NCT07373444

Westlake Aging Cohort (WeAC)

Westlake Aging Cohort

• Status: Not Yet Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 2,800 (estimated)
• Sponsor: Westlake University · Academic / Other
• Sex: All
• Age: 55 Years – 90 Years
• Healthy volunteers: Accepted

Summary

The Westlake Ageing Cohort (WeAC) is a longitudinal cohort study conducted in Hangzhou, Zhejiang Province, China. The investigators aim to enroll 2,800 participants aged 55 years and older for long-term follow-up. The population will include individuals with neurodegenerative diseases or those at the prodromal stage of cognitive impairment, as well as healthy middle-aged and older adults serving as controls. The investigators will collect their sociodemographic, dietary, lifestyle, clinical, and neuroimaging data, as well as biological samples.

Detailed description

The investigators will recruit middle-aged and aged participants, including healthy controls and individuals with neurodegenerative disorders such as mild cognitive impairment (MCI), Alzheimer's disease (AD), Parkinson's disease dementia (PDD), and dementia with Lewy bodies (DLB), etc. The aim of this study is to construct a longitudinal database that includes sociodemographic, lifestyle, clinical, neuroimaging, and multi-omics data. This database will be used to characterize the molecular signatures of neurodegenerative disorders. In addition, the investigators will identify biomarkers associated with neurodegenerative diseases. Furthermore, the investigators aim to uncover the mechanisms underlying the progression of mild cognitive impairment (MCI) and other neurodegenerative disorders.

Conditions

• Aging
• Cognition Improvement
• Cognition Disorders
• Cognition

Timeline

• Start date: 2026-01-01
• Primary completion: 2030-12-31
• Completion: 2031-12-31
• First posted: 2026-01-28
• Last updated: 2026-01-28

Locations

2 sites across 1 country: China