Sciences | Phase 2 / Phase 3 |
| Completed | Risk Factors for Inter-eye Asymmetry in Keratoconus Severity NCT07468253 | Centre Hospitalier Régional Metz-Thionville | — |
| Unknown | Keratoconus, Corneal Diseases and Transplant Registry NCT04164407 | University Hospital, Montpellier | — |
| Completed | Corneal Uptake of Riboflavin Eye Drops NCT04062435 | Luzerner Kantonsspital | N/A |
| Unknown | Intrastromal Corneal Ring Segments and Toric Phakic Posterior Intra-ocular Lenses Implantation in Keratoconus NCT05055349 | Minia University | N/A |
| Completed | CHOICE OF SUBJECTIVE OCULAR REFRACTION TECHNIQUE AND CORNEAL TOPOGRAPHY OF KERATOCONUS NCT04174209 | University Hospital, Clermont-Ferrand | N/A |
| Unknown | Corneal Biomechanical Changes of Allergic Conjunctivitis NCT04299399 | Zhongshan Ophthalmic Center, Sun Yat-sen University | — |
| Withdrawn | Myofibroblastic Transformation Secondary to Epithelial-stromal Interactions in the Keratoconus NCT03990740 | Fondation Ophtalmologique Adolphe de Rothschild | — |
| Completed | Retrospective Observational Study of Posterior Keratometry Measured NCT04422080 | University Hospital, Montpellier | — |
| Completed | Agreement and Accuracy of Different Devices Corneal Measurements NCT04383366 | Gerald Schmidinger | — |
| Recruiting | Safety and Effectiveness of the PXL-Platinum 330 System for Corneal Cross-Linking in Eyes With Corneal Ectasia NCT04094090 | Goodman Eye Center | Phase 2 |
| Unknown | Astigmatism in Keratoconus Patients NCT03450213 | Assiut University | N/A |
| Unknown | Prevelance of Keratoconus NCT04092426 | Assiut University | — |
| Recruiting | High Resolution, High-speed Multimodal Ophthalmic Imaging NCT04129021 | Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts | N/A |
| Withdrawn | Eye Rubbing and Keratoconus in Montpellier CHU NCT04249180 | University Hospital, Montpellier | — |
| Completed | Pocket Versus Tunnel ICRS for Treatment of Keratoconus NCT05748847 | Assiut University | N/A |
| Active Not Recruiting | Fresh Corneal Lenticule Implantation and Autologous Serum - Case Report NCT04594512 | Eye Hospital Pristina Kosovo | N/A |
| Unknown | Cross Linking Corneal Biomechanical Evaluation of CATS Tonometer Prism NCT04180111 | Intuor Technologies, Inc. | — |
| Recruiting | Comparison of Standard vs. Accelerated Corneal Crosslinking NCT03922542 | Price Vision Group | Phase 2 / Phase 3 |
| Completed | Photorefractive Intrastromal Crosslinking (PiXL) for the Treatment of Progressive Keratoconus NCT03990506 | Umeå University | N/A |
| Unknown | Epi-on PiXL for the Treatment of Progressive Keratoconus. NCT04668924 | Umeå University | N/A |
| Unknown | Corneal Collagen Cross-Linking (CXL) Performed With "Epi-ON" Versus "Epi-OFF" in Eyes With Keratoconus and Oth NCT03858036 | Center for Sight, Sacramento, CA | Phase 3 |
| Completed | Safety and Preliminary Efficacy of IVMED-80 Eye Drops in Keratoconus Patients NCT05241145 | iVeena Delivery Systems, Inc. | Phase 1 / Phase 2 |
| Completed | Supplementation With a Highly-Concentrated Docosahexaenoic Acid (DHA) Triglyceride in Patients With Keratoconu NCT05756062 | Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana | N/A |
| Unknown | Femtolaser Assisted Keratoplasty Versus Conventional Keratoplasty NCT03619434 | University of Southampton | N/A |
| Terminated | Optic Nerve Head Structural Response to IOP Elevation in Patients With Keratoconus NCT03560609 | NYU Langone Health | N/A |
| Completed | Refractive Corneal Cross-linking for Progressive Keratoconus NCT03531047 | Moorfields Eye Hospital NHS Foundation Trust | N/A |
| Completed | Custom Anterior Surfacing of Scleral Lens for Vision Quality Improvement in Patients With Keratoconus NCT03647046 | University of Rochester | N/A |
| Completed | Combined Corneal Wavefront-guided TPRK and ACXL Following ICRS Implantation in Management of Moderate Keratoco NCT04383301 | Shaaban Elwan | N/A |
| Completed | Endothelial Cell Loss After Penetrating Keratoplasty NCT04457063 | Alexandria University | Phase 2 / Phase 3 |
| Recruiting | Collagen Cross-linking in Keratoconus NCT03760432 | Oregon Health and Science University | N/A |
| Completed | Effect of Intracorneal Ring Segments on Posterior Corneal Tomography in Eyes With Keratoconus NCT04748198 | Ain Shams University | N/A |
| Unknown | The Possible Role of Thyroxine in Keratoconus Development NCT03637673 | Alexandria University | — |
| Unknown | Effects of Corneal Anatomical Match Between Donor and Recipient During DALK Surgery on Final Visual and Refrac NCT04130334 | Shahid Beheshti University of Medical Sciences | Phase 2 / Phase 3 |
| Recruiting | OCT in Diagnosis of Irregular Corneas NCT03504800 | Oregon Health and Science University | — |
| Completed | Preoperative Corneal Measurements Estimate the Corrected Distance Visual Acuity After Corneal Cross-linking NCT06522789 | Sistina Ophthalmology Hospital | N/A |
| Recruiting | Dresden Corneal Disease and Treatment Study NCT04251143 | Technische Universität Dresden | — |
| Unknown | Surface Ablation With Corneal Cross Linking in Mild Keratoconus NCT05176171 | Shahid Beheshti University | N/A |
| Unknown | Riboflavin at 4ºC for the Management of Pain After Crosslinking for Keratoconus Patients NCT03760770 | Instituto de Oftalmología Fundación Conde de Valenciana | N/A |
| Completed | Corneal Tomographic Parameters in TGD NCT04433936 | Ameera Gamal Abdelhameed | — |
| Unknown | Transepithelial Customized Cross-linking NCT04820608 | Ophthalmica Eye Institute | N/A |
| Unknown | Corneal Lenticule Implantation in Keratoconus Disease With Relex Smile Surgery NCT04591587 | Dr. Faruk Semiz | N/A |
| Unknown | Transepithelial Corneal Collagen Crosslinking in Eyes With Progressive Keratoconus NCT03584243 | University Hospital, Toulouse | N/A |
| Completed | Reliability of Topography Measurements in Keratoconus NCT03511495 | Milton S. Hershey Medical Center | — |
| Completed | Retrospective Digital Computer Analysis of Keratoconus Evolution - REDCAKE NCT03235856 | University Hospital, Antwerp | — |
| Completed | Topo-pachimetric Accelerated Epi-On Cross-linking Compared to Dresden Protocol Using Riboflavin With Vitamin E NCT05019768 | Ciro Caruso | N/A |
| Unknown | Corneal Stroma Implantation for the Treatment of Keratoconus NCT03229239 | Shandong Eye Hospital | N/A |
| Completed | Epi-On Corneal Crosslinking for Keratoconus NCT03245853 | Comprehensive EyeCare of Central Ohio | Phase 4 |
| Unknown | Corneal Thickness Changes With Scleral Contact Lenses NCT03249233 | University of Waterloo | N/A |
| Terminated | Dietary Riboflavin (Vitamin B-2) and Cornea Cross-Linking NCT03095235 | University of Missouri-Columbia | N/A |
| Unknown | Topography Versus Non-Topography-Guided PRK With CXL in Keratoconus NCT03890718 | Shahid Beheshti University | N/A |
| Completed | Impact of Scleral Contact Lens Wear on Corneal Nerves in Keratoconus NCT03091101 | University of Waterloo | N/A |
| Completed | Immunosuppression During Penetrating Keratoplasty, Using a Subconjunctival Implant Releasing Dexamethasone : T NCT02834260 | Centre Hospitalier Universitaire de Saint Etienne | Phase 2 |
| Completed | Epithelium-on Cross-linking Versus Observation of Fellow Eyes of Patients With Unilateral Clinically Evident K NCT06267495 | Assiut University | — |
| Terminated | Collagen Cross-Linking With Ultraviolet-A in Asymmetric Corneas NCT03029104 | Cxlusa | Phase 2 |
| Completed | KERatoconus and Metalloproteinases InvesTigation NCT02891655 | Fondation Ophtalmologique Adolphe de Rothschild | — |
| Completed | Performance and Safety Assessment of T4020 in Managing Corneal Epithelial Defect Following Epi-off Accelerated NCT02979054 | Laboratoires Thea | N/A |
| Completed | A Study to Test the Potential of Brillouin Microscopy for Biomechanical Properties Measurements in Human Corne NCT03220529 | Massachusetts General Hospital | N/A |
| Unknown | Keratoconus - Biomarkers and Questionnaire NCT02887326 | University of Aarhus | — |
| Completed | Evaluation of Safety and Efficacy of a Bioengineered Corneal Implant for Treatment of Keratoconus NCT04653922 | LinkoCare Life Sciences AB | N/A |
| Unknown | Evaluation of the Keratoconic Cornea After Corneal Collagen Cross Linking. NCT03879421 | Reham Mahmoud Abdelrahman | N/A |
| Completed | Accelerated Corneal Cross-linking With Different Riboflavin Solutions NCT03187912 | Medical University of Vienna | Phase 3 |
| Active Not Recruiting | McNeel Eye Center Corneal Crosslinking Study NCT02921009 | McNeel Eye Center | N/A |
| Unknown | Changes of Visual Function, Ocular Surface Structures and Physiology After Long-Termed Contact Lens Wear NCT02894489 | National Taiwan University Hospital | N/A |
| Completed | Changes in the Tear Film With Scleral Contact Lens Wear for Keratoconic Eyes NCT02806921 | University of Waterloo | N/A |
| Unknown | Safety and Effectiveness of Corneal Crosslinking (CXL): Keratoconus and Post-Refractive Ectasia NCT03080077 | Icahn School of Medicine at Mount Sinai | Phase 3 |
| Recruiting | Corneal Elastography and Patient Specific Modeling NCT03030755 | The Cleveland Clinic | — |
| Unknown | Corneal Transplantation Guided by OCT RESCAN NCT02736877 | Federal University of São Paulo | N/A |
| Completed | Epi-on CuRV and Epi-off aCXL Protocols in the Management of Keratoconus NCT07173907 | Gemini Eye Clinic | — |
| Unknown | Refractive Treatment of Early Keratoconus NCT02613780 | Ottawa Hospital Research Institute | Phase 3 |
| Recruiting | The K-Map Study, Global Prevalence of KC NCT03115710 | University Hospital, Geneva | — |
| Unknown | Corneal Tissue Inlay for Keratoconus NCT02649738 | Cornea and Laser Eye Institute | N/A |
| Unknown | Autologous Adipose-Derived Adult Stem Cell Transplantation for Corneal Diseases NCT02932852 | Vissum, Instituto Oftalmológico de Alicante | EARLY_Phase 1 |
| Completed | Scleral Versus Corneal RGP Contact Lenses in Irregular Cornea Disorders NCT02444923 | London South Bank University | N/A |
| Terminated | Corneal De-epithelization Associated With a Therapeutic Photokeratectomy in Patients With Evolutive Keratoconu NCT02857881 | Fondation Ophtalmologique Adolphe de Rothschild | N/A |
| Completed | Correlation Between Eye Rubbing and Keratoconus Severity in a Treatment-naive Keratoconic Population NCT02883881 | Centre Hospitalier Régional Metz-Thionville | — |
| Unknown | Cross-Linking ACcéléré Iontophorèse Confocal kératocONE NCT03429569 | University Hospital, Clermont-Ferrand | Phase 4 |
| Completed | Evaluation of Tomographic and Genetic Aspects of Keratoconus Patients Compared to Sounds Corneas NCT03071302 | Sao Jose do Rio Preto Medical School | N/A |
| Unknown | Biomechanical Properties of Keratoconic Eyes NCT02476149 | University of Plymouth | — |
| Completed | Astigmatic Vector Analysis of Posterior Cornea - a Comparison Among Healthy, Forme Fruste and Overt Keratoconu NCT02698709 | University of Sao Paulo | — |
| Unknown | Comparison Between Standard Deep Anterior Lamellar Keratoplasty (S-DALK) and Intralase Enabled Deep Anterior L NCT03732599 | University of Toronto | N/A |
| Unknown | A Novel Method to Assess the Cornea Biomechanical Properties With Schiotz Tonometer NCT02475343 | Zhiwei Li | N/A |
| Completed | Corneal Changes After Crosslinking in Keratoconus Patients Compared to the Untreated Fellow Eye NCT02428166 | Heidelberg University | — |
| Completed | Long Term Cornea Graft Survival Study NCT02849808 | Centre Hospitalier Universitaire de Besancon | — |
| Completed | Intraestromal Corneal Ring in Mild Keratoconus NCT03127163 | University of Sao Paulo | N/A |
| Completed | Distinguishing Healthy and Keratoconic Eyes Using Ultrahigh-Resolution OCT NCT03184610 | Medical University of Vienna | — |
| Completed | Familial Analysis of Keratoconus Risk NCT02812563 | University Hospital, Bordeaux | — |
| Completed | Fourier Transform of Videokeratography Data: Clinical Usefulness in Moderate and Frome Fruste Keratoconus NCT02617368 | Democritus University of Thrace | — |
| Completed | Impact of Cataract Surgery on Keratoplasty Graft Survival NCT02875145 | Centre Hospitalier Universitaire de Besancon | — |
| Unknown | Adapted Fluence Settings for Corneal Collagen Cross-linking in Mild to Moderate Progressive Keratoconus NCT02507362 | Tehran University of Medical Sciences | Phase 1 / Phase 2 |
| Completed | Simultaneous TransPRK and Corneal Collagen Cross-Linking NCT02208089 | Bruce Allan | N/A |
| Completed | Effect of CACICOL20 on Corneal Epithelial Healing After Cross-linking in Patients With Keratoconus NCT02119039 | Medical University of Vienna | Phase 4 |
| Completed | Epi Off Versus Epi on Corneal Collagen Cross-linking in Keratoconus Patients NCT03598634 | University of Molise | N/A |
| Completed | Investigation of Different Scanning Protocols for 3 Dimensional High-resolution Imaging of the Human Cornea Wi NCT01843101 | Medical University of Vienna | Phase 2 |
| Unknown | Treatment of Keratoconus With Advanced CXL-II NCT02514200 | Umeå University | Phase 2 |
| Completed | Tobacco Smoking Among Crosslinked-keratoconus Patients NCT03462355 | Centre Hospitalier Régional Metz-Thionville | — |
| Completed | Prevalence of Keratoconus in Inflammatory Bowel Diseases NCT02861339 | Central Hospital, Nancy, France | N/A |
| Completed | Objective and Subjective Diagnostic Parameters in the Fellow Eye of Unilateral Keratoconus NCT03288116 | Dar Al Shifa Hospital | — |
| Completed | Central Versus Peripheral Air Injection for DALK (Deep Anterior Lamellar Keratoplasty) NCT02485951 | Shahid Beheshti University of Medical Sciences | N/A |
| Terminated | Safety and Efficacy of Corneal Collagen Cross-Linking in Eyes With Keratoconus NCT01972854 | Glaukos Corporation | Phase 3 |
| Unknown | Study of the Safety and Effectiveness of Collagen Cross-Linking at an Irradiance of 9 mW/cm2 and 18 mW/cm2 NCT02009709 | Robert Mack, M.D. | Phase 1 |
| Terminated | OCT-guided LALAK for KCN NCT01901614 | Oregon Health and Science University | N/A |
| Completed | Corneal Epithelial and Stromal Thickness Distribution in Keratoconus NCT02023619 | SynsLaser Kirurgi AS | — |
| Completed | Treatment of Keratoconus With PALK Versus PK NCT02625467 | Instituto de Oftalmología Fundación Conde de Valenciana | Phase 1 |
| Recruiting | A Study to Test the Diagnostic Potential of Brillouin Microscopy for Corneal Ectasia NCT02118922 | Massachusetts General Hospital | — |
| Unknown | Myoring Versus Keraring Implantation for Keratoconus NCT01869517 | Shahid Beheshti University of Medical Sciences | Phase 2 |
| Completed | Iontophoretic Transepithelial Corneal Cross-linking in Pediatric Patients NCT03661164 | Luca Buzzonetti | — |
| Unknown | Identification and Validation of Functional Biomarkers for Keratoconus NCT01746823 | Narayana Nethralaya | — |
| Unknown | Evaluating the Safety and Efficacy of the KXL System for Corneal Collagen Cross-Linking in Eyes Having Keratoc NCT02638376 | Singapore Eye Research Institute | Phase 3 |
| Terminated | CXL-04 A Study of Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas NCT01956474 | Cxlusa | Phase 2 |
| Completed | Iontophoretic Transepithelial Collagen Cross-linking Versus Epithelium-off Collagen Cross-linking in Pediatric NCT03753009 | Bambino Gesù Hospital and Research Institute | — |
| Completed | Botulinum Toxin A for the Treatment of Keratoconus NCT01691651 | Federal University of São Paulo | N/A |
| Terminated | Study of the Safety and Effectiveness of Photochemically Induced Collagen Cross-Linking in Eyes With Keratocon NCT02762253 | Nvision Laser Eye Centers | Phase 2 |
| Unknown | Clinical and Structural Outcome of Conventional Versus Accelerated Corneal Collagen Cross-linking (CXL). NCT02883478 | Oslo University Hospital | Phase 1 / Phase 2 |
| Completed | Microwave Treatment and Corneal Collagen Crosslinking for Keratoconus NCT01672814 | Cornea and Laser Eye Institute | Phase 3 |
| Terminated | Safety & Efficacy of Corneal Collagen Cross-Linking in Eyes With Keratoconus or Corneal Ectasia After Refracti NCT01459679 | American-European Congress of Ophthalmic Surgery | Phase 3 |
| Completed | Safety and Efficacy Study of Corneal Collagen Cross-Linking in Eyes With Keratoconus NCT01643226 | Glaukos Corporation | Phase 3 |
| Completed | Comparison of Partial Removal and Total Removal of the Corneal Epithelium on Keratoconus NCT01809977 | Isfahan University of Medical Sciences | Phase 2 |
| Completed | Safety and Efficacy Study of Corneal Collagen Cross-Linking in Eyes With Keratoconus NCT01344187 | Glaukos Corporation | Phase 3 |
| Active Not Recruiting | Collagen Crosslinking for Keratoconus - a Randomized Controlled Clinical Trial NCT01604135 | Sahlgrenska University Hospital | Phase 3 |
| Completed | Conventional Collagen Crosslinking in Young Keratoconus NCT02008175 | Vasan Eye Care Hospital | N/A |
| Completed | CEI Van Outreach Screening Study NCT01510392 | Oregon Health and Science University | — |
| Completed | Femtosecond Laser-assisted Anterior Lamellar Keratoplasty NCT02301598 | The S.N. Fyodorov Eye Microsurgery State Institution | N/A |
| Unknown | Comparative Analysis of the Visual Performance After TICL Implantation in Patients With Stable Keratoconus NCT02833649 | Shahid Beheshti University | N/A |
| Unknown | Transepithelial Corneal Collagen Crosslinking for Keratoconus and Corneal Ectasia NCT01464268 | Cornea and Laser Eye Institute | Phase 3 |
| Terminated | Measurement of High Order Aberrations in Late Stages Keratoconus NCT01295164 | University Hospital, Toulouse | N/A |
| Completed | Accuracy of Curvature and Wavefront Aberrations of Posterior Corneal Surface, in Keratoconic and Post-CXL Corn NCT01527708 | Democritus University of Thrace | — |
| Completed | Standard Versus Transepithelial Corneal Crosslinking NCT02349165 | Nienke Soeters | N/A |
| Terminated | Twelve Month Clinical Evaluation of KeraSoft IC Soft Contact Lenses NCT01416272 | Bausch & Lomb Incorporated | N/A |
| Unknown | UVA-Riboflavin Crosslinking Treatment of Corneal Ectasia NCT01325298 | Mercy Center for Corrective Eye Surgery | Phase 2 |
| Completed | Variability of Pentacam-derived Back Elevation Measurements in Keratoconus and Cross-linked Corneas NCT01471873 | Democritus University of Thrace | — |
| Terminated | PENTACON Trial: Partial ENdothelial Trepanation in Addition to Anterior Lamellar Keratoplasty in keratoCONus NCT01145937 | UMC Utrecht | N/A |
| Completed | Photorefractive Keratectomy and Corneal Cross-linking in Keratoconus NCT02189447 | The Eye Center and The Eye Foundation for Research in Ophthalmology | N/A |
| Completed | MyoRing Implantation With Corneal Collagen Crosslinking for Keratoconus NCT02590549 | Ufa Eye Research Institute | N/A |
| Recruiting | The Homburg Keratoconus Center (HKC) NCT03923101 | Universität des Saarlandes | — |
| Completed | Laser Assisted Procedures in Penetrating Keratoplasty NCT02173847 | Ospedale Santo Stefano | N/A |
| Recruiting | Intacs Prescription Inserts for Keratoconus Patients NCT02138669 | University of Texas Southwestern Medical Center | N/A |
| Completed | Keratoconus Detection by Ultrasound NCT01403129 | Columbia University | — |
| Withdrawn | Higher Irradiance in Keratoconus Ectasia NCT01789333 | Stephen Trokel | N/A |
| Completed | Blurring Strength & Aberrometric Changes Following Corneal Cross-linking (CxL) and CxL Combined With Photorefr NCT01527721 | Democritus University of Thrace | N/A |
| Terminated | Safety Study of the VEGA UV-A System to Treat Keratoconus NCT01190306 | Topcon Medical Systems, Inc. | Phase 3 |
| Completed | Transepithelial Corneal Collagen Cross-linking (CXL) in Treatment of Keratoconus NCT01181219 | University Hospital of North Norway | Phase 2 |
| Unknown | Corneal Collagen Crosslinking for Progressive Keratoconus and Ectasia Using Riboflavin/Dextran and Hypotonic R NCT01152541 | Cornea and Laser Eye Institute | Phase 3 |
| Completed | Corneal Crosslinking in Patients With Keratoconus and Post-Refractive Ectasia NCT01143389 | Price Vision Group | Phase 2 |
| Unknown | Corneal Collagen Crosslinking and Intacs for Keratoconus and Ectasia NCT01112072 | Cornea and Laser Eye Institute | Phase 3 |
| Terminated | Cross-linking of Corneal Collagen (CXL) With Ultraviolet-A in Asymmetric Corneas NCT01189864 | Cxlusa | — |
| Completed | Standard Corneal Collagen Crosslinking Versus Transepithelial Corneal Crosslinking by Iontophoresis of Ribofla NCT02456961 | Ufa Eye Research Institute | N/A |
| Terminated | Corneal Cross Linking and Topography Guided Excimer Laser Treatment NCT01682993 | Medical University of Vienna | Phase 3 |
| Completed | Feasibility Study of the Vedera KXS for Treatment of Keratoconus NCT01069848 | Glaukos Corporation | N/A |
| Terminated | Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas (2) NCT01097447 | Cxlusa | — |
| Completed | Treatment of Keratoconus With Advanced Corneal Crosslinking NCT02425150 | Umeå University | N/A |
| Terminated | Collagen Crosslinking With Ultraviolet-A in Asymmetric Corneas NCT01024322 | Cxlusa | — |
| Completed | Corneal Collagen Cross-linking With Hypotonic Riboflavin in Corneas Thinner Than 400 Microns NCT00890266 | Moorfields Eye Hospital NHS Foundation Trust | N/A |
| Completed | Impact of Keratoconus, Cross-linking and Cross-linking Combined With Topo-guided Photorefractive Keratectomy o NCT01845714 | Democritus University of Thrace | N/A |
| Completed | Corneal Sensitivity Cross-linking Keratoconus NCT01743443 | Instituto de Olhos de Goiania | Phase 2 / Phase 3 |
| Completed | Comparison of WaveLight Analyzer and Alcon LadarWave NCT00863876 | WaveLight AG | — |
| Unknown | Orthokeratology for Keratoconus NCT00816569 | Hadassah Medical Organization | N/A |
| Unknown | Collagen Cross-Linking for Keratoconus/Ectasia With and Without Intacs NCT01081561 | Yaron S. Rabinowitz M.D. | Phase 2 / Phase 3 |
| Completed | T-Cat Laser & Cross-linking for Keratoconus NCT00777322 | Moorfields Eye Hospital NHS Foundation Trust | N/A |
| Unknown | Treatment of Keratoconus Using Collagen Cross-Linking NCT00841386 | University at Buffalo | Phase 2 / Phase 3 |
| Completed | Comparison of Anwar and Melles Techniques in Deep Anterior Lamellar Keratoplasty (DALK) for Keratoconus Patien NCT00850148 | Shahid Beheshti University of Medical Sciences | N/A |
| Completed | Evaluation of Topical Riboflavin Exposed to UVA Radiation and Implantation of Corneal Ring NCT00832897 | Federal University of São Paulo | N/A |
| Completed | Intrastromal Corneal Ring Segment Implantation in 219 Keratoconic Eyes at Different Stages NCT01261013 | Fernandez-Vega Ophthalmological Institute | — |
| Completed | Femtosecond Laser-Assisted Keratoplasty NCT01695811 | University of Michigan | — |
| Active Not Recruiting | German Corneal Cross Linking Register NCT00560651 | Suphi Taneri | — |
| Completed | Femtosecond Laser Assisted Keratoplasty NCT00802776 | University of Michigan | N/A |
| Completed | Corneal Topographer Fluorescein Patterns NCT00584285 | Christine Sindt | — |
| Completed | Riboflavin Mediated Corneal Crosslinking for Stabilizing Progression of Keratoconus NCT00626717 | University Hospital Freiburg | Phase 2 / Phase 3 |
| Unknown | Outcomes in a Comparison of Manual Penetrating Keratoplasty and the IntraLase® Enabled Keratoplasty NCT00566605 | Hospital Oftalmologico de Sorocaba | Phase 1 |
| Completed | Corneal Biomechanical Properties and Anterior Segment Parameters, in Forme Fruste Keratoconus NCT01448408 | Democritus University of Thrace | — |
| Unknown | Evaluating Collagen Cross-Linking (CCL) Treatment in Norway NCT00435799 | Ullevaal University Hospital | Phase 2 / Phase 3 |
| Unknown | Corneal Collagen Crosslinking With Riboflavin for Keratoconus Treatment: A Brazilian Study NCT00642044 | Universidade Federal do Rio de Janeiro | N/A |
| Unknown | Comparison of Penetrating Keratoplasty and Deep Lamellar Keratoplasty With the Big Bubble Technique for Kerato NCT00371202 | Shahid Beheshti University of Medical Sciences | Phase 3 |
| Completed | Relationship Between Central Corneal Thickness and Intraocular Pressure Measures Instruments. NCT00347191 | Aston University | — |
| Completed | Deep Anterior Lamellar Keratoplasty (DALK) NCT00887900 | Hospital Oftalmologico de Brasilia | Phase 3 |
| Completed | Lamellar Transplant With Lyophilized Corneas NCT00409955 | Federal University of São Paulo | Phase 2 |
| Unknown | Intacs for Keratoconus NCT00347230 | Singapore National Eye Centre | N/A |
| Completed | A Clinical Study of Keratoconus in Asian Patients and Assessment of Different Topographic Patterns of Keratoco NCT00347074 | Singapore National Eye Centre | — |
| Terminated | Management of Patients With Keratoconus With Intacs NCT00384501 | University Hospital of Crete | N/A |
| Unknown | The Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study NCT00000155 | National Eye Institute (NEI) | — |
| No Longer Available | Progressive Keratoconus or Ectasia Treatment Plan NCT01384773 | Stephen Trokel | — |