Trials / Recruiting
RecruitingNCT04439552
fMRI and IVCM Cornea Microscopy of CXL in Keratoconus
Neuroplasticity of Pain Pathways and Corneal Afferent Regeneration Following Corneal Crosslinking (CXL) in Keratoconus
- Status
- Recruiting
- Phase
- —
- Study type
- Observational
- Enrollment
- 60 (estimated)
- Sponsor
- Boston Children's Hospital · Academic / Other
- Sex
- All
- Age
- 8 Years – 35 Years
- Healthy volunteers
- Accepted
Summary
Evaluation of neuroplasticity of pain pathways and corneal afferent nerve regeneration following corneal crosslinking (CXL) in keratoconus patients using fMRI and corneal In Vivo Confocal Microscopy (IVCM).
Detailed description
Our long-term goal is to evaluate the transition from acute to chronic pain that sometimes occurs following CXL in keratoconus patients. This study will determine whether these changes can be structurally and functionally quantified using functional neuroimaging and in vivo corneal microscopy (IVCM), and whether they can be predicted based on predisposing biological and psychological factors. Our central hypothesis is that CXL produces acute pain through activation of trigeminal afferents, and that post-operative chronic pain outcomes are related to neuroplastic changes in trigeminal circuitry, corneal afferent regeneration, and psychological factors.
Conditions
- Pain, Postoperative
- Pain, Chronic
- Pain, Acute
- Surgical Injury
- Surgical Wound
- Cornea Injury
- Cornea
- Keratoconus
Timeline
- Start date
- 2021-10-04
- Primary completion
- 2027-08-01
- Completion
- 2027-12-01
- First posted
- 2020-06-19
- Last updated
- 2025-12-19
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT04439552. Inclusion in this directory is not an endorsement.