NCT01206127

DSAEK- Postoperative Positioning and Transplant Dislocation

• Status: Unknown
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: Oslo University Hospital · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Corneal transplant is a surgical procedure where a damaged or diseased cornea is replaced by donated corneal tissue (the graft) in its entirety (penetrating keratoplasty) or in part (lamellar keratoplasty). One type of lamellar keratoplasty is DSAEK (Descemet's Stripping Automated Endothelial Keratoplasty), where only the damaged posterior section of the cornea is replaced. The purpose of this study is to investigate how immediate postoperative positioning of the patient affects the dislocation rate of the corneal graft. Since this is a new surgical method, little scientific documentation has been published in this area.

Detailed description

Corneal transplant is a surgical procedure where a damaged or diseased cornea is replaced by donated corneal tissue (the graft) in its entirety (penetrating keratoplasty) or in part (lamellar keratoplasty). One type of lamellar keratoplasty is DSAEK (Descemet's Stripping Automated Endothelial Keratoplasty), where only the damaged posterior section of the cornea is replaced. To get the graft in the right position inside the eyes anterior chamber, the anterior chamber is fully filled with air, and the patient is placed in a supine position looking facing up for different amount of time depending on the surgeon. In this way the air bubble will press the graft in the right position and prevent dislocation. Our experience is that since the anterior chamber of the eye already is fully filled with air, it does not matter how the patient is positioned postoperatively regarding graft dislocation. Our hypothesis is that the immediate postoperative positioning is insignificant. If this can be significantly proved this may enhance the patients comfort postoperatively.

Conditions

• Corneal Transplantation
• Descemet Stripping Automated Endothelial Keratoplasty
• Fuchs' Endothelial Dystrophy
• Corneal Dystrophies, Hereditary

Interventions

Type	Name	Description
OTHER	Postoperative positioning: Bed rest	Patients in this group should be lying down facing up 2 hours postoperatively
OTHER	Postoperative positioning: Sitting up	Patients in this group should be sitting up in a chair 2 hours postoperative

Timeline

• Start date: 2010-09-01
• Primary completion: 2018-01-01
• Completion: 2018-01-01
• First posted: 2010-09-21
• Last updated: 2010-09-21

Locations

1 site across 1 country: Norway