NCT00560651

German Corneal Cross Linking Register

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 7,500 (actual)
• Sponsor: Suphi Taneri · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Corneal Cross Linking is new treatment modality for patients with keratoconus. A keratoconus is characterized by progressive bulging and thinning of the eye's cornea. Keratoconus is a potentially severely sight impairing condition that may necessitate corneal transplantation in the progressive state. Corneal Cross Linking is designed to * increase the cornea's mechanical stability * to stop progression of bulging and thinning of the cornea * to prevent the need for corneal transplantation Corneal Cross Linking is performed by 1. Applying Riboflavin (Vitamin B2) eye drops every 2 minutes for 30 minutes to the cornea 2. Illuminating the cornea with UV-light This register of Corneal Cross Linking procedures performed in Germany serves to * gather long-term results * detect rare complications and side-effects * evaluate the efficacy in a large number of patients

Conditions

• Keratoconus

Interventions

Type	Name	Description
PROCEDURE	CCL (Corneal Cross Linking)	Apply Riboflavin 0.1% in Dextran 500 20% in NaCl solution Illuminate with UV-light of 365 nm wave-length and 3.0 mW/cm² intensity at 5 cm distance

Timeline

• Start date: 2007-11-01
• Primary completion: 2024-11-01
• Completion: 2027-11-01
• First posted: 2007-11-20
• Last updated: 2025-01-10

Locations

2 sites across 1 country: Germany