| Recruiting | PVEK Corneal Implant For Treatment of Corneal Edema NCT07325097 | Precise Bio | Phase 1 |
| Not Yet Recruiting | Brillouin Microscopy Used to Evaluate Corneal Mechanical Properties NCT06914817 | Vienna Institute for Research in Ocular Surgery | N/A |
| Recruiting | The Effects of Ripasudil in Patients With FED Undergoing Femtosecond Laser Assisted Cataract Surgery NCT06048380 | Singapore Eye Research Institute | Phase 3 |
| Recruiting | The OPTIMISE Study NCT05716945 | Maastricht University Medical Center | Phase 4 |
| Recruiting | Plasma Rich in Growth Factors in Corneal Endothelial Transplantation NCT06261346 | University of Miami | N/A |
| Recruiting | FECD-TRACE: Fuchs' Endothelial Corneal Dystrophy TRAjectory and Correlation With Genotype in the United Kingdo NCT06881771 | University College, London | — |
| Recruiting | Descemet Endothelial Thickness Comparison Trial II NCT05275972 | Stanford University | Phase 3 |
| Recruiting | Study to Assess Safety and Tolerability of Multiple Doses of EO2002 NCT05636579 | Asociación para Evitar la Ceguera en México | Phase 1 |
| Recruiting | The Belgian Endothelial Surgical Transplant of the Cornea NCT05436665 | University Hospital, Antwerp | N/A |
| Completed | Supine Positioning for Graft Attachment After Descemet Membrane Endothelial Keratoplasty NCT05399095 | University Eye Hospital, Freiburg | N/A |
| Completed | Impact of Donor Diabetes on DMEK Success and Endothelial Cell Loss NCT05134480 | Case Western Reserve University | N/A |
| Recruiting | Endothelial Side Up Inverted Femtosecond Laser Assisted DSAEK NCT06652321 | Dar El Oyoun Hospital | N/A |
| Completed | Netarsudil Use After Descemtorhexis Without Endothelial Keratoplasty NCT04752020 | Massachusetts Eye and Ear Infirmary | EARLY_Phase 1 |
| Completed | TTHX1114(NM141) in Combination With DWEK/DSO NCT04676737 | Trefoil Therapeutics, Inc. | Phase 2 |
| Active Not Recruiting | A Comparison of Visual Functions and Side-effects After DSAEK or DMEK for Fuchs' Endothelial Dystrophy NCT04417959 | University of Aarhus | N/A |
| Completed | Eye Drops for Early Morning-Associated Corneal Swelling of the Cornea NCT04140422 | University Eye Hospital, Freiburg | N/A |
| Completed | Rhopressa for Corneal Edema Associated With Fuchs Dystrophy NCT04051463 | Price Vision Group | Phase 2 / Phase 3 |
| Terminated | Trial of Netarsudil for Acceleration of Corneal Endothelial Restoration NCT03971357 | Price Vision Group | Phase 2 / Phase 3 |
| Withdrawn | Evaluation of Amphotericin B in Optisol-GS for Prevention of Post-Keratoplasty Fungal Infections. NCT04018417 | Cornea Research Foundation of America | Phase 2 / Phase 3 |
| Completed | The Effect Of Preoperative Parameters On Success After DMEK Surgery NCT04420429 | Beyoglu Eye Research and Education Hospital | — |
| Unknown | Ripasudil for Enhanced Corneal Clearing Following Descemet Membrane Endothelial Keratoplasty in Fuchs' Dystrop NCT03813056 | Michael D. Straiko, MD | Phase 2 |
| Completed | Netarsudil Use After Descemetorhexis Without Endothelial Keratoplasty NCT04057053 | Massachusetts Eye and Ear Infirmary | EARLY_Phase 1 |
| Unknown | Ripasudil 0.4% Eye Drops in Fuchs Endothelial Corneal Dystrophy NCT03575130 | University of Erlangen-Nürnberg Medical School | Phase 2 |
| Recruiting | Glanatec(R) for Descemet Stripping in Fuch's Endothelial Dystrophy NCT03249337 | Marian Macsai, MD | Phase 4 |
| Recruiting | Safety and Efficacy of Tissue Engineered Endothelial Keratoplasty NCT04319848 | Singapore Eye Research Institute | Phase 1 |
| Completed | Assessment of Corneal Graft Attachment in Patients With Fuchs Endothelial Corneal Dystrophy Following DMEK Usi NCT02542644 | Medical University of Vienna | N/A |
| Unknown | Air Versus SF6 for Descemet's Membrane Endothelial Keratoplasty (DMEK) NCT03407755 | Glostrup University Hospital, Copenhagen | N/A |
| Completed | Trial of Netarsudil for Prevention of Corticosteroid-induced Intraocular Pressure Elevation NCT03248037 | Cornea Research Foundation of America | Phase 3 |
| Completed | Risk Assessment for Progression to DMEK Following Cataract Surgery in Fuchs Endothelial Corneal Dystrophy NCT04072029 | Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal | — |
| Completed | Immunosuppression During Penetrating Keratoplasty, Using a Subconjunctival Implant Releasing Dexamethasone : T NCT02834260 | Centre Hospitalier Universitaire de Saint Etienne | Phase 2 |
| Completed | DMEK Versus DSAEK Study NCT02793310 | Maastricht University Medical Center | N/A |
| Unknown | Evaluation of the Efficacy of Descemet Membrane Transplantation for the Treatment of Fuchs' Endothelial Dystro NCT03275896 | Singapore National Eye Centre | EARLY_Phase 1 |
| Unknown | Phase 1 Study to Evaluate the Safety and Tolerability of EO1404 in the Treatment of Corneal Edema NCT04191629 | Valeria Sanchez-Huerta | Phase 1 |
| Completed | ODM 5 in the Treatment of Corneal Edematous Fuchs' Endothelial Dystrophy NCT02332109 | TRB Chemedica AG | — |
| Completed | Long Term Cornea Graft Survival Study NCT02849808 | Centre Hospitalier Universitaire de Besancon | — |
| Completed | Technique And Results In Endothelial Keratoplasty NCT02470793 | EDUARD PEDEMONTE-SARRIAS | N/A |
| Completed | Impact of Cataract Surgery on Keratoplasty Graft Survival NCT02875145 | Centre Hospitalier Universitaire de Besancon | — |
| Recruiting | DISCOVER Study: Microscope-integrated Intraoperative OCT Study NCT02423213 | The Cleveland Clinic | — |
| Recruiting | A Study to Test the Diagnostic Potential of Brillouin Microscopy for Corneal Ectasia NCT02118922 | Massachusetts General Hospital | — |
| Completed | The Molecular Pathogenesis of Late-onset Fuchs' Endothelial Corneal Dystrophy NCT01795001 | Universitaire Ziekenhuizen KU Leuven | — |
| Terminated | OCT-guided DSAEK Graft Shaping and Smoothing NCT01586234 | Oregon Health and Science University | N/A |
| Completed | PIONEER: Intraoperative and Perioperative OCT Study NCT02423161 | The Cleveland Clinic | — |
| Terminated | Using the Optovue OCT to Select IOL Power NCT01361282 | Legacy Health System | — |
| Unknown | DSAEK- Postoperative Positioning and Transplant Dislocation NCT01206127 | Oslo University Hospital | N/A |
| Completed | Fuchs' Torsional Phaco Study NCT00781027 | Maastricht University Medical Center | Phase 4 |
| Completed | Study of Eye Bank Pre-cut Donor Grafts for Endothelial Keratoplasty NCT00624221 | Cornea Research Foundation of America | N/A |