NCT00315575

Memory Imaging of Normal Aging

BOLD and Perfusion fMRI of Alzheimer's Disease Risk

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 90 (estimated)
• Sponsor: National Institute on Aging (NIA) · NIH
• Sex: All
• Age: 25 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to develop imaging techniques that can distinguish functional brain changes in people at high risk for dementia years prior to onset of clinical memory problems from those with normal changes of aging.

Detailed description

The overall goals of this project are to identify consistent patterns of variance in brain function in patients at risk for Alzheimer's Disease by using APOE ε4 as a marker for disease risk. The activation Blood Oxygen Level Dependency (BOLD) signal will be compared to both resting and activation perfusion signals to assess the variability of cerebral blood flow as it relates to the BOLD signal. Each participant will be imaged on a 3T MRI scanner while performing an associate episodic memory task. A total of 90 individuals will be recruited for this study. Participants will be non-demented, right handed, adults with or without at least one APOE ε4 allele. Groups will be split as follows: A) ages 25-39: non-ε4 (n=15); B) ages 25-39: +ε4 (n=15); C) ages 40-49: non-ε4 (n=15); D) ages 40-49: +ε4 (n=15);.E) ages 50-65: non-ε4: F) ages 50-65: +ε4 (n=15). These groups will be matched for mean age, mean years of education, gender distribution, as well as the presence or absence of a family history of AD in a first degree relative. There will be 2 scanning sessions for each participant. Scan session #1 and Scan session #2 will be acquired within 2 weeks of each other and will take approximately one hour each.

Conditions

• Alzheimer's Disease

Interventions

Type	Name	Description
PROCEDURE	BOLD and Perfusion brain MRI	Blood oxygenation and perfusion functional MRI performed twice, two weeks apart; each scan lasts 1 hour

Timeline

• Start date: 2005-08-01
• Primary completion: 2008-07-01
• Completion: 2008-07-01
• First posted: 2006-04-18
• Last updated: 2009-01-26

Locations

1 site across 1 country: United States