NCT06802029

PUER ("Previously Unrecognized Emerging Risks") Life Clinical Study (PUER) in Ages 6 Through 18

A Prospective, Non-Randomized, Multi-Center Observational Study to Establish a Physical Baseline Profile for Individual Study Subjects Using Various Modalities and Identify Deviations Via Longitudinal Monitoring for Participants Ages 6 Through 18

• Status: Enrolling By Invitation
• Phase: —
• Study type: Observational
• Enrollment: 10,000 (estimated)
• Sponsor: Puer Research, LLC · Network
• Sex: All
• Age: 6 Years – 18 Years
• Healthy volunteers: —

Summary

The goal of this observational study is to learn about changes in health in children that develop over time that may impact overall health and a healthy lifespan. The main questions it aims to answer are: * What are the changes in health that impact overall health and lifespan in children; and * What test(s) are best at finding changes in health in children?

Detailed description

The two parts of the PUER Research study include (1) Baseline health assessment and (2) blood tests including genetic, molecular, and laboratory profiling. The Baseline assessment will consist of a health history questionnaire interview. Genetic assessment will be conducted using peripheral blood samples. Molecular and laboratory assessments will be conducted using peripheral blood samples and, potentially, urine, stool, and/or saliva samples. The study will result in cross-sectional and longitudinal real world data collection to inform if any tests used can inform of health changes for individuals and may predict long-term health outcomes. Researchers at study sites will not be blinded to the data being collected during this study.

Conditions

• Aging

Interventions

Type	Name	Description
GENETIC	Whole Genome Sequencing Analysis	Laboratory blood analysis

Timeline

• Start date: 2025-09-01
• Primary completion: 2029-12-31
• Completion: 2030-12-31
• First posted: 2025-01-30
• Last updated: 2025-08-07

Locations

1 site across 1 country: United States