NCT06556706

Impact of Urolithin A (Mitopure) on Mitochondrial Quality in Muscle of Frail Older Adults

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 26 (actual)
• Sponsor: Amazentis SA · Industry
• Sex: All
• Age: 65 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

The study is a single-center, randomized, placebo-control double-blind study in frail older adults over 65yrs. to investigate the impact of Mitopure (Urolithin A) supplementation on muscle mitochondrial quality in frail older adults after 8-weeks of supplementation

Conditions

• Frailty
• Sarcopenia
• Aging
• Muscle Atrophy

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Mitopure (Urolithin A)	UA is produced by the gut microbiome following the digestion of dietary precursors (polyphenols such as ellagitannins and punicalagins) present in fruits and nuts such as pomegranate, nuts and berries. In mouse models of aging and muscle dystrophy, UA was shown to induce mitophagy and mitochondrial function in the skeletal muscle. This was associated with improved muscle strength and endurance (Nat. Med, 2016; Sci Tran Med, 2021). In humans, UA was shown to be safe and bioavailable in multiple clinical studies (Nat. Met, 2019; Cell Rep Med, 2022; JAMA Network Open, 2022).
DIETARY_SUPPLEMENT	Placebo	Placebo containing excipients other than Urolithin A (Mitopure)

Timeline

• Start date: 2024-08-15
• Primary completion: 2025-04-25
• Completion: 2025-04-25
• First posted: 2024-08-16
• Last updated: 2025-05-28

Locations

1 site across 1 country: Canada