NCT07149337

Assessing How the Body Responds to Increased Phosphate Intake, and How This Response Depends on Age and Sex.

Assessing Human Phosphate Tolerance and Its Dependency on Age and Sex

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (estimated)
• Sponsor: University of Zurich · Academic / Other
• Sex: All
• Age: 25 Years – 70 Years
• Healthy volunteers: Accepted

Summary

Kidney function declines with age and this could affect phosphate balance after an acute phosphate load (increased phosphate intake). In daily life, we regularly experience acute phosphate loads through our diet. The aim of this clinical study is to determine whether the body's response to increased phosphate intake changes with age and whether there are sex differences in this response.

Detailed description

Forty subjects (males and females aged 18-25 or 63-70) will ingest an oral phosphate load, after which their body's response will be assessed by collecting blood and urine samples over a period of ten hours.

Conditions

• Aging
• Kidney Disease
• Mineral Metabolism

Interventions

Type	Name	Description
OTHER	Oral phosphate load	Participants ingest an oral phosphate load containing 558 mg of phosphorus once.

Timeline

• Start date: 2025-09-30
• Primary completion: 2026-09-30
• Completion: 2027-09-01
• First posted: 2025-09-02
• Last updated: 2025-09-02