NCT00000175

The Effects of Sex Hormones on Cognition and Mood in Older Adults

• Status: Terminated
• Phase: N/A
• Study type: Interventional
• Enrollment: —
• Sponsor: National Institute on Aging (NIA) · NIH
• Sex: All
• Age: 65 Years – 90 Years
• Healthy volunteers: Accepted

Summary

This study is investigating the effects of hormone replacement therapy on memory, mental abilities and mood in older adults aged 65-90. During the nine month long study, men will take testosterone for three months and women will take estrogen for three months. At four points during the study (once every three months), participants will complete a test battery and have blood drawn.

Detailed description

Double-blind, placebo-controlled, crossover study investigating the effects of estrogen replacement and testosterone replacement on cognition and mood in older adults. Women who have not had a hysterectomy will be given Prempro (estrogen with progesterone to protect the uterine lining), and hysterectomized women will be given Premarin (estrogen only).

Conditions

• Cognition Disorders
• Mood Disorders

Interventions

Type	Name	Description
DRUG	Estrogen
DRUG	Testosterone

Timeline

• Primary completion: 2005-06-01
• Completion: 2005-06-01
• First posted: 1999-11-01
• Last updated: 2009-12-11

Locations

1 site across 1 country: United States