NCT00099151

CALERIE (PBRC, Baton Rouge) - Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy

Metabolic Adaptations to Six Month Caloric Restriction

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 48 (planned)
• Sponsor: National Institute on Aging (NIA) · NIH
• Sex: All
• Age: 25 Years – 50 Years
• Healthy volunteers: Accepted

Summary

This study is one of three CALERIE trials that test the hypothesis that a reduced calorie, nutritionally sound diet improves biomarkers of aging and prevents some age-related chronic diseases such as cancer, diabetes, and cardiovascular disease. The three sites that are participating in the CALERIE trial represent a diversity of subject populations and interventional strategies.

Detailed description

This study tests whether chronic caloric restriction improves risk factors of longevity in humans as it is known to do in animals, by measuring a variety of factors dealing with metabolism and oxidative stress, through physical evaluations and laboratory tests. Participants will receive dietary counseling and free medical evaluations. In addition, each volunteer will be asked to do one of the following: 1. Follow a reduced calorie diet 2. Follow a reduced calorie diet using a liquid diet 3. Increase physical activity while on a reduced calorie diet 4. Follow a standard diet. Three separate five-day inpatient stays are required.

Conditions

• Aging
• Cardiovascular Disease
• Diabetes Mellitus

Interventions

Type	Name	Description
BEHAVIORAL	Caloric Restriction (CR)
BEHAVIORAL	Exercise

Timeline

• Start date: 2002-03-01
• Primary completion: 2006-05-01
• Completion: 2006-05-01
• First posted: 2004-12-09
• Last updated: 2009-12-11

Locations

1 site across 1 country: United States