NCT00099099

CALERIE (Tufts) - Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy

Dietary Energy Restriction and Metabolic Aging in Humans

• Status: Completed
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 44 (planned)
• Sponsor: National Institute on Aging (NIA) · NIH
• Sex: All
• Age: 25 Years – 50 Years
• Healthy volunteers: Accepted

Summary

This study is one of three CALERIE trials that test the hypothesis that a reduced calorie, nutritionally sound diet increases the length of life and prevents some age-related chronic diseases such as cancer, diabetes, and cardiovascular disease. The three sites that are participating in the CALERIE trial represent a diversity of subject populations and interventional strategies.

Detailed description

Researchers at the Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University are enrolling overweight men and women aged 20-42 in a 1-year study to develop an effective calorie restricted regimen that minimizes hunger and prevents weight regain. The study also examines the effects of weight loss on body composition, metabolism and aging. Two different diets containing usual foods and a healthy balance of nutrients will be tested at 2 levels of caloric restriction, 10% and 30% (in other words, 90% or 70% of what one would normally eat). Weight loss is expected for most volunteers participating in this study, but cannot be guaranteed.

Conditions

• Aging

Interventions

Type	Name	Description
BEHAVIORAL	Caloric Restriction (CR)

Timeline

• Start date: 2002-03-01
• Primary completion: 2004-12-01
• Completion: 2004-12-01
• First posted: 2004-12-09
• Last updated: 2009-12-11

Locations

1 site across 1 country: United States