| Not Yet Recruiting | Implementation of Routine Walking Speed Measurements in Older Veterans NCT07513805 | VA Office of Research and Development | N/A |
| Not Yet Recruiting | Vagus Nerve Stimulation to Enhance Memory in Aging NCT07214194 | Stanford University | N/A |
| Recruiting | Technical Development of Multi-Parametric Renocerebral MRI NCT02831335 | University of Minnesota | — |
| Not Yet Recruiting | Feasibility of A Smartphone Application Intervention in Community Settings: A Pretest-Posttest Pilot Study NCT07313540 | The University of Texas Medical Branch, Galveston | N/A |
| Not Yet Recruiting | Using Technology to Improve Function for Older Latinos With Disabilities in Underserved Areas NCT06425510 | University of Puerto Rico | N/A |
| Not Yet Recruiting | Cognitive Enhancement in Recurrent Depression (The COG-D-R Study) NCT07527273 | Vanderbilt University Medical Center | N/A |
| Not Yet Recruiting | Older Age and Generalization NCT07440017 | Caitlin Bowman | N/A |
| Not Yet Recruiting | AMPLIFI: Adaptive Modulation of Plasticity Through Lactate and Fitness Interventions NCT06950060 | University of Alabama at Birmingham | N/A |
| Not Yet Recruiting | Memory Enhancement in Aging With Optimal Dosing NCT07461584 | Boston University Charles River Campus | EARLY_Phase 1 |
| Not Yet Recruiting | Healthy Aging Through Optimized Exercise NCT07093216 | University of Alabama at Birmingham | N/A |
| Not Yet Recruiting | Anti-aging Efficacy Study on One Cosmetic Product Containing Mitopure NCT07517887 | Amazentis SA | N/A |
| Suspended | The Targeted Neurocognitive Training (TNT) Study NCT05773430 | University of Alabama at Birmingham | N/A |
| Not Yet Recruiting | Cognitive-Motor Training for AD/ADRD Prevention NCT07160582 | University of Illinois at Chicago | N/A |
| Recruiting | Amyloid PET Imaging in the Baltimore Longitudinal Study of Aging NCT07099053 | National Institute on Aging (NIA) | — |
| Not Yet Recruiting | IMAT Quality in Aging NCT07506681 | Washington University School of Medicine | N/A |
| Not Yet Recruiting | PrecisionAge Pilot Study NCT07523061 | Heike A. Bischoff-Ferrari, Prof. Dr. med., DrPH | N/A |
| Not Yet Recruiting | Multicomponent Exercise and Virtual Reality for Older Adults NCT07529743 | European University Miguel de Cervantes | N/A |
| Not Yet Recruiting | Precision Microbiota Interventions for Senoreduction Trial NCT07462767 | Louisiana State University Health Sciences Center in New Orleans | Phase 1 / Phase 2 |
| Not Yet Recruiting | Italian Validation of the Dynamic Neurocognitive Adaptation (dNA) Scale and Its Correlation With Neurocognitiv NCT07533084 | Neuromed IRCCS | — |
| Enrolling By Invitation | Low-intensity Hippocampal Transcranial Ultrasound Stimulation for Managing Cognitive and Sleep Dysfunction in NCT07298876 | Chinese University of Hong Kong | N/A |
| Not Yet Recruiting | Oral Antioxidant Therapy Targeted to the Mitochondria for Improving Brain Artery Health in Postmenopausal Wome NCT07406243 | Colorado State University | N/A |
| Recruiting | Effects of Physical Exercise and a Nutritional Supplement on Body Composition, Metabolic Function, and Overall NCT07504068 | University of Valencia | N/A |
| Recruiting | Effects of Three Different Exercise Programs on Dynamic Balance in Community-Dwelling Older Adults NCT07525453 | Fenerbahce University | N/A |
| Not Yet Recruiting | Older Adult Traditional Balance Training vs Traditional Balance Training Plus Neck Strengthening NCT07503899 | Ohio University | N/A |
| Not Yet Recruiting | Neuromuscular and Multi-Omics Synergy of Combined Creatine × HMB Supplementation Plus Exercise to Improve Musc NCT07275996 | Universidad de Burgos | N/A |
| Active Not Recruiting | Morning-Evening Specific Longevity Food Supplement NCT07416396 | University of Primorska | Phase 1 |
| Active Not Recruiting | Sex-Speciffic Longevity Food Supplements NCT07404449 | University of Primorska | Phase 1 |
| Recruiting | Skeletal Muscle Aging and Responsiveness in Aged People With MS NCT07500727 | Oklahoma Medical Research Foundation | N/A |
| Recruiting | Pain in Aging Former Athletes, Master's Athletes, and Nonathletes NCT07502742 | Marquette University | N/A |
| Not Yet Recruiting | The Impact of Aerobic Exercise Program on Immunosenescence Institutionalized Older Adults NCT07476911 | Instituto Politécnico de Castelo Branco | N/A |
| Not Yet Recruiting | Deciphering the Factors of Longevity Through a Multi-Omics Study in Long-Lived Individuals in Hong Kong NCT07356700 | Hong Kong University of Science and Technology | — |
| Not Yet Recruiting | SickleFit Randomized Control Trial NCT07442851 | Duke University | N/A |
| Not Yet Recruiting | Integrating Systematic Data of Medicine to Explore the Solution for Healthy Aging (ISDHA) Phase 4 NCT07414680 | Chang Gung Memorial Hospital | — |
| Active Not Recruiting | Obesity and Aging: Impacts of Nutritional Counseling and Physical Exercise on Telomeres and Senescence Paramet NCT07479940 | University of Sao Paulo | N/A |
| Recruiting | Tirzepatide to Slow Biological Aging NCT07220473 | The University of Texas Medical Branch, Galveston | Phase 2 |
| Recruiting | The GLUCID Study: Effect of Alcohol Reduction and Probiotic Interventions on Cognition and Brain Glucose Metab NCT07415707 | University of Miami | N/A |
| Recruiting | Testing Effectiveness of a Stochastic Noise Stimulator to Immediately Improve Balance and Gait NCT06688578 | Massachusetts Eye and Ear Infirmary | N/A |
| Recruiting | Effect of a Daily Supplement on Plasma PAI-1 Levels NCT07469475 | University of California, Los Angeles | Phase 1 / Phase 2 |
| Recruiting | Nicotinamide Mononucleotide Supplementation for Exercise Tolerance Improvement in Healthy Older Adults NCT07144527 | Scott Silveira | N/A |
| Recruiting | Video Game Intervention In Older Adults NCT07433608 | Biruni University | N/A |
| Active Not Recruiting | Effects of Adapted Sports on Balance, Physical Function, and Cognitive Function in Older Adults NCT07457996 | Alanya Alaaddin Keykubat University | N/A |
| Recruiting | Aurora: AI-Based Narrative Intervention to Support Emotional Well-Being in Clinical and Non-Clinical Populatio NCT07494110 | Universitat Autonoma de Barcelona | N/A |
| Not Yet Recruiting | Assessing Biological Aging in a Real-World Medical Weight Loss Program Using the LinAge2 Clinical Clock NCT07444073 | National University of Singapore | — |
| Not Yet Recruiting | Strength and Pain-Coping Through Resilience and Knowledge NCT07228520 | Johns Hopkins University | N/A |
| Active Not Recruiting | Effects of Functional Task Training on Muscle Health and Function in Older Adults With Sarcopenia NCT07494916 | Universidad de Granada | N/A |
| Recruiting | Effects of Telerehabilitation-Based Dual-Task Exercises on Balance, Fall Risk, Cognitive Function, and Sleep Q NCT07472101 | Bulent Ecevit University | N/A |
| Recruiting | The Role of Sirolimus in Preventing Functional Decline in Older Adults NCT05237687 | Irina Timofte | Phase 2 |
| Recruiting | MTOR Inhibitors in Older Adults NCT06727305 | University of Texas Southwestern Medical Center | Phase 1 / Phase 2 |
| Not Yet Recruiting | PhoRTE® Therapy Efficacy: In-Person Versus Telehealth NCT06934265 | University of Southern California | N/A |
| Not Yet Recruiting | Macrophage/Monocyte Driven Inflammation and Anesthetic Sensitivity in Aging NCT07372417 | University of Chile | — |
| Recruiting | Cognitive Remediation NCT07171450 | Cutter Lindbergh | N/A |
| Not Yet Recruiting | Comprehensive Geriatric Assessment in Primary Care NCT07341061 | Nova Scotia Health Authority | N/A |
| Not Yet Recruiting | Restructuring the Alpha-Gamma Code in Aging Vision NCT07208318 | Boston University Charles River Campus | EARLY_Phase 1 |
| Recruiting | A Randomized Controlled Trial Comparing Whole Body Vibration Therapy With Usual Care and Usual Care to Improve NCT07205133 | Changi General Hospital | N/A |
| Recruiting | Annual Wellness Visits vs GRACE-augmented Annual Wellness Visits For Older Adults With High Needs - Phase 2 NCT07166861 | Massachusetts General Hospital | N/A |
| Recruiting | Molecular Indicators of Systematic Fitness NCT07393841 | VO Health, Inc. | — |
| Not Yet Recruiting | Aquatic Exercise and Reactive Balance NCT05107817 | Eadric Bressel | N/A |
| Not Yet Recruiting | The Impact of Brief Behavioral Treatment for Insomnia Versus Brief Mindfulness Treatment on Cognition and Slee NCT07272863 | University of Alabama, Tuscaloosa | N/A |
| Not Yet Recruiting | TA-65 and Aging Associated Microvascular Dysfunction NCT05598359 | Medical College of Wisconsin | N/A |
| Not Yet Recruiting | Westlake Aging Cohort (WeAC) NCT07373444 | Westlake University | — |
| Not Yet Recruiting | Effects of Rehabilitative Exergame Training on Foot Muscle Activity, Balance, and Mobility in Older Adults NCT07357662 | Tarsus University | N/A |
| Recruiting | Impact of Funcional Exercise and Supplementation in Perimenopausal Women's Health NCT07251296 | University of Valencia | N/A |
| Recruiting | Supplement and Exercise Effects on Stationary Immunity and Health in Older Adults NCT07251244 | University of Valencia | N/A |
| Recruiting | Evaluation of the Effect of Seasonality on Biological Age in Adults NCT07242833 | Société des Produits Nestlé (SPN) | — |
| Recruiting | Understanding Aided Speech Perception in Noise NCT06377215 | University of South Florida | N/A |
| Enrolling By Invitation | Neural Control of Gait & Navigation in ADRD NCT06501820 | University of Florida | N/A |
| Not Yet Recruiting | Effect of a Multicomponent Therapeutic Exercise Program in Primary Care on Frailty and Sarcopenia in Older Adu NCT07132632 | Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina | N/A |
| Recruiting | Investigating the Persisting Effects of a Single Dose of Psilocybin on Structural Plasticity in Healthy Older NCT06367738 | University of California, Berkeley | Phase 1 |
| Not Yet Recruiting | Elderberry Functional Gum and Cognitive & Oral Health in Older Adults NCT07054645 | Burdur Mehmet Akif Ersoy University | N/A |
| Recruiting | Ultrasound for Healthy Aging NCT07168525 | The University of Texas Health Science Center at San Antonio | N/A |
| Completed | Investigation of Flexibility, Strength, and Posture in Women Practicing Reformer Pilates Across Different Age NCT07358091 | Istanbul Medipol University Hospital | N/A |
| Recruiting | FAXAGE: Fasting And Exercise To Slow Aging In Humans NCT07207044 | University of Copenhagen | N/A |
| Not Yet Recruiting | Assessing How the Body Responds to Increased Phosphate Intake, and How This Response Depends on Age and Sex. NCT07149337 | University of Zurich | N/A |
| Recruiting | Exploratory Study on a Multi-nutrient Supplement and Exercise Program for Improving Health Markers Associated NCT07454616 | National University of Singapore | N/A |
| Recruiting | IH, Brain Health, and T2D NCT07173543 | Darren P Casey | N/A |
| Active Not Recruiting | Research on the Evolution, Geometry, and Alterations of the Periorbital Region Based on Age and Deformations NCT07080320 | Centre Hospitalier Universitaire, Amiens | N/A |
| Recruiting | Evaluation of Urolithin A and Fisetin on Improving Sleep and Aging Biomarkers NCT06990256 | Huazhong University of Science and Technology | N/A |
| Not Yet Recruiting | Clinical Performance and Safety of STYLAGE® HydroMax NCT07153237 | Laboratoires Vivacy | N/A |
| Recruiting | Walking Sensation Study NCT06975423 | University of Florida | N/A |
| Recruiting | Aquatic Exercises Combined With Cognitive Tasks for Older Adults NCT07156708 | Federal University of Pelotas | N/A |
| Not Yet Recruiting | Emotion, Aging, and Decision Making NCT06071130 | DePaul University | N/A |
| Recruiting | Emotional Well-being and Measures of Healthy Aging NCT07334106 | Northwestern University | N/A |
| Recruiting | Effect of Heated Water-Based Versus Land-Based Exercise Training on Hemodynamic Variables, Functional Capacity NCT07131748 | Universidade Estadual Paulista Júlio de Mesquita Filho | N/A |
| Not Yet Recruiting | Study of the Safety and Efficacy of Natural Genome Reconstruction Technology of Hematopoietic Stem Cells in Ad NCT06877377 | S.LAB (SOLOWAYS) | N/A |
| Enrolling By Invitation | PUER ("Previously Unrecognized Emerging Risks") Life Clinical Study (PUER) in Ages 6 Through 18 NCT06802029 | Puer Research, LLC | — |
| Withdrawn | Impact of T Cells on Age-related Vascular Dysfunction: A Translational Approach NCT04344873 | University of Utah | EARLY_Phase 1 |
| Not Yet Recruiting | Effects of Exercise, Cognitive Training, and Their Combination in Institutionalized Older Adults NCT07082504 | University of Salamanca | N/A |
| Not Yet Recruiting | Plant vs Animal-based Protein Sources as an Anabolic and Metabolic-protective Options for SO in Older Adults NCT07030738 | Tel-Aviv Sourasky Medical Center | N/A |
| Enrolling By Invitation | Iterative Design Trial to Assess Dietary Supplements and Other Aging-targeted Therapies NCT07202403 | Atria Research and Global Health Institute (ARGHI) | N/A |
| Recruiting | Effects of Polyphenol Supplementation and Exercise on Physical Performance in Older Adults NCT07441343 | Dr. Chris McGlory, PhD | N/A |
| Recruiting | Cognitive Vitality Pilot Study NCT07208279 | Arizona State University | N/A |
| Recruiting | Pain and Split-belt Motor Learning in Older Adults NCT07054840 | University of Delaware | N/A |
| Active Not Recruiting | Evaluation of the Efficacy of Calcium a -Ketoglutarate(AKG-Ca) in Improving Human Aging NCT07114536 | Shenzhen Hygieia Biotech Co., Ltd | N/A |
| Recruiting | Effects of Whole-body Electrical Muscle Stimulation Exercise on Spinal Motoneuronal Activation in Older Adults NCT06689618 | University of Missouri-Columbia | N/A |
| Recruiting | BID WM Digital Intervention in Aging NCT06918704 | University of California, San Francisco | N/A |
| Recruiting | RESTOR: PK/PD mTORi Inhibition in Older Adults NCT06658093 | The University of Texas Health Science Center at San Antonio | EARLY_Phase 1 |
| Completed | Efficacy of Four Topical Products to Improve Skin Longevity NCT07118943 | Amazentis SA | N/A |
| Completed | Using Reinforcement Learning to Personalize Electronic Health Record Tools to Facilitate Deprescribing NCT06660979 | Brigham and Women's Hospital | N/A |
| Recruiting | The Impact of Biological Mechanisms of Aging on Response Variability to Resistance Training in Older Adults NCT06940037 | Mayo Clinic | N/A |
| Withdrawn | Age-independent Decline in Manual Dexterity of Middle-aged and Older Adults NCT03803566 | University of Colorado, Boulder | N/A |
| Active Not Recruiting | Impact of a Novel Brain Longevity Supplement Containing the Postbiotic Urolithin A (Mitopure) on Cognitive Fun NCT07060898 | Amazentis SA | N/A |
| Active Not Recruiting | Fortifying Healthy Behaviors, Optimizing Medical Therapies and Enhancing Cognitive Function in Older Adults-pi NCT07000734 | Washington University School of Medicine | Phase 2 |
| Active Not Recruiting | Combination Gerotherapeutic Interventions for Healthspan Improvement NCT07475546 | AgelessRx | Phase 3 |
| Recruiting | Identifying the Limits of Survivability in Heat-exposed Older Females NCT07032493 | University of Ottawa | N/A |
| Recruiting | Dehydration, Rehydration, and Impact on Physiology NCT07084675 | Texas Tech University | N/A |
| Not Yet Recruiting | Chinese Art Activities or Combined With Peer Group Participation on Psychological Well Being NCT06841133 | Prince of Songkla University | N/A |
| Recruiting | Tesamorelin as an Adjunct to Exercise for Improving Physical Function in HIV NCT06554717 | Massachusetts General Hospital | Phase 2 |
| Recruiting | Project SIRT6 Activator NCT07500649 | National University of Singapore | N/A |
| Withdrawn | Safety, Tolerability, and Pharmacokinetics of an Oral Withania Somnifera Product in Older Adults NCT07008300 | Oregon Health and Science University | EARLY_Phase 1 |
| Recruiting | Brain Research Assessing Impacts of Neurophysiological Processing Speed Training in Veterans NCT06217575 | University of Alabama at Birmingham | N/A |
| Recruiting | Cognitive-Motor Exergame Training in Frail Adults NCT07074639 | Eleftheria Giannouli | N/A |
| Completed | Effects of Short-Term Resistance Training on Diaphragm Thickness, Hepatic Fat Density, and Quality of Life in NCT07449767 | Gümüşhane Universıty | N/A |
| Recruiting | Effect of Walnuts on Cognitive Function and Gut Microbiome in Older Adults NCT06942351 | Oregon State University | N/A |
| Completed | Effect of Inspiratory Muscle Training on Diaphragm Muscle Thickness, Fatty Liver Density and Aerobic Capacity NCT07193082 | Gümüşhane Universıty | N/A |
| Active Not Recruiting | Sustainable Exercise and Nutrition Programs for Managing Metabolic Disorders in Older Women NCT07015307 | University of Alicante | N/A |
| Not Yet Recruiting | Theory-Driven Manualized Approach to Improving New Learning and Memory in Healthy Aging and MCI NCT06269939 | Kessler Foundation | N/A |
| Recruiting | Heterogeneity of Vascular Adaptations to Exercise With Aging in Women and Men NCT06912984 | University of Colorado, Denver | N/A |
| Active Not Recruiting | Metabolite Changes Following Consumption Of Different Protein Drinks In Singapore Older Adults NCT06956131 | National University of Singapore | N/A |
| Completed | Effectiveness of Graded Training in the Vivifrail Exercise Program Among Long-Term Care Residents NCT06975449 | China Medical University Hospital | N/A |
| Recruiting | Effect of Snacks on Aging NCT06879626 | University of California, Los Angeles | N/A |
| Not Yet Recruiting | Project ICOPE Brazil: Assessment of Intrinsic Capacity in Brazilian Older Adults NCT06968702 | University of Sao Paulo | — |
| Completed | Beta Glucan 500 and Biological Age and Immune Age NCT07104929 | OvationLab | Phase 2 |
| Recruiting | Implementation of Neuromuscular Electrical Stimulation After Total Knee Arthroplasty NCT06953375 | University of Colorado, Denver | N/A |
| Recruiting | Examining the Effects of Theta Burst TMS on Brain Connectivity and Balance Ability in Older Adults With Balanc NCT06779188 | Weinberg Medical Physics LLC | EARLY_Phase 1 |
| Recruiting | Metabolic Control of Aging and Disease - the MetAGE Deep Phenotyping Cohort NCT06511297 | Thomas Scherer | — |
| Withdrawn | Trunk Control Training and Walking in Older Adults NCT06782919 | Beth Israel Deaconess Medical Center | N/A |
| Recruiting | Heat, Microvascular Function and Aging NCT06633198 | William Hughes | EARLY_Phase 1 |
| Recruiting | Arterial Stiffness and Blood Pressure NCT06495710 | VA Office of Research and Development | N/A |
| Completed | Age-dependent EEG Characteristics During Desflurane Anesthesia From Adults to Elderlies NCT07240870 | Chinese PLA General Hospital | — |
| Recruiting | Links Between Cognitive Deficits During Normal or Pathological Aging and Slow Waves Measured in EEG NCT06501495 | Assistance Publique - Hôpitaux de Paris | N/A |
| Completed | Anti-aging Efficacy of Food Supplement and Cosmetic Routine NCT06932770 | Amazentis SA | N/A |
| Not Yet Recruiting | Use of Virtual Reality for the Assessment of Attentional and Reaction Abilities for Fall Risk Evaluation NCT06940245 | I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio | — |
| Not Yet Recruiting | Systemic Activation of Inflammasomes and Frailty in Older Candidates to Kidney Transplantation NCT06887075 | University Hospital, Bordeaux | N/A |
| Recruiting | Sedentary or Exercised : Neuromuscular and Immunometabolic Observations and Retrospection NCT06692543 | Centre Hospitalier Universitaire de Nice | N/A |
| Recruiting | The Effects of Cosmetic Acupuncture NCT06952959 | China Medical University Hospital | N/A |
| Not Yet Recruiting | Emotion, Aging, and Forgiveness: Protocol for a Feasibility of Randomized Controlled Trial NCT06679452 | University of Maia | N/A |
| Not Yet Recruiting | Monitoring of Brain Metabolites Using Proton and Deuterium MR Techniques NCT06705010 | Insel Gruppe AG, University Hospital Bern | N/A |
| Recruiting | The Efficacy of a Technology-Assisted Block Training Program on Cognitive Function, Hand Dexterity, and Grip S NCT07315724 | National Taipei University of Nursing and Health Sciences | N/A |
| Recruiting | Improving PCP Advance Care Planning for People With ADRD NCT06565169 | University of Pittsburgh | N/A |
| Recruiting | Brain Activity During Complex Walking in People With Atypical Parkinsonian Syndromes NCT06906276 | Karolinska Institutet | — |
| Recruiting | Continuous Connected Patient Care (CCPC), a Pilot Testing a Novel Device for Continuous Vitals Monitoring - Ol NCT06638060 | Medtronic - MITG | — |
| Recruiting | Ketone Ester And Salt (KEAS) in Older Adults NCT06868719 | Indiana University | N/A |
| Recruiting | Exploring the Role of the Prefrontal Cortex in Decision-Making NCT07080489 | University of Bern | N/A |
| Recruiting | Role of Menopause in Thermoregulation NCT06798571 | Penn State University | Phase 4 |
| Recruiting | Robot-based Intervention to Improve Physical Activity in Older Adults NCT06843161 | University of Ottawa | N/A |
| Active Not Recruiting | A Pilot Study on Reverse Aging (The REVERSE Study) NCT07354620 | The Christ Hospital | EARLY_Phase 1 |
| Recruiting | Apple Health Study NCT06958523 | Apple Inc. | — |
| Not Yet Recruiting | Interactive Exergaming With Otago Exercise Program on Mobility in Community-Dwelling Older Adults NCT06814678 | National Taiwan University | N/A |
| Recruiting | Skin Barrier Function and Inflammation in Aging: The BIA Study NCT06750653 | University of California, San Francisco | Phase 4 |
| Recruiting | Targeting Aging With a Ketone Ester for Function in Frailty NCT06645847 | Buck Institute for Research on Aging | N/A |
| Recruiting | Optimizing Strength Training in Older Adults NCT06812143 | Queens College, The City University of New York | N/A |
| Recruiting | Impact of Extreme Heat on Myocardial Blood Flow and Flow Reserve in Young and Older Adults NCT06842784 | University of Texas Southwestern Medical Center | — |
| Completed | Multidomain Interventions for Elderly Individuals in Residential Structures NCT06820710 | Istituto di Neuroscienze Consiglio Nazionale delle Ricerche | N/A |
| Not Yet Recruiting | Evolution of the Relationship Between Central and Peripheral Arterial Wave Velocities as a Function of Age NCT06742775 | University Hospital, Grenoble | — |
| Completed | Crossfit in Special Population NCT07199114 | University of Jaén | N/A |
| Recruiting | Multidimensional Predictive Modeling to Understand Mechanisms of Exercise Response Heterogeneity in Older Adul NCT06507189 | Florida Institute for Human and Machine Cognition | N/A |
| Recruiting | Mindfulness for Cognition in Early-stage Alzheimer's Disease NCT06792877 | VA Boston Healthcare System | N/A |
| Recruiting | Spinal Networks of Balance Learning and Retention in Older Adults NCT06517043 | University of Florida | N/A |
| Recruiting | Mechanisms of Anabolic Resistance in Older Humans NCT06617195 | Mayo Clinic | — |
| Enrolling By Invitation | Simulation-informed Modelling and Personalized Evaluation (SIMPLE) in Ageing Populations NCT06572332 | Chinese University of Hong Kong | — |
| Recruiting | Fiber and Calcium Absorption in Older Men NCT06519877 | VA Office of Research and Development | Phase 2 |
| Recruiting | Leveraging Social Networks to Improve Sleep and Mindfulness Among Older Adults in Residential Housing Faciliti NCT06989619 | Brigham and Women's Hospital | N/A |
| Recruiting | The NADage Study: Nicotinamide Riboside Replenishment Therapy Against Functional Decline in Aging NCT06208527 | Haukeland University Hospital | Phase 2 |
| Completed | Effects of Action Observation Therapy in Geriatric Individuals NCT07418970 | Hasan Kalyoncu University | N/A |
| Recruiting | The Association Between Core Temperature and Health NCT06432491 | Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences | N/A |
| Completed | Development, Validity, and Reliability of the Reactive Skill Test in Older Adults NCT07103837 | Balikesir University | N/A |
| Not Yet Recruiting | Oral 'Breath Test' to Measure Anabolic Sensitivity to a Protein Meal Across the Age and Physical Activity Spec NCT06744491 | University of Toronto | — |
| Recruiting | Effectiveness of Alternative Therapies in Maintaining Weight Loss Achieved by GLP-1 Medications Post-Cessation NCT07092618 | AgelessRx | Phase 2 / Phase 3 |
| Completed | Augmented Reality Treadmill Walking for Cognitive and Physical Health in Older Adults NCT07074613 | National Taiwan College of Performing Arts | N/A |
| Enrolling By Invitation | Geriatric Oncology Care in Brazil: Remote Geriatric Assessment-Driven Interventions With Supportive Care NCT07084454 | Cristiane Decat Bergerot, PhD | Phase 3 |
| Recruiting | Multicomponent Prehabilitation in Older Adults With Breast Cancer NCT07531836 | Fundacion Miguel Servet | N/A |
| Recruiting | Optimizing Prevention of Hospital-Acquired Disability Through Multidomain Interventions NCT06611228 | University of Milano Bicocca | N/A |
| Withdrawn | Methylglyoxal (MGO) Lowering Cocktail to Reduce Appetite in Obese Individuals NCT05083546 | University of California, San Francisco | Phase 1 / Phase 2 |
| Recruiting | Study on Aging and Cognitive Impairment in China NCT06679296 | First Affiliated Hospital of Wenzhou Medical University | — |
| Completed | Lagged Relationships Between Sleep, Balance, and Cognition in Older Adults NCT06584136 | University of Florida | — |
| Recruiting | Enhancing Heat Resiliency in Older Adults During Indoor Overheating Via Heat Acclimation by Warm Water Immersi NCT06670365 | University of Ottawa | N/A |
| Completed | Effect of Creatine+HMB Supplementation in Physically Active Older Adults NCT05951439 | Universidad de Burgos | N/A |
| Active Not Recruiting | Digital Literacy Intervention to Address Support, Literacy and Communication in Older Adults NCT06479707 | Johns Hopkins University | N/A |
| Completed | Development of Web-Based Mind-Body Trainings for Adults With Subjective Concerns NCT06410807 | Ohio State University | — |
| Not Yet Recruiting | DNA Methylation Trajectories in Aging NCT06582992 | University of Campania Luigi Vanvitelli | — |
| Recruiting | Lifestyle for the BRAin Health - Time Restricted Eating and Mindfulness NCT07042087 | St. Anne's University Hospital Brno, Czech Republic | N/A |
| Enrolling By Invitation | Adaptive Cognitive Training on Cognitive Function in Elderly Diabetes Patients in the Community NCT06524388 | Fanfan Zheng | N/A |
| Enrolling By Invitation | Adaptive Cognitive Training on Cognitive Function in Elderly Hypertension Patients in the Community NCT06512922 | Peking University | N/A |
| Recruiting | Modulating Neurocognitive Processes of Learning to Trust and Distrust in Aging NCT05457725 | University of Florida | N/A |
| Active Not Recruiting | Personalized Approach to Promote Healthy Aging NCT06734468 | Arizona State University | N/A |
| Recruiting | The Mito-Frail Trial: Effects of MitoQ on Vasodilation, Mobility and Cognitive Performance in Frail Older Adul NCT06027554 | UConn Health | Phase 2 |
| Terminated | Early Variations in Immune Aging NCT06295354 | Radboud University Medical Center | — |
| Recruiting | Aging, Beta Blockers, and Thermoregulatory Responses NCT06582680 | University of Texas Southwestern Medical Center | Phase 4 |
| Recruiting | Non-randomized Clinical Trial on Cognitive Stimulation With Virtual Reality in Patients With Mild Cognitive Im NCT06977815 | Badalona Serveis Assistencials | N/A |
| Completed | Health Effects of Taekwondo Training for Elderly Over the Age of 60 Years NCT07451288 | Vegard Vereide Iversen | N/A |
| Active Not Recruiting | One Year of Velocity-based Resistance Training in Older People Living in Nursing Homes NCT07027397 | University of Castilla-La Mancha | N/A |
| Recruiting | Fisetin to Reduce Senescence and Mobility Impairment in PAD NCT06399809 | Northwestern University | Phase 2 |
| Recruiting | Impact of Grape Powder Consumption on Eye Health and Glycemic Status in Singapore Older Adults NCT06349304 | National University of Singapore | N/A |
| Recruiting | Study of the Evolution of the Expression of the LAMP-2 Protein During the Advance in Age NCT06357923 | Centre Hospitalier Universitaire de Nice | N/A |
| Recruiting | Early Neurovascular Adaptations in Aging Women NCT06520982 | University of Missouri-Columbia | EARLY_Phase 1 |
| Recruiting | Molecular Optimization Via Exercise (MOVE) NCT06540287 | Buck Institute for Research on Aging | — |
| Recruiting | Precision Vibration Therapy for Neuromuscular and Functional Improvement in Older Adults and Stroke Survivors NCT07351877 | National Health Research Institutes, Taiwan | N/A |
| Active Not Recruiting | Accelerating Cognitive Gains From Digital Inverventions With Noninvasive Brain Stimulation NCT06633952 | University of California, San Francisco | N/A |
| Recruiting | Studying the Effects of Digital Interventions on Cognition, Wellbeing, Stress, and Sleep in Older Adults NCT06633978 | University of California, San Francisco | N/A |
| Not Yet Recruiting | Psycho-educational Intervention Programme for Comprehensive Preparation for Retirement: Study Protocol NCT06533202 | University of Salamanca | N/A |
| Recruiting | Chronic Wounds and Blood Circulation Detection NCT07330635 | National Health Research Institutes, Taiwan | N/A |
| Active Not Recruiting | Greens-Based Crossover Trial to Improve Epigenetic Aging in Adults NCT06537232 | Auburn University | N/A |
| Completed | A Multidimensional Health Perspective: Analysis of the Effects of Yoga Intervention on Sleep Disorders in Olde NCT07061158 | Beijing Sport University | N/A |
| Completed | Effect of Acupressure on Quality of Life, Sleep Quality, and Hopelessness in Older Adults NCT07435246 | Kocaeli Sağlık ve Teknoloji Üniversitesi | N/A |
| Recruiting | Arlington Aging Study NCT06857877 | The University of Texas at Arlington | — |
| Unknown | Effects of Resveratrol Supplementation on Oocyte Quality NCT06235294 | Unidade Local de Saúde de Coimbra, EPE | N/A |
| Recruiting | Lifestyle for the BRAin Health - Nutrition and Exercise Training Intervention NCT06986096 | Slovak Academy of Sciences | N/A |
| Recruiting | Effects of Resistance-band Training and Creatine Supplementation Strategies in Healthy Older Adults NCT06606704 | University of Regina | N/A |
| Completed | Effects of Acute Pain on Motor Learning in Young vs Older Adults NCT05471557 | University of Delaware | N/A |
| Recruiting | Empagliflozin Reversal of Arterial StiffnEss in Aging NCT06506422 | University of Missouri-Columbia | Phase 2 / Phase 3 |
| Completed | Impact of Urolithin A (Mitopure) on Mitochondrial Quality in Muscle of Frail Older Adults NCT06556706 | Amazentis SA | N/A |
| Recruiting | ENhancing Exercise With LIGHT to Improve Functioning in PAD NCT06399900 | Northwestern University | N/A |
| Recruiting | Synbiotic to Attenuate Resorption of the Skeleton NCT06389539 | Hebrew SeniorLife | N/A |
| Enrolling By Invitation | Evaluating Implementation and Impact of the Adapted Choose to Move (CTM) Program NCT06252259 | University of British Columbia | N/A |
| Active Not Recruiting | Non-Invasive Vagus Nerve Stimulation Combine Postural Training in the Elderly NCT06768112 | National Cheng-Kung University Hospital | N/A |
| Recruiting | Western Diet on Cardiometabolic and Immune Function NCT06528977 | University of Delaware | N/A |
| Recruiting | Impact of Regular Consumption of Eggs and Nutrients Fortified Eggs on Eczema Condition in Singapore Individual NCT06454942 | National University of Singapore | N/A |
| Recruiting | Transient Receptor Potential Channels NCT06444594 | Penn State University | EARLY_Phase 1 |
| Completed | Effects of a Very Low Carbohydrate Ketogenic Diet or Mediterranean Diet on Markers of Musculoskeletal Health i NCT06203392 | University of Florida | N/A |
| Not Yet Recruiting | Buyuan-zhixiao Formula in the Treatment of Elderly Patients With Diabetes and Multiple Metabolic Disorders NCT06358118 | Qing Ni | N/A |
| Recruiting | Resistance Exercise Training in the Older Population With Obesity NCT06367296 | Universidad de La Frontera | N/A |
| Active Not Recruiting | DIAMOND-Lewy Guidelines for Antipsychotic Use in Older Patients NCT06357195 | Ohio State University | — |
| Recruiting | Pilot Study on Evaluating the Geroprotective Effect of Metformin NCT06459310 | Xuanwu Hospital, Beijing | Phase 2 |
| Active Not Recruiting | Novel Respiratory Training as Part of Palliative Care for Older Adults With Heart Failure NCT06576297 | University of Pittsburgh | N/A |
| Completed | The Balance Recovery Confidence (Brc) Scale NCT06444061 | Necmettin Erbakan University | — |
| Recruiting | The Peripheral Blood Multi-Omics Study on Sleep Loss NCT06492109 | First Affiliated Hospital of Zhejiang University | N/A |
| Enrolling By Invitation | Effects of Asymmetries on Binaural-Hearing Abilities Across the Lifespan NCT06953700 | University of Maryland, College Park | N/A |
| Active Not Recruiting | RHA® Redensity With New Anesthetic Agent Perioral Rhytids (PAS) NCT06378086 | Teoxane SA | N/A |
| Recruiting | Impact of Early Aging and Menopause on the Vascular Responses to Hypoxia NCT06417177 | University of Missouri-Columbia | EARLY_Phase 1 |
| Recruiting | Cardiometabolic Consequences of the Loss of Ovarian Function NCT06264882 | University of Colorado, Denver | Phase 4 |
| Unknown | Metabolic Dysregulation as Biomarker of Frailty: Role of the Mitochondrial Dysfunction NCT06433427 | University Hospital of Ferrara | — |
| Recruiting | Effect of Multicomponent Exercises VIVIFRAIL® in Older Adults NCT06271239 | Pontificia Universidade Católica do Rio Grande do Sul | N/A |
| Unknown | Effect of Infections and Global DNA Methylation on Frailty Trajectories in Hospitalized Older Patients (INFRAG NCT06430073 | University Hospital of Ferrara | — |
| Not Yet Recruiting | Tai Chi Chuan Combined With Walking on Physical and Mental Parameters of Older Adults NCT06380413 | Federal University of Pelotas | N/A |
| Completed | Nordic Walking Training Program for Sustaining Independent Walking in Older Adult Evacuees NCT06404216 | University of Haifa | N/A |
| Recruiting | Rapalog Pharmacology (RAP PAC) Study NCT05949658 | University of Wisconsin, Madison | Phase 1 |
| Completed | The Effect of Intermittent Fasting on Brain Health NCT06019195 | University of Oklahoma | N/A |
| Recruiting | Breaking Sitting with High-intensity Interval Training for Brain Health NCT06243016 | University of Illinois at Urbana-Champaign | N/A |
| Not Yet Recruiting | Hydraulic Resistance and Older Adults NCT06353438 | College of Staten Island, the City University of New York | N/A |
| Not Yet Recruiting | Development and Content Validation of the Childhood Early Oral Aging Syndrome (CEOAS) Index for the Deciduous NCT06378385 | University of Nove de Julho | — |
| Completed | Music, Virtual Reality for Patients in IUGM NCT06296199 | Centre integre universitaire de sante et de services sociaux du Centre-Sud-de-l'Île-de-Montréal | N/A |
| Recruiting | Childhood Early Oral Aging Syndrome: Prevalence, Etiological Factors, and Consequences on Occlusion NCT06381414 | University of Nove de Julho | — |
| Completed | Cooling Strategies for Older Adults in the Heat NCT06349616 | Penn State University | N/A |
| Completed | Sustainable Insect-based Protein Supplement in the Elderly: a Pilot Study NCT07456319 | Universitat Oberta de Catalunya | N/A |
| Unknown | The Relationship Between Leisure Activities and Aging Anxiety in Women NCT06206057 | Marmara University Pendik Training and Research Hospital | — |
| Recruiting | Studies Into Touch in Healthy Humans to Provide Sensory Feedback in Prostheses NCT05548322 | Institut National de la Santé Et de la Recherche Médicale, France | N/A |
| Recruiting | Fatty Acid Modulation of Brain Function in Older Adults NCT06192407 | University of Vermont | N/A |
| Not Yet Recruiting | Development and Validation of the Polish Geriatric Core Set. NCT06365996 | University of Rzeszow | — |
| Recruiting | Evaluating a National Person-Centered Training Program to Strengthen the Dementia Care Workforce NCT06239688 | University of North Carolina, Chapel Hill | N/A |
| Completed | Inspiratory Muscle Training in Postmenopausal Women NCT06459674 | Indiana University | N/A |
| Recruiting | Sleep Apnea and Cognition in Older Adults NCT06423118 | Sunnybrook Health Sciences Centre | — |
| Terminated | Ashwagandha Pharmacokinetics Study in Older Adults NCT06171724 | Oregon Health and Science University | EARLY_Phase 1 |
| Recruiting | Evaluation of Efficacy of Anthelios Sunscreen on Face Versus Usual Routine on Signs of Aging NCT06697288 | Cosmetique Active International | N/A |
| Recruiting | Enhancing Attention and Wellbeing Using Digital Therapeutics NCT06397469 | University of California, San Francisco | N/A |
| Recruiting | Gerofit and Cognition NCT06107842 | VA Office of Research and Development | N/A |
| Completed | Zinde Zihin Program to Reduce Alzheimer's Disease Risk in Adults Aged 65 and Older NCT07244848 | Burdur Mehmet Akif Ersoy University | N/A |
| Completed | Effects of HIIT in Older Adults NCT07170579 | Instituto Politécnico de Bragança | N/A |
| Not Yet Recruiting | Study Human Digital Support Transitional Care NCT06354166 | Divoluci | N/A |
| Completed | The Effect of Horticultural Therapy on Loneliness and Life Satisfaction in Elderly Adults Living in Nursing Ho NCT06311825 | Istanbul University - Cerrahpasa | N/A |
| Recruiting | Skeletal Muscle Mitochondria in Ageing NCT06539078 | VU University of Amsterdam | — |
| Recruiting | Magnetic Resonance Imaging (MRI) and Eye-tracking Predictive Markers of Cognitive Ageing. NCT06058897 | University Hospital, Toulouse | N/A |
| Recruiting | The Preventive Role of Fractionated Laser Resurfacing Against Actinic Neoplasia in an At-Risk Geriatric Popula NCT06428721 | Wright State University | N/A |
| Completed | The Immu-KNEE-ty Study NCT05920148 | Wageningen University | — |
| Active Not Recruiting | Music Improvisation Training on Cognitive Function in Older Adults NCT06721390 | University of California, San Francisco | N/A |
| Unknown | Physical Literacy-Based Intervention for Chronic Disease Management NCT06325306 | University of Liege | N/A |
| Recruiting | Autonomous At Home with Occupational Therapy Support and Assistive Devices NCT06819982 | Université Catholique de Louvain | N/A |
| Completed | Impact of Sociodemographic, Psychological, and Quality of Life Factors on Dual-Task Performance in Elderly Ira NCT06476561 | Çankırı Karatekin University | — |
| Recruiting | Large-scale Multi-omics Analysis of Cerebrospinal Fluid NCT06636201 | Second Affiliated Hospital, School of Medicine, Zhejiang University | — |
| Unknown | Spatial and Ocular Trajectories for the Early Diagnosis of Alzheimer's Disease. NCT06213766 | Hospices Civils de Lyon | N/A |
| Recruiting | bpMedManage: Digital Technology to Support Adherence to Hypertension Medications NCT06307574 | University of Arizona | N/A |
| Recruiting | Guided Episodic Future Thinking to Increase Physical Activity Adherence and Promote Healthy Brain Aging NCT06123182 | University of Kansas Medical Center | N/A |
| Active Not Recruiting | Evaluation Of DNA Methylation Pattern In Healthy, Sarcopenic, Obese And Sarcopenic Obese Older Women: A Cross- NCT06618430 | University of Sao Paulo | — |
| Enrolling By Invitation | Effects of Resistance Training and Supplementation in Elderly: Cardiorespiratory and Metabolic Variables NCT06682221 | Federal University of São Paulo | Phase 3 |
| Recruiting | Far Red Light to Improve Functioning in PAD NCT06165016 | Northwestern University | N/A |
| Completed | Effects of Regular Exercise on Sensory-motor Functions and Fall Risk in the Elderly NCT06891014 | Cyprus International University | N/A |
| Recruiting | Threonine Requirement in Adults >60 Years of Age NCT06225648 | The Hospital for Sick Children | N/A |
| Completed | A Study to Evaluate Efficacy of Dietary Ingredient in Vitality and Metabolic Factors in Healthy Individuals NCT06188949 | Vedic Lifesciences Pvt. Ltd. | N/A |
| Unknown | EXercise Capacity and TRAinability in Type 2 Diabetes (EXTRA-T2D) NCT05860842 | University of Roma La Sapienza | N/A |
| Unknown | Investigating the Effects of a Museum Intervention on the Psychological and Cardiac Health of Older Adults NCT06130358 | Louis Bherer | N/A |
| Completed | THE EFFECT OF EXERGAMING APPLICATION AND AUTOGENIC RELAXATION TECHNIQUE ON PSYCHOLOGICAL WELL-BEING AND LIFE E NCT06965959 | Cumhuriyet University | N/A |
| Active Not Recruiting | Time-specific Exercise in Circadian Context NCT06746649 | Comenius University | N/A |
| Unknown | Environmentally Sustainable Nutrition for Older Adults (55+) With Obesity NCT06192732 | Amsterdam University of Applied Sciences | N/A |
| Not Yet Recruiting | Cognitive and Neural Assessment Platform and Localized Norm for Macau Older Adults. NCT06239922 | University of Macau | — |
| Completed | Effects of an Aging Simulation Suit on Clinical Empathy in Healthcare Professionals Working in Long-Term Care NCT07280689 | Universidad Rey Juan Carlos | N/A |
| Active Not Recruiting | Towards Understanding Between ADT Treatment, Circadian Rhythm, and Physiological Responsiveness NCT05968144 | University of Maryland, Baltimore | Phase 1 / Phase 2 |
| Active Not Recruiting | NEUROmuscular Training for Enhanced AGE Longevity NCT06620666 | University of Valencia | N/A |
| Recruiting | Development and Evaluation of TRIVEL Smart Bike Training Prescription Programs. NCT06386536 | Sylvie Nadeau | N/A |
| Recruiting | Adipose Tissue Blood Flow in Aging Humans NCT06096532 | Mayo Clinic | N/A |
| Completed | Assessing Cognitive and Health Improvements in the Elderly Via Exercise (ACHIEVE) - Study. NCT06052644 | University of Jaén | N/A |
| Completed | Effect of Vitamin D on Body Composition and Functionality of Older Adults NCT07275177 | Universidad Autónoma Benito Juárez de Oaxaca | N/A |
| Completed | Self-Adaptive Immersive Virtual Reality Serious Game to Enhance Motor Skill Learning and Attention in Older Ad NCT06141642 | Laval University | N/A |
| Recruiting | The Role of Neutrophils in the Age-driven Decline in Anti-pneumococcal Vaccine Responses NCT06128915 | State University of New York at Buffalo | Phase 4 |
| Completed | Physical Function From the Perspective of Active Ageing NCT06733818 | Suleyman Demirel University | — |
| Completed | L-Citrulline and Endothelial Function NCT05722860 | University of Oklahoma | Phase 1 |
| Terminated | Heat Waves and the Elderly With COPD NCT06295523 | University of Texas Southwestern Medical Center | N/A |
| Completed | DaxibotulinimtoxinA for Treatment of Platysmal Neck Bands NCT06225492 | Main Line Center for Laser Surgery | Phase 4 |
| Completed | Taurine in Periodontitis and Aging NCT06635369 | Istanbul Medipol University Hospital | N/A |
| Enrolling By Invitation | Twins MR Imaging Study NCT06014567 | King's College London | — |
| Completed | Efficacy of Ceiling Fans for Mitigating Thermal Strain During Bed Rest in Older Adults During Heat Waves NCT06142890 | University of Ottawa | N/A |
| Active Not Recruiting | Isa-Pom-Dex in Elderly/Frail Subjects With RRMM NCT05911321 | UNC Lineberger Comprehensive Cancer Center | Phase 2 |