NCT03504800

OCT in Diagnosis of Irregular Corneas

Optical Coherence Tomography-Aided Differential Diagnosis and Treatment of Irregular Corneas

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 445 (estimated)
• Sponsor: Oregon Health and Science University · Academic / Other
• Sex: All
• Age: 14 Years – 85 Years
• Healthy volunteers: Accepted

Summary

This main goal of this study is to improve the detection, classification, monitoring, and treatment of irregular corneas due to keratoconus, warpage, dry eye, scar, stromal dystrophies, and other corneal conditions. The primary goal will be achieved by using optical coherence tomography (OCT) to: 1. Develop an OCT-based system to classify and evaluate corneal-shape irregularities. 2. Develop OCT metrics for more sensitive detection of keratoconus progression. 3. Develop OCT-and-topography guided phototherapeutic keratectomy (PTK) for irregular corneas.

Conditions

• Keratoconus
• Corneal Opacity
• Corneal Dystrophy

Interventions

Type	Name	Description
DEVICE	Optical Coherence Tomography	This device will be used to tightly classify corneal irregularities and determine eligibility of candidates from Group A into Groups B \& C.

Timeline

• Start date: 2018-05-01
• Primary completion: 2030-02-28
• Completion: 2031-02-28
• First posted: 2018-04-20
• Last updated: 2025-09-09

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated device study