Trials / Completed
CompletedNCT02891655
KERatoconus and Metalloproteinases InvesTigation
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 23 (actual)
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild · Network
- Sex
- All
- Age
- 18 Years
- Healthy volunteers
- Not accepted
Summary
Corneal stromal thinning observed in keratoconic eyes could result from an increased synthesis of MMP at the level of the anterior stroma and the corneal epithelium induced by an overexpression of the Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) and Galectin-3 by epithelial cells. A differential expression of EMMPRIN, Galectin-3 and metalloproteinases (MMP) may be observed between the apex of the keratoconus and the peripheral cornea. Highlighting the implication of EMMPRIN and Galectin-3 could lead to the development of specific inhibitors to slow or to stop keratoconus evolution.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| OTHER | immuno-histo-chemical analysis | in vitro immuno-histo-chemical analysis of corneal epithelium |
Timeline
- Start date
- 2016-12-02
- Primary completion
- 2020-06-26
- Completion
- 2020-11-26
- First posted
- 2016-09-07
- Last updated
- 2020-12-10
Locations
1 site across 1 country: France
Source: ClinicalTrials.gov record NCT02891655. Inclusion in this directory is not an endorsement.