NCT07415707

The GLUCID Study: Effect of Alcohol Reduction and Probiotic Interventions on Cognition and Brain Glucose Metabolism in Normal Aging Adults Who Are High-Risk Alcohol Drinkers

Effect of Alcohol Reduction and Probiotic Interventions on Cognition and Brain Glucose Metabolism in Normal Aging Adults Who Are High-Risk Alcohol Drinkers

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: University of Miami · Academic / Other
• Sex: All
• Age: 65 Years – 84 Years
• Healthy volunteers: Not accepted

Summary

The goal of this pilot study is to explore a combination of two interventions: (1) a behavioral alcohol-reduction intervention using motivational interviewing, and (2) a blinded probiotic microbiome or placebo intervention. The study examines whether these interventions improve cognitive and neurophysiological function, including brain metabolism, in older adults who are high-risk alcohol drinkers.

Conditions

• Aging
• Alcohol Drinking

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Visbiome	Participants will receive 900 billion Colony Forming Units (CFU) once daily for 30 days
BEHAVIORAL	Motivational Interviewing	Participants will receive one counseling session at baseline via video call, lasting up to 30 minutes
OTHER	Placebo	Participants will receive a standard placebo designed to resemble the probiotic once daily for 30 days

Timeline

• Start date: 2026-02-26
• Primary completion: 2027-04-30
• Completion: 2027-04-30
• First posted: 2026-02-17
• Last updated: 2026-03-04

Locations

1 site across 1 country: United States