| Recruiting | Effects of Urolithin A Supplementation on Glucose Metabolism in Healthy Adults 55 >= Years Old: A Randomized T Healthy Volunteer | N/A | 2026-04-22 |
| Recruiting | Amyloid PET Imaging in the Baltimore Longitudinal Study of Aging Aging | — | 2026-04-22 |
| Recruiting | Pediatric Neuroimaging Neurogimaging | — | 2025-04-21 |
| Completed | Deprescribing Potentially Inappropriate Medications in the Emergency Department for Persons Living With Dement Dementia | N/A | 2024-07-09 |
| Recruiting | Measuring Protein Turnover in Humans Across the Lifespan by Metabolic Labeling With Deuterium Oxide Healthy Volunteers | — | 2024-06-26 |
| Completed | Ketone Ester Effects on Biomarkers of Brain Metabolism and Cognitive Performance in Cognitively Intact Adults Metabolic Syndrome, Normal Cognition | N/A | 2021-06-24 |
| Active Not Recruiting | A Clinical Observational Study of SARS-CoV-2 Specific CD8 T-Cell Responses to COVID-19 Vaccines in Humans COVID-19 | — | 2021-04-20 |
| Active Not Recruiting | Identification and Characterization of SARS-CoV-2 Specific CD8 T Cells in Humans COVID-19 | — | 2020-09-22 |
| Unknown | On Site Sensors Monitoring Impacts of Cognitive Decline on ADLs Dementia, Dementia Alzheimers | — | 2020-09-14 |
| Recruiting | Collection of Bone Marrow Aspirate From Normal Volunteers Normal Aging | — | 2019-05-08 |
| Completed | Sodium-glucose Co Transporter 2 (sGLT2) Inhibitor and Endogenous Ketone Production Empaglifozin, Physiological Effects of Drugs, Hypoglycemic Agents | Phase 1 | 2019-03-28 |
| Recruiting | Taste Bud-Derived Stem Cells in Humans Diabetes | — | 2017-12-18 |
| Completed | Study of Skin Cells That Stop Replicating (Senescent) During Wound Healing Healthy Volunteers | — | 2016-06-30 |
| Terminated | Resveratrol and Cardiovascular Health in the Elderly Vascular Resistance, Hypertension | Phase 1 / Phase 2 | 2015-07-14 |
| Completed | Intermittent Calorie Restriction, Insulin Resistance, and Biomarkers of Brain Function Alzheimer's Disease, Obesity, Diabetes Mellitus | N/A | 2015-06-22 |
| Recruiting | Genetic and Epigenetic Signatures of Translational Aging Laboratory Testing (GESTALT) Healthy Volunteers, Non-Healthy/Non-Frail, Frail | — | 2015-03-15 |
| Completed | The Role of Phosphodiesterase Inhibitors in Incretin Secretion Healthy Volunteers | Phase 1 | 2015-02-13 |
| Recruiting | Baltimore Longitudinal Study of Aging Aging | — | 2014-02-03 |
| Completed | Bisnorcymserine in Healthy Adult Volunteers Healthy Volunteers | Phase 1 | 2013-01-29 |
| Completed | Calcium Channel Splice Variant Expression in Cardiovascular Disease and Aging Atherosclerosis | — | 2012-08-01 |
| Completed | Mechanisms Accounting for Unexplained Anemia in the Elderly Anemia | Phase 1 | 2012-03-29 |
| Completed | The Role of Endocannabinoids in Insulin Production and Action Healthy Volunteers | Phase 1 | 2012-01-05 |
| Terminated | Age-Related Changes in Body Composition Hypertension, Atherosclerosis | — | 2012-01-02 |
| Completed | Initial Study of Fenoterol as a Treatment for Heart Failure Congestive Heart Failure | Phase 1 | 2011-07-10 |
| Completed | CARDIA Brain MRI Substudy Brain Aging, Obesity, Diabetes | — | 2010-12-22 |
| Terminated | A Pilot Clinical Trial of Exendin-4 in Alzheimer's Disease Alzheimer's Disease, Mild Cognitive Impairment | Phase 2 | 2010-11-21 |
| Terminated | Muscle Biopsies in Healthy Volunteers Sarcopenia, Frailty, Aging | N/A | 2010-05-17 |
| Unknown | Amyloid Plaque and Tangle Imaging in Alzheimer's Disease and Down Syndrome Down Syndrome, Alzheimer's Disease | — | 2009-08-01 |
| Active Not Recruiting | Healthy Aging in Neighborhoods of Diversity Across the Life Span (HANDLS) Diabetes, Cerebrovascular Disease, Age-Associated Decline | — | 2009-07-01 |
| Unknown | Glucose Metabolic, Amyloid, and Tau Brain Imaging in Down Syndrome and Dementia Down Syndrome, Alzheimer's Disease | — | 2009-07-01 |
| Completed | Safety and Tolerability of the Derma Vax(Trademark) Clinical Intradermal Electroporation System in Healthy Sub Intradermal Electroporation | Phase 1 | 2009-06-25 |
| Unknown | Marinobufagenin as a Target for DIGIBIND in Hypertensive Patients With End-stage Renal Disease Hypertension, Hemodialysis | Phase 4 | 2009-04-01 |
| Completed | The Relationship Between Uric Acid and Inflammatory Markers Healthy Volunteers | Phase 1 | 2009-03-31 |
| Unknown | Prosocial Behavior and Exercise Among Older Adults Health-Related Quality of Life, Physical Activity, Physical Function | N/A | 2008-12-01 |
| Recruiting | Development of 3T Magnetic Resonance Research Methods for NIA Studies Normal Physiology | — | 2008-11-03 |
| Unknown | Implications of Amyloid Pathology Alzheimer's Disease | — | 2008-11-01 |
| Terminated | Androgen Deprivation Therapy Study Hypogonadism, Metabolic Syndrome, Diabetes | — | 2008-10-01 |
| Terminated | AMS Study: Inflammatory and Biomechanical Contributors to Arthritis Development Following Arthroscopic Menisce Osteoarthritis | — | 2008-05-01 |
| Terminated | A Prospective Study of Postpartum Depression in Women With Major Depression Postpartum Depression | — | 2007-11-09 |
| Completed | Improving Depression Treatment for Older Minority Adults Depression | N/A | 2007-02-01 |
| Completed | Exercise, Executive Processes and the Aging Brain Cognition, Aging | Phase 3 | 2006-12-01 |
| Unknown | Effects of Chronic Sleep Restriction in Young and Older People Aging, Sleep Deprivation, Metabolic Syndrome | N/A | 2006-12-01 |
| Completed | Growth Hormone Administration and the Human Immune System Healthy Volunteers | Phase 1 | 2006-10-19 |
| Completed | Marinobufagenin as a Target for DIGIBIND in Preeclampsia Preeclampsia | — | 2006-08-16 |
| Unknown | Treatment Routes for Exploring Agitation Dementia, Behavior Problems | N/A | 2006-06-01 |
| Suspended | Light Exposure to Treat Sleep Disruption in Older People Sleep Initiation and Maintenance Disorders, Circadian Rhythm Sleep Disorders, Hypersomnia | N/A | 2006-06-01 |
| Completed | Proximity Alarms to Reduce Patient Falls Aging | N/A | 2006-05-01 |
| Unknown | Evolution of Memory Related Activity Alzheimer's Disease, Mild Cognitive Impairment | — | 2006-05-01 |
| Completed | Breathe: Slow Paced Breathing to Lower Blood Pressure High Blood Pressure | N/A | 2006-04-01 |
| Unknown | Noise-Enhanced Sensory Function in Elders at Risk for Falls Aging, Somatosensory Deficit | N/A | 2006-04-01 |
| Completed | An Intervention to Increase Physical Activity Among African American Women Sedentary Lifestyle, Inactivity | N/A | 2006-04-01 |
| Terminated | Etiology of Anemia Anemia | — | 2006-01-01 |
| Completed | Anti-Oxidant Treatment of Alzheimer's Disease Alzheimer's Disease | Phase 1 | 2006-01-01 |
| Unknown | BONSAI: Biomarkers of Nonsteroidal Anti-Inflammatories Alzheimer's Disease | Phase 1 | 2005-10-01 |
| Unknown | Effect of a PPAR-Alpha Agonist on the Age Related Changes in Myocardial Metabolism and Mechanical Function Cardiovascular Diseases | N/A | 2005-10-01 |
| Completed | REVEAL: Reduction of Infarct Expansion and Ventricular Remodeling With Erythropoietin After Large Myocardial I Acute ST Elevation Myocardial Infarction | Phase 2 | 2005-09-01 |
| Completed | Caminemos! Trial to Increase Walking Among Sedentary Older Latinos Aging, Sedentary Lifestyle | N/A | 2005-09-01 |
| Completed | Memory Imaging of Normal Aging Alzheimer's Disease | — | 2005-08-01 |
| Completed | A Study of the Function of Hormones Present In Taste Buds Diabetes, Obesity, Pre-Diabetes | — | 2005-05-26 |
| Completed | Osteopuncture for Osteoarthritis-Associated Knee Pain & Disability Osteoarthritis | Phase 2 | 2004-10-01 |
| Completed | Alzheimer's Caregiver Communication Study Alzheimer's Disease | — | 2004-10-01 |
| Completed | Memory Aid for Informed Consent in Alzheimer's Research Alzheimer's Disease, Aging | N/A | 2004-09-01 |
| Completed | Serum, Dietary and Supplemental Vitamin D's Association With Cognitive Decline Cognitive Decline, Cognitive Impairment | — | 2004-08-18 |
| Completed | Vitamin D-related Genes and Metabolic Disorders Metabolic Syndrome, Obesity, Central Obesity | — | 2004-08-18 |
| Terminated | Idiopathic Anemia of Aging (IAA) Anemia, Aging | Phase 2 | 2004-08-01 |
| Completed | Comparison of an Easy to Read Advance Directive Versus a Standard Advance Directive Aging | N/A | 2004-08-01 |
| Completed | Sleepiness and the Risk of Falling Aging, Balance, Sleep | N/A | 2004-08-01 |
| Completed | Bryostatin 1 and Rituximab in Treating Patients With B-Cell Non-Hodgkin's Lymphoma or Chronic Lymphocytic Leuk Leukemia, Lymphoma | Phase 2 | 2004-07-01 |
| Terminated | Vascular Aging: The Link That Bridges Age to Atherosclerosis (The VALIDATE Study) Atherosclerosis, Cardiovascular Disease, Vascular Diseases | — | 2004-06-22 |
| Completed | Age, Lifestyle, Muscle Mechanisms in Insulin Resistance Obesity, Glucose Intolerance, Exercise Capacity | N/A | 2004-06-01 |
| Unknown | PET Changes in Alzheimer's Disease (AD) Alzheimer Disease | — | 2004-05-01 |
| Completed | The LIFE Study: Lifestyle Interventions and Independence for Elders, Pilot Physically Challenged, Aging | Phase 1 / Phase 2 | 2004-04-01 |
| Unknown | Effects of Age and Exercise on Blood Pressure Regulation Cardiovascular Disease, Aging | — | 2004-04-01 |
| Completed | Huperzine A in Alzheimer's Disease Alzheimer Disease | Phase 2 | 2004-04-01 |
| Completed | Effects of Aromatase Inhibition Versus Testosterone in Older Men With Low Testosterone: Randomized-Controlled Hypogonadism, Diabetes, Sarcopenia | Phase 2 | 2004-03-01 |
| Completed | Fast Food Study: Assessment of the Effects of Fast-Food on Inflammatory Markers Heart Diseases, Diabetes, Obesity | — | 2004-03-01 |
| Completed | Hormone Replacement Therapy (HRT) Website Tool Communication, Menopause, Hormone Replacement Therapy | Phase 2 | 2004-03-01 |
| Completed | The Effects of Metformin on Blood Vessel Structure and Function Obesity, Hypertension, Hypercholesterolemia | Phase 2 | 2004-01-01 |
| Completed | Genetics and Epidemiology of Aging Associated Conditions in the Sardinian Population Heart Disease, Physical Frailty, Exaggerated Personality Traits | — | 2003-11-19 |
| Completed | ABC Trial: Awakening and Breathing Controlled Aging, Respiration, Artificial | N/A | 2003-10-01 |
| Completed | Lymphoma Follow-up Lymphoma | — | 2003-10-01 |
| Unknown | Exercise Adherence Among Older Adults With Osteoarthritis Osteoarthritis | N/A | 2003-10-01 |
| Unknown | Nicotine Treatment of Mild Cognitive Impairment (MCI) Age-Related Memory Disorders | Phase 1 | 2003-09-01 |
| Unknown | Predictors of Cognitive Decline in Normal Aging Alzheimer Disease, Dementia | — | 2003-09-01 |
| Unknown | Obstructive Sleep Apnea (OSA) and Metabolic Syndrome: Role of Oxidative Stress Obstructive Sleep Apnea, Metabolic Syndrome X | N/A | 2003-09-01 |
| Completed | Effects of Hormonal Infertility Treatment on Cognition in Pre-Menopausal Women Infertility | — | 2003-09-01 |
| Unknown | Effects of Exercise on Endothelial Function in Stroke Patients Stroke, Cerebrovascular Disorders | N/A | 2003-08-01 |
| Recruiting | Genetic Characterization of Movement Disorders and Dementias Dementia, Movement Disorder | — | 2003-07-14 |
| Completed | The TLC2 (Teaching Healthy Lifestyles to Caregivers 2)/CALM (Counseling Advice for Lifestyle Management) Study Health Behavior, Psychological Stress, Healthy | Phase 2 | 2003-07-01 |
| Recruiting | Tissue Procurement for Biomedical Research Normal Volunteers | — | 2003-06-26 |
| Completed | Forearm Vascular Relaxation Healthy | — | 2003-05-01 |
| Completed | Risk Evaluation and Education for Alzheimer's Disease (REVEAL) II Alzheimer Disease | — | 2003-05-01 |
| Unknown | Biomarkers and Early Alzheimer's Disease Alzheimer's Disease | — | 2003-04-01 |
| Completed | Early Markers of Cognitive Change and Alzheimer s Disease Alzheimer's Disease | — | 2003-03-19 |
| Completed | The Genetic Characterization of Dementia Dementia | — | 2003-03-14 |
| Terminated | Early Markers of Alzheimer's Disease: Structural and Functional Brain Changes Alzheimer's Disease | — | 2003-03-10 |
| Completed | Analysis of Atropine and Propranolol Induced Changes Healthy | Phase 1 | 2003-03-01 |
| Completed | Salt Study: Inhibited Breathing Pattern and Sodium Inhibitors in Sodium Sensitivity of Blood Pressure Hypertension | — | 2003-03-01 |
| Completed | Screening Protocol to Evaluate Volunteers for NIA Approved Studies Volunteers | — | 2003-02-28 |
| Completed | GIP: Glucose-dependent Insulinotropic Peptide Type 2 Diabetes | Phase 1 | 2003-02-01 |
| Completed | Research on Aging Project in Iceland: Second Stage Atherosclerosis, Osteoporosis, Obesity | — | 2003-01-31 |
| Completed | The InChianti Follow-Up Study Aging, Decrease in Ambulation | — | 2003-01-31 |
| Recruiting | Cytapheresis of Volunteer Donors Healthy Volunteers | — | 2003-01-30 |
| Completed | Studies of Heritable Disorders of Connective Tissue Ehlers-Danlos Syndrome, Stickler Syndrome, Marfan Syndrome | — | 2003-01-21 |
| Terminated | Osteoarthritis and Body Composition: Evaluation of Systematic Mediators Knee Osteoarthritis | — | 2003-01-01 |
| Completed | VITAL - VITamins to Slow ALzheimer's Disease (Homocysteine Study) Alzheimer's Disease | Phase 3 | 2003-01-01 |
| Completed | Cholesterol Lowering Agent to Slow Progression (CLASP) of Alzheimer's Disease Study Alzheimer Disease | Phase 3 | 2002-12-01 |
| Completed | Dietary Energy Restriction and Metabolic Aging in Humans Obesity | N/A | 2002-11-01 |
| Completed | HORMA: Hormonal Regulators of Muscle and Metabolism in Aging Sarcopenia, Muscle Weakness, Frailty | Phase 2 | 2002-09-01 |
| Completed | MIRAGE: Multi-Institutional Research in Alzheimer's Genetic Epidemiology Alzheimer's Disease | — | 2002-09-01 |
| Completed | Effects of Dehydroepiandrosterone (DHEA) in Humans Aging | Phase 3 | 2002-09-01 |
| Completed | The Immune Function Intervention Trial Immune Response | N/A | 2002-08-01 |
| Completed | Treatment of Agitation/Psychosis in Dementia/Parkinsonism (TAP/DAP) Dementia, Parkinson Disease | Phase 4 | 2002-07-01 |
| Completed | Collection of Bone Marrow Aspirate From Volunteer Donors Aging | — | 2002-07-01 |
| Completed | Race, Menopause and Metabolism After Exercise and Diet Obesity, Insulin Resistance, Sedentary Lifestyle | N/A | 2002-03-01 |
| Completed | CALERIE (PBRC, Baton Rouge) - Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy Aging, Cardiovascular Disease, Diabetes Mellitus | N/A | 2002-03-01 |
| Completed | CALERIE (Tufts) - Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy Aging | Phase 1 | 2002-03-01 |
| Completed | CALERIE (Washington University): Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy Aging | Phase 1 | 2002-03-01 |
| Completed | GRACE: Geriatric Resources for Assessment and Care of Elders Functional Decline, Aging | N/A | 2002-03-01 |
| Completed | Pioglitazone in Alzheimer Disease Alzheimer Disease | Phase 2 | 2002-01-01 |
| Completed | Work and Iron Status Evaluation Aging | N/A | 2002-01-01 |
| Completed | Testosterone Effects on Bone and Frailty Aging, Frailty, Osteoporosis | Phase 4 | 2001-11-01 |
| Completed | Effect of Vitamin K on Age-Related Bone Loss and Vascular Calcification Osteoporosis, Vascular Calcification, Inflammation | Phase 3 | 2001-10-01 |
| Completed | The HIP Impact Protection Program (HIP PRO) Hip Fractures | N/A | 2001-09-01 |
| Completed | A Comparison of Weighted Vest Exercise and Strength Training Mobility Limitations, Aging | Phase 3 | 2001-07-01 |
| Completed | Shingles: Immune Effects of Tai Chi Aging, Herpes Zoster | Phase 2 | 2001-07-01 |
| Completed | Biologic Effects of Dehydroepiandrosterone (DHEA) in Humans Aging, Obesity, Insulin Resistance | N/A | 2001-06-01 |
| Completed | Osteoarthritis: Weakness From Inflammation Osteoarthritis | — | 2001-04-01 |
| Completed | PPV: Pneumococcal Polysaccharide Vaccine in Older Adults Aging | Phase 4 | 2001-04-01 |
| Completed | SeniorWISE: Improving Everyday Memory in At-Risk Elderly Aging | Phase 3 | 2001-03-01 |
| Completed | BVAIT: B-Vitamin Atherosclerosis Intervention Trial Atherosclerosis | Phase 2 / Phase 3 | 2000-11-01 |
| Completed | PACT: Providers and Alzheimer's Caregivers Together Alzheimer's Disease, Dementia | N/A | 2000-10-01 |
| Completed | Problem Solving/Physical Interventions and Aging Aging | Phase 3 | 2000-09-01 |
| Completed | Brain Imaging and Mental Disorders of Aging Intervention Cognition Disorders | Phase 4 | 2000-09-01 |
| Completed | Biological Effects of Dehydroepiandrosterone (DHEA) in the Elderly Healthy | N/A | 2000-08-01 |
| Completed | Exercise for Elderly Peripheral Revascularized Patients Peripheral Artery Disease, Intermittent Claudication | N/A | 2000-07-01 |
| Completed | Alternative Therapies for Menopause: A Randomized Trial Menopause, Hot Flashes | N/A | 2000-07-01 |
| Completed | A Trial to Reduce Delirium in Aged Post Acute Patients Delirium, Aging | Phase 3 | 2000-05-01 |
| Completed | Obesity Prevention After Smoking Cessation in Menopause Obesity, Menopause | N/A | 2000-03-01 |
| Completed | AFTER: Altering Fat Through Estrogen and Raloxifene Postmenopause | Phase 2 | 2000-03-01 |
| Completed | A Trial of Tap Water Treatment in the Elderly Diarrhea, Gastrointestinal Diseases | N/A | 2000-01-01 |
| Completed | Homeostatic Sleep Regulation in Older Persons Healthy, Aging | N/A | 1999-09-01 |
| Completed | Bryostatin 1 and Interleukin-2 in Treating Patients With Refractory Solid Tumors or Lymphoma Lymphoma, Small Intestine Cancer, Unspecified Adult Solid Tumor, Protocol Specific | Phase 1 | 1999-09-01 |
| Completed | The CHAT (Community Health Advice by Telephone) Study Health Behavior, Healthy | Phase 2 | 1999-06-01 |
| Completed | Memory Impairment Study (Mild Cognitive Impairment Study) Alzheimer Disease | Phase 3 | 1999-03-01 |
| Completed | Metabolic Syndrome, Inflammation, and Risk of Cognitive Decline Cognitive Decline | — | 1997-01-01 |
| Completed | VEAPS: Vitamin E Atherosclerosis Prevention Study Atherosclerosis | Phase 2 / Phase 3 | 1996-07-01 |
| Completed | Estrogen Hormone Protocol Alzheimer Disease | Phase 3 | 1995-10-01 |
| Completed | EPAT: Estrogen in the Prevention of Atherosclerosis Trial Atherosclerosis, Postmenopause | Phase 2 / Phase 3 | 1994-04-01 |
| Completed | Exercise Rehabilitation of Younger and Older People With Claudication Intermittent Claudication | N/A | 1994-02-01 |
| Completed | A Multicenter Trial of Rofecoxib and Naproxen in Alzheimer's Disease (NSAID Study) Alzheimer Disease | Phase 2 / Phase 3 | — |
| Terminated | The Effects of Sex Hormones on Cognition and Mood in Older Adults Cognition Disorders, Mood Disorders | N/A | — |
| Completed | Multicenter Trial of Prednisone in Alzheimer's Disease Alzheimer Disease | Phase 3 | — |
| Completed | Agitation in Alzheimer's Disease Alzheimer Disease | Phase 3 | — |
| Completed | Healthy Aging and Memory Study Alzheimer Disease | — | — |
| Completed | AIT-082 Phase 1B Study Memory Disorders | Phase 1 | — |
| Completed | Study of Melatonin: Sleep Problems in Alzheimer's Disease Alzheimer Disease, Dyssomnias | Phase 3 | — |
| Completed | Alzheimer's Disease Prevention Trial Alzheimer Disease, Memory Disorders | Phase 3 | — |
| Completed | Effectiveness of A Nutritional Brain Metabolic Enhancer for Alzheimer Disease Alzheimer Disease | Phase 2 | — |