Trials / Recruiting
RecruitingNCT07207044
FAXAGE: Fasting And Exercise To Slow Aging In Humans
FAXAGE: A Randomized, Controlled Clinical Trial Of Fasting And Exercise To Slow Aging In Humans
- Status
- Recruiting
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- 240 (estimated)
- Sponsor
- University of Copenhagen · Academic / Other
- Sex
- All
- Age
- 20 Years
- Healthy volunteers
- Accepted
Summary
FAXAge is a randomized controlled trial investigating the effects of fasting and exercise on human aging. 240 participants over the age of 65 will be divided into 4 groups - an exercise group, a fasting group, a combined exercise and fasting group and a control group. The intervention will last for one year, and tests of biomarkers of aging will be performed at baseline, after 3 months, 6 months and at the end of the intervention. A reference group of participants over the age of 20 equally distributed by age and sex will be used to train an algorithm for determination of biological age. The study will include both physical, molecular and digital biomarkers including DNA-methylation, VO2max, body composition and face- and voice-age. The main outcome of the project is DNA-methylation age at week 52. Secondary outcomes are the rest of the tested biomarkers at week 52. It is hypothesised that the intervention groups will have similar superior benefits after the 52 weeks of intervention.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| BEHAVIORAL | Exercise - Strength + Cardio | Supervised strength training 2x/week + self-administered cardio training 2x/week. |
| BEHAVIORAL | Time-restricted feeding | Time-restricted feeding in a 16/8 regimen - 16 hours of fast and 8 hours of eating per day. |
| BEHAVIORAL | Time-restricted feeding + Exercise | Strength and cardio exercise 2x/week each combined with time-restricted feeding in a 16/8 regimen. |
Timeline
- Start date
- 2025-10-01
- Primary completion
- 2027-08-30
- Completion
- 2042-08-30
- First posted
- 2025-10-03
- Last updated
- 2026-01-28
Locations
1 site across 1 country: Denmark
Source: ClinicalTrials.gov record NCT07207044. Inclusion in this directory is not an endorsement.