NCT02875145

Impact of Cataract Surgery on Keratoplasty Graft Survival

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 453 (actual)
• Sponsor: Centre Hospitalier Universitaire de Besancon · Academic / Other
• Sex: All
• Age: 40 Years
• Healthy volunteers: Not accepted

Summary

The follow up time after keratoplasty now routinely exceeds multiple decades. It is common for keratoplasty patients to also undergo cataract surgery at a later date in their lives. Keratoplasties and cataract surgery both result in local inflammation. This may influence the density of endothelial cells, and on average there is a loss of 10% in endothelial cells within 3 months of the cataract surgery. Yet, a sufficient density of endothelial cells is required to maintain graft transparency. It may be therefore difficult to strike a balance between loss of visual acuity due to the cataract of to the loss of graft transparency over the long term. The investigators aim to compare graft survival in patients with clear crystalline lens with and without cataract surgery.

Conditions

• Cataract
• Fuchs' Endothelial Dystrophy
• Keratoconus

Interventions

Type	Name	Description
PROCEDURE	Cataract surgery

Timeline

• Start date: 2014-08-01
• Primary completion: 2015-08-01
• Completion: 2015-08-01
• First posted: 2016-08-23
• Last updated: 2016-08-23

Locations

1 site across 1 country: France