| Not Yet Recruiting | Frailty Improvement Through Technology With Informal Caregiver Supported Exercise (FITWISE) for Pre-frail and NCT07519642 | National University of Singapore | N/A |
| Suspended | Perioperative Prehabilitation on Markers of Fitness and Frailty in Patients Undergoing Elective Surgery NCT05977556 | University of Alberta | Phase 1 |
| Not Yet Recruiting | Longitudinal Tracking and Intervention Platform for Medicare Advantage Patients NCT04658160 | Stanford University | N/A |
| Not Yet Recruiting | Exercise-based Frailty Intervention in Lung Transplantation (XFIT) NCT06960421 | University of California, San Francisco | N/A |
| Not Yet Recruiting | Tele-Rehabilitation in Adults With Cystic Fibrosis NCT07500493 | King Saud University | N/A |
| Not Yet Recruiting | Multicomponent Exercise and Virtual Reality for Older Adults NCT07529743 | European University Miguel de Cervantes | N/A |
| Not Yet Recruiting | Orthopedic Procedures and Postoperative Delirium in Older Adults in the Czech Republic NCT07432009 | Tomas Bata Hospital, Czech Republic | — |
| Not Yet Recruiting | Prehab and Creatine/Whey Supplementation in Frailty Among Patients With Cirrhosis NCT07029243 | University of California, San Francisco | N/A |
| Not Yet Recruiting | Telehealth-Supported Discharge Programme for Frail Older Adults NCT07490847 | Chinese University of Hong Kong | N/A |
| Not Yet Recruiting | G8 Screening Tool Validation in Older Adults With Cancer in Portugal NCT07487298 | Hospital de Braga | — |
| Recruiting | Frailty and Nottingham Hip Fracture Score for Predicting 90-Day Mortality After Hip Fracture Surgery NCT07481188 | Trakya University | — |
| Not Yet Recruiting | Neuromuscular and Multi-Omics Synergy of Combined Creatine × HMB Supplementation Plus Exercise to Improve Musc NCT07275996 | Universidad de Burgos | N/A |
| Not Yet Recruiting | Comprehensive Geriatric Assessment in Adults Aged 40 Years and Older Living With HIV NCT07453303 | Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital | — |
| Recruiting | Frailty in Older Adults With Chronic Obstructive Pulmonary Disease (COPD) and Outcomes of the VIVIFRAIL Progra NCT07519603 | National Geriatric Hospital | N/A |
| Not Yet Recruiting | Mortality Predictors in Patients 80+ After Major Abdominal Surgery: Role of Frailty and Physiological Reserve NCT07440095 | Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital | — |
| Not Yet Recruiting | Catheter Ablation Plus LAAO Versus Anticoagulation in Frail Elderly Patients With Atrial Fibrillation NCT07441382 | Guangdong Provincial People's Hospital | N/A |
| Not Yet Recruiting | Association Between Geriatric Frailty and Medication Related Problems in the Emergency Department to Help Clin NCT07282379 | Pharmacie des Hopitaux de l'Est Lemanique | — |
| Not Yet Recruiting | Preoperative Oral Nutrition And Outcomes In Frail Elderly Patients With Femur Fractures NCT07463352 | Duzce University | — |
| Not Yet Recruiting | Chronic and Acute Cardiovascular Diseases in Elderly Intensive Care Patients NCT07385482 | Heinrich-Heine University, Duesseldorf | — |
| Not Yet Recruiting | AI-Enabled Frailty Risk Prediction in Adult Congenital Heart Disease NCT07479654 | Mackay Memorial Hospital | N/A |
| Not Yet Recruiting | Benefits of Strength Training in Informal Caregivers of Patients With Alzheimer's Disease NCT07388186 | University of Salamanca | N/A |
| Not Yet Recruiting | Digital Pathway to Healthy Aging: Sarcopenia-Frailty Integrated Training NCT07345832 | The University of Hong Kong | N/A |
| Recruiting | Nicotinamide Mononucleotide Supplementation for Exercise Tolerance Improvement in Healthy Older Adults NCT07144527 | Scott Silveira | N/A |
| Recruiting | Multicomponent Exercise Program on Physical Function, Cognition and Falls Risk Among Older Adults Living in Nu NCT07392944 | Universidade do Porto | N/A |
| Not Yet Recruiting | Physiotherapy Interventions on Functional Capacity, Balance and Mental Domains in Community-Dwelling Older Adu NCT07424274 | Aveiro University | N/A |
| Not Yet Recruiting | Older Kidney Patient Optimisation Pretransplant NCT07419945 | Guy's and St Thomas' NHS Foundation Trust | N/A |
| Not Yet Recruiting | Integrating Vaccination Into Hospital Care Pathways for Vulnerable Patients NCT07391046 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | — |
| Recruiting | Ultrasound Indicators of Nutritional Status and Treatment Outcomes in Surgical Patients in the Intensive Care NCT07475767 | Osijek University Hospital | — |
| Not Yet Recruiting | BandPass: A Remote Monitoring System for Sarcopenia and Functional Decline Phase II Aim 4 NCT07421648 | SynchroHealth LLC | N/A |
| Recruiting | Supporting Uptake of Evidence for Physical Activity in Older Adults With Complex Health Care Needs NCT06894914 | University of British Columbia | N/A |
| Not Yet Recruiting | Predicting of Frailty NCT07332052 | ali ihsan uysal | — |
| Not Yet Recruiting | Comprehensive Geriatric Assessment in Primary Care NCT07341061 | Nova Scotia Health Authority | N/A |
| Recruiting | A Randomized Controlled Trial Comparing Whole Body Vibration Therapy With Usual Care and Usual Care to Improve NCT07205133 | Changi General Hospital | N/A |
| Not Yet Recruiting | Virtual Reality-Based vs Traditional Physiotherapy for Balance, Frailty, and Fall Prevention in Adults Aged 45 NCT07322861 | Umm Al-Qura University | N/A |
| Not Yet Recruiting | FreeFrail Project: A Multicomponent Intervention for the Management of Frailty in Primary Care: A Randomized C NCT07205016 | Universitat de Lleida | N/A |
| Not Yet Recruiting | Elderly Health Profile in a Rural Village of Assiut NCT07263087 | Assiut University | — |
| Not Yet Recruiting | Patient-centered REhabilitation Program to Advance REcovery NCT07189000 | Korea University Anam Hospital | N/A |
| Completed | Exercise and Gezaixi Interventions on Community-Dwelling Older Adults NCT07302568 | National Taipei University of Nursing and Health Sciences | N/A |
| Active Not Recruiting | Improving Physical Ability and Cellular Senescence Elimination in HIV NCT07144293 | National Institute of Allergy and Infectious Diseases (NIAID) | Phase 2 |
| Recruiting | ICOPE Program Feasibility in the Management of Myeloma Patients NCT06247189 | University Hospital, Toulouse | N/A |
| Not Yet Recruiting | Prospective Observational Cohort Study on Impact of Frailty on Risk Prediction, Treatment Strategies, and Shor NCT07190274 | Assiut University | — |
| Recruiting | The Impact of Frailty on Cardiopulmonary Resuscitation Adverse Outcomes in Patients Requiring Code Blue Activa NCT06405581 | Umraniye Education and Research Hospital | — |
| Recruiting | MultidISciplinary Care paThway tailoRed on frAilty in Cancer Patients Referred to Outpatient paLliative Care NCT07469761 | Augusto Caraceni | N/A |
| Not Yet Recruiting | Effect of a Multicomponent Therapeutic Exercise Program in Primary Care on Frailty and Sarcopenia in Older Adu NCT07132632 | Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina | N/A |
| Not Yet Recruiting | Role of Frailty in Bleeding Risk Prediction in Acute Coronary Syndrome NCT07158788 | Assiut University | — |
| Not Yet Recruiting | Feasibility of a Multidisciplinary Student-Led Program to Improve Frailty in Nursing Home Residents NCT07182747 | Universidad de Almeria | N/A |
| Not Yet Recruiting | Impact of Frailty on Nalbuphine Dose for Postoperative Analgesia in Elderly Patients Undergoing Laparoscopic G NCT06953570 | Yongtao Sun | — |
| Recruiting | Plant-based Diets and Healthy Aging NCT07151365 | National Health Research Institutes, Taiwan | — |
| Recruiting | Effects of Polyphenol Supplementation and Exercise on Physical Performance in Older Adults NCT07441343 | Dr. Chris McGlory, PhD | N/A |
| Not Yet Recruiting | Frailty and Health-related Quality of Life in Older Women With Breast Carcinoma NCT07159321 | Ain Shams University | — |
| Not Yet Recruiting | Effect of Music Activities on Depression and Sleep Quality in Frail Older Adults NCT07049445 | National Chung Hsing University | N/A |
| Completed | Relationship Between Frailty and Gut Microbiota in Older Adults: An Educational Program for Healthy Aging NCT07251322 | University of Cadiz | — |
| Recruiting | Healthy Older Adults Through Movement and Engagement NCT07136168 | Linkoeping University | N/A |
| Not Yet Recruiting | Home-based Empowerment Through Physical Exercise Assisted by Technology for Frail Patients NCT07118761 | University Hospital of Ferrara | N/A |
| Recruiting | Taining Golden Lake Comprehensive Chronic Disease Management Initiative NCT07308314 | First Affiliated Hospital of Fujian Medical University | — |
| Active Not Recruiting | Healthy Ageing: a Feasibility Study to Evaluate Digitally-enabled Ways to Support Healthy Ageing NCT07112352 | Imperial College London | Phase 2 |
| Recruiting | A High Protein Egg White Pudding for People With Kidney Failure (HiPE KF) NCT06343727 | Seven Oaks Hospital Chronic Disease Innovation Centre | N/A |
| Recruiting | Auricular Acupressure in Prehabilitation NCT06516198 | University of Chicago | N/A |
| Recruiting | Frailty Among Renal Transplant Recipients and Relation to Chronic Allograft Dysfunction NCT07181096 | Alexandria University | N/A |
| Recruiting | Tesamorelin as an Adjunct to Exercise for Improving Physical Function in HIV NCT06554717 | Massachusetts General Hospital | Phase 2 |
| Recruiting | Personalized Health Coaching for Patients With HF NCT07111585 | Gachon University Gil Medical Center | N/A |
| Recruiting | The Relationship Between Preoperative Frailty and Postoperative AKI and the Mediating Effect of Intraoperative NCT07030179 | Lanyue Zhu | — |
| Completed | Dual-task Training for Frail Older Adults With Chronic Musculoskeletal Pain (Pilot) NCT07035327 | The Hong Kong Polytechnic University | N/A |
| Not Yet Recruiting | The Effect of Nature and Game Based Activities on Older People NCT06609408 | Ondokuz Mayıs University | N/A |
| Not Yet Recruiting | BalL Exercises tO Prevent FrAilty in OldeR ADults (LEOPARD) NCT07023328 | American University of Beirut Medical Center | N/A |
| Recruiting | Precision Stratification for Frailty and Cognitive Decline NCT07081282 | National University of Singapore | N/A |
| Recruiting | Frailty and Muscle Strength Tests in Older Adults Undergoing Major Surgery NCT06988176 | University of North Carolina, Chapel Hill | — |
| Not Yet Recruiting | The VIP3 (Very Old Intensive Care Patients) Study: Family Involvement in Treatment Decisions for Old ICU Patie NCT07035951 | St George's, University of London | — |
| Recruiting | Cognitive-Motor Exergame Training in Frail Adults NCT07074639 | Eleftheria Giannouli | N/A |
| Recruiting | Cognitive Groove (Brought to You by GERAS DANCE) NCT06870149 | McMaster University | N/A |
| Recruiting | Urinary Infection and Colonization in Bone Procedures NCT06896643 | Tomas Bata Hospital, Czech Republic | — |
| Active Not Recruiting | Sustainable Exercise and Nutrition Programs for Managing Metabolic Disorders in Older Women NCT07015307 | University of Alicante | N/A |
| Completed | The Effect of Hemsball in the Older People NCT07344662 | Selcuk University | N/A |
| Recruiting | Patient-centered Personalized Cardiac Rehabilitation in Post Acute Coronary Syndrome (BREAK-trial) NCT07038265 | Institut d'Investigació Biomèdica de Bellvitge | N/A |
| Recruiting | Strength-based Tailored-Exercise Program at Home for Geriatric Patients NCT06820021 | The University of Hong Kong | N/A |
| Completed | Effectiveness of Graded Training in the Vivifrail Exercise Program Among Long-Term Care Residents NCT06975449 | China Medical University Hospital | N/A |
| Recruiting | Dose Adjusted Chemoradiotherapy in HPV-Associated Oropharynx Cancer of the Elderly NCT06309225 | Omar Mahmoud | N/A |
| Recruiting | Preventing Falls in Older Adults With Cognitive Frailty NCT06854731 | University of British Columbia | N/A |
| Not Yet Recruiting | Project ICOPE Brazil: Assessment of Intrinsic Capacity in Brazilian Older Adults NCT06968702 | University of Sao Paulo | — |
| Completed | Cognitive and Physical Frailty as Predictors of Decision Satisfaction in Geriatric Gynecologic Oncology NCT07085000 | Izmir City Hospital | — |
| Not Yet Recruiting | Impact of Sleep Disorders and Digital Support on Older People's Health NCT06944600 | University of Parma | — |
| Not Yet Recruiting | Safety and Efficacy of Isomyosamine in Reducing Inflammation and Treating Muscle Loss in Older Adults After Hi NCT06942182 | TNF Pharmaceuticals, Inc. | Phase 2 |
| Not Yet Recruiting | Comparison of Preoperative Frailty Assessment Tools NCT06889545 | Universitätsklinikum Hamburg-Eppendorf | — |
| Not Yet Recruiting | Systemic Activation of Inflammasomes and Frailty in Older Candidates to Kidney Transplantation NCT06887075 | University Hospital, Bordeaux | N/A |
| Recruiting | Visual Frailty in Ageing NCT06604104 | University of Edinburgh | — |
| Recruiting | Implementation of Decade of Healthy Ageing Action Plan to Screen and Prevent Decline in Intrinsic Capacity in NCT07525583 | National University Hospital, Singapore | — |
| Recruiting | Optimised Post-discharge Care in Older Patients After Surgery for Colon Cancer (ERAS 3.0) NCT06802991 | Copenhagen University Hospital at Herlev | N/A |
| Recruiting | Measuring Ultrasound Guided Skeletal Muscle Mass of Lower Extremity as a Predictor of Post-Operative Length of NCT06816836 | Tata Medical Center | — |
| Recruiting | Prehabilitation for Kidney Transplant Candidates NCT06886256 | The Methodist Hospital Research Institute | N/A |
| Enrolling By Invitation | Targeted Prehabilitation With Physical Exercise and Inspiratory Muscle Training for Elderly Frail Patients Pri NCT06874413 | Prisma Health-Upstate | N/A |
| Completed | Frailty Score and Postoperative Morbidity in Colorectal Cancer Surgery NCT06866678 | Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital | — |
| Not Yet Recruiting | An Intrinsic Capacity Identification and Management Programme for Older Adults in Singapore's Primary Care NCT06753643 | Geriatric Education and Research Institute | — |
| Completed | Predictive Ability of Different Frailty Indices for Postoperative Infections in Elderly Patients NCT06985771 | Chinese PLA General Hospital | — |
| Recruiting | South Korean Study to Prevent Frailty and Aging-related Diseases Through Lifestyle Intervention NCT06891573 | Seong Hye Choi, MD | N/A |
| Recruiting | Inpatient Post-Acute Rehabilitation For Patients in the Midwest: a Prospective Cohort Study of Clinical Charac NCT07351526 | University of Limerick | — |
| Recruiting | SEDentary Lifestyle, Mortality and Major Adverse Clinical Outcomes in Chronic KIDney Disease NCT06935786 | Turku University Hospital | N/A |
| Recruiting | Cognitive Impact Associated With Surgery For Gastric Or Esophageal Cancer NCT06687291 | Karolinska Institutet | — |
| Recruiting | A Prospective Cohort Study of Clinical and Process Outcomes of Older Adults That Transition Through the Geriat NCT07237334 | University of Limerick | — |
| Recruiting | The Effect of Pectin Supplementation on Geriatric With Frailty: A Randomised Placebo-Controlled Dietary Interv NCT06955975 | University of Nottingham | N/A |
| Recruiting | Effects of a Multidisciplinary Intervention on Fall Risk and Urinary Incontinence in Older Women NCT06839040 | Fundación Universidad Católica de Valencia San Vicente Mártir | N/A |
| Recruiting | ASSIST 2.0: a Reablement Program for Healthy Ageing NCT06749080 | Aileen Bergström | N/A |
| Not Yet Recruiting | ASSESSMENT of FRAILTY AS a PROGNOSTIC FACTOR for MORTALITY, DISABILITY, and QUALITY of LIFE AFTER ICU ADMISSIO NCT06793462 | Hospital Universitari Vall d'Hebron Research Institute | — |
| Not Yet Recruiting | The Impact of a Home-Based Walking Exercise Program on Heart Failure NCT06791967 | National Taiwan University Hospital | N/A |
| Recruiting | Evaluation of the Impact of Interventional Treatments for Symptomatic, Severe Tricuspid Valve Insufficiency on NCT07464106 | Robert Bosch Medical Center | — |
| Completed | ED50 of Remimazolam for Anesthesia Induction in Frail Elderly Patients NCT07467603 | The First Hospital of Hebei Medical University | N/A |
| Recruiting | The VICTORY Trial: Virtual, Innovative, Postsurgical Care To Optimize Return Home for Older People With frailt NCT06503198 | Ottawa Hospital Research Institute | N/A |
| Completed | Evaluation of Prioritized Assessment for Older Patients Living With Frailty Presenting to the Emergency Depart NCT06869148 | University Hospital, Linkoeping | — |
| Not Yet Recruiting | Frailty and Spinal Anesthesia-Induced Hypotension in Elderly NCT06757439 | Selcuk University | — |
| Recruiting | Managing Frailty Through Mobilization in Males and Female Inpatients with Cardiovascular Disease NCT06810661 | Université de Sherbrooke | N/A |
| Recruiting | The NADage Study: Nicotinamide Riboside Replenishment Therapy Against Functional Decline in Aging NCT06208527 | Haukeland University Hospital | Phase 2 |
| Not Yet Recruiting | Investigating the Combined Effects of Protein, Blueberries, and Exercise on Cardiovascular Health and Frailty NCT06693271 | Nova Scotia Health Authority | N/A |
| Not Yet Recruiting | A Study of Human Allogeneic Bone-marrow-derived Mesenchymal Stromal Cell Product (StromaForte) in Patients Wit NCT06070532 | Cellcolabs Clinical LTD. | Phase 1 / Phase 2 |
| Completed | Study of the Validity and Reliability of Two Digital Dynamometers in Older People NCT06623019 | University of Salamanca | — |
| Not Yet Recruiting | Effects of Intermittent Hypoxia-Hyperoxia in Older Adults NCT06686316 | Sierra Varona SL | N/A |
| Recruiting | Body Composition, Frailty, and Function in Rehabilitation NCT06527742 | Changi General Hospital | — |
| Recruiting | Multicomponent Prehabilitation in Older Adults With Breast Cancer NCT07531836 | Fundacion Miguel Servet | N/A |
| Recruiting | Implementation of the Personalized Care Plan (PCP) Proposed at the End of Step 2 of the ICOPE Program NCT07379099 | MSPU de Pins-Justaret | — |
| Unknown | Establishing Video Decision Aids for Geriatric Patients With Frailty to Promote Advance Care Planning NCT06708494 | National Taiwan University Hospital | — |
| Not Yet Recruiting | Comparative Analysis of Sarcopenia in Rehabilitation Outcomes Following Femoral Neck Fracture: a Study in Norm NCT06705166 | Shmuel Harofeh Hospital, Geriatric Medical Center | — |
| Not Yet Recruiting | Effect of an Oral Frailty Measures Intervention Programs in Institutionalized Elders NCT06536985 | Hangzhou Normal University | N/A |
| Recruiting | A Service-Learning Program for Comprehensive Geriatric Assessment and Health Promotion in Older Adults NCT06890325 | University of Vic - Central University of Catalonia | N/A |
| Completed | Exploring the User Experience of CGA-Q NCT06646575 | Guy's and St Thomas' NHS Foundation Trust | — |
| Recruiting | Virtual Home-based Physical Pre-habilitation in Kidney Transplant Candidates NCT06089473 | McGill University Health Centre/Research Institute of the McGill University Health Centre | N/A |
| Recruiting | Geriatric Assessment at Discharge From the Intensive Care Unit in Patients Aged 75 Years and Older: a Feasibil NCT06513130 | University Hospital, Strasbourg, France | N/A |
| Recruiting | SCM Muscle as a Marker for Frailty in Patients Undergoing ENT Surgery NCT06704256 | Icahn School of Medicine at Mount Sinai | — |
| Recruiting | Reducing Frailty for Older Cancer Survivors Using Supplements II NCT06068543 | University of Rochester | Phase 2 |
| Recruiting | The Mito-Frail Trial: Effects of MitoQ on Vasodilation, Mobility and Cognitive Performance in Frail Older Adul NCT06027554 | UConn Health | Phase 2 |
| Not Yet Recruiting | Multimedia Education for Frail Patients NCT06579534 | Asia University | N/A |
| Active Not Recruiting | Safety and Impact of Low Resistance Exercise Training on Quality of Life in Pulmonary Arterial Hypertension NCT06543745 | University of Pennsylvania | N/A |
| Unknown | Viability of an Educational Program for Lifestyle Changes and an Algorithm for the Derivation of Exercise Prog NCT05772910 | University of Cadiz | N/A |
| Recruiting | Occupational Therapy and Registered Dietitian Services to Reduce Fall Risk Among Home Delivered Meal Clients NCT06586970 | Ohio State University | N/A |
| Completed | Impact of Urolithin A (Mitopure) on Mitochondrial Quality in Muscle of Frail Older Adults NCT06556706 | Amazentis SA | N/A |
| Recruiting | Vivifrail Program on the Degree of Debilitation in Hospitalized Patients After Venous Hemolysis in Acute Ische NCT06391502 | Affiliated Hospital of Nantong University | N/A |
| Not Yet Recruiting | Ultrasound of the Quadriceps Femoris Compared With the Clinical Frailty Scale NCT06523348 | University Hospital, Toulouse | — |
| Completed | Pilot of Cognitive Stimulation Therapy for Pre-frail Stroke Survivors NCT06733103 | University of East Anglia | N/A |
| Recruiting | The Impact of Geriatric Assessment on the Treatment Plan of Elderly Patients With T2DM NCT06469437 | Hospital de Clinicas de Porto Alegre | N/A |
| Completed | Regional Muscle Balance and Hip Fracture Patterns NCT07443046 | Ankara City Hospital Bilkent | — |
| Recruiting | A Personalized Video-based Exercise Program for Fall Prevention in Frail and Pre-frail Older Adult NCT06363942 | McGill University Health Centre/Research Institute of the McGill University Health Centre | N/A |
| Active Not Recruiting | Novel Respiratory Training as Part of Palliative Care for Older Adults With Heart Failure NCT06576297 | University of Pittsburgh | N/A |
| Recruiting | Precision Medicine in Cardiovascular Surgery Associated Acute Kidney Injury NCT06471621 | Insel Gruppe AG, University Hospital Bern | — |
| Recruiting | Relationship Between Albumin/Creatine Ratio, B12, Folate, and Frailty Index NCT06393647 | Ankara Etlik City Hospital | — |
| Recruiting | Whole Grain Job's Tear, Muscle Health, Blood Glucose and Lipid Level NCT06503172 | Taipei Veterans General Hospital, Taiwan | Phase 2 |
| Recruiting | Frailty in Outpatient Digestive Endoscopy NCT06507527 | Parc de Salut Mar | — |
| Completed | RESTORE-TAVI Pilot NCT06121921 | Barts & The London NHS Trust | N/A |
| Active Not Recruiting | Remote Exercise Video Adaptations to Maximize Physical Activity in Childhood Cancer NCT06411704 | St. Jude Children's Research Hospital | — |
| Recruiting | INTEgRated Health CARE for Patients With Frailty and Heart Failure NCT06444321 | Vestre Viken Hospital Trust | N/A |
| Recruiting | Bridging the Gap: Creating a Continuum of Care NCT06368674 | Göteborg University | N/A |
| Not Yet Recruiting | The Effectiveness of a Dual-task Training Program NCT06450119 | Taipei Medical University | N/A |
| Completed | Sarcopenia Predictors in Patients With COPD NCT07509528 | Hacettepe University | — |
| Recruiting | Home-based Psychoeducation for Older Adults With Frailty: A Randomised Controlled Trial NCT06415604 | TAO An | N/A |
| Completed | Association of Urinary Incontinence With Depression, Insomnia, Frailty and Falls in Older Adults NCT06627400 | Kastamonu University | — |
| Unknown | Metabolic Dysregulation as Biomarker of Frailty: Role of the Mitochondrial Dysfunction NCT06433427 | University Hospital of Ferrara | — |
| Recruiting | Effect of Multicomponent Exercises VIVIFRAIL® in Older Adults NCT06271239 | Pontificia Universidade Católica do Rio Grande do Sul | N/A |
| Recruiting | Nicotinamide Supplementation Improves Physical Performance in Older Adults at Risk of Falls NCT06465602 | University of Chile | Phase 2 |
| Unknown | Effect of Infections and Global DNA Methylation on Frailty Trajectories in Hospitalized Older Patients (INFRAG NCT06430073 | University Hospital of Ferrara | — |
| Active Not Recruiting | The PREPARE for Cancer Surgery Study NCT06503185 | Ottawa Hospital Research Institute | — |
| Recruiting | Exercise Program and Protein Intake Counselling for Frailty Prevention in Singapore NCT06418425 | National Healthcare Group Polyclinics | N/A |
| Enrolling By Invitation | VR for Surgical Prehabilitation and Rehabilitation NCT06334380 | Stanford University | N/A |
| Recruiting | Get Fit for Function NCT06359652 | University of Chicago | N/A |
| Recruiting | Improving Quality of Life in Older Patients With Frailty and Hematological Cancer Through Geriatric Assessment NCT06373471 | Odense University Hospital | N/A |
| Recruiting | A Partnered Evaluation to Improve the Identification and Management of Functional Impairment and Frailty Among NCT06404970 | VA Office of Research and Development | N/A |
| Completed | Effects of Exergames and Resistance Training NCT05920577 | Hong Kong Metropolitan University | N/A |
| Recruiting | Non-pharmacological Prevention of POD in Frailty Elderly Undergoing Elective Surgery Applied by Nursing Teams NCT05993754 | Pontificia Universidad Catolica de Chile | N/A |
| Unknown | Intrinsic Capacity and Functional Ability Monitoring With an Integrated Data Eco-System for Healthy Ageing. NCT06270979 | Prof. Ivan Bautmans | — |
| Completed | The 'Outdoor Rehab-Fit' App-based Physical Activity Education Intervention for Frail Older Adults in Hong Kong NCT06326710 | The Hong Kong Polytechnic University | N/A |
| Not Yet Recruiting | Trajectory of Frailty and Cognitive Dysfunction in Older Adults NCT06276166 | Zheng Li | — |
| Recruiting | A Study of the Association Between Frailty and Acute Postoperative Pain in Elderly Thoracoscopic Surgery Patie NCT06281275 | Huazhong University of Science and Technology | — |
| Active Not Recruiting | Effects of the Combined Intervention of Exercise, Fruit, and Vitamin Supplementation on Frailty in Older Adult NCT06225271 | Nanjing Medical University | N/A |
| Recruiting | Age-related Conditions in the Context of Multimorbidity and Frailty: Relative Weight of Frailty in Determining NCT06324149 | IRCCS San Raffaele | — |
| Recruiting | Autonomous At Home with Occupational Therapy Support and Assistive Devices NCT06819982 | Université Catholique de Louvain | N/A |
| Active Not Recruiting | Protocol for Inpatient Nursing Frailty Assessment (INFA) NCT06469723 | Tan Tock Seng Hospital | N/A |
| Recruiting | Frailty in the Perioperative Period NCT05893342 | Dr. Negrin University Hospital | — |
| Completed | Turkish Validity and Reliability of the Social Frailty Index NCT06288789 | Pamukkale University | N/A |
| Recruiting | I4F: Isla for Frailty Feasibility Study NCT06504641 | Imperial College London | — |
| Recruiting | Effect of Home-based Training Program for Kidney Transplant Recipients (HOMETRAIN-KTR) NCT06379009 | Oslo University Hospital | N/A |
| Not Yet Recruiting | Digital Home-Based Prehabilitation Before Surgery NCT06231576 | Vestre Viken Hospital Trust | N/A |
| Enrolling By Invitation | Slow Gait Speed as an Indicator of Overweight, Dynapenic Obesity and Sarcopenic Obesity in Elderly People in t NCT06413030 | University of Americas | — |
| Unknown | Smart Taiko-Drum Playing for Older Adults With Cognitive Frailty NCT06115889 | The Hong Kong Polytechnic University | N/A |
| Unknown | PATH Program for for Severely Frail or Cognitively Impaired Patients Scheduled for Cancer Surgery. NCT06022666 | Nova Scotia Health Authority | N/A |
| Recruiting | High Intensity Interval Training (HIIT) to Reduce Frailty and Enhance Resilience in Older Veterans NCT05625204 | VA Office of Research and Development | N/A |
| Active Not Recruiting | Towards Understanding Between ADT Treatment, Circadian Rhythm, and Physiological Responsiveness NCT05968144 | University of Maryland, Baltimore | Phase 1 / Phase 2 |
| Recruiting | Exercise Engagement in People Over 60 at Risk of Falls NCT06100445 | East Lancashire Hospitals NHS Trust | — |
| Active Not Recruiting | Risk-Based Geriatric Assessment-Driven Management in Older Patients Starting Chemotherapy NCT07485634 | The University of Hong Kong | N/A |
| Completed | A Study of the Correlation Between the Debilitating State of the Elderly and Propofol Sensitivity NCT06870357 | Second Hospital of Shanxi Medical University | EARLY_Phase 1 |
| Active Not Recruiting | The Impact of Domiciliary Versus 'Hub' Based Comprehensive Geriatric Assessment on Clinical and Process Outcom NCT06205238 | University of Limerick | N/A |
| Completed | Frailty Scales for Predicting Chemotherapy Toxicity in Older Adults With Gastrointestinal Cancers NCT07184047 | Ankara Etlik City Hospital | — |
| Recruiting | Incidence of Residual Neuromuscular Blockade in Fraility in OncoGynae Surgery NCT06216002 | Mahidol University | N/A |
| Unknown | Advers Events in Patients Undergoing Gastrointestinal Procedural Sedation NCT06044298 | Uludag University | — |
| Completed | Effect of a Multicomponent Exercise Program With Virtual Reality (MEP-VR) vs Standard Approaches on Functional NCT06469554 | Fundacion Miguel Servet | N/A |
| Recruiting | Effectiveness of Physical Exercise of Patients With Chronic Non-communicable Disease NCT06476015 | Fundacion Universitaria Maria Cano | — |
| Active Not Recruiting | The Utility of Treatment With Nasogastric Tube Placement for Small Bowel Obstruction NCT06262815 | Daniel Wilhelms | — |
| Unknown | An Integrated Solution for Sustainable Care for Multimorbid Elderly Patients With Dementia NCT05104593 | Complejo Hospitalario Universitario de Albacete | N/A |
| Unknown | Effects of Preoperative Frailty on Postoperative Recovery NCT06185270 | Seoul National University Hospital | — |
| Unknown | Evaluation of Patients With Diffuse Parenchymal Lung Diseases Regarding Frailty NCT06171425 | Hacettepe University | — |
| Unknown | A Prehabilitation Program for Frail Patients Undergoing Cardiac Surgeries/Procedures NCT06323317 | The University of Hong Kong | N/A |
| Completed | Outcomes That Matter and Questionnaires for Older People With Frailty NCT06099691 | Royal Devon and Exeter NHS Foundation Trust | — |
| Completed | Role of Exercise in Chronic Liver Disease Patients Undergoing Liver Transplantation NCT06163001 | Institute of Liver and Biliary Sciences, India | N/A |
| Recruiting | The Sarcopenia Study NCT05888688 | University of Leicester | — |
| Active Not Recruiting | The Sedentary to Active Rising to Thrive (START) Trial NCT06023680 | Johns Hopkins Bloomberg School of Public Health | N/A |
| Unknown | Prognostic Value of Exhaled Isoprene Levels for Morbidity and Functional Outcome in Cardiosurgical Patients NCT06175429 | University of Rostock | — |
| Completed | Home-based Psychoeducation for Older Adults With Frailty: A Feasibility Trial NCT06415617 | TAO An | N/A |
| Completed | Multimodal Exercise Training to Reduce Frailty in People With Multiple Sclerosis NCT06042244 | University of Kansas Medical Center | N/A |
| Recruiting | Predictors of Emergency Department Use in Frail Patients NCT07259499 | University of Pisa | — |
| Completed | Family-based Frailty Self Management Model and the Effects of the FRAIL-SM Program Among Patients With Heart F NCT05765721 | National Yang Ming Chiao Tung University | N/A |
| Recruiting | Precision Medicine and Physical Function NCT05877846 | University of North Carolina, Chapel Hill | N/A |
| Completed | Assessing the Relationship Between Chronic Pain and Frailty in Older Adults NCT06672003 | Celal Bayar University | — |
| Recruiting | Human/Machine Interface: What the HeartMate 3 ® Device Tells Us About the Future NCT06039176 | International Consortium of Circulatory Assist Clinicians | — |
| Completed | Knowledges and Use of Cannabidiol in Older Adults NCT06094582 | University Hospital, Toulouse | — |
| Recruiting | Expanding the Scope of Post-transplant HLA-specific Antibody Detection and Monitoring in Renal Transplant Reci NCT06025240 | Liverpool University Hospitals NHS Foundation Trust | — |
| Unknown | Complexity and Frailty in Cardiothoracic and Vascular Anesthesia (CAfCA). Prospective Multicentric Observation NCT05968456 | Istituto Clinico Humanitas | — |
| Completed | EEG Characteristics and Postoperative Delirium NCT06102967 | Zhuo Liu | — |
| Completed | AGE SELF CARE: Promoting Healthy Aging Through a Group Visit Program NCT06079762 | Brigham and Women's Hospital | N/A |
| Recruiting | Identifying Modifiable PAtient Centered Therapeutics (IMPACT) Frailty NCT04717869 | University of California, Los Angeles | — |
| Completed | Smart Home Technologies for Assessing and Monitoring Frailty in Older Adults NCT05961319 | University of Alberta | — |
| Completed | Sleep Health Enhancement in Older Adults to Address Frailty NCT05968820 | University of Kansas Medical Center | Phase 1 |
| Unknown | Open Label Study for the Use of Transcranial Ultrasound for Treatment of Age-Related Frailty NCT04770350 | Neurological Associates of West Los Angeles | EARLY_Phase 1 |
| Recruiting | Effects of Physical Exercise on Frailty, Mental and Physical Health of Older Adults in Rural Areas. NCT06556537 | Universidad de Zaragoza | N/A |
| Recruiting | Evaluation of the Clinical Frailty Scale (CFS) as a Risk Factor of Mortality in Adult Patients ≤65 Years of Ag NCT05928767 | Centre Hospitalier de Lens | — |
| Recruiting | Mouth Odor on Preventing Pneumonia by Oral Frailty NCT05987982 | National Cheng-Kung University Hospital | N/A |
| Recruiting | The Beijing Longitudinal Disability Survey in Community Elderly NCT06863727 | Xuanwu Hospital, Beijing | — |
| Unknown | Multimodal Assessment of Frailty in Acute Stroke Patients NCT06031909 | University of Giessen | — |
| Active Not Recruiting | Multivariate Biomarker Study for Sarcopenia in Heart Failure NCT06217640 | University of Liverpool | — |
| Completed | Cognitive Function in Geriatric Colonoscopy Patients NCT07384169 | Ankara City Hospital Bilkent | — |
| Active Not Recruiting | Improving Physical Function in Older Adults Using an Anti-inflammation Drug: The RIGHT Study NCT05727384 | Anne B. Newman | Phase 2 |
| Completed | Investigation of the Effects of Frailty and Sarcopenia on Postoperative Recovery and Complications in Geriatri NCT06889714 | Eskisehir Osmangazi University | — |
| Unknown | Home-based Exercise for Frail Individuals Prior to Cardiac Surgery NCT05834556 | Dr. Todd A Duhamel | N/A |
| Unknown | Comparison of ASA and CFS in Anesthesiology NCT05998746 | Osijek University Hospital | — |
| Unknown | The Effect of Frailty on Blood Biology Indicators, Quality of Life and Survival of Patients With Radical Prost NCT05941104 | Anhui Provincial Hospital | — |
| Recruiting | Effect of an Exercise Program for Frail Older Adults NCT05946109 | Universitair Ziekenhuis Brussel | N/A |
| Recruiting | Tai Chi for Improving Functions of Frail Older Adults NCT05629728 | Chungnam National University | N/A |
| Withdrawn | Long-term Effects of WISE Program Improving Frailty Status and Quality of Life for Adolescents With CHD NCT05533346 | National Yang Ming Chiao Tung University | N/A |
| Completed | Strength Training in Hospitalized Patients Using the Ghostly App: a Feasibility Study NCT05258500 | Vrije Universiteit Brussel | N/A |
| Recruiting | Frailty Assessments for Risk Assessment in Gynecologic Oncology Patients NCT05738252 | Population Health Research Institute | — |
| Recruiting | A Mouth Education Program for Dry Mouth NCT05964959 | Leiden University Medical Center | N/A |
| Completed | Post-acute Multicomponent Frailty Intervention NCT05906446 | Hebrew SeniorLife | N/A |
| Completed | The Effect of Health Promotion Comprehensive Education Intervention on the Frailty Levels of Elderly Family Ca NCT06064227 | Fatma Banu Demirdas | N/A |
| Unknown | HEalthy Aging Team Supported Home-care Services (HEAT-YASAM) NCT05993572 | Gulhane Training and Research Hospital | — |
| Active Not Recruiting | Preparing Older Adults for Major Surgery With Preoperative Comprehensive Geriatric Assessments NCT06184919 | University of Wisconsin, Madison | — |
| Completed | The Oral Symptom Assessment Scale in Older Patients With Frailty NCT06286982 | Our Lady's Hospice and Care Services | — |
| Completed | Pilot Mobile for Dementia and Frailty NCT05827094 | University of Washington | N/A |
| Unknown | Application of Frailty Prevention Care Management Program of Community Elderly Adults NCT05883423 | Chang Gung Memorial Hospital | N/A |
| Terminated | Remote Monitoring to Prevent Frailty Progression in the Elderly NCT05173870 | Neuromed IRCCS | — |
| Completed | Investigation of the Effects of Aerobic Exercise, Balance Exercise and Combined Exercise Practices on Frailty, NCT05839743 | Yuksek Ihtisas University | N/A |
| Completed | VIVIFRAIL Program in Improving the Frailty and Physical Function in the Elderly NCT05935319 | National Taipei University of Nursing and Health Sciences | N/A |
| Recruiting | Assisted Ambulation to Improve Health Outcomes for Older Medical Inpatients NCT05725928 | The Cleveland Clinic | N/A |
| Completed | AI-based Frailty Assessment Tool for Patients Undergoing Cardiac Surgery NCT06096922 | China National Center for Cardiovascular Diseases | — |
| Unknown | Effectiveness of Protein Supplementation on Frailty Improvement, Muscle Strength and Physical Performance Amon NCT05648617 | Universiti Putra Malaysia | EARLY_Phase 1 |
| Recruiting | The "SPARCOL" Study NCT05734300 | Zealand University Hospital | N/A |
| Unknown | Pilot-testing the Effect of Magnetic Mitohormesis Therapy for Treating Frailty in Older Adults NCT05930470 | Auburn University | N/A |
| Recruiting | Preoperative Frailty and Postoperative Neurocognitive Disorders in Geriatric Patients in Georgia NCT06700291 | New Hospitals Georgia | — |
| Recruiting | Effect of Gut Microbiome Intervention on Aging Via Oral FMT NCT05598112 | Chinese Academy of Medical Sciences, Fuwai Hospital | EARLY_Phase 1 |
| Completed | Frailty and Non-Fragile Congenital Heart Disease NCT05824650 | Hacettepe University | — |
| Recruiting | Effectiveness of Integrated Care Combined Nutrition and Lifestyle Counselling in Frail Older Patients With Dia NCT05721599 | Buddhist Tzu Chi General Hospital | N/A |
| Recruiting | Frailty, Hip Fractures and Inflammatory Biomarkers NCT06614478 | University of Thessaly | — |
| Completed | Multi-Component Prehabilitation for Major Elective Surgery NCT05752474 | Beth Israel Deaconess Medical Center | N/A |
| Unknown | E-health Enhanced Motor-cognitive Training for AED Discharged Older Adults With Cognitive Frailty NCT05750121 | The Hong Kong Polytechnic University | N/A |
| Recruiting | Prevention of Disability in the Frail Elderly Person Through an Innovative Customised and Multidimensional Tra NCT06377436 | University of Milan | N/A |
| Unknown | Frailty Assessment in Vascular Hot Clinic Setting - Feasibility and Prognostic Value NCT06040658 | University of Glasgow | — |
| Unknown | Elderly Falls Prevention With sLiFE Program in Primary Care NCT05912088 | Fundacion para la Investigacion y Formacion en Ciencias de la Salud | N/A |
| Completed | Health Determinants in Older Adults Living At Home NCT05837728 | University of Stavanger | — |
| Terminated | Exercise Program for Maintaining Physical Function and Frailty on Dwelling Older Adults NCT05726214 | University of the Basque Country (UPV/EHU) | N/A |
| Unknown | Brief Health Promotion Intervention for Older People in Mental Health NCT06127680 | University College Cork | — |
| Active Not Recruiting | Home Exercise And Resiliency Training (Heart) Club NCT05543733 | University of Michigan | N/A |
| Recruiting | Evaluation of the Walk With Ease Program for Fall Prevention NCT05693025 | Iowa State University | Phase 1 / Phase 2 |
| Completed | Effect of Exercise-education Program PERMANENTO in Late Life NCT06133894 | Charles University, Czech Republic | N/A |
| Unknown | Mapping Sedentary Behaviour in Older Adults Who Are Frail NCT05661058 | Isabel Rodrigues | — |
| Recruiting | Effects of Low-dose Esmolol on Myocardial Injury After Non-cardiac Surgery in Elderly Frail Patients NCT05635877 | Yongtao Sun | Phase 4 |
| Unknown | Validation and Application of a Multi-dimentional Frailty Assessment Tool-Cohort Intervention and Follow up NCT05731167 | National Taiwan University Hospital | N/A |
| Unknown | Secure and Focused Primary Care for Older pEople NCT05706272 | Linkoeping University | N/A |
| Recruiting | FRAGINOC Study: Screening and Geriatric Assessment and Intervention in Older Patients With Epithelial Ovarian NCT05810701 | Odense University Hospital | N/A |
| Active Not Recruiting | Fall, Fracture and Frailty NCT05712252 | Region Skane | — |
| Withdrawn | Mesenchymal Stem Cells for Age-Related Frailty NCT05284604 | VA Office of Research and Development | Phase 1 / Phase 2 |
| Completed | Understanding the Measurement of Girdle Dissociation in the Fall of the Older People Subject. NCT05574309 | Centre Hospitalier Universitaire de Saint Etienne | N/A |
| Unknown | A Holistic Patient-centred Intervention to Improve Outcomes of Older People Living With Frailty and Chronic He NCT06386640 | University of Leicester | — |
| Recruiting | PREhabilitation of Candidates for REnal Transplantation NCT05489432 | University Medical Center Groningen | N/A |
| Terminated | Implementation Study of the ICOPE Program for the Detection of Frailty in the Elderly Within the Territorial H NCT05541731 | University Hospital, Brest | — |
| Active Not Recruiting | Preventing and Approaching Crises for Frail Community-dwelling Patients Through Through Innovative Care (PRACT NCT05651659 | Sykehuset Innlandet HF | N/A |
| Recruiting | Virtual PREHAB Study for Patients Undergoing TAVI NCT05617196 | Nova Scotia Health Authority | N/A |
| Recruiting | Prehabilitation for Ovarian Cancer Patients NCT05364879 | Nova Scotia Health Authority | N/A |
| Completed | A Nurse-led Intervention on Frailty Status of Ethiopian Older Persons NCT05754398 | University of Wollongong | N/A |
| Completed | PRISMA 7 and SARC-F in Predicting Emergency Department Readmission and Mortality NCT06525038 | Firat University | — |
| Completed | Association Between Frailty and Postoperative Adverse Outcomes in Patients Undergoing Urological Surgery NCT05871879 | Taipei Medical University Hospital | — |
| Completed | Combating Hospital-related Function Decline Among Prefrail Older Adults: A Pilot Study NCT06191276 | The University of Hong Kong | N/A |
| Completed | E-health and People Living With Major Neurocognitive Disorder - CARE© and ESOGER© Applications NCT05571553 | Centre integre universitaire de sante et de services sociaux du Centre-Sud-de-l'Île-de-Montréal | N/A |
| Completed | Implementation of ProMuscle in Daily Practice NCT05672004 | UMC Utrecht | N/A |
| Recruiting | Digital Voice Analysis as a Measure of Frailty and Distress NCT05783401 | University Hospital, Basel, Switzerland | — |
| Recruiting | +AGIL Barcelona: Integrated Care for Community-Dwelling Frail Older Adults NCT06836167 | Parc Sanitari Pere Virgili | N/A |
| Unknown | Impact of Hand Grip Strength on Length of Hospital Stay After Cardiac Surgery Among Elderly Patients NCT05546671 | Kartal Kosuyolu High Speciality Training and Research Hospital | — |
| Recruiting | Light in Frail Elderly - the Effect of a Dynamic Light for Sleep and Circadian Rhythm NCT05107947 | Region Skane | N/A |
| Completed | Frail2Fit Study: Online Nutrition and Exercise Support for Older Adults With Frailty NCT05384730 | University Hospital Southampton NHS Foundation Trust | N/A |
| Active Not Recruiting | Voice-Activated Technology to Improve Mobility in Multimorbid, Frail, Homebound Older Adults (EngAGE) NCT05337514 | University of Chicago | N/A |
| Completed | A Technology-based Intervention to Support Older Adults in Living Independently NCT05626556 | Istituto Nazionale di Ricovero e Cura per Anziani | N/A |
| Completed | Home Physiotherapy in Frailty in Patients With Parkinson's Disease NCT05607862 | University of Oviedo | N/A |
| Completed | Blood Flow Restriction and High-intense Resistance Training in Aging: Interactions Between Neuroplasticity and NCT05744167 | Lithuanian Sports University | N/A |
| Recruiting | Investigating the Role of Energy Balance Modification on Health Responses in Chronic Lymphocytic Leukaemia NCT06379282 | University of Surrey | N/A |
| Completed | Synergizing Home Health Rehabilitation Therapy NCT05411393 | University of Florida | N/A |
| Unknown | Comprehensive Geriatric Assessment in the Elderly Subjects (PROMISING) NCT05822154 | Istituto Nazionale di Ricovero e Cura per Anziani | — |
| Not Yet Recruiting | Heterogeneously Hypofractionated Radiotherapy for Locally Advanced NSCLC NCT05548504 | Odense University Hospital | Phase 2 |
| Completed | Improving Quality of Life in Frail, Older Patients with Hematological Cancer Through Geriatric Assessment and NCT06689332 | Odense University Hospital | N/A |
| Completed | The Effects of Medication Induced Blood Pressure Reduction on Cerebral Hemodynamics in Hypertensive Frail Elde NCT05529147 | Radboud University Medical Center | — |