NCT07272863

The Impact of Brief Behavioral Treatment for Insomnia Versus Brief Mindfulness Treatment on Cognition and Sleep Health in Adults (Age 50+) With HIV

The Impact of BBTI on Cognition and Sleep Health in Older Adults With HIV

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 214 (estimated)
• Sponsor: University of Alabama, Tuscaloosa · Academic / Other
• Sex: All
• Age: 50 Years – 99 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to examine the effects of a telephone-delivered Brief Behavioral Treatment Insomnia (BBTI) versus a Brief Mindfulness Treatment (BMT) on cognitive and sleep outcomes in older adults with HIV. The main questions it aims to answer are: What are the effects of BBTI vs BMT on self-reported and observed sleep outcomes in older adults with HIV and insomnia up to 1-year post-intervention? What are the effects of BBTI vs BMT on self-reported and observed cognitive comes in older adults with HIV and insomnia up to 1-year post-intervention? What is the association between Alzheimer's Disease biomarkers and sleep and cognitive outcomes in older adults with HIV receiving BBTI vs BMT? Participants will: * Complete 4 weeks of telephone-delivered BBTI or BMT * Attend baseline, post-intervention, and 1-year post in-person visits for sleep and cognitive assessments * Have blood collected at all three time points

Conditions

• Insomnia
• Cognition
• Aging
• HIV

Interventions

Type	Name	Description
BEHAVIORAL	BBTI	4-week intervention delivered via telephone (once a week for 30 minutes)
BEHAVIORAL	BMT	4-week intervention delivered via telephone (once a week for 30 minutes)

Timeline

• Start date: 2026-01-01
• Primary completion: 2030-09-01
• Completion: 2030-09-01
• First posted: 2025-12-09
• Last updated: 2026-01-29

Locations

2 sites across 1 country: United States